... in generating hydrogen sulfide (H 2 S), a gaseous signaling molecule with diverse regulatory functions within the vascular, nervous, and immune systems. In this study, we present the clinical and biochemical characterization of two novel CBS missense mutations that do not respond to pyridoxine treatment, namely...

...Stephen E. Wilkie; Gillian Borland; Roderick N. Carter; Nicholas M. Morton; Colin Selman Hydrogen sulfide (H 2 S) modulates many biological processes, including ageing. Initially considered a hazardous toxic gas, it is now recognised that H 2 S is produced endogenously across taxa and is a key...

...Yuichiro Kezuka; Tetsuo Ishida; Yasuo Yoshida; Takamasa Nonaka Hydrogen sulfide (H 2 S) plays important roles in the pathogenesis of periodontitis. Oral pathogens typically produce H 2 S from l -cysteine in addition to pyruvate and . However, fn1055 from Fusobacterium nucleatum subsp. nucleatum...

...Zheng-Wei Lee; Yi-Lian Low; Shufen Huang; Tianxiao Wang; Lih-Wen Deng Hydrogen sulfide (H 2 S) has been implicated to exhibit antioxidative properties in many models. CSE (cystathionine γ-lyase) is an important enzyme responsible for endogenous H 2 S production in mammalian systems, but little...

... by inhibition of HIFs (hypoxia-inducible factors). ChIP assays demonstrated that HIFs bound directly to the CBS gene in response to hypoxia. cerebral circulation cystathionine β-synthase (CBS) hydrogen sulfide hypoxia-inducible factor (HIF) oxygen U87-MG cells were cultured in DMEM...

...Roman Vozdek; Aleš Hnízda; Jakub Krijt; Marta Kostrouchová; Viktor Kožich CBSs (cystathionine β-synthases) are eukaryotic PLP (pyridoxal 5 *-phosphate)-dependent proteins that maintain cellular homocysteine homoeostasis and produce cystathionine and hydrogen sulfide. In the present study, we...

...Milos R. Filipovic; Jan Miljkovic; Andrea Allgäuer; Ricardo Chaurio; Tatyana Shubina; Martin Herrmann; Ivana Ivanovic-Burmazovic The reaction of hydrogen sulfide (H 2 S) with peroxynitrite (a key mediator in numerous pathological states) was studied in vitro and in different cellular models...