... a duplex that encoded the GDDDTSRMEEVD sequence found at the C-terminal of hsp90 and ligating it with the pre-cut T7 415-1b arms (Novagen). heat-shock protein (hsp) immunophilin phage display protein phosphatase 5 (PP5) steroid receptor tetratricopeptide repeat (TPR) domains...

... be addressed (email [email protected] ). 3 12 2008 17 2 2009 18 2 2009 18 2 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 arrhythmogenic cardiac disease FKBP12.6 immunophilin protein interaction redox regulation ryanodine receptor...

...Miriam Laxa; Janine König; Karl-Josef Dietz; Andrea Kandlbinder Cyps (cyclophilins) are ubiquitous proteins of the immunophilin superfamily with proposed functions in protein folding, protein degradation, stress response and signal transduction. Conserved cysteine residues further suggest a role...

... of the immunosuppressant is used. Recently, immunophilin interchange has been identified as a first step in glucocorticoid receptor activation following ligand activation. We show here that the FKB51 (FK506-binding protein 51)–FKB52 switch is differentially regulated by glucocorticoid and FK506 treatment strategy. 1...

..., London ©2002 2002 calcium immunophilin InsP 3 R ryanodine receptor Abbreviations used: FKBP12, FK506-binding protein; Ins P 3 , Ins(1,4,5) P 3 ; InsP 3 R, Ins P 3 receptor; RyR, ryanodine receptor; SERCA, sarcoplasmic/endoplasmic-reticulum Ca 2+ -ATPase. Biochem. J. (2002) 361...

..., in contrast to RyR1 and RyR3, did not display a specific, high-affinity interaction with FKBP12. 1 To whom correspondence should be addressed (e-mail [email protected] ). 29 8 2000 5 12 2000 3 1 2001 The Biochemical Society, London © 2001 2001 immunophilin...