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Keywords: high-throughput screening
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Biochem J (2020) 477 (4): 801–814.
Published: 27 February 2020
... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy chemical biology high-throughput screening kinases Macroautophagy (referred to as autophagy here for simplicity) is a lysosome-dependent degradative pathway...
Includes: Supplementary data
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Biochem J (2010) 429 (3): 527–532.
Published: 14 July 2010
... protease with six mutations. Moreover, analysis of this compound suggests an allosteric non-competitive mechanism of inhibition and may represent a starting point for an additional strategy for anti-retroviral therapy. anti-retroviral therapy high-diversity chemical library high-throughput screening...
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Biochem J (2008) 412 (2): e7–e9.
Published: 14 May 2008
... drug design G-protein-coupled receptor dimerization high-throughput screening imaging-based protein–protein interaction assay δ-opioid receptor The idea that GPCRs (G-protein-coupled receptors) act as monomers remains a pervasive feature in attempts to develop drugs that target this class...
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Biochem J (2002) 366 (3): 977–981.
Published: 15 September 2002
...Heike ROSS; Christopher G. ARMSTRONG; Philip COHEN The generation of drugs that modulate the activities of particular protein kinases has become a prime focus of the pharmaceutical and biotechnology industry. Consequently, improved methods for the development of high-throughput screening formats...
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Biochem J (2001) 356 (3): 813–819.
Published: 08 June 2001
.... These assays, which can be used directly on tissue homogenates, are the most sensitive and selective described to date for ECE, and are easily automated for a high-throughput screening of inhibitors. 1 To whom correspondence should be addressed (e-mail roques@pharmacie.univ-paris5.fr ). 2 1 2001...
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