1-8 of 8
Keywords: hypusine
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles

Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma

Chad R. Schultz, Dirk Geerts, Marie Mooney, Raid El-Khawaja, Jan Koster, André S. Bachmann
Journal: Biochemical Journal
Biochem J (2018) 475 (2): 531–545.
https://doi.org/10.1042/BCJ20170597
Published: 31 January 2018
...Chad R. Schultz; Dirk Geerts; Marie Mooney; Raid El-Khawaja; Jan Koster; André S. Bachmann The eukaryotic initiation factor 5A (eIF5A), which contributes to several crucial processes during protein translation, is the only protein that requires activation by a unique post-translational hypusine...
View article titled, Synergistic drug combination GC7&#x2F;DFMO suppresses <span class="search-highlight">hypusine</span>&#x2F;spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma
Open the PDF for Synergistic drug combination GC7/DFMO suppresses <span class="search-highlight">hypusine</span>/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma in another window
Includes: Supplementary data
Articles

Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1)

Seung Bum Lee, Jong Hwan Park, John E. Folk, Jason A. Deck, Anthony E. Pegg, Masaaki Sokabe, Christopher S. Fraser, Myung Hee Park
Journal: Biochemical Journal
Biochem J (2011) 433 (1): 205–213.
https://doi.org/10.1042/BJ20101322
Published: 15 December 2010
...Seung Bum Lee; Jong Hwan Park; John E. Folk; Jason A. Deck; Anthony E. Pegg; Masaaki Sokabe; Christopher S. Fraser; Myung Hee Park eIF5A (eukaryotic translation initiation factor 5A) is the only cellular protein containing hypusine [ N ϵ -(4-amino-2-hydroxybutyl)lysine]. eIF5A is activated...
View article titled, Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its <span class="search-highlight">hypusine</span> residue by spermidine&#x2F;spermine acetyltransferase 1 (SSAT1)
Open the PDF for Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its <span class="search-highlight">hypusine</span> residue by spermidine/spermine acetyltransferase 1 (SSAT1) in another window
Articles

Independent roles of eIF5A and polyamines in cell proliferation

Kazuhiro NISHIMURA, Kaori MUROZUMI, Akira SHIRAHATA, Myung Hee PARK, Keiko KASHIWAGI, Kazuei IGARASHI
Journal: Biochemical Journal
Biochem J (2005) 385 (3): 779–785.
https://doi.org/10.1042/BJ20041477
Published: 24 January 2005
...Kazuhiro NISHIMURA; Kaori MUROZUMI; Akira SHIRAHATA; Myung Hee PARK; Keiko KASHIWAGI; Kazuei IGARASHI To examine the roles of active hypusinated eIF5A (eukaryotic translation initiation factor 5A) and polyamines in cell proliferation, mouse mammary carcinoma FM3A cells were treated...
View article titled, Independent roles of eIF5A and polyamines in cell proliferation
Open the PDF for Independent roles of eIF5A and polyamines in cell proliferation in another window
Articles

Identification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential display

Aiguo XU, David Li-En JAO, Kuang Yu CHEN
Journal: Biochemical Journal
Biochem J (2004) 384 (3): 585–590.
https://doi.org/10.1042/BJ20041232
Published: 07 December 2004
...Aiguo XU; David Li-En JAO; Kuang Yu CHEN Eukaryotic initiation factor 5A (eIF-5A) is the only protein in nature that contains hypusine, an unusual amino acid formed post-translationally by deoxyhypusine synthase and deoxyhypusine hydroxylase. Genetic and pharmacological evidence suggests that eIF...
View article titled, Identification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential display
Open the PDF for Identification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential display in another window
Articles

Inhibition of cell growth through inactivation of eukaryotic translation initiation factor 5A (eIF5A) by deoxyspergualin

Kazuhiro NISHIMURA, Yuji OHKI, Tomomi FUKUCHI-SHIMOGORI, Kaori SAKATA, Kan SAIGA, Takanobu BEPPU, Akira SHIRAHATA, Keiko KASHIWAGI, Kazuei IGARASHI
Journal: Biochemical Journal
Biochem J (2002) 363 (3): 761–768.
https://doi.org/10.1042/bj3630761
Published: 24 April 2002
... is strongly involved in the inhibition of cell growth by deoxyspergualin. 1 To whom correspondence should be addressed (e-mail [email protected] ). 18 7 2001 3 1 2002 8 2 2002 The Biochemical Society, London ©2002 2002 spermidine hypusine FM3A cells...
View article titled, Inhibition of cell growth through inactivation of eukaryotic translation initiation factor 5A (eIF5A) by deoxyspergualin
Open the PDF for Inhibition of cell growth through inactivation of eukaryotic translation initiation factor 5A (eIF5A) by deoxyspergualin in another window
Articles

Structure–function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NAD

Chang Hoon LEE, Patrick Y. UM, Myung Hee PARK
Journal: Biochemical Journal
Biochem J (2001) 355 (3): 841–849.
https://doi.org/10.1042/bj3550841
Published: 24 April 2001
...Chang Hoon LEE; Patrick Y. UM; Myung Hee PARK Deoxyhypusine synthase catalyses the first step in the biosynthesis of hypusine [ N ε -(4-amino-2-hydroxybutyl)lysine]. The crystal structure of human deoxyhypusine synthase in complex with NAD revealed four NAD-binding sites per enzyme tetramer...
View article titled, Structure–function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NAD
Open the PDF for Structure–function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NAD in another window
Articles

Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates

Chang Hoon LEE, Myung Hee PARK
Journal: Biochemical Journal
Biochem J (2000) 352 (3): 851–857.
https://doi.org/10.1042/bj3520851
Published: 08 December 2000
... 2000 26 9 2000 The Biochemical Society, London © 2000 2000 eIF5A hypusine spermidine Biochem. J. (2000) 352, 851 857 (Printed in Great Britain) 851 Human deoxyhypusine synthase : interrelationship between binding of NAD and substrates Chang Hoon LEE and Myung Hee PARK1 Building 30...
View article titled, Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates
Open the PDF for Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates in another window
Articles

Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor

Young Bok LEE, Young Ae JOE, Edith C. WOLFF, Emilios K. DIMITRIADIS, Myung Hee PARK
Journal: Biochemical Journal
Biochem J (1999) 340 (1): 273–281.
https://doi.org/10.1042/bj3400273
Published: 10 May 1999
...Young Bok LEE; Young Ae JOE; Edith C. WOLFF; Emilios K. DIMITRIADIS; Myung Hee PARK Deoxyhypusine synthase catalyses the first step in the post-translational synthesis of hypusine [ N ϵ -(4-amino-2-hydroxybutyl) lysine] in a single cellular protein, the precursor of eukaryotic initiation factor 5A...
View article titled, Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor
Open the PDF for Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor in another window