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Keywords: huntingtin
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Biochem J (2013) 452 (1): 1–17.
Published: 25 April 2013
... (huntingtin) aggregates] can also move between cells and seed the misfolding of their normal conformers. These findings have enormous implications. On the one hand they question the therapeutical use of transplants, and on the other they indicate that it may be possible to bring these diseases to an early...
Biochem J (2008) 412 (2): 191–209.
Published: 14 May 2008
... trinucleotide repeat expansion encoding an abnormally long polyglutamine tract in the huntingtin protein. Much has been learnt since the mutation was identified in 1993. We review the functions of wild-type huntingtin. Mutant huntingtin may cause toxicity via a range of different mechanisms. The primary...