... either homodimerize or heterodimerize in vivo , we hypothesized that heterodimerization of APPL proteins might account for the mechanism. By solving the crystal structure of APPL1–APPL2 BAR-PH heterodimer, we find that the overall structure is crescent-shaped with a longer curvature radius of 76...

... examined the functional roles of conserved histidine residues located within E1 and E2. The E1 mutations, H222A/R, H298R and H352A, disrupted E1–E2 heterodimerization and reduced virus entry. A total of five out of six histidine residues located within the E2 RBD (receptor-binding domain) were important...

... cytoplasmic tail heterodimerization intercellular adhesion molecule (ICAM) integrin transmembrane helix Integrins are heterodimeric type I membrane adhesion molecules formed by non-covalent association of an α- and β-subunits [ 1 ]. They are bona fide signalling receptors, which mediate...

...Guozheng WANG; Shu ZHANG; David G. FERNIG; David SPILLER; Marisa MARTIN-FERNANDEZ; Hongmei ZHANG; Yi DING; Zihe RAO; Philip S. RUDLAND; Roger BARRACLOUGH With the widespread use of yeast two-hybrid systems, many heterodimeric forms of S100 proteins have been found, although their biological...

...Thomas BERGMAN; Vincent C. HENRICH; Uwe SCHLATTNER; Markus LEZZI Ecdysteroids (Ecs) enhance the formation of Ec receptor–ultraspiracle protein (EcR–USP) heterodimers which regulate gene transcription. To study EcR–USP heterodimerization, fusion proteins were constructed from the LBDs (ligand...

... To whom correspondence should be addressed (e-mail [email protected] ). 9 4 1999 22 6 1999 28 7 1999 The Biochemical Society, London © 1999 1999 coexpression heterodimerization receptor dimer regulation of G protein-coupled receptors Biochem. J. (1999) 343, 231 239...