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1-31 of 31
Keywords: hepatocyte
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Articles
Hao Liu, Junjie Yu, Tingting Xia, Yuzhong Xiao, Qian Zhang, Bin Liu, Yajie Guo, Jiali Deng, Yalan Deng, Shanghai Chen, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Feifan Guo
Journal:
Biochemical Journal
Biochem J (2014) 464 (2): 281–289.
Published: 14 November 2014
...) for treating insulin resistance and its associated metabolic diseases including Type 2 diabetes. db/db mice extracellular-signal-regulated kinase 1/2 (ERK1/2) glucose hepatocyte insulin signalling liver serum- and glucocorticoid-regulated kinase 1 (SGK1) SGK1 (serum- and glucocorticoid...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 463 (2): 201–213.
Published: 22 September 2014
... conclude that MAL2 and the constitutively active STK16 function to sort secretory soluble cargo into the constitutive secretory pathway at the TGN ( trans -Golgi network) in polarized hepatocytes. 1 Present address: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 458 (1): 95–107.
Published: 20 January 2014
... constitutively active, in hepatocytes CAR is normally held quiescent through a tethering mechanism in the cytosol, anchored to a protein complex that includes several components, including heat-shock protein 90. Release and subsequent nuclear translocation of CAR is triggered through either direct binding...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 454 (2): 267–274.
Published: 09 August 2013
... the mRNA and protein expression of DGKθ in the HepG2 cell line and in primary human hepatocytes. Reporter gene studies using 1.5 kB of the DGKθ promoter fused to the luciferase gene revealed that bile acids increase DGKθ transcriptional activity. Mutation of putative FXR-binding sites attenuated...
Articles
Tomoko Yamazaki, Jun-ichi Suehiro, Hideki Miyazaki, Takashi Minami, Tatsuhiki Kodama, Kohei Miyazono, Tetsuro Watabe
Journal:
Biochemical Journal
Biochem J (2013) 452 (2): 345–357.
Published: 10 May 2013
... units/ml streptomycin and 50 units/ml penicillin (Life Technologies). For HepG2 cells, non-essential amino acids (Life Technologies) and sodium pyruvate were also supplemented. dominant negative hepatocyte nuclear receptor transcriptional repression Cyp7a1 (cytochrome P450, family 7...
Includes: Supplementary data
Articles
Laurent Bultot, Bruno Guigas, Alexander Von Wilamowitz-Moellendorff, Liliane Maisin, Didier Vertommen, Nusrat Hussain, Monique Beullens, Joan J. Guinovart, Marc Foretz, Benoît Viollet, Kei Sakamoto, Louis Hue, Mark H. Rider
Journal:
Biochemical Journal
Biochem J (2012) 443 (1): 193–203.
Published: 14 March 2012
... to enzyme inactivation by decreasing the affinity for both UDP-Glc (UDP-glucose) [assayed in the absence of Glc-6- P (glucose-6-phosphate)] and Glc-6- P (assayed at low UDP-Glc concentrations). Incubation of freshly isolated rat hepatocytes with the pharmacological AMPK activators AICA riboside (5...
Includes: Supplementary data
Articles
Catherine Arden, Susan J. Tudhope, John L. Petrie, Ziad H. Al-Oanzi, Kirsty S. Cullen, Alex J. Lange, Howard C. Towle, Loranne Agius
Journal:
Biochemical Journal
Biochem J (2012) 443 (1): 111–123.
Published: 14 March 2012
...). Allosteric mechanisms involving glucose 6-phosphate or xylulose 5-phosphate and covalent modification of ChREBP (carbohydrate-response element-binding protein) have been implicated in this mechanism. However, evidence supporting an essential role for a specific metabolite or pathway in hepatocytes remains...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 439 (3): 497–504.
Published: 13 October 2011
... © The Authors Journal compilation © 2011 Biochemical Society 2011 apical targeting cholesterol epithelium hepatocyte lipid raft myelin and lymphocyte protein (MAL) Isolation of low-buoyancy membrane fractions was performed as described in [ 24 ]. WIF-B cells were rinsed in ice...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 437 (3): 477–482.
Published: 13 July 2011
...Marie-Laure Island; Nadia Fatih; Patricia Leroyer; Pierre Brissot; Olivier Loreal Hepcidin, a hormone mainly synthesized by hepatocytes and secreted in plasma, controls iron bioavailability. Thus, by inducing the internalization of the iron exporter ferroportin, it regulates iron release from...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 423 (3): 303–314.
Published: 12 October 2009
.... HCV is an enveloped virus bearing two surface glycoproteins, E1 and E2. It only infects humans through blood transmission, and hepatocytes are its only target cells. Hepatic trabeculae are formed by hepatocyte rows surrounded by sinusoid capillaries, irrigating hepatic cells. Hepatocytes are polarized...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 411 (1): 1–18.
Published: 13 March 2008
... of these cells in diseased liver originate from the bone marrow. In addition, fibrogenic fibroblasts may also be generated through liver epithelial (hepatocyte and biliary epithelial cell)–mesenchymal transition. Whatever their origin, it is clear that fibrogenic fibroblast activity is sensitive to (and may...
Articles
Miguel M. Murillo, Irene Carmona-Cuenca, Gaelle del Castillo, Conrad Ortiz, César Roncero, Aránzazu Sánchez, Margarita Fernández, Isabel Fabregat
Journal:
Biochemical Journal
Biochem J (2007) 405 (2): 251–259.
Published: 27 June 2007
...Miguel M. Murillo; Irene Carmona-Cuenca; Gaelle del Castillo; Conrad Ortiz; César Roncero; Aránzazu Sánchez; Margarita Fernández; Isabel Fabregat The TGF-β (transforming growth factor-β) induces survival signals in foetal rat hepatocytes through transactivation of EGFR (epidermal growth factor...
Articles
Bruno Guigas, Nellie Taleux, Marc Foretz, Dominique Detaille, Fabrizio Andreelli, Benoit Viollet, Louis Hue
Journal:
Biochemical Journal
Biochem J (2007) 404 (3): 499–507.
Published: 29 May 2007
... in cell energy homoeostasis. In the present study, we investigated the effects of AICA riboside on mitochondrial oxidative; phosphorylation. AICA riboside was found to dose-dependently inhibit the oligomycin-sensitive J O 2 (oxygen consumption rate) of isolated rat hepatocytes. A decrease in P i...
Includes: Supplementary data
Articles
Amalia Fernández-Martínez, Belén Mollá, Rafael Mayoral, Lisardo Boscá, Marta Casado, Paloma Martín-Sanz
Journal:
Biochemical Journal
Biochem J (2006) 398 (3): 371–380.
Published: 29 August 2006
... 2006 apoptosis cyclo-oxygenase (COX) hepatocyte hydrodynamic transfection liver prostaglandin COX (cyclo-oxygenase) enzymes catalyse the first step in the biosynthesis of PGs (prostaglandins) and thromboxanes [ 1 , 2 ]. The COX-1 isoform is constitutively expressed in many tissues [ 3...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 395 (1): 49–55.
Published: 15 March 2006
... hepatocytes. The intracellular fluorescence was not only quenched by an addition of a highly lipophilic 8-hydroxyquinoline–iron(III) complex but also was dequenched by the addition of an excess of the membrane-permeable iron chelator CP94 (1,2-diethyl-3-hydroxypyridin-4-one). The time course of uptake of iron...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 394 (2): e3.
Published: 10 February 2006
...Frank J. Gonzalez IL-1β (interleukin-1β) treatment of hepatocytes results in an NF-κB (nuclear factor-κB)-mediated activation of the iNOS (induced nitric oxide synthase) gene, and this increase in gene expression is further augmented by oxidative stress. Oxidative stress alone has no influence...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 386 (2): 237–244.
Published: 22 February 2005
...Hamid R. SAMARI; Michael T. N. MØLLER; Lise HOLDEN; Tonje ASMYHR; Per O. SEGLEN Autophagic activity in isolated rat hepatocytes is strongly suppressed by OA (okadaic acid) and other PP (protein phosphatase)-inhibitory toxins as well as by AICAR (5-aminoimidazole-4-carboxamide riboside), a direct...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 385 (1): 207–216.
Published: 14 December 2004
...). Insulin increases the expression of the SREBP-1c gene in intact liver and in hepatocytes cultured in vitro . To learn the mechanism of this stimulation, we analysed the activation of the rat SREBP-1c promoter and its truncated or mutated congeners driving a luciferase reporter gene in transiently...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 385 (1): 165–171.
Published: 14 December 2004
... repeat) proteins. Insulin treatment increased EIIH mRNA levels in the hepatocytes of suckling, fasted adult and STZ (streptozotocin)-treated diabetic rats, where insulin was required to maintain the basal level of EIIH expression. EIIH expression was induced during the suckling/weaning transition...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2004) 380 (1): 203–209.
Published: 15 May 2004
...-oxygenation (H/R)-induced cell death and/or survival, and the underlying mechanisms of any such effects. H/R was shown to induce apoptotic cell death of rat hepatocytes. The addition of a STAT1-specific inhibitor, fludarabine, significantly increased the fraction of apoptotic cells after H/R. Following H/R...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 377 (1): 195–204.
Published: 01 January 2004
... and compartmentation of phosphorylase in hepatocytes. Glucose 6-P levels were modulated in hepatocytes by glucokinase overexpression or inhibition with 5-thioglucose and the effects of AMP were tested using AICAR (5-aminoimidazole-4-carboxamide 1-β- d -ribofuranoside), which is metabolized to an AMP analogue...
Articles
Janne MÄKINEN, Mika REINISALO, Kaisa NIEMI, Pirkko VIITALA, Johanna JYRKKÄRINNE, Hinfan CHUNG, Olavi PELKONEN, Paavo HONKAKOSKI
Journal:
Biochemical Journal
Biochem J (2003) 376 (2): 465–472.
Published: 01 December 2003
... and chlorpromazine. Also, the induction of CYP2B10 mRNA by oestrogens was less pronounced in mouse primary hepatocytes. Yeast two-hybrid assays indicated that, unlike androstenol and the established activators, oestrogens attracted both nuclear receptor co-repressors and co-activators to the mCAR ligand-binding...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 375 (2): 441–447.
Published: 15 October 2003
... Society, London ©2003 2003 adaptive regulation cysteine dioxygenase hepatocyte osmolyte taurine transporter Abbreviations used: CDO, cysteine dioxygenase; CSA, cysteine sulphinic acid; TAUT, taurine transporter; TonE, tonicity-responsive enhancer; TREE, taurine-responsive element...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 354 (3): 531–537.
Published: 08 March 2001
...Thomas KIETZMANN; Yvonne CORNESSE; Katja BRECHTEL; Said MODARESSI; Kurt JUNGERMANN The cDNAs of three hypoxia-inducible factor (HIF) α-subunits were cloned from RNA of primary rat hepatocytes by reverse transcriptase PCR. All three cDNAs encoded functionally active proteins, of 825, 874 and 662...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 352 (3): 929–933.
Published: 08 December 2000
...Charles E. ADKINS; Frank WISSING; Barry V. L. POTTER; Colin W. TAYLOR Adenophostin A, the most potent known agonist of inositol 1,4,5-trisphosphate (Ins P 3 ) receptors, stimulated 45 Ca 2+ release from the intracellular stores of permeabilized hepatocytes. The concentration of adenophostin...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 351 (3): 811–816.
Published: 24 October 2000
...Roger R. GOMIS; Juan C. FERRER; Joan J. GUINOVART We have used recombinant adenoviruses (AdCMV-RLGS and AdCMV-GK) to overexpress the liver isoforms of glycogen synthase (GS) and glucokinase (GK) in primary cultured rat hepatocytes. Glucose activated overexpressed GS in a dose-dependent manner...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 350 (3): 685–692.
Published: 08 September 2000
... are not well known. However, given the central role of the liver in amino acid metabolism, we developed a rat primary hepatocyte model in which homocysteine (and cysteine) production and export were examined. The dependence of homocysteine export from incubated hepatocytes on methionine concentration fitted...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 348 (1): 215–222.
Published: 09 May 2000
... to the cytoplasm after brief perfusion of the liver with a perfusate containing 20 mM glucose [8]. Using isolated hepatocytes, Agius and Peak showed that the fraction of total glucokinase released in soluble form after cell permeabili- zation with low concentrations of digitonin increased after Abbreviations used...
Articles
Roland B. GREGORY, Robert A. WILCOX, Leise A. BERVEN, Nicole C. R. VAN STRATEN, Gijs A. VAN DER MAREL, Jacques H. VAN BOOM, Gregory J. BARRITT
Journal:
Biochemical Journal
Biochem J (1999) 341 (2): 401–408.
Published: 08 July 1999
... the activation of store-operated Ca 2+ channels (SOCs) in isolated rat hepatocytes were investigated. Adenophostin A, a potent agonist at Ins(1,4,5) P 3 receptors, induced ER Ca 2+ release and the activation of Ca 2+ inflow. The concentration of adenophostin A that gave half-maximal stimulation of Ca 2+ inflow...
Articles
Takashi TANAKA, Tetsuya INAZU, Kazuya YAMADA, Zaw MYINT, Vincent W. KENG, Yoshiko INOUE, Naoyuki TANIGUCHI, Tamio NOGUCHI
Journal:
Biochemical Journal
Biochem J (1999) 339 (1): 111–117.
Published: 25 March 1999
... only slightly increased in liver of rats refed with a high-carbohydrate diet or after partial hepatectomy. Whereas the expression of Hex mRNA was detected in hepatocytes isolated from adult rat liver and also in highly differentiated hepatoma cells, no Hex mRNA was detected in poorly differentiated...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 337 (3): 497–501.
Published: 25 January 1999
...John W. PHILLIPS; Debra C. HENLY; Michael N. BERRY The stimulation of glucose phosphorylation in isolated hepatocytes by low fructose concentrations is transient due to the rapid metabolism of fructose. To prolong this stimulatory effect fructose was enzymically generated in the incubation medium...
