.... In the present paper we show that CIC mRNA and protein markedly increase in lipopolysaccharide-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of NO, reactive oxygen species and prostaglandins. These results demonstrate for the first time that CIC...

...Claire E. EYERS; Helen McNEILL; Axel KNEBEL; Nick MORRICE; Simon J. C. ARTHUR; Ana CUENDA; Philip COHEN A protein expressed in immune cells and muscle was detected in muscle extracts as a substrate for several SAPKs (stress-activated protein kinases). It interacted specifically with the F-actin...

...Mathias ZIEGLER; Marc NIERE NAD + and its metabolites serve important functions in intracellular signalling. NAD + -mediated regulatory processes also take place on the cell surface, particularly of immune cells. In this issue of the Biochemical Journal , Gerth et al. have demonstrated a new...