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Articles

Structural basis of a chemokine heterodimer binding to glycosaminoglycans

Krishna Mohan Sepuru, Krishna Rajarathnam

Biochem J (2021) 478 (5): 1009–1021.

https://doi.org/10.1042/BCJ20200927

Published: 04 March 2021

... impact chemokine monomer/dimer levels, chemotactic and haptotactic gradients, life time, and presentation for receptor binding. Here, we show that Cxcl1 and Cxcl2 also form heterodimers. Using a disulfide-trapped Cxcl1–Cxcl2 heterodimer, we characterized its binding to free heparin using nuclear magnetic...

View article titled, Structural basis of a chemokine heterodimer binding to glycosaminoglycans

Includes: Supplementary data

Articles

New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Dominic P. Byrne, Yong Li, Krithika Ramakrishnan, Igor L. Barsukov, Edwin A. Yates, Claire E. Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers

Biochem J (2018) 475 (15): 2417–2433.

https://doi.org/10.1042/BCJ20180265

Published: 14 August 2018

... glycan sulfation is based around small-molecule inhibitors of sulfatase-2 (Sulf-2), such as OKN-007 [ 14 ] or heparanase inhibitors and HS mimics, including roneparstat and PG545, which have been employed for basic and clinical investigation [ 15 ]. heparan sulfate heparin inhibitor kinase...

View article titled, New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Includes: Supplementary data

Articles

Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif

Chandramohan Kattamuri, Kristof Nolan, Thomas B. Thompson

Biochem J (2017) 474 (7): 1093–1107.

https://doi.org/10.1042/BCJ20161050

Published: 08 March 2017

... to interact with heparin and heparan sulfate (HS). Structural studies of DAN family members Gremlin-1 and Gremlin-2 (Grem2) have revealed a dimeric growth factor-like fold where a series of lysine residues cluster along one face of the protein. In the present study, we used mutagenesis, heparin-binding...

View article titled, Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif

Includes: Supplementary data

Articles

Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance

Peter G.W. Gettins, Steven T. Olson

Biochem J (2016) 473 (15): 2273–2293.

https://doi.org/10.1042/BCJ20160014

Published: 28 July 2016

.... 1 Correspondence may be addressed to either author (email [email protected] or [email protected] ). 22 1 2016 24 3 2016 31 3 2016 © 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2016 allosteric regulation heparin...

View article titled, Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance

Articles

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

Prem Raj B. Joseph, Philip D. Mosier, Umesh R. Desai, Krishna Rajarathnam

Biochem J (2015) 472 (1): 121–133.

https://doi.org/10.1042/BJ20150059

Published: 30 October 2015

... ligand. To resolve these issues, we characterized the binding of a series of heparin-derived oligosaccharides [heparin disaccharide (dp2), heparin tetrasaccharide (dp4), heparin octasaccharide (dp8) and heparin 14-mer (dp14)] to the wild-type (WT) dimer and a designed monomer using solution NMR...

View article titled, Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

Includes: Supplementary data

Articles

Mapping the heparin-binding site of the BMP antagonist gremlin by site-directed mutagenesis based on predictive modelling

Arnold Junior Tatsinkam, Barbara Mulloy, Christopher C. Rider

Biochem J (2015) 470 (1): 53–64.

https://doi.org/10.1042/BJ20150228

Published: 06 August 2015

... development and is re-expressed during tissue fibrosis. Gremlin binds strongly to heparin and heparan sulfate and, in the present study, we sought to investigate its heparin-binding site. In order to explore a putative non-contiguous binding site predicted by computational molecular modelling, we substituted...

View article titled, Mapping the heparin-binding site of the BMP antagonist gremlin by site-directed mutagenesis based on predictive modelling

Articles

Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices

Nobuaki Higashi, Michihiko Waki, Mayumi Sue, Yusuke Kogane, Hiroaki Shida, Naoki Tsunekawa, Ahasanul Hasan, Takeshi Sato, Ayumi Kitahara, Tatsuhiko Kasaoka, Yoshihiro Hayakawa, Motowo Nakajima, Tatsuro Irimura

Biochem J (2014) 458 (2): 291–299.

https://doi.org/10.1042/BJ20131463

Published: 14 February 2014

...Nobuaki Higashi; Michihiko Waki; Mayumi Sue; Yusuke Kogane; Hiroaki Shida; Naoki Tsunekawa; Ahasanul Hasan; Takeshi Sato; Ayumi Kitahara; Tatsuhiko Kasaoka; Yoshihiro Hayakawa; Motowo Nakajima; Tatsuro Irimura Heparanase cleaves macromolecular heparin in the secretory granules of connective tissue...

View article titled, Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices

Includes: Supplementary data

Articles

An unusual antithrombin-binding heparin octasaccharide with an additional 3-O-sulfated glucosamine in the active pentasaccharide sequence

Marco Guerrini, Stefano Elli, Pierre Mourier, Timothy R. Rudd, Davide Gaudesi, Benito Casu, Christian Boudier, Giangiacomo Torri, Christian Viskov

Biochem J (2013) 449 (2): 343–351.

https://doi.org/10.1042/BJ20121309

Published: 14 December 2012

...Marco Guerrini; Stefano Elli; Pierre Mourier; Timothy R. Rudd; Davide Gaudesi; Benito Casu; Christian Boudier; Giangiacomo Torri; Christian Viskov The 3-O-sulfation of N-sulfated glucosamine is the last event in the biosynthesis of heparin/heparan sulfate, giving rise to the antithrombin-binding...

View article titled, An unusual antithrombin-binding heparin octasaccharide with an additional 3-O-sulfated glucosamine in the active pentasaccharide sequence

Includes: Supplementary data

Articles

Conformational flexibility and allosteric regulation of cathepsin K

Marko Novinec, Lidija Kovačič, Brigita Lenarčič, Antonio Baici

Biochem J (2010) 429 (2): 379–389.

https://doi.org/10.1042/BJ20100337

Published: 28 June 2010

... on the enzyme, whereas heparin binds at an additional site and has a strongly stabilizing effect that is unique among human glycosaminoglycans. All glycosaminoglycans stimulate the elastinolytic activity of cathepsin K at physiological plasma pH, but only heparin also increases the collagenolytic activity...

View article titled, Conformational flexibility and allosteric regulation of cathepsin K

Includes: Supplementary data

Articles

Interaction of acetylcholinesterase with the G4 domain of the laminin α1-chain

Glynis Johnson, Chrisna Swart, Samuel W. Moore

Biochem J (2008) 411 (3): 507–514.

https://doi.org/10.1042/BJ20071404

Published: 14 April 2008

... 2789 -Ile-Lys-Arg-Lys 2793 and Val 2817 -Glu-Arg-Lys 2820 , on the mouse laminin α1 G4 domain. ELISAs using synthetic peptides confirmed the involvement of the AG-73 site (2719–2729). This site overlaps extensively with laminin's heparin-binding site, and AChE was observed to compete with heparan...

View article titled, Interaction of acetylcholinesterase with the G4 domain of the laminin α1-chain

Articles

The major determinant of the heparin binding of glial cell-line-derived neurotrophic factor is near the N-terminus and is dispensable for receptor binding

Ivan Alfano, Parvez Vora, Rosemary S. Mummery, Barbara Mulloy, Christopher C. Rider

Biochem J (2007) 404 (1): 131–140.

https://doi.org/10.1042/BJ20061747

Published: 26 April 2007

...Ivan Alfano; Parvez Vora; Rosemary S. Mummery; Barbara Mulloy; Christopher C. Rider GDNF (glial cell-line-derived neurotrophic factor), and the closely related cytokines artemin and neurturin, bind strongly to heparin. Deletion of a basic amino-acid-rich sequence of 16 residues N-terminal...

View article titled, The major determinant of the heparin binding of glial cell-line-derived neurotrophic factor is near the N-terminus and is dispensable for receptor binding

Articles

Conformational transitions induced in heparin octasaccharides by binding with antithrombin III

Marco Guerrini, Sara Guglieri, Daniela Beccati, Giangiacomo Torri, Christian Viskov, Pierre Mourier

Biochem J (2006) 399 (2): 191–198.

https://doi.org/10.1042/BJ20060656

Published: 27 September 2006

...Marco Guerrini; Sara Guglieri; Daniela Beccati; Giangiacomo Torri; Christian Viskov; Pierre Mourier The present study deals with the conformation in solution of two heparin octasaccharides containing the pentasaccharide sequence GlcN NAc,6S -GlcA-GlcN NS,3,6S -IdoA 2S -GlcN NS,6S [AGA*IA; where...

View article titled, Conformational transitions induced in heparin octasaccharides by binding with antithrombin III

Articles

A positively charged cluster in the epidermal growth factor-like domain of Factor VII-activating protease (FSAP) is essential for polyanion binding

Boran Altincicek, Aya Shibamiya, Heidi Trusheim, Eleni Tzima, Michael Niepmann, Dietmar Linder, Klaus T. Preissner, Sandip M. Kanse

Biochem J (2006) 394 (3): 687–692.

https://doi.org/10.1042/BJ20051563

Published: 24 February 2006

... autoactivation in the presence of polyanionic macromolecules such as heparin and RNA. Competition experiments suggest that RNA and heparin bind to the same or overlapping interaction sites. A proteolysis approach, where FSAP was hydrolysed into smaller fragments, was used to identify the polyanion-binding site...

View article titled, A positively charged cluster in the epidermal growth factor-like domain of Factor VII-activating protease (FSAP) is essential for polyanion binding

Includes: Supplementary data

Articles

Multimers of the fibroblast growth factor (FGF)–FGF receptor–saccharide complex are formed on long oligomers of heparin

Nicholas J. Harmer, Christopher J. Robinson, Lucy E. Adam, Leopold L. Ilag, Carol V. Robinson, John T. Gallagher, Tom L. Blundell

Biochem J (2006) 393 (3): 741–748.

https://doi.org/10.1042/BJ20050985

Published: 13 January 2006

..., multimers of the minimal complex composed of two FGF1 and two FGFR2 protomers can form on a single chain of the co-receptor heparin. Using size-exclusion chromatography, we show that two complexes can form on heparin chains as small as 16 saccharide units. We also show by MS that discrete complexes...

View article titled, Multimers of the fibroblast growth factor (FGF)–FGF receptor–saccharide complex are formed on long oligomers of heparin

Articles

Human ADA2 belongs to a new family of growth factors with adenosine deaminase activity

Andrey V. Zavialov, Åke Engström

Biochem J (2005) 391 (1): 51–57.

https://doi.org/10.1042/BJ20050683

Published: 26 September 2005

... cells are activated. In the present study, we report that ADA2 is a heparin-binding protein. This allowed us to obtain a highly purified enzyme and to study its biochemistry. ADA2 was identified as a member of a new class of ADGFs (ADA-related growth factors), which is present in almost all organisms...

View article titled, Human ADA2 belongs to a new family of growth factors with adenosine deaminase activity

Articles

Oxidation of heparan sulphate by hypochlorite: role of N-chloro derivatives and dichloramine-dependent fragmentation

Martin D. Rees, David I. Pattison, Michael J. Davies

Biochem J (2005) 391 (1): 125–134.

https://doi.org/10.1042/BJ20050630

Published: 26 September 2005

... at inflammatory foci. 1 To whom correspondence should be addressed (email [email protected] ). 18 4 2005 1 6 2005 3 6 2005 3 6 2005 The Biochemical Society, London 2005 glycosaminoglycan heparan sulphate heparin hypochlorite myeloperoxidase oxidation TNB (5...

View article titled, Oxidation of heparan sulphate by hypochlorite: role of N-chloro derivatives and dichloramine-dependent fragmentation

Includes: Supplementary data

Articles

Identification and characterization of photomedins: novel olfactomedin-domain-containing proteins with chondroitin sulphate-E-binding activity

Yutaka Furutani, Ri-ichiroh Manabe, Ko Tsutsui, Tomiko Yamada, Nagisa Sugimoto, Shiro Fukuda, Jun Kawai, Nobuo Sugiura, Koji Kimata, Yoshihide Hayashizaki, Kiyotoshi Sekiguchi

Biochem J (2005) 389 (3): 675–684.

https://doi.org/10.1042/BJ20050120

Published: 26 July 2005

... was selectively expressed in the outer segment of photoreceptor cells and photomedin-2 was expressed in all retinal neurons. Among a panel of ECM components, including glycosaminoglycans, photomedins preferentially bound to chondroitin sulphate-E and heparin. These results, together, indicate that photomedins...

View article titled, Identification and characterization of photomedins: novel olfactomedin-domain-containing proteins with chondroitin sulphate-E-binding activity

Articles

Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1

Ding XU, Vaibhav TIWARI, Guoqing XIA, Christian CLEMENT, Deepak SHUKLA, Jian LIU

Biochem J (2005) 385 (2): 451–459.

https://doi.org/10.1042/BJ20040908

Published: 07 January 2005

... Databases under accession number AY574375. 28 5 2004 21 7 2004 10 8 2004 10 8 2004 The Biochemical Society, London 2005 heparan sulphate heparin herpes simplex virus (HSV) sulphotransferase viral entry Heparan sulphate (HS) is a highly sulphated and unbranched...

View article titled, Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1

Articles

Mammalian and Drosophila cells adhere to the laminin α4 LG4 domain through syndecans, but not glypicans

Hironobu YAMASHITA, Akira GOTO, Tatsuhiko KADOWAKI, Yasuo KITAGAWA

Biochem J (2004) 382 (3): 933–943.

https://doi.org/10.1042/BJ20040558

Published: 07 September 2004

...Hironobu YAMASHITA; Akira GOTO; Tatsuhiko KADOWAKI; Yasuo KITAGAWA We have previously shown that the LG4 (laminin G-like) domain of the laminin α4 chain is responsible for the significantly higher affinity of the α4 chain to heparin than found for other α chains [Yamaguchi, Yamashita, Mori, Okazaki...

View article titled, Mammalian and Drosophila cells adhere to the laminin α4 LG4 domain through syndecans, but not glypicans

Articles

Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1

David BERRY, Zachary SHRIVER, Barbara NATKE, Chi-Pong KWAN, Ganesh VENKATARAMAN, Ram SASISEKHARAN

Biochem J (2003) 373 (1): 241–249.

https://doi.org/10.1042/bj20021760

Published: 01 July 2003

...David BERRY; Zachary SHRIVER; Barbara NATKE; Chi-Pong KWAN; Ganesh VENKATARAMAN; Ram SASISEKHARAN Fibroblast growth factor (FGF) signalling is involved in a wide range of important biological activities with differential effects in various cell types. The activity of FGF is modulated by heparin...

View article titled, Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1

Articles

Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases

Emanuel SMEDS, Hiroko HABUCHI, Anh-Tri DO, Eva HJERTSON, Helena GRUNDBERG, Koji KIMATA, Ulf LINDAHL, Marion KUSCHE-GULLBERG

Biochem J (2003) 372 (2): 371–380.

https://doi.org/10.1042/bj20021666

Published: 01 June 2003

... Society, London ©2003 2003 antithrombin glycosaminoglycan glucosaminyl 6-O-sulphotransferase heparan sulphate heparin O-sulphation Biochem. J. (2003) 372, 371 380 (Printed in Great Britain) 371 Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases Emanuel...

View article titled, Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases

Articles

Cell-surface prion protein interacts with glycosaminoglycans

Tao PAN, Boon-Seng WONG, Tong LIU, Ruliang LI, Robert B. PETERSEN, Man-Sun SY

Biochem J (2002) 368 (1): 81–90.

https://doi.org/10.1042/bj20020773

Published: 15 November 2002

..., hyaluronic acid, and heparin. rPrP binding to GAGs occurs via the N-terminus, a region known to bind divalent cations. Additionally, rPrP binding to GAGs is enhanced in the presence of Cu 2+ and Zn 2+ , but not Ca 2+ and Mn 2+ . rPrP binds heparin strongest, and the binding is inhibited by certain heparin...

View article titled, Cell-surface prion protein interacts with glycosaminoglycans

Articles

Multimerization of monocyte chemoattractant protein-1 is not required for glycosaminoglycan-dependent transendothelial chemotaxis

Simi ALI, Adrian C. V. PALMER, Sarah J. FRITCHLEY, Yvonne MALEY, John A. KIRBY

Biochem J (2001) 358 (3): 737–745.

https://doi.org/10.1042/bj3580737

Published: 10 September 2001

... for the same site on the surface of HEK-293 cells expressing the CCR2b chemokine receptor. The interaction between either chemokine species and endothelial cell surface GAGs was antagonized by the addition of the heparan sulphate-like molecule, heparin. Both MCP-1 and MCP-1–SEAP induced a Ca 2+ -flux...

View article titled, Multimerization of monocyte chemoattractant protein-1 is not required for glycosaminoglycan-dependent transendothelial chemotaxis

Articles

Thrombospondin-1 binds to polyhistidine with high affinity and specificity

Vijay K. VANGURI, Shuxia WANG, Svetlana GODYNA, Sripriya RANGANATHAN, Gene LIAU

Biochem J (2000) 347 (2): 469–473.

https://doi.org/10.1042/bj3470469

Published: 10 April 2000

... or imidazole, indicating that the imidazole ring is not sufficient for recognition by TSP1. Heparin was a potent inhibitor of binding with a K i of 50 nM, suggesting that the heparin-binding domain of TSP1 may be involved in this interaction. This was confirmed by the ability of a recombinant heparin-binding...

View article titled, Thrombospondin-1 binds to polyhistidine with high affinity and specificity

Articles

Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes

Yoshihiko URATANI, Keiko TAKIGUCHI-HAYASHI, Nobuhiko MIYASAKA, Michio SATO, Ming-hao JIN, Yasuyoshi ARIMATSU

Biochem J (2000) 346 (3): 817–826.

https://doi.org/10.1042/bj3460817

Published: 07 March 2000

... released latexin from the granules, suggesting that latexin is non-covalently associated with a heparin-like component of the granules. MCCPA and histamine were released from the mast cells after non-immunological and immunological stimulation with compound 48/80, A23187 and anti-IgE antibody, whereas...

View article titled, Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes

Articles

Purification and characterization of heparan sulphate proteoglycan from bovine brain

Youmie PARK, Guyong YU, Nur Sibel GUNAY, Robert J. LINHARDT

Biochem J (1999) 344 (3): 723–730.

https://doi.org/10.1042/bj3440723

Published: 08 December 1999

... with a mixture of heparin lyases followed by high-resolution capillary electrophoresis, showed that they differed primarily by degree of sulphation. The most highly sulphated proteoglycan isolated had a disaccharide composition similar to heparan sulphate glycosaminoglycans found in brain tissue. Based...

View article titled, Purification and characterization of heparan sulphate proteoglycan from bovine brain

Articles

Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation

Kenneth W. YOUNG, R. A. John CHALLISS, Stefan R. NAHORSKI, John J. MACKRILL

Biochem J (1999) 343 (1): 45–52.

https://doi.org/10.1042/bj3430045

Published: 24 September 1999

...) P 3 and stimulated [ 3 H]Ins P accumulation in the presence of Li + . In contrast, LPA failed to stimulate detectable phosphoinositide turnover. Chronic down-regulation of Ins(1,4,5) P 3 receptor (Ins P 3 R) proteins with MCh did not affect Ca 2+ responses to LPA. In addition, heparin, a competitive...

View article titled, Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation

Articles

Evidence that platelet and tumour heparanases are similar enzymes

Craig FREEMAN, Anna M. BROWNE, Christopher R. PARISH

Biochem J (1999) 342 (2): 361–368.

https://doi.org/10.1042/bj3420361

Published: 24 August 1999

... heparanase, which cleaves heparan sulphate (HS), an important structural component of the vascular BL. Previously, tumour-derived heparanase activity (which has been shown to be related to the metastatic potential of murine and human melanoma cell lines) was reported to cleave HS and be inhibited by heparin...

View article titled, Evidence that platelet and tumour heparanases are similar enzymes

Articles

Microheterogeneity of beta-2 glycoprotein I: implications for binding to anionic phospholipids

Timothy A. BRIGHTON, Yan-Ping DAI, Philip J. HOGG, Colin N. CHESTERMAN

Biochem J (1999) 340 (1): 59–67.

https://doi.org/10.1042/bj3400059

Published: 10 May 1999

... upon phospholipid binding. These results highlight the importance of assessing the determinants of the interaction of β 2 GPI with anionic phospholipids assembled in unilamellar vesicles. heparin protein binding protein structure vesicles 1 To whom correspondence should be addressed (e...

View article titled, Microheterogeneity of beta-2 glycoprotein I: implications for binding to anionic phospholipids

NARROW

Structural basis of a chemokine heterodimer binding to glycosaminoglycans

New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif

Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

Mapping the heparin-binding site of the BMP antagonist gremlin by site-directed mutagenesis based on predictive modelling

Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices

An unusual antithrombin-binding heparin octasaccharide with an additional 3-O-sulfated glucosamine in the active pentasaccharide sequence

Conformational flexibility and allosteric regulation of cathepsin K

Interaction of acetylcholinesterase with the G4 domain of the laminin α1-chain

The major determinant of the heparin binding of glial cell-line-derived neurotrophic factor is near the N-terminus and is dispensable for receptor binding

Conformational transitions induced in heparin octasaccharides by binding with antithrombin III

A positively charged cluster in the epidermal growth factor-like domain of Factor VII-activating protease (FSAP) is essential for polyanion binding

Multimers of the fibroblast growth factor (FGF)–FGF receptor–saccharide complex are formed on long oligomers of heparin

Human ADA2 belongs to a new family of growth factors with adenosine deaminase activity

Oxidation of heparan sulphate by hypochlorite: role of N-chloro derivatives and dichloramine-dependent fragmentation

Identification and characterization of photomedins: novel olfactomedin-domain-containing proteins with chondroitin sulphate-E-binding activity

Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1

Mammalian and Drosophila cells adhere to the laminin α4 LG4 domain through syndecans, but not glypicans

Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1

Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases

Cell-surface prion protein interacts with glycosaminoglycans

Multimerization of monocyte chemoattractant protein-1 is not required for glycosaminoglycan-dependent transendothelial chemotaxis

Thrombospondin-1 binds to polyhistidine with high affinity and specificity

Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes

Purification and characterization of heparan sulphate proteoglycan from bovine brain

Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation

Evidence that platelet and tumour heparanases are similar enzymes

Microheterogeneity of beta-2 glycoprotein I: implications for binding to anionic phospholipids

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