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Keywords: hydrogen deuterium exchange mass spectrometry
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Biochem J (2021) 478 (1): 99–120.
Published: 13 January 2021
... that reconstituted the IgG binding to CD20. Using light chain-7 as a reference sequence, hydrogen deuterium exchange mass spectrometry was used to identify the dominant CDR region implicated in CD20 antigen binding. Early in the deuteration reaction, the CD20 antigen suppressed deuteration at CDR3 (V H ). In later...
Includes: Supplementary data