.... DNA damage response DNA repair DNA replication E3 ligase human disease ubiquitin Precise genome duplication and maintenance of its stability are central to all life. Therefore, cells have evolved a dedicated set of proteins and pathways to preserve genomic integrity. In mammalian cells...

... phosphorylate and dephosphorylate distinct phosphoinositide species. Many of these enzymes have been implicated in regulating membrane trafficking and, accordingly, their dysregulation has been linked to a number of human diseases. In the present review, we focus on the inositol phosphatases, concentrating...