... Society under a transformative agreement with Jisc. bacteriophages CRISPR endonucleases immunology non-coding RNA Type III CRISPR systems stand out for their reliance on signalling pathways to confer complex and multifaceted immune response [ 10 ]. Most subtype III-A (Csm, Cas subtype...

... viral proteins [ 52 ], are known to contain functional RHIMs: RIPK1 [ 21 ], RIPK3 [ 21 ], TRIF [ 68 , 69 ], and ZBP1 [ 70 ]. TRIF is an adaptor protein that mediates immunological responses to invading pathogens upon ligation of TLR3 and -4, whereas ZBP1 is an intracellular receptor that recognizes Z...

... by CD2 and CD28 co-stimulation lead to distinct functional immune responses in T-cell proliferation and cytokine production. In conclusion, CD2 and CD28 co-stimulation induces distinct signalling responses and functional outcomes in T-cells. co-stimulation immunology nuclear factor κB (NF-κB...