... a reduced level of the RyR2 protein to determine the impact of reduced RyR2 protein expression on the susceptibility to VT, cardiac alternans, cardiac hypertrophy, and sudden death. Electrocardiographic analysis revealed that after the injection of relatively high doses of caffeine and epinephrine (agents...

...Dong Woo Song; Jae Yong Ryu; Jin Ock Kim; Eun Jeong Kwon; Do Han Kim Progressive cardiac hypertrophy owing to pathological stimuli, such as pressure overload, is frequently associated with the development of heart failure, a major cause of morbidity and mortality worldwide. Growing evidence has...

...Alejandro Giraldo; Oliver P. T. Barrett; Marcus J. Tindall; Stephen J. Fuller; Emre Amirak; Bonhi S. Bhattacharya; Peter H. Sugden; Angela Clerk Endothelin-1 promotes cardiomyocyte hypertrophy by inducing changes in gene expression. Immediate early genes including Atf3 (activating transcription...

..., BC V6T 1Z3 Canada. 2 To whom correspondence should be addressed (email [email protected] ). 15 11 2004 16 2 2005 10 3 2005 10 3 2005 The Biochemical Society, London 2005 Cardiac hypertrophy is a major risk factor for heart failure and is characterized...

... is kinase-dependent. The hypertrophic effect of H11 at high doses was unmasked when apoptosis was inhibited by the caspase inhibitor DEVD-CHO, suggesting that H11 stimulates both hypertrophy and apoptosis in parallel. H11-KI induced hypertrophy even at high doses, indicating that H11 stimulates hypertrophy...

...Elodie MASSON; Nicolas WIERNSPERGER; Michel LAGARDE; Samer El BAWAB Alterations in proliferation and hypertrophy of renal mesangial cells are typical features of diabetic nephropathy. The HP (hexosamine pathway) has been proposed as a biochemical hypothesis to explain microvascular alterations due...

...Yves GORIN; Jill M. RICONO; Brent WAGNER; Nam-Ho KIM; Basant BHANDARI; Goutam Ghosh CHOUDHURY; Hanna E. ABBOUD Angiotensin II (Ang II) stimulates hypertrophy of glomerular mesangial cells. The signalling mechanism by which Ang II exerts this effect is not precisely known. Downstream potential...

... in the translational efficiency. 1 To whom correspondence should be addressed (e-mail [email protected] ). 18 2 2004 13 3 2004 19 3 2004 19 3 2004 The Biochemical Society, London ©2004 2004 hypertrophy mammalian target of rapamycin (mTOR) mechanotransduction protein synthesis...

...: cardiocyte, eIF4E (eukaryotic initiation factor 4E), hypertrophy, Mnk1 (MAP kinase signal-integrating kinase 1), protein synthesis, translation. INTRODUCTION Adult cardiac muscle cells (cardiocytes) are terminally differen- tiated and, therefore, growth of the myocardium occurs predomi- nantly via mechanisms...

... by specifically blocking G-protein αi activation. In contrast with wild-type cells, stable expression of the 3′-UTR ‘decoy’ produced AngII-stimulated protein synthesis and cellular hypertrophy as demonstrated by a significant increase in [ 3 H]leucine incorporation and no increase in [ 3 H]thymidine incorporation...

... correspondence should be addressed (e-mail [email protected] ). 9 1 2001 29 5 2001 25 6 2001 The Biochemical Society, London ©2001 2001 cell signalling hypertrophy mitogen-activated protein kinase Abbreviations used: ANF, atrial natriuretic factor; AP-1, activator...

... of INTRODUCTION The adult heart compensates for haemodynamic overload by undergoing hypertrophic growth, whereby an increase in left ventricle mass normalizes myocardial wall stress within a normal range [1 3]. During hypertrophy, accelerating the steady-state rate of protein synthesis by approx. 25 50% produces...