... instructions. Data are shown as relative luciferase activity by firefly luminescence normalized to the renilla luminescence. c-Jun C7ORF41 hepatic steatosis inflammation NF-κB Nonalcoholic fatty liver disease (NAFLD) is one of the most important causes of liver disease worldwide, which...

... (18:1) increases TAG accumulation in livers of ATF4 −/− mice. Taken together, these results suggest that ATF4 deficiency is protective for HCD-induced hepatic steatosis and impairment of glucose tolerance and insulin sensitivity. Furthermore, the resistance to hepatic steatosis is at least in part due...

..., hyperinsulinaemia, glucose intolerance, hepatic steatosis and obesity. Previous studies have shown that PDHK4 deficiency lowers blood glucose by limiting the supply of three carbon gluconeogenic substrates to the liver. There is concern, however, that the increase in glucose oxidation caused by less inhibition...

... of rapamycin (mTORC1) hepatic steatosis hepatitis B virus (HBV) oxysterol statin steatohepatitis References 1 Nguyen D. H. Ludgate L. Hu J. Hepatitis B virus–cell interactions and pathogenesis J. Cell. Physiol. 2008 216 289 294 2 Kim K. Kim K. H. Kim H. H...

... carcinoma) [ 1 – 3 ]. In addition, CHB (chronic viral hepatitis B) and CHC (chronic viral hepatitis C) are both associated frequently with hepatic steatosis; the frequency of steatosis in CHB ranges from 27 to 51%, whereas in CHC, it is between 31 and 72% [ 4 – 8 ]. Among the four proteins that originate...