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Keywords: heparin-binding exosite
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Articles
Ixolaris: a Factor Xa heparin-binding exosite inhibitor
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2005) 387 (3): 871–877.
Published: 26 April 2005
... ketone-treated FXa (DEGR-FXa; active-site-blocked FXa), indicating that exosites are involved in the FX(a)–Ixolaris interaction. Here we provide evidence that Ixolaris binds specifically to the FXa HBE (heparin-binding exosite), since (i) it markedly decreases the inhibition of FXa by the antithrombin...
