... as agonists or antagonists on various cell types. TGMs, which function by molecularly mimicking binding of the host cytokine to the host TGF-β receptors, are examples of highly evolved immunomodulators from parasites, including those that block interleukin (IL)-13 and IL-33 signalling, modulate macrophage...

... instructions and images were recorded using a ChemiDoc™ Imaging System (Bio-Rad). immunomodulation NAD nicotinamide adenine dinucleotide purinergic signalling schistosome Schistosoma is a genus of parasitic intravascular platyhelminths, commonly called blood flukes. These worms...

.... Correspondence: Isabel Mérida ( [email protected] ) 15 2 2019 29 3 2019 1 4 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 endosomal sorting immunomodulation protein kinase C synapses synaptic plasticity T cells...

... activation of the classical complement pathway and down-regulated effector responses of dendritic cells, which implicate PfCCp1 and related proteins in immunomodulation of the host that likely benefits the parasite. PfCCp1 belongs to a multi-domain protein family that exists as multimeric protein complexes...

..., demonstrating an important role of EBP50 in this complex. In summary, both the biochemical and functional data indicate that targeting the Ezrin–EBP interaction could be a novel and potent strategy for immunomodulation. 1 Present address: Department of Biochemistry, Institute of Basic Medical Sciences...