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Keywords: hypoxia inducible factors
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Articles

Regulation of chromatin accessibility by hypoxia and HIF

In Collection
Towards systems biochemistry
Michael Batie, Julianty Frost, Dilem Shakir, Sonia Rocha
Journal: Biochemical Journal
Biochem J (2022) 479 (6): 767–786.
https://doi.org/10.1042/BCJ20220008
Published: 28 March 2022
... to hypoxia is of great importance. The family of transcription factors called Hypoxia Inducible Factors (HIFs) co-ordinate a transcriptional programme required for survival and adaptation to hypoxia. However, the effects of HIF on chromatin accessibility are currently unclear. Here, using genome wide mapping...
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Includes: Supplementary data
Articles

Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling

In Collection
Towards systems biochemistry
Michael Batie, Niall S. Kenneth, Sonia Rocha
Journal: Biochemical Journal
Biochem J (2022) 479 (3): 245–257.
https://doi.org/10.1042/BCJ20210554
Published: 04 February 2022
... under the Creative Commons Attribution License 4.0 (CC BY) . genomics hypoxia hypoxia inducible factors proteomics transcriptomics Molecular oxygen is best known for its connection to oxidative phosphorylation and ATP production. Changes to oxygen availability give rise to complex...
View articletitled, Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling
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