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Keywords: hydrophobic motif
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Articles

Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif

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Jianchuan Wang, Chen Zhong, Fang Wang, Fangfang Qu, Jianping Ding
Journal: Biochemical Journal
Biochem J (2013) 454 (1): 39–47.
https://doi.org/10.1042/BJ20121863
Published: 26 July 2013
...Jianchuan Wang; Chen Zhong; Fang Wang; Fangfang Qu; Jianping Ding The activity of S6K1 (p70 ribosomal protein subunit 6 kinase 1) is stimulated by phosphorylation of Thr 389 in the hydrophobic motif by mTORC1 (mammalian target of rapamycin complex 1) and phosphorylation of Thr 229 in the activation...
View articletitled, Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif
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Includes: Supplementary data
Articles

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5) P 3 -dependent mechanisms leading to resistance to PDK1 inhibitors

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Ayaz Najafov, Natalia Shpiro, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2012) 448 (2): 285–295.
https://doi.org/10.1042/BJ20121287
Published: 07 November 2012
...-dependent kinase-1) and its C-terminal hydrophobic motif (Ser 473 ) by mTORC2 [mTOR (mammalian target of rapamycin) complex 2]. Potent PDK1 inhibitors such as GSK2334470 have recently been elaborated as potential anti-cancer agents. However, these compounds were surprisingly ineffective at suppressing Akt...
View articletitled, Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5) P 3 -dependent mechanisms leading to resistance to PDK1 inhibitors
Open the PDF for Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5) P 3 -dependent mechanisms leading to resistance to PDK1 inhibitors in another window
Includes: Supplementary data