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Keywords: immunomodulation
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Articles
Journal:
Biochemical Journal
Biochem J (2025) 482 (09): 433–449.
Published: 29 April 2025
... as agonists or antagonists on various cell types. TGMs, which function by molecularly mimicking binding of the host cytokine to the host TGF-β receptors, are examples of highly evolved immunomodulators from parasites, including those that block interleukin (IL)-13 and IL-33 signalling, modulate macrophage...
Articles
NAD-catabolizing ectoenzymes of Schistosoma mansoni
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Journal:
Biochemical Journal
Biochem J (2022) 479 (11): 1165–1180.
Published: 08 June 2022
... instructions and images were recorded using a ChemiDoc™ Imaging System (Bio-Rad). immunomodulation NAD nicotinamide adenine dinucleotide purinergic signalling schistosome Schistosoma is a genus of parasitic intravascular platyhelminths, commonly called blood flukes. These worms...
Articles
Diacylglycerol kinase control of protein kinase C
Available to PurchaseIn Collection
Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019
Journal:
Biochemical Journal
Biochem J (2019) 476 (8): 1205–1219.
Published: 18 April 2019
.... Correspondence: Isabel Mérida ( [email protected] ) 15 2 2019 29 3 2019 1 4 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 endosomal sorting immunomodulation protein kinase C synapses synaptic plasticity T cells...
Articles
Interaction with complement proteins and dendritic cells implicates LCCL domain-containing proteins (CCps) of malaria parasites in immunomodulation
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Journal:
Biochemical Journal
Biochem J (2018) 475 (21): 3311–3314.
Published: 06 November 2018
... activation of the classical complement pathway and down-regulated effector responses of dendritic cells, which implicate PfCCp1 and related proteins in immunomodulation of the host that likely benefits the parasite. PfCCp1 belongs to a multi-domain protein family that exists as multimeric protein complexes...
Articles
The adaptor protein EBP50 is important for localization of the protein kinase A–Ezrin complex in T-cells and the immunomodulating effect of cAMP
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Journal:
Biochemical Journal
Biochem J (2010) 425 (2): 381–388.
Published: 23 December 2009
..., demonstrating an important role of EBP50 in this complex. In summary, both the biochemical and functional data indicate that targeting the Ezrin–EBP interaction could be a novel and potent strategy for immunomodulation. 1 Present address: Department of Biochemistry, Institute of Basic Medical Sciences...