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1-31 of 31
Keywords: hepatocyte
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Articles
Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2)
Available to PurchaseHao Liu, Junjie Yu, Tingting Xia, Yuzhong Xiao, Qian Zhang, Bin Liu, Yajie Guo, Jiali Deng, Yalan Deng, Shanghai Chen, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Feifan Guo
Journal:
Biochemical Journal
Biochem J (2014) 464 (2): 281–289.
Published: 14 November 2014
... kinase 1/2 (ERK1/2) glucose hepatocyte insulin signalling liver serum- and glucocorticoid-regulated kinase 1 (SGK1) SGK1 (serum- and glucocorticoid-regulated kinase 1) belongs to the family of serine/threonine kinases and is ubiquitously expressed in body tissues and organs, including liver...
Includes: Supplementary data
Articles
Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2014) 463 (2): 201–213.
Published: 22 September 2014
... conclude that MAL2 and the constitutively active STK16 function to sort secretory soluble cargo into the constitutive secretory pathway at the TGN ( trans -Golgi network) in polarized hepatocytes. 1 Present address: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD...
Includes: Supplementary data
Articles
Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2014) 458 (1): 95–107.
Published: 20 January 2014
... constitutively active, in hepatocytes CAR is normally held quiescent through a tethering mechanism in the cytosol, anchored to a protein complex that includes several components, including heat-shock protein 90. Release and subsequent nuclear translocation of CAR is triggered through either direct binding...
Includes: Supplementary data
Articles
Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2013) 454 (2): 267–274.
Published: 09 August 2013
... the mRNA and protein expression of DGKθ in the HepG2 cell line and in primary human hepatocytes. Reporter gene studies using 1.5 kB of the DGKθ promoter fused to the luciferase gene revealed that bile acids increase DGKθ transcriptional activity. Mutation of putative FXR-binding sites attenuated...
Articles
The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII
Available to PurchaseTomoko Yamazaki, Jun-ichi Suehiro, Hideki Miyazaki, Takashi Minami, Tatsuhiki Kodama, Kohei Miyazono, Tetsuro Watabe
Journal:
Biochemical Journal
Biochem J (2013) 452 (2): 345–357.
Published: 10 May 2013
... not yet been elucidated. dominant negative hepatocyte nuclear receptor transcriptional repression Cyp7a1 (cytochrome P450, family 7, subfamily a, polypeptide 1; also known as cholesterol 7α-hydroxylase) catalyses the first and rate-limiting step in the catabolism of cholesterol to bile...
Includes: Supplementary data
Articles
AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase
Available to PurchaseLaurent Bultot, Bruno Guigas, Alexander Von Wilamowitz-Moellendorff, Liliane Maisin, Didier Vertommen, Nusrat Hussain, Monique Beullens, Joan J. Guinovart, Marc Foretz, Benoît Viollet, Kei Sakamoto, Louis Hue, Mark H. Rider
Journal:
Biochemical Journal
Biochem J (2012) 443 (1): 193–203.
Published: 14 March 2012
... to enzyme inactivation by decreasing the affinity for both UDP-Glc (UDP-glucose) [assayed in the absence of Glc-6- P (glucose-6-phosphate)] and Glc-6- P (assayed at low UDP-Glc concentrations). Incubation of freshly isolated rat hepatocytes with the pharmacological AMPK activators AICA riboside (5...
Includes: Supplementary data
Articles
Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes
Available to PurchaseCatherine Arden, Susan J. Tudhope, John L. Petrie, Ziad H. Al-Oanzi, Kirsty S. Cullen, Alex J. Lange, Howard C. Towle, Loranne Agius
Journal:
Biochemical Journal
Biochem J (2012) 443 (1): 111–123.
Published: 14 March 2012
...). Allosteric mechanisms involving glucose 6-phosphate or xylulose 5-phosphate and covalent modification of ChREBP (carbohydrate-response element-binding protein) have been implicated in this mechanism. However, evidence supporting an essential role for a specific metabolite or pathway in hepatocytes remains...
Articles
MAL, but not MAL2, expression promotes the formation of cholesterol-dependent membrane domains that recruit apical proteins
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Journal:
Biochemical Journal
Biochem J (2011) 439 (3): 497–504.
Published: 13 October 2011
... be addressed (email [email protected] ). 5 5 2011 24 6 2011 7 7 2011 7 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 apical targeting cholesterol epithelium hepatocyte lipid raft myelin and lymphocyte protein (MAL) According to the original...
Articles
GATA-4 transcription factor regulates hepatic hepcidin expression
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Journal:
Biochemical Journal
Biochem J (2011) 437 (3): 477–482.
Published: 13 July 2011
...Marie-Laure Island; Nadia Fatih; Patricia Leroyer; Pierre Brissot; Olivier Loreal Hepcidin, a hormone mainly synthesized by hepatocytes and secreted in plasma, controls iron bioavailability. Thus, by inducing the internalization of the iron exporter ferroportin, it regulates iron release from...
Articles
The hepatitis C virus and its hepatic environment: a toxic but finely tuned partnership
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2009) 423 (3): 303–314.
Published: 12 October 2009
.... HCV is an enveloped virus bearing two surface glycoproteins, E1 and E2. It only infects humans through blood transmission, and hepatocytes are its only target cells. Hepatic trabeculae are formed by hepatocyte rows surrounded by sinusoid capillaries, irrigating hepatic cells. Hepatocytes are polarized...
Articles
Liver fibrosis
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Journal:
Biochemical Journal
Biochem J (2008) 411 (1): 1–18.
Published: 13 March 2008
... of these cells in diseased liver originate from the bone marrow. In addition, fibrogenic fibroblasts may also be generated through liver epithelial (hepatocyte and biliary epithelial cell)–mesenchymal transition. Whatever their origin, it is clear that fibrogenic fibroblast activity is sensitive to (and may...
Articles
Activation of NADPH oxidase by transforming growth factor-β in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-κB-dependent mechanism
Available to PurchaseMiguel M. Murillo, Irene Carmona-Cuenca, Gaelle del Castillo, Conrad Ortiz, César Roncero, Aránzazu Sánchez, Margarita Fernández, Isabel Fabregat
Journal:
Biochemical Journal
Biochem J (2007) 405 (2): 251–259.
Published: 27 June 2007
...Miguel M. Murillo; Irene Carmona-Cuenca; Gaelle del Castillo; Conrad Ortiz; César Roncero; Aránzazu Sánchez; Margarita Fernández; Isabel Fabregat The TGF-β (transforming growth factor-β) induces survival signals in foetal rat hepatocytes through transactivation of EGFR (epidermal growth factor...
Articles
AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside
Available to PurchaseBruno Guigas, Nellie Taleux, Marc Foretz, Dominique Detaille, Fabrizio Andreelli, Benoit Viollet, Louis Hue
Journal:
Biochemical Journal
Biochem J (2007) 404 (3): 499–507.
Published: 29 May 2007
... in cell energy homoeostasis. In the present study, we investigated the effects of AICA riboside on mitochondrial oxidative; phosphorylation. AICA riboside was found to dose-dependently inhibit the oligomycin-sensitive J O 2 (oxygen consumption rate) of isolated rat hepatocytes. A decrease in P i...
Includes: Supplementary data
Articles
Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells
Available to PurchaseAmalia Fernández-Martínez, Belén Mollá, Rafael Mayoral, Lisardo Boscá, Marta Casado, Paloma Martín-Sanz
Journal:
Biochemical Journal
Biochem J (2006) 398 (3): 371–380.
Published: 29 August 2006
... 2006 apoptosis cyclo-oxygenase (COX) hepatocyte hydrodynamic transfection liver prostaglandin pcDNA3 and pEGFP-N1 were obtained from Invitrogen and BD Biosciences (Clontech) respectively. Human full-length COX-2 cDNA [ 23 ] in pcDNA1/Amp was a gift from Dr S. Prescott (Huntsman Cancer...
Articles
Chelation and determination of labile iron in primary hepatocytes by pyridinone fluorescent probes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2006) 395 (1): 49–55.
Published: 15 March 2006
... hepatocytes. The intracellular fluorescence was not only quenched by an addition of a highly lipophilic 8-hydroxyquinoline–iron(III) complex but also was dequenched by the addition of an excess of the membrane-permeable iron chelator CP94 (1,2-diethyl-3-hydroxypyridin-4-one). The time course of uptake of iron...
Articles
Role of HNF4α in the superinduction of the IL-1β-activated iNOS gene by oxidative stress
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Journal:
Biochemical Journal
Biochem J (2006) 394 (2): e3.
Published: 10 February 2006
...Frank J. Gonzalez IL-1β (interleukin-1β) treatment of hepatocytes results in an NF-κB (nuclear factor-κB)-mediated activation of the iNOS (induced nitric oxide synthase) gene, and this increase in gene expression is further augmented by oxidative stress. Oxidative stress alone has no influence...
Articles
Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2005) 386 (2): 237–244.
Published: 22 February 2005
...Hamid R. SAMARI; Michael T. N. MØLLER; Lise HOLDEN; Tonje ASMYHR; Per O. SEGLEN Autophagic activity in isolated rat hepatocytes is strongly suppressed by OA (okadaic acid) and other PP (protein phosphatase)-inhibitory toxins as well as by AICAR (5-aminoimidazole-4-carboxamide riboside), a direct...
Articles
Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis -acting elements
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2005) 385 (1): 207–216.
Published: 14 December 2004
...). Insulin increases the expression of the SREBP-1c gene in intact liver and in hepatocytes cultured in vitro . To learn the mechanism of this stimulation, we analysed the activation of the rat SREBP-1c promoter and its truncated or mutated congeners driving a luciferase reporter gene in transiently...
Articles
Identification of a novel rat hepatic gene induced early by insulin, independently of glucose
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Journal:
Biochemical Journal
Biochem J (2005) 385 (1): 165–171.
Published: 14 December 2004
... repeat) proteins. Insulin treatment increased EIIH mRNA levels in the hepatocytes of suckling, fasted adult and STZ (streptozotocin)-treated diabetic rats, where insulin was required to maintain the basal level of EIIH expression. EIIH expression was induced during the suckling/weaning transition...
Includes: Supplementary data
Articles
Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 380 (1): 203–209.
Published: 15 May 2004
...-oxygenation (H/R)-induced cell death and/or survival, and the underlying mechanisms of any such effects. H/R was shown to induce apoptotic cell death of rat hepatocytes. The addition of a STAT1-specific inhibitor, fludarabine, significantly increased the fraction of apoptotic cells after H/R. Following H/R...
Articles
Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose
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Journal:
Biochemical Journal
Biochem J (2004) 377 (1): 195–204.
Published: 01 January 2004
... and compartmentation of phosphorylase in hepatocytes. Glucose 6-P levels were modulated in hepatocytes by glucokinase overexpression or inhibition with 5-thioglucose and the effects of AMP were tested using AICAR (5-aminoimidazole-4-carboxamide 1-β- d -ribofuranoside), which is metabolized to an AMP analogue...
Articles
Dual action of oestrogens on the mouse constitutive androstane receptor
Available to PurchaseJanne MÄKINEN, Mika REINISALO, Kaisa NIEMI, Pirkko VIITALA, Johanna JYRKKÄRINNE, Hinfan CHUNG, Olavi PELKONEN, Paavo HONKAKOSKI
Journal:
Biochemical Journal
Biochem J (2003) 376 (2): 465–472.
Published: 01 December 2003
... and chlorpromazine. Also, the induction of CYP2B10 mRNA by oestrogens was less pronounced in mouse primary hepatocytes. Yeast two-hybrid assays indicated that, unlike androstenol and the established activators, oestrogens attracted both nuclear receptor co-repressors and co-activators to the mCAR ligand-binding...
Articles
Functional characterization and regulation of the taurine transporter and cysteine dioxygenase in human hepatoblastoma HepG2 cells
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2003) 375 (2): 441–447.
Published: 15 October 2003
...- ever, there has been no report focusing on the regulation of both TAUT and taurine biosynthetic enzymes in human hepatic cells. In the hepatocyte, Timbrell et al. [22] have reported that taurine had a cytoprotective effect on the hepatotoxicity induced by chemical compounds such as hydrazine, 1,4...
Articles
Perivenous expression of the mRNA of the three hypoxia-inducible factor α-subunits, HIF1α, HIF2α and HIF3α, in rat liver
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 354 (3): 531–537.
Published: 08 March 2001
...Thomas KIETZMANN; Yvonne CORNESSE; Katja BRECHTEL; Said MODARESSI; Kurt JUNGERMANN The cDNAs of three hypoxia-inducible factor (HIF) α-subunits were cloned from RNA of primary rat hepatocytes by reverse transcriptase PCR. All three cDNAs encoded functionally active proteins, of 825, 874 and 662...
Articles
Rapid activation and partial inactivation of inositol trisphosphate receptors by adenophostin A
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Journal:
Biochemical Journal
Biochem J (2000) 352 (3): 929–933.
Published: 08 December 2000
...Charles E. ADKINS; Frank WISSING; Barry V. L. POTTER; Colin W. TAYLOR Adenophostin A, the most potent known agonist of inositol 1,4,5-trisphosphate (Ins P 3 ) receptors, stimulated 45 Ca 2+ release from the intracellular stores of permeabilized hepatocytes. The concentration of adenophostin...
Articles
Shared control of hepatic glycogen synthesis by glycogen synthase and glucokinase
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 351 (3): 811–816.
Published: 24 October 2000
...Roger R. GOMIS; Juan C. FERRER; Joan J. GUINOVART We have used recombinant adenoviruses (AdCMV-RLGS and AdCMV-GK) to overexpress the liver isoforms of glycogen synthase (GS) and glucokinase (GK) in primary cultured rat hepatocytes. Glucose activated overexpressed GS in a dose-dependent manner...
Articles
Characterization of homocysteine metabolism in the rat liver
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Journal:
Biochemical Journal
Biochem J (2000) 350 (3): 685–692.
Published: 08 September 2000
... are not well known. However, given the central role of the liver in amino acid metabolism, we developed a rat primary hepatocyte model in which homocysteine (and cysteine) production and export were examined. The dependence of homocysteine export from incubated hepatocytes on methionine concentration fitted...
Articles
Glucokinase and glucokinase regulatory protein: mutual dependence for nuclear localization
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Journal:
Biochemical Journal
Biochem J (2000) 348 (1): 215–222.
Published: 09 May 2000
... that this protein can shuttle between the two compartments. 1 To whom correspondence should be addressed (e-mail iynedjian@;medecine.unige.ch). 11 11 1999 23 2 2000 13 3 2000 The Biochemical Society, London © 2000 2000 glucose metabolism hepatocyte liver nuclear import/export...
Articles
Evidence for the involvement of a small subregion of the endoplasmic reticulum in the inositol trisphosphate receptor-induced activation of Ca2+ inflow in rat hepatocytes
Available to PurchaseRoland B. GREGORY, Robert A. WILCOX, Leise A. BERVEN, Nicole C. R. VAN STRATEN, Gijs A. VAN DER MAREL, Jacques H. VAN BOOM, Gregory J. BARRITT
Journal:
Biochemical Journal
Biochem J (1999) 341 (2): 401–408.
Published: 08 July 1999
... the activation of store-operated Ca 2+ channels (SOCs) in isolated rat hepatocytes were investigated. Adenophostin A, a potent agonist at Ins(1,4,5) P 3 receptors, induced ER Ca 2+ release and the activation of Ca 2+ inflow. The concentration of adenophostin A that gave half-maximal stimulation of Ca 2+ inflow...
Articles
cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein
Available to PurchaseTakashi TANAKA, Tetsuya INAZU, Kazuya YAMADA, Zaw MYINT, Vincent W. KENG, Yoshiko INOUE, Naoyuki TANIGUCHI, Tamio NOGUCHI
Journal:
Biochemical Journal
Biochem J (1999) 339 (1): 111–117.
Published: 25 March 1999
... only slightly increased in liver of rats refed with a high-carbohydrate diet or after partial hepatectomy. Whereas the expression of Hex mRNA was detected in hepatocytes isolated from adult rat liver and also in highly differentiated hepatoma cells, no Hex mRNA was detected in poorly differentiated...
Articles
Long-term maintenance of low concentrations of fructose for the study of hepatic glucose phosphorylation
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 337 (3): 497–501.
Published: 25 January 1999
...John W. PHILLIPS; Debra C. HENLY; Michael N. BERRY The stimulation of glucose phosphorylation in isolated hepatocytes by low fructose concentrations is transient due to the rapid metabolism of fructose. To prolong this stimulatory effect fructose was enzymically generated in the incubation medium...
