... of isolated eNOS to HOSCN or MPO/H 2 O 2 /SCN − decreased active dimeric eNOS levels, and increased inactive monomer and Zn 2+ release, compared with controls, HOCl (hypochlorous acid)- or MPO/H 2 O 2 /Cl − -treated samples. eNOS activity was increasingly compromised by MPO/H 2 O 2 /Cl − with increasing SCN...

...Martin D. Rees; Steven E. Bottle; Kathryn E. Fairfull-Smith; Ernst Malle; John M. Whitelock; Michael J. Davies Tissue damage resulting from the extracellular production of HOCl (hypochlorous acid) by the MPO (myeloperoxidase)-hydrogen peroxide-chloride system of activated phagocytes is implicated...

...D. Tim Harwood; Anthony J. Kettle; Christine C. Winterbourn GSH is rapidly oxidized by HOCl (hypochlorous acid), which is produced physiologically by the neutrophil enzyme myeloperoxidase. It is converted into, mainly, oxidized glutathione. Glutathione sulfonamide is an additional product...

..., hypochlorous acid, oxidative stress, oxidized low-density lipoprotein. structures of the resulting adducts generated in ŠiŠo are still unclear. One potential pathway for LDL oxidation involves myelo- peroxidase, an abundant haem protein secreted by activated phagocytes [8]. Catalytically active myeloperoxidase...

... © 2000 2000 amphipathic helix hypochlorous acid primary structure secondary structure Biochem. J. (2000) 346, 345 354 (Printed in Great Britain) 345 Reagent or myeloperoxidase-generated hypochlorite affects discrete regions in lipid-free and lipid-associated human apolipoprotein A-I...

... The Biochemical Society, London © 1999 1999 chlorination hypochlorous acid NADPH co-oxidation Biochem. J. (1999) 343, 603 613 (Printed in Great Britain) 603 NADPH as a co-substrate for studies of the chlorinating activity of myeloperoxidase Françoise AUCHE RE and Chantal CAPEILLE RE-BLANDIN1...