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Keywords: heparin
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Biochem J (2021) 478 (5): 1009–1021.
Published: 04 March 2021
... impact chemokine monomer/dimer levels, chemotactic and haptotactic gradients, life time, and presentation for receptor binding. Here, we show that Cxcl1 and Cxcl2 also form heterodimers. Using a disulfide-trapped Cxcl1–Cxcl2 heterodimer, we characterized its binding to free heparin using nuclear magnetic...
Includes: Supplementary data
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Biochem J (2017) 474 (7): 1093–1107.
Published: 08 March 2017
... to interact with heparin and heparan sulfate (HS). Structural studies of DAN family members Gremlin-1 and Gremlin-2 (Grem2) have revealed a dimeric growth factor-like fold where a series of lysine residues cluster along one face of the protein. In the present study, we used mutagenesis, heparin-binding...
Includes: Supplementary data
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Biochem J (2016) 473 (15): 2273–2293.
Published: 28 July 2016
... on behalf of the Biochemical Society 2016 allosteric regulation heparin metastability polymerization proteinase inhibition protein folding receptor binding serpin The initial identification of a relationship that would grow into the serpin superfamily of proteins was made in 1980...
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Biochem J (2010) 429 (2): 379–389.
Published: 28 June 2010
... on the enzyme, whereas heparin binds at an additional site and has a strongly stabilizing effect that is unique among human glycosaminoglycans. All glycosaminoglycans stimulate the elastinolytic activity of cathepsin K at physiological plasma pH, but only heparin also increases the collagenolytic activity...
Includes: Supplementary data
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Biochem J (2008) 411 (3): 507–514.
Published: 14 April 2008
... 2789 -Ile-Lys-Arg-Lys 2793 and Val 2817 -Glu-Arg-Lys 2820 , on the mouse laminin α1 G4 domain. ELISAs using synthetic peptides confirmed the involvement of the AG-73 site (2719–2729). This site overlaps extensively with laminin's heparin-binding site, and AChE was observed to compete with heparan...
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Biochem J (2006) 399 (2): 191–198.
Published: 27 September 2006
...Marco Guerrini; Sara Guglieri; Daniela Beccati; Giangiacomo Torri; Christian Viskov; Pierre Mourier The present study deals with the conformation in solution of two heparin octasaccharides containing the pentasaccharide sequence GlcN NAc,6S -GlcA-GlcN NS,3,6S -IdoA 2S -GlcN NS,6S [AGA*IA; where...
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Biochem J (2005) 391 (1): 51–57.
Published: 26 September 2005
... cells are activated. In the present study, we report that ADA2 is a heparin-binding protein. This allowed us to obtain a highly purified enzyme and to study its biochemistry. ADA2 was identified as a member of a new class of ADGFs (ADA-related growth factors), which is present in almost all organisms...
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Biochem J (2005) 391 (1): 125–134.
Published: 26 September 2005
... at inflammatory foci. 1 To whom correspondence should be addressed (email m.davies@hri.org.au ). 18 4 2005 1 6 2005 3 6 2005 3 6 2005 The Biochemical Society, London 2005 glycosaminoglycan heparan sulphate heparin hypochlorite myeloperoxidase oxidation...
Includes: Supplementary data
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Biochem J (2004) 382 (3): 933–943.
Published: 07 September 2004
...Hironobu YAMASHITA; Akira GOTO; Tatsuhiko KADOWAKI; Yasuo KITAGAWA We have previously shown that the LG4 (laminin G-like) domain of the laminin α4 chain is responsible for the significantly higher affinity of the α4 chain to heparin than found for other α chains [Yamaguchi, Yamashita, Mori, Okazaki...
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Biochem J (2003) 372 (2): 371–380.
Published: 01 June 2003
... Society, London ©2003 2003 antithrombin glycosaminoglycan glucosaminyl 6-O-sulphotransferase heparan sulphate heparin O-sulphation Abbreviations used: aMan R , 2,5-anhydro- d -mannitol (formed by reduction of terminal 2,5-anhydromannose residues using NaBH 4 ); AT, antithrombin; HS...
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Biochem J (2002) 368 (1): 81–90.
Published: 15 November 2002
..., hyaluronic acid, and heparin. rPrP binding to GAGs occurs via the N-terminus, a region known to bind divalent cations. Additionally, rPrP binding to GAGs is enhanced in the presence of Cu 2+ and Zn 2+ , but not Ca 2+ and Mn 2+ . rPrP binds heparin strongest, and the binding is inhibited by certain heparin...
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Biochem J (2001) 358 (3): 737–745.
Published: 10 September 2001
... for the same site on the surface of HEK-293 cells expressing the CCR2b chemokine receptor. The interaction between either chemokine species and endothelial cell surface GAGs was antagonized by the addition of the heparan sulphate-like molecule, heparin. Both MCP-1 and MCP-1–SEAP induced a Ca 2+ -flux...
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Biochem J (2000) 347 (2): 469–473.
Published: 10 April 2000
... or imidazole, indicating that the imidazole ring is not sufficient for recognition by TSP1. Heparin was a potent inhibitor of binding with a K i of 50 nM, suggesting that the heparin-binding domain of TSP1 may be involved in this interaction. This was confirmed by the ability of a recombinant heparin-binding...
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Biochem J (1999) 344 (3): 723–730.
Published: 08 December 1999
... with a mixture of heparin lyases followed by high-resolution capillary electrophoresis, showed that they differed primarily by degree of sulphation. The most highly sulphated proteoglycan isolated had a disaccharide composition similar to heparan sulphate glycosaminoglycans found in brain tissue. Based...
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Biochem J (1999) 342 (2): 361–368.
Published: 24 August 1999
... heparanase, which cleaves heparan sulphate (HS), an important structural component of the vascular BL. Previously, tumour-derived heparanase activity (which has been shown to be related to the metastatic potential of murine and human melanoma cell lines) was reported to cleave HS and be inhibited by heparin...
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Biochem J (1999) 340 (1): 59–67.
Published: 10 May 1999
... 25 2 1999 The Biochemical Society, London © 1999 1999 heparin protein binding protein structure vesicles Biochem. J. (1999) 340, 59 67 (Printed in Great Britain) 59 Microheterogeneity of beta-2 glycoprotein I : implications for binding to anionic phospholipids Timothy...