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Macromolecular crowding and bicarbonate enhance the hydrogen peroxide-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase

Rebecca H. J. Bloemen, Rafael Radi, Michael J. Davies, Eduardo Fuentes-Lemus

Biochem J (2024) 481 (23): 1855–1866.

https://doi.org/10.1042/BCJ20240597

Published: 04 December 2024

...Rebecca H. J. Bloemen; Rafael Radi; Michael J. Davies; Eduardo Fuentes-Lemus The active site Cys residue in glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is sensitive to oxidation by hydrogen peroxide (H 2 O 2), with this resulting in enzyme inactivation. This re-routes the carbon flux from...

View articletitled, Macromolecular crowding and bicarbonate enhance the hydrogen peroxide-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase

Includes: Supplementary data

Articles

Permeation mechanisms of hydrogen peroxide and water through Plasma Membrane Intrinsic Protein aquaporins

Jonathan Chevriau, Gerardo Zerbetto De Palma, Cintia Jozefkowicz, Victoria Vitali, Agustina Canessa Fortuna, Nicolas Ayub, Gabriela Soto, Gerd Patrick Bienert, Ari Zeida, Karina Alleva

Biochem J (2024) 481 (19): 1329–1347.

https://doi.org/10.1042/BCJ20240310

Published: 25 September 2024

...Jonathan Chevriau; Gerardo Zerbetto De Palma; Cintia Jozefkowicz; Victoria Vitali; Agustina Canessa Fortuna; Nicolas Ayub; Gabriela Soto; Gerd Patrick Bienert; Ari Zeida; Karina Alleva Hydrogen peroxide (H 2 O 2) transport by aquaporins (AQP) is a critical feature for cellular redox signaling...

View articletitled, Permeation mechanisms of hydrogen peroxide and water through Plasma Membrane Intrinsic Protein aquaporins

Includes: Supplementary data

Articles

Pepper catalase: a broad analysis of its modulation during fruit ripening and by nitric oxide

Salvador González-Gordo, Javier López-Jaramillo, Marta Rodríguez-Ruiz, Jorge Taboada, José M. Palma, Francisco J. Corpas

Biochem J (2024) 481 (13): 883–901.

https://doi.org/10.1042/BCJ20240247

Published: 03 July 2024

...), and ripe red (R). (A) Representative picture of a gel stained for catalase activity. (B) Relative quantification of the band activity was determined using ImageJ software. catalase fruit ripening hydrogen peroxide nitration nitric oxide Pepper belongs to the Solanaceae, a family...

View articletitled, Pepper catalase: a broad analysis of its modulation during fruit ripening and by nitric oxide

Includes: Supplementary data

Articles

Thioredoxin-like2/2-Cys peroxiredoxin redox cascade acts as oxidative activator of glucose-6-phosphate dehydrogenase in chloroplasts

Keisuke Yoshida, Eriko Uchikoshi, Satoshi Hara, Toru Hisabori

Biochem J (2019) 476 (12): 1781–1790.

https://doi.org/10.1042/BCJ20190336

Published: 26 June 2019

... modulation by using hydrogen peroxide (H 2 O 2 ) as an oxidizing force. This system plays a key role in switching chloroplast metabolism (e.g. Calvin–Benson cycle) during light to dark transitions; however, information on its function is still limited. In this study, we report a novel protein-activation...

View articletitled, Thioredoxin-like2/2-Cys peroxiredoxin redox cascade acts as oxidative activator of glucose-6-phosphate dehydrogenase in chloroplasts

Includes: Supplementary data

Articles

Plastidic glucose-6-phosphate dehydrogenases are regulated to maintain activity in the light

In Collection

Photosynthesis

Alyssa L. Preiser, Nicholas Fisher, Aparajita Banerjee, Thomas D. Sharkey

Biochem J (2019) 476 (10): 1539–1551.

https://doi.org/10.1042/BCJ20190234

Published: 31 May 2019

... that the half-saturation concentration of G6PDH isoform 1 is increased under reducing conditions. The other two isoforms exhibit less redox regulation, however, isoform 2 is strongly inhibited by NADPH. Redox regulation of G6PDH1 can be partially reversed by hydrogen peroxide or protected against...

View articletitled, Plastidic glucose-6-phosphate dehydrogenases are regulated to maintain activity in the light

Includes: Supplementary data

Articles

Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons

Cecilia Chavarría, Sebastián Rodríguez-Bottero, Celia Quijano, Patricia Cassina, José M. Souza

Biochem J (2018) 475 (19): 3153–3169.

https://doi.org/10.1042/BCJ20180297

Published: 12 October 2018

... and cytotoxicity revealed differences between the assessed α-syn species. Only oligomers induced mitochondrial dysfunction in astrocytes and significantly increased extracellular hydrogen peroxide production by these cells. Besides, TNF-α and IL-1β (interleukin 1β) expression presented different kinetics...

View articletitled, Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons

Includes: Supplementary data

Articles

Real-time imaging of intracellular hydrogen peroxide in pancreatic islets

Adam Neal, Austin Rountree, Kelly Kernan, Brian Van Yserloo, Huiliang Zhang, Benjamin J. Reed, William Osborne, Wang Wang, Ian R. Sweet

Biochem J (2016) 473 (23): 4443–4456.

https://doi.org/10.1042/BCJ20160481

Published: 25 November 2016

...Adam Neal; Austin Rountree; Kelly Kernan; Brian Van Yserloo; Huiliang Zhang; Benjamin J. Reed; William Osborne; Wang Wang; Ian R. Sweet A real-time method to measure intracellular hydrogen peroxide (H 2 O 2 ) would be very impactful in characterizing rapid changes that occur in physiologic...

View articletitled, Real-time imaging of intracellular hydrogen peroxide in pancreatic islets

Includes: Supplementary data

Articles

Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation

Rebecca A. Poynton, Alexander V. Peskin, Alexina C. Haynes, W. Todd Lowther, Mark B. Hampton, Christine C. Winterbourn

Biochem J (2016) 473 (4): 411–421.

https://doi.org/10.1042/BJ20150572

Published: 09 February 2016

... to hyperoxidation is partly explained by differences in four C-terminal amino acids. In addition, only one active-site cysteine in the Prx3 homodimer is susceptible to hyperoxidation whereas both become hyperoxidized in Prx2. hydrogen peroxide kinetics peroxiredoxin inactivation thiol antioxidants...

View articletitled, Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation

Articles

Oxygen reactivity of mammalian sulfite oxidase provides a concept for the treatment of sulfite oxidase deficiency

Abdel A. Belaidi, Juliane Röper, Sita Arjune, Sabina Krizowski, Aleksandra Trifunovic, Guenter Schwarz

Biochem J (2015) 469 (2): 211–221.

https://doi.org/10.1042/BJ20140768

Published: 06 July 2015

... that determine the reactivity of PSO towards oxygen, remained unknown. In the present study, we generated mammalian haem-deficient and truncated SO variants and demonstrated their oxygen reactivity by hydrogen peroxide formation and oxygen-consumption studies. We found that intramolecular electron transfer...

View articletitled, Oxygen reactivity of mammalian sulfite oxidase provides a concept for the treatment of sulfite oxidase deficiency

Includes: Supplementary data

Articles

Lys 1110 of TRPM2 is critical for channel activation

Taek-Keun Kim, Joo Hyun Nam, Won-Gyun Ahn, Nam-Ho Kim, Hwa-Yong Ham, Chang-Won Hong, Ju-Suk Nam, Jongho Lee, Sung-Oh Huh, Insuk So, Sung Joon Kim, Dong-Keun Song

Biochem J (2013) 455 (3): 319–327.

https://doi.org/10.1042/BJ20130303

Published: 10 October 2013

... (titrated with KOH). The bath solution contained 90 mM NaCl, 50 mM sodium aspartate, 3 mM KCl, 2 mM CaCl 2 , 1 mM MgCl 2 , 10 mM glucose and 10 mM Hepes, pH 7.4 (titrated with NaOH). adenosine diphosphoribose (ADPR) chloride hydrogen peroxide positive charge point mutation Changes...

View articletitled, Lys 1110 of TRPM2 is critical for channel activation

Includes: Supplementary data

Articles

Hyperoxidized peroxiredoxin 2 interacts with the protein disulfide- isomerase ERp46

Paul E. Pace, Alexander V. Peskin, Min-Hi Han, Mark B. Hampton, Christine C. Winterbourn

Biochem J (2013) 453 (3): 475–485.

https://doi.org/10.1042/BJ20130030

Published: 12 July 2013

... ], completing the catalytic cycle. Figure 1 Schematic diagram of Prx redox cycling (a) and structural transitions (b) *, sulfinic acid. hydrogen peroxide hyperoxidation oxidative stress protein–protein interaction signalling thiol Prxs (peroxiredoxins) belong to a highly conserved...

View articletitled, Hyperoxidized peroxiredoxin 2 interacts with the protein disulfide- isomerase ERp46

Includes: Supplementary data

Articles

Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic β-cells using ratiometric fluorescent proteins: confounding effects of pH with HyPer but not roGFP1

Leticia P. Roma, Jessica Duprez, Hilton K. Takahashi, Patrick Gilon, Andreas Wiederkehr, Jean-Christophe Jonas

Biochem J (2012) 441 (3): 971–978.

https://doi.org/10.1042/BJ20111770

Published: 16 January 2012

... changes in mitochondrial hydrogen peroxide concentration and glutathione redox state in adenovirus-infected rat islet cell clusters. Because of the reported pH sensitivity of HyPer, the results were compared with those obtained with the mitochondrial pH sensors mt-AlpHi and mt-SypHer. The fluorescence...

View articletitled, Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic β-cells using ratiometric fluorescent proteins: confounding effects of pH with HyPer but not roGFP1

Articles

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

Andrew G. Cox, Christine C. Winterbourn, Mark B. Hampton

Biochem J (2010) 425 (2): 313–325.

https://doi.org/10.1042/BJ20091541

Published: 23 December 2009

... to inactivation by hyperoxidation in the presence of excess peroxide and the ability to form complex oligomeric structures. These properties, combined with a high cellular abundance and reactivity with hydrogen peroxide, have led to speculation that the Prxs function as redox sensors that transmit signals as part...

View articletitled, Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

Articles

Oxidation of methionine residues: the missing link between stress and signalling responses in plants

Michael J. Emes

Biochem J (2009) 422 (2): e1–e2.

https://doi.org/10.1042/BJ20091063

Published: 13 August 2009

[email protected] 13 7 2009 16 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 hydrogen peroxide methionine oxidation protein phosphorylation recognition element signalling Plants are sessile organisms that live under a constant barrage of biotic...

View articletitled, Oxidation of methionine residues: the missing link between stress and signalling responses in plants

Articles

Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins

Andrew G. Cox, Andree G. Pearson, Juliet M. Pullar, Thomas J. Jönsson, W. Todd Lowther, Christine C. Winterbourn, Mark B. Hampton

Biochem J (2009) 421 (1): 51–58.

https://doi.org/10.1042/BJ20090242

Published: 12 June 2009

...Andrew G. Cox; Andree G. Pearson; Juliet M. Pullar; Thomas J. Jönsson; W. Todd Lowther; Christine C. Winterbourn; Mark B. Hampton The Prxs (peroxiredoxins) are a family of cysteine-dependent peroxidases that decompose hydrogen peroxide. Prxs become hyperoxidized when a sulfenic acid formed during...

View articletitled, Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins

Includes: Multimedia, Supplementary data

Articles

How mitochondria produce reactive oxygen species

Michael P. Murphy

Biochem J (2009) 417 (1): 1–13.

https://doi.org/10.1042/BJ20081386

Published: 12 December 2008

...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. complex I hydrogen peroxide mitochondrion reactive oxygen species (ROS) respiratory chain superoxide Mitochondria...

View articletitled, How mitochondria produce reactive oxygen species

Includes: Multimedia, Supplementary data

Articles

Plant plasma membrane water channels conduct the signalling molecule H 2 O 2

Marek Dynowski, Gabriel Schaaf, Dominique Loque, Oscar Moran, Uwe Ludewig

Biochem J (2008) 414 (1): 53–61.

https://doi.org/10.1042/BJ20080287

Published: 29 July 2008

... constant. aquaglyceroporins aquaporin hydrogen peroxide reactive oxygen species (ROS) Water channels, aquaporins, have been identified in most organisms, including plants, and have specific physiological functions related to water facilitation in many tissues [ 1 – 3 ]. Aquaporins...

View articletitled, Plant plasma membrane water channels conduct the signalling molecule H 2 O 2

Includes: Supplementary data

Articles

NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation

Lena Serrander, Laetitia Cartier, Karen Bedard, Botond Banfi, Bernard Lardy, Olivier Plastre, Andrzej Sienkiewicz, Lászlo Fórró, Werner Schlegel, Karl-Heinz Krause

Biochem J (2007) 406 (1): 105–114.

https://doi.org/10.1042/BJ20061903

Published: 26 July 2007

... correlation between NOX4 mRNA and ROS generation might hint towards a function as an inducible NOX isoform. 20 12 2006 2 4 2007 15 5 2007 15 5 2007 © 2007 Biochemical Society 2007 1 To whom correspondence should be addressed (email [email protected] ). hydrogen...

View articletitled, NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation

Articles

Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1–Cn protein interactions occurring in vitro and in vivo

Abdulbaki Agbas, Dongwei Hui, Xinsheng Wang, Vekalet Tek, Asma Zaidi, Elias K. Michaelis

Biochem J (2007) 405 (1): 51–59.

https://doi.org/10.1042/BJ20061202

Published: 13 June 2007

... The Authors Journal compilation © 2007 Biochemical Society 2007 brain calcineurin hydrogen peroxide iron superoxide dismutase zinc Cn (calcineurin) is an Fe- and Zn-containing metallophosphatase [ 1 – 6 ]. The active form of the enzyme is a heterodimer of CnA and CnB. Activation of Cn...

View articletitled, Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1–Cn protein interactions occurring in vitro and in vivo

Articles

Mechanism of nitrite oxidation by eosinophil peroxidase: implications for oxidant production and nitration by eosinophils

Christine J. van Dalen, Christine C. Winterbourn, Anthony J. Kettle

Biochem J (2006) 394 (3): 707–713.

https://doi.org/10.1042/BJ20051470

Published: 24 February 2006

...Christine J. van Dalen; Christine C. Winterbourn; Anthony J. Kettle Eosinophil peroxidase is a haem enzyme of eosinophils that is implicated in oxidative tissue injury in asthma. It uses hydrogen peroxide to oxidize thiocyanate and bromide to their respective hypohalous acids. Nitrite is also...

View articletitled, Mechanism of nitrite oxidation by eosinophil peroxidase: implications for oxidant production and nitration by eosinophils

Articles

Redox activation of mitochondrial intermembrane space Cu,Zn-superoxide dismutase

Pedro IÑARREA, Hadi MOINI, Daniel RETTORI, Derick HAN, Jesús MARTÍNEZ, Inés GARCÍA, Erika FERNÁNDEZ-VIZARRA, María ITURRALDE, Enrique CADENAS

Biochem J (2005) 387 (1): 203–209.

https://doi.org/10.1042/BJ20041683

Published: 22 March 2005

... groups is necessary for its activation. 1 To whom correspondence should be addressed (email [email protected] ). 4 10 2004 5 11 2004 10 11 2004 10 11 2004 The Biochemical Society, London 2005 Cu,Zn-superoxide dismutase hydrogen peroxide mitochondrial...

View articletitled, Redox activation of mitochondrial intermembrane space Cu,Zn-superoxide dismutase

Articles

A novel NADPH:(bound) NADP + reductase and NADH:(bound) NADP + transhydrogenase function in bovine liver catalase

Gian F. GAETANI, Anna M. FERRARIS, Paola SANNA, Henry N. KIRKMAN

Biochem J (2005) 385 (3): 763–768.

https://doi.org/10.1042/BJ20041495

Published: 24 January 2005

... of tightly bound NADPH. 1 To whom correspondence should be addressed (email [email protected] ). 2 9 2004 22 9 2004 29 9 2004 29 9 2004 The Biochemical Society, London 2005 catalase glucose-6-phosphate dehydrogenase hydrogen peroxide NADH NADPH oxidative...

View articletitled, A novel NADPH:(bound) NADP + reductase and NADH:(bound) NADP + transhydrogenase function in bovine liver catalase

Articles

Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage

Tino KURZ, Alan LEAKE, Thomas von ZGLINICKI, Ulf T. BRUNK

Biochem J (2004) 378 (3): 1039–1045.

https://doi.org/10.1042/bj20031029

Published: 15 March 2004

... Society, London ©2004 2004 DNA damage hydrogen peroxide lysosomal iron lysosome oxidative stress telomere Abbreviations used: AO, Acridine Orange; DFO, desferrioxamine; FADU, fluorescence-detected alkaline DNA unwinding; HMM-DFO, high-molecular-mass DFO; MSDH, O -methyl-serine...

View articletitled, Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage

Articles

Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain

Se-Ho CHANG, Jairo GARCIA, J. Andres MELENDEZ, Michael S. KILBERG, Anupam AGARWAL

Biochem J (2003) 371 (3): 877–885.

https://doi.org/10.1042/bj20021731

Published: 01 May 2003

... gene by glucose deprivation is mediated by a glucose metabolic response pathway via generation of ROS and that the pathway requires a functional electron-transport chain. Key words: antioxidant, hydrogen peroxide, mitochondrial respiration, oxidant stress. INTRODUCTION Metabolic stressors...

View articletitled, Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain

Articles

Oxidative stress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells

Marie-Odile PARAT, Rafal Z. STACHOWICZ, Paul L. FOX

Biochem J (2002) 361 (3): 681–688.

https://doi.org/10.1042/bj3610681

Published: 25 January 2002

... To whom correspondence should be addressed (e-mail [email protected] ). 4 10 2001 20 10 2001 19 11 2001 The Biochemical Society, London ©2002 2002 caveolae hydrogen peroxide post-translational modification Abbreviation used: ECs, endothelial cells. Biochem. J. (2002...

View articletitled, Oxidative stress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells

Articles

Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation

Natalia A. RIOBÓ, Emilio CLEMENTI, Mariana MELANI, Alberto BOVERIS, Enrique CADENAS, Salvador MONCADA, Juan J. PODEROSO

Biochem J (2001) 359 (1): 139–145.

https://doi.org/10.1042/bj3590139

Published: 24 September 2001

... anions, hydrogen peroxide and peroxynitrite, the latter shown by nitration of mitochondrial proteins. Long-term incubation of mitochondrial membranes with NO resulted in a persistent inhibition of NADH:cytochrome c reductase activity, interpreted as inhibition of NADH:ubiquinone reductase (Complex I...

View articletitled, Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation

Articles

Semicarbazide-sensitive amine oxidase activation promotes adipose conversion of 3T3-L1 cells

Nathalie MERCIER, Marthe MOLDES, Khadija EL HADRI, Bruno FÈVE

Biochem J (2001) 358 (2): 335–342.

https://doi.org/10.1042/bj3580335

Published: 24 August 2001

.... In addition, methylamine-induced adipocyte maturation was mimicked by 3T3-L1 cell treatment with other SSAO substrates. Finally, the large reversion of methylamine action by catalase indicated that hydrogen peroxide generated by SSAO was involved, at least in part, in the modulation of adipocyte maturation...

View articletitled, Semicarbazide-sensitive amine oxidase activation promotes adipose conversion of 3T3-L1 cells

Articles

Ferritin and the response to oxidative stress

Kouichi ORINO, Lori LEHMAN, Yoshiaki TSUJI, Hitoshi AYAKI, Suzy V. TORTI, Frank M. TORTI

Biochem J (2001) 357 (1): 241–247.

https://doi.org/10.1042/bj3570241

Published: 25 June 2001

...2001 2001 hydrogen peroxide iron iron storage proteins reactive oxygen species transfection Abbreviations used: CAT, chloramphenicol acetyltransferase; DCF, 2′,7′-dichlorofluorescein; DMEM, Dulbecco's modified Eagle's medium; DTT, dithiothreitol; FBS, fetal bovine serum; H 2 DCF-DA...

View articletitled, Ferritin and the response to oxidative stress

Articles

Oxidative stress impairs insulin but not platelet-derived growth factor signalling in 3T3-L1 adipocytes

Amir TIROSH, Assaf RUDICH, Ruth POTASHNIK, Nava BASHAN

Biochem J (2001) 355 (3): 757–763.

https://doi.org/10.1042/bj3550757

Published: 24 April 2001

... and metabolic actions in both early and fully differentiated 3T3-L1 adipocytes. This emphasizes compart- ment-specific activation of PI 3-kinase as an oxidation-sensitive step specifically leading to insulin resistance. Key words: diabetes, hydrogen peroxide, insulin resistance, PI 3-kinase. consequently...

View articletitled, Oxidative stress impairs insulin but not platelet-derived growth factor signalling in 3T3-L1 adipocytes

Articles

Reactive oxygen species involved in trichosanthin-induced apoptosis of human choriocarcinoma cells

Chun-yang ZHANG, Yi-xuan GONG, Hui MA, Cheng-cai AN, Die-yan CHEN

Biochem J (2001) 355 (3): 653–661.

https://doi.org/10.1042/bj3550653

Published: 24 April 2001

... ). 30 10 2000 18 1 2001 13 2 2001 The Biochemical Society, London © 2001 2001 calcium caspase-3 hydrogen peroxide hydroxyl radical superoxide radical anion Biochem. J. (2001) 355, 653 661 (Printed in Great Britain) 653 Reactive oxygen species involved in trichosanthin...

View articletitled, Reactive oxygen species involved in trichosanthin-induced apoptosis of human choriocarcinoma cells

Articles

Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

Derick HAN, Everett WILLIAMS, Enrique CADENAS

Biochem J (2001) 353 (2): 411–416.

https://doi.org/10.1042/bj3530411

Published: 08 January 2001

...Derick HAN; Everett WILLIAMS; Enrique CADENAS It has been generally accepted that superoxide anion generated by the mitochondrial respiratory transport chain are vectorially released into the mitochondrial matrix, where they are converted to hydrogen peroxide through the catalytic action of Mn...

View articletitled, Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

Articles

Contrasting effects of alloxan on islets and single mouse pancreatic β-cells

Gisela DREWS, Claudia KRÄMER, Martina DÜFER, Peter KRIPPEIT-DREWS

Biochem J (2000) 352 (2): 389–397.

https://doi.org/10.1042/bj3520389

Published: 24 November 2000

... activity, hydrogen peroxide, intracellular free Ca#+ concentration, mitochondrial membrane potential, reactive oxygen species. glucokinase inhibition is the oxidation of two adjacent thiol groups in the sugar-binding site of the enzyme [12]. Some authors have postulated that the alloxan effect is due...

View articletitled, Contrasting effects of alloxan on islets and single mouse pancreatic β-cells

Articles

Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress

James E. CLARK, Roberta FORESTI, Colin J. GREEN, Roberto MOTTERLINI

Biochem J (2000) 348 (3): 615–619.

https://doi.org/10.1042/bj3480615

Published: 07 June 2000

... oxidase hydrogen peroxide smooth-muscle cells tin protoporphyrin IX Biochem. J. (2000) 348, 615 619 (Printed in Great Britain) 615 Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress James E. CLARK Roberta FORESTI, Colin J. GREEN...

View articletitled, Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress

Articles

Involvement of cytosolic phospholipase A2, and the subsequent release of arachidonic acid, in signalling by Rac for the generation of intracellular reactive oxygen species in Rat-2 fibroblasts

Chang-Hoon WOO, Zee-Won LEE, Byung-Chul KIM, Kwon-Soo HA, Jae-Hong KIM

Biochem J (2000) 348 (3): 525–530.

https://doi.org/10.1042/bj3480525

Published: 07 June 2000

... by catalase. These findings indicate that phospholipase A # and subsequent AA metabolism by 5-lipoxygenase act as downstream mediators in a Rac signalling pathway leading to the generation of ROS. Key words: hydrogen peroxide, leukotrienes, 5-lipoxygenase, signal transduction. AA metabolism by 5-LO...

View articletitled, Involvement of cytosolic phospholipase A2, and the subsequent release of arachidonic acid, in signalling by Rac for the generation of intracellular reactive oxygen species in Rat-2 fibroblasts

Articles

Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells

Hsin-Chen LEE, Pen-Hui YIN, Ching-You LU, Chin-Wen CHI, Yau-Huei WEI

Biochem J (2000) 348 (2): 425–432.

https://doi.org/10.1042/bj3480425

Published: 23 May 2000

... through cell-cycle arrest. 1 To whom correspondence should be addressed (e-mail joeman@;mailsrv.ym.edu.tw). 30 9 1999 8 3 2000 29 3 2000 The Biochemical Society, London © 2000 2000 aging cell-cycle arrest hydrogen peroxide mtDNA copy number reactive oxygen species...

View articletitled, Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells

Articles

The repression of nuclear factor I/CCAAT transcription factor (NFI/CTF) transactivating domain by oxidative stress is mediated by a critical cysteine (Cys-427)

Yannick MOREL, Robert BAROUKI

Biochem J (2000) 348 (1): 235–240.

https://doi.org/10.1042/bj3480235

Published: 09 May 2000

... gene expression hepatoma cells hydrogen peroxide redox regulation transcription Biochem. J. (2000) 348, 235 240 (Printed in Great Britain) 235 The repression of nuclear factor I/CCAAT transcription factor (NFI/CTF) transactivating domain by oxidative stress is mediated by a critical cysteine...

View articletitled, The repression of nuclear factor I/CCAAT transcription factor (NFI/CTF) transactivating domain by oxidative stress is mediated by a critical cysteine (Cys-427)

Articles

Stress stimuli increase calcium-induced arachidonic acid release through phosphorylation of cytosolic phospholipase A 2

Marcus BUSCHBECK, Farideh GHOMASHCHI, Michael H. GELB, Steve P. WATSON, Angelika G. BÖRSCH-HAUBOLD

Biochem J (1999) 344 (2): 359–366.

https://doi.org/10.1042/bj3440359

Published: 24 November 1999

... phosphorylation. In io, this mech- anism would lead to the sensitization of platelet activation and may be an important risk factor in thrombotic disease. Key words: arsenite, hydrogen peroxide, platelets, sorbitol, stress-activated protein kinase. activates platelets via a tyrosine-kinase dependent pathway...

View articletitled, Stress stimuli increase calcium-induced arachidonic acid release through phosphorylation of cytosolic phospholipase A 2

Articles

Barley (Hordeum vulgare) oxalate oxidase is a manganese-containing enzyme

Laura REQUENA, Stephen BORNEMANN

Biochem J (1999) 343 (1): 185–190.

https://doi.org/10.1042/bj3430185

Published: 24 September 1999

...-mail [email protected] ). 14 7 1999 30 7 1999 9 8 1999 The Biochemical Society, London © 1999 1999 EPR germin homology model hydrogen peroxide Biochem. J. (1999) 343, 185 190 (Printed in Great Britain) 185 Barley (Hordeum vulgare) oxalate oxidase is a manganese-containing...

View articletitled, Barley (Hordeum vulgare) oxalate oxidase is a manganese-containing enzyme

Articles

Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity

Peter KOTSONIS, Armin FREY, Lothar G. FRÖHLICH, Heinrich HOFMANN, Andreas REIF, David A. WINK, Martin FEELISCH, Harald H. H. W. SCHMIDT

Biochem J (1999) 340 (3): 745–752.

https://doi.org/10.1042/bj3400745

Published: 08 June 1999

... affecting enzyme activity. 1 To whom correspondence should be addressed (e-mail [email protected]). 5 1 1999 8 3 1999 20 3 1999 The Biochemical Society, London © 1999 1999 autoregulation hydrogen peroxide NOS catalysis Biochem. J. (1999) 340, 745 752...

View articletitled, Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity

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