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Histone deacetylase 7 activates 6-phosphogluconate dehydrogenase via an enzyme-independent mechanism that involves the N-terminal protein-protein interaction domain

Yizhuo Wang, James E.B. Curson, Divya Ramnath, Kaustav Das Gupta, Robert C. Reid, Denuja Karunakaran, David P. Fairlie, Matthew J. Sweet

Biochem J (2024) 481 (21): 1569–1584.

https://doi.org/10.1042/BCJ20240380

Published: 25 October 2024

.... Sweet ( [email protected] ) * Present address: Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia. 6-phosphogluconate dehydrogenase HDACs histone deacetylase 7 inflammation lysine deacetylase scaffolding...

View article titled, Histone deacetylase 7 activates 6-phosphogluconate dehydrogenase via an enzyme-independent mechanism that involves the N-terminal protein-protein interaction domain

Articles

Identification of a 10-mer peptide from the death domain of MyD88 which attenuates inflammation and insulin resistance and improves glucose metabolism

Mehmood Ali, Tripti Kumari, Arvind Gupta, Sariyah Akhtar, Rahul Dev Verma, Jimut Kanti Ghosh

Biochem J (2024) 481 (4): 191–218.

https://doi.org/10.1042/BCJ20230369

Published: 13 February 2024

...Mehmood Ali; Tripti Kumari; Arvind Gupta; Sariyah Akhtar; Rahul Dev Verma; Jimut Kanti Ghosh Insulin resistance (IR) is the key pathophysiological cause of type 2 diabetes, and inflammation has been implicated in it. The death domain (DD) of the adaptor protein, MyD88 plays a crucial role...

View article titled, Identification of a 10-mer peptide from the death domain of MyD88 which attenuates inflammation and insulin resistance and improves glucose metabolism

Includes: Supplementary data

Articles

Understanding interleukin 11 as a disease gene and therapeutic target

Stuart A. Cook

Biochem J (2023) 480 (23): 1987–2008.

https://doi.org/10.1042/BCJ20220160

Published: 06 December 2023

..., ERK/P90RSK, LKB1/mTOR and GSK3β/SNAI1 in autocrine and paracrine. This activates a program of mesenchymal transition of epithelial, stromal, and endothelial cells to cause inflammation, fibrosis, and stalled endogenous tissue repair, leading to organ failure. The role of IL11 signalling in cell...

View article titled, Understanding interleukin 11 as a disease gene and therapeutic target

Articles

Protein targeting by the itaconate family in immunity and inflammation

Emily A. Day, Luke A.J. O'Neill

Biochem J (2022) 479 (24): 2499–2510.

https://doi.org/10.1042/BCJ20220364

Published: 22 December 2022

...-inflammatory therapeutics. Correspondence: Emily A. Day ( [email protected] ) 31 10 2022 6 12 2022 7 12 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 immunometabolism infection inflammation itaconate post...

View article titled, Protein targeting by the itaconate family in immunity and inflammation

Articles

Mechanisms of TNF-independent RIPK3-mediated cell death

Bart Tummers, Douglas R. Green

Biochem J (2022) 479 (19): 2049–2062.

https://doi.org/10.1042/BCJ20210724

Published: 14 October 2022

... Attribution License 4.0 (CC BY) . apoptosis cell death immunology inflammation necroptosis RIPK3 Regulated cell death is a biological process with essential functions in organismal development, tissue homeostasis, and immune defense. Regulated cell death comes in many forms [ 1 ], the best...

View article titled, Mechanisms of TNF-independent RIPK3-mediated cell death

Articles

Programmed cell death: the pathways to severe COVID-19?

In Collection

Cell death and survival , Coronavirus

Stefanie M. Bader, James P. Cooney, Marc Pellegrini, Marcel Doerflinger

Biochem J (2022) 479 (5): 609–628.

https://doi.org/10.1042/BCJ20210602

Published: 04 March 2022

... roll-out and the emergence of novel variants of concern such as omicron underscore the critical importance of identifying the mechanisms that contribute to this disease. Overt inflammation and cell death have been proposed to be central drivers of severe pathology in COVID-19 patients...

View article titled, Programmed cell death: the pathways to severe COVID-19?

Articles

Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway

Dipanjan Chattopadhyay, Snehasis Das, Suktara Guria, Soumyadeep Basu, Sutapa Mukherjee

Biochem J (2021) 478 (22): 4027–4043.

https://doi.org/10.1042/BCJ20210442

Published: 26 November 2021

...Dipanjan Chattopadhyay; Snehasis Das; Suktara Guria; Soumyadeep Basu; Sutapa Mukherjee In the context of obesity-induced adipose tissue (AT) inflammation, migration of macrophages and their polarization from predominantly anti-inflammatory to proinflammatory subtype is considered a pivotal event...

View article titled, Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway

Includes: Supplementary data

Articles

Gut microbiome a promising target for management of respiratory diseases

Riddhi Trivedi, Kalyani Barve

Biochem J (2020) 477 (14): 2679–2696.

https://doi.org/10.1042/BCJ20200426

Published: 29 July 2020

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 asthma dysbiosis inflammation microfluidics respiratory diseases Microbiota refers to a concoction of microbial flora present in the body. Microbiota are ecological communities of commensal...

View article titled, Gut microbiome a promising target for management of respiratory diseases

Articles

The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice

In Collection

Celebrating 100 years of insulin research

Emily A. Day, Rebecca J. Ford, Jessie H. Lu, Rachel Lu, Lucie Lundenberg, Eric M. Desjardins, Alex E. Green, James S.V. Lally, Jonathan D. Schertzer, Gregory R. Steinberg

Biochem J (2020) 477 (12): 2347–2361.

https://doi.org/10.1042/BCJ20200278

Published: 26 June 2020

... with type 2 diabetes through mechanisms that are not fully understood. Canagliflozin has been shown to increase the activity of the AMP-activated protein kinase (AMPK), a metabolic energy sensor important for increasing fatty acid oxidation and energy expenditure and suppressing lipogenesis and inflammation...

View article titled, The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice

Includes: Supplementary data

Articles

The NLRP3 inflammasome regulates adipose tissue metabolism

In Collection

Adipose biology

Nicole G. Barra, Brandyn D. Henriksbo, Fernando F. Anhê, Jonathan D. Schertzer

Biochem J (2020) 477 (6): 1089–1107.

https://doi.org/10.1042/BCJ20190472

Published: 23 March 2020

... the coordination of adipocyte lipogenesis and lipolysis. These defects in adipose tissue metabolism can promote ectopic lipid deposition and inflammation in insulin-sensitive tissues such as skeletal muscle and liver. Sustained caloric excess can expand white adipose tissue to a point of maladaptation exacerbating...

View article titled, The NLRP3 inflammasome regulates adipose tissue metabolism

Articles

C-Jun/C7ORF41/NF-κB axis mediates hepatic inflammation and lipid accumulation in NAFLD

Feng-Juan Yan, Xu Wang, Song-En Wang, Hai-Ting Hong, Jun Lu, Qin Ye, Yuan-Lin Zheng, Yong-Jian Wang

Biochem J (2020) 477 (3): 691–708.

https://doi.org/10.1042/BCJ20190799

Published: 11 February 2020

... poorly understood. Here, we showed that hepatic C7ORF41, a critical regulator of innate immune response, was markedly decreased in diet or genetic-induced NAFLD model. We also demonstrated that C7ORF41 overexpression significantly ameliorated hepatic inflammation and lipid accumulation in palmitic acid...

View article titled, C-Jun/C7ORF41/NF-κB axis mediates hepatic inflammation and lipid accumulation in NAFLD

Includes: Supplementary data

Articles

CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction

Joji Kusuyama, Kenjiro Bandow, Tomokazu Ohnishi, Muhammad Subhan Amir, Kaori Shima, Ichiro Semba, Tetsuya Matsuguchi

Biochem J (2019) 476 (22): 3533–3548.

https://doi.org/10.1042/BCJ20190709

Published: 27 November 2019

... as CXCR5 knockdown by specific siRNA effectively inhibited DFO-induced inflammation. The phosphorylation of Akt2, a protective factor of adipose inflammation, was significantly inhibited by CXCL13 treatment during adipogenic differentiation. Mechanistically, CXCL13 induces the expression of PHLPP1, an Akt2...

View article titled, CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction

Articles

The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally

Lisa Schmidtke, Katharina Schrick, Sabrina Saurin, Rudolf Käfer, Fabian Gather, Julia Weinmann-Menke, Hartmut Kleinert, Andrea Pautz

Biochem J (2019) 476 (2): 333–352.

https://doi.org/10.1042/BCJ20180522

Published: 31 January 2019

... of the Biochemical Society 2019 inflammation interferons mRNA decay The interferon (IFN) cytokine family consists of type I, II and III IFNs. All family members have important antiviral and antimicrobial activities in innate and adaptive immune responses. Type III IFNs, also known as interferon...

View article titled, The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally

Includes: Supplementary data

Articles

Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

In Collection

Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019

Hiroyuki Nakayama, Kinya Otsu

Biochem J (2018) 475 (5): 839–852.

https://doi.org/10.1042/BCJ20170714

Published: 06 March 2018

...Hiroyuki Nakayama; Kinya Otsu Mitochondria play a central role in multiple cellular functions, including energy production, calcium homeostasis, and cell death. Currently, growing evidence indicates the vital roles of mitochondria in triggering and maintaining inflammation. Chronic inflammation...

View article titled, Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

Articles

Globular C1q receptor (p33) binds and stabilizes pro-inflammatory MCP-1: a novel mechanism for regulation of MCP-1 production and function

Emma Anders, Daniel Nebel, Johannes Westman, Heiko Herwald, Bengt-Olof Nilsson, Daniel Svensson

Biochem J (2018) 475 (4): 775–786.

https://doi.org/10.1042/BCJ20170857

Published: 23 February 2018

... ) 9 11 2017 16 1 2018 18 1 2018 22 1 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cytokine gC1qR (gC1qBP) inflammation MCP-1 (CCL2) periodontal ligament cells (PDL cells) protein–protein interactions...

View article titled, Globular C1q receptor (p33) binds and stabilizes pro-inflammatory MCP-1: a novel mechanism for regulation of MCP-1 production and function

Includes: Supplementary data

Articles

Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate

Sandra Kümper, Thorsten Gantke, Chao-Sheng Chen, Yasmina Soneji, Michael J. Pattison, Probir Chakravarty, Svend Kjær, Daniel Thomas, Carl Haslam, Bill J. Leavens, David House, David J. Powell, Steven C. Ley

Biochem J (2018) 475 (1): 329–340.

https://doi.org/10.1042/BCJ20170579

Published: 11 January 2018

...) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . high-throughput assay inflammation kinase TPL-2 The pro-inflammatory cytokine tumour necrosis...

View article titled, Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate

Includes: Supplementary data

Articles

Buddleja thyrsoides Lam. crude extract presents antinociceptive effect on an arthritic pain model in mice

Maria Fernanda Pessano Fialho, Indiara Brusco, Evelyne da Silva Brum, Mariana Piana, Aline Augusti Boligon, Gabriela Trevisan, Sara Marchesan Oliveira

Biochem J (2017) 474 (17): 2993–3010.

https://doi.org/10.1042/BCJ20170008

Published: 17 August 2017

... 2017 17 7 2017 19 7 2017 24 7 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 arthritis Barbasco Cambará nociception pain inflammation Arthritis is a chronic inflammatory systemic autoimmune disease...

View article titled, Buddleja thyrsoides Lam. crude extract presents antinociceptive effect on an arthritic pain model in mice

Articles

Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway

Chunyang Du, Tao Zhang, Xia Xiao, Yonghong Shi, Huijun Duan, Yunzhuo Ren

Biochem J (2017) 474 (16): 2733–2747.

https://doi.org/10.1042/BCJ20170272

Published: 02 August 2017

...Chunyang Du; Tao Zhang; Xia Xiao; Yonghong Shi; Huijun Duan; Yunzhuo Ren Protease-activated receptor-2 (PAR2), which belongs to a specific class of the G-protein-coupled receptors, is central to several inflammation processes. However, the precise molecular mechanism involved remains undefined...

View article titled, Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway

Articles

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages

Nicola J. Darling, Rachel Toth, J. Simon C. Arthur, Kristopher Clark

Biochem J (2017) 474 (4): 521–537.

https://doi.org/10.1042/BCJ20160646

Published: 03 February 2017

... inflammation macrophage salt-inducible kinase TNF-α Macrophages play diverse roles in the immune response due to their innate ability to adapt their physiology to the changing needs of the host [ 1 – 3 ]. In response to infection or tissue damage, macrophages acquire an inflammatory phenotype...

View article titled, Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages

Includes: Supplementary data

Articles

TNF up-regulates ST3GAL4 and sialyl-Lewis x expression in lung epithelial cells through an intronic ATF2-responsive element

Florent Colomb, Marie-Ange Krzewinski-Recchi, Agata Steenackers, Audrey Vincent, Anne Harduin-Lepers, Philippe Delannoy, Sophie Groux-Degroote

Biochem J (2017) 474 (1): 65–78.

https://doi.org/10.1042/BCJ20160602

Published: 22 December 2016

... the binding of ATF2 to the TNF-responsive element. Altogether, these data suggest that ATF2 could be a potential target to prevent inflammation-induced P. aeruginosa binding in the lung of patients suffering from lung diseases such as chronic bronchitis or cystic fibrosis. Correspondence: Sophie Groux...

View article titled, TNF up-regulates ST3GAL4 and sialyl-Lewis x expression in lung epithelial cells through an intronic ATF2-responsive element

Articles

HCN2 ion channels: basic science opens up possibilities for therapeutic intervention in neuropathic pain

Christoforos Tsantoulas, Elizabeth R. Mooney, Peter A. McNaughton

Biochem J (2016) 473 (18): 2717–2736.

https://doi.org/10.1042/BCJ20160287

Published: 12 September 2016

... 4 2016 16 5 2016 18 5 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 cAMP HCN2 ivabradine inflammation Pain is as old as animals — a low-level sensory system that has warned us of harm from time immemorial...

View article titled, HCN2 ion channels: basic science opens up possibilities for therapeutic intervention in neuropathic pain

Articles

8,9-Dehydrohispanolone-15,16-lactol diterpene prevents LPS-triggered inflammatory responses by inhibiting endothelial activation

Lidia Jiménez-García, Paqui G. Través, Raquel López-Fontal, Sandra Herranz, María Angeles Higueras, Beatriz de las Heras, Sonsoles Hortelano, Alfonso Luque

Biochem J (2016) 473 (14): 2061–2071.

https://doi.org/10.1042/BCJ20160343

Published: 12 July 2016

..., vascular-targeted therapies constitute promising strategies for the treatment of inflammatory pathologies. In the present study, we evaluated the effect of 8,9-dehydrohispanolone-15,16-lactol diterpene (DT) on lung endothelium during inflammation. Lung endothelial cells pre-treated with DT and activated...

View article titled, 8,9-Dehydrohispanolone-15,16-lactol diterpene prevents LPS-triggered inflammatory responses by inhibiting endothelial activation

Articles

The arterial microenvironment: the where and why of atherosclerosis

Arif Yurdagul, Jr, Alexandra C. Finney, Matthew D. Woolard, A. Wayne Orr

Biochem J (2016) 473 (10): 1281–1295.

https://doi.org/10.1042/BJ20150844

Published: 11 May 2016

... factors and the local arterial microenvironment. Multiple components of the arterial microenvironment contribute to plaque formation, including vessel mechanics, matrix composition and local production and deposition of soluble factors that perpetuate atherogenic inflammation ( Figure 1 ). Haemodynamics...

View article titled, The arterial microenvironment: the where and why of atherosclerosis

Articles

Characterization of a double-CRD-mutated Gal-8 recombinant protein that retains co-stimulatory activity on antigen-specific T-cell response

Matías Nicolás Schroeder, María Virginia Tribulatti, Julieta Carabelli, Gwenaëlle André-Leroux, Julio Javier Caramelo, Valentina Cattaneo, Oscar Campetella

Biochem J (2016) 473 (7): 887–898.

https://doi.org/10.1042/BJ20150409

Published: 29 March 2016

...-operativity of the curves. galectin glycan affinity inflammation T-cell proliferation T-cell receptor co-stimulation Galectins (Gals) constitute a family of secreted mammalian lectins with affinity for β-galactosides that bind glycoreceptors on target cells and induce multiple biological...

View article titled, Characterization of a double-CRD-mutated Gal-8 recombinant protein that retains co-stimulatory activity on antigen-specific T-cell response

Includes: Supplementary data

Articles

Analysis of the intricate relationship between chronic inflammation and cancer

Edna Zhi Pei Chai, Kodappully Sivaraman Siveen, Muthu K. Shanmugam, Frank Arfuso, Gautam Sethi

Biochem J (2015) 468 (1): 1–15.

https://doi.org/10.1042/BJ20141337

Published: 05 May 2015

... microenvironment is not entirely understood owing to the complex cross-talk between pro-inflammatory and tumorigenic mediators such as cytokines, chemokines, oncogenes, enzymes, transcription factors and immune cells. These molecular mediators are critical linchpins between inflammation and cancer...

View article titled, Analysis of the intricate relationship between chronic inflammation and cancer

Articles

Calcium/Ask1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium

Geetha Samak, Kamaljit K. Chaudhry, Ruchika Gangwar, Damodaran Narayanan, Jonathan H. Jaggar, RadhaKrishna Rao

Biochem J (2015) 465 (3): 503–515.

https://doi.org/10.1042/BJ20140450

Published: 22 January 2015

... kinase (JNK) intestine inflammation MKK7 Src tight junction Delineation of the signalling mechanism involved in disruption of epiithelial tight junctions by DSS, a widely used chemical stress in inducing ulcerative colitis. This study shows that calcium/Ask1/MKK7/JNK2/cSrc signalling cascade...

View article titled, Calcium/Ask1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium

Includes: Supplementary data

Articles

The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

James Ozanne, Alan R. Prescott, Kristopher Clark

Biochem J (2015) 465 (2): 271–279.

https://doi.org/10.1042/BJ20141165

Published: 06 January 2015

...James Ozanne; Alan R. Prescott; Kristopher Clark Macrophages switch to an anti-inflammatory, ‘regulatory’-like phenotype characterized by the production of high levels of interleukin (IL)-10 and low levels of pro-inflammatory cytokines to promote the resolution of inflammation. A potential...

View article titled, The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

Includes: Supplementary data

Articles

Priming IKKβ kinase for action

Steven C. Ley, Rudi Beyaert

Biochem J (2014) 463 (1): e1–e2.

https://doi.org/10.1042/BJ20140989

Published: 08 September 2014

... 8 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 inflammation inhibitor of NF-κB kinase β (IKKβ) nuclear factor κB (NF-κB) transforming growth factor β-activated kinase-1 (TAK1) phosphorylation ubiquitination The NF-κB (nuclear factor κB...

View article titled, Priming IKKβ kinase for action

Articles

Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependent oxidation of epicatechins

Nina Dickerhof, Nicholas J. Magon, Joel D. A. Tyndall, Anthony J. Kettle, Mark B. Hampton

Biochem J (2014) 462 (2): 303–314.

https://doi.org/10.1042/BJ20140612

Published: 07 August 2014

... proline of the pro-inflammatory cytokine MIF at equimolar concentrations. dopachrome tautomerase epicatechin inflammation macrophage migration inhibitory factor (MIF) myeloperoxidase (MPO) MIF (macrophage migration inhibitory factor) is emerging as an important therapeutic target...

View article titled, Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependent oxidation of epicatechins

Includes: Supplementary data

Articles

Mitochondrial–nuclear genome interactions in non-alcoholic fatty liver disease in mice

Angela M. Betancourt, Adrienne L. King, Jessica L. Fetterman, Telisha Millender-Swain, Rachel D. Finley, Claudia R. Oliva, David R. Crowe, Scott W. Ballinger, Shannon M. Bailey

Biochem J (2014) 461 (2): 223–232.

https://doi.org/10.1042/BJ20131433

Published: 26 June 2014

... macrosteatosis, inflammation and fibrosis compared with mice containing the C3H/HeN nuclear genome when fed the atherogenic diet. These changes were associated with parallel alterations in inflammation and fibrosis gene expression in wild-type mice, with intermediate responses in MNX mice. Mice with the C57BL/6J...

View article titled, Mitochondrial–nuclear genome interactions in non-alcoholic fatty liver disease in mice

Includes: Supplementary data

Articles

Chitinase-3-like protein 1 protects skeletal muscle from TNFα-induced inflammation and insulin resistance

Sven W. Görgens, Kristin Eckardt, Manuela Elsen, Norbert Tennagels, Jürgen Eckel

Biochem J (2014) 459 (3): 479–488.

https://doi.org/10.1042/BJ20131151

Published: 11 April 2014

... of inflammation, the function of this protein is not completely understood. In the present study, we examined the regulation of CHI3L1 in primary human skeletal muscle cells. Moreover, we analysed potential autocrine effects of CHI3L1. We show that myotubes express CHI3L1 in a differentiation-dependent manner...

View article titled, Chitinase-3-like protein 1 protects skeletal muscle from TNFα-induced inflammation and insulin resistance

Includes: Supplementary data

Articles

Liver X receptor: from metabolism to cancer

Nicolas Venteclef, Pascal Ferré

Biochem J (2014) 459 (2): e1–e3.

https://doi.org/10.1042/BJ20140211

Published: 28 March 2014

... in the pathogenesis of atherosclerosis and related cardiovascular disease pathogenesis [ 6 ]. The oxysterols have been reported to modulate innate inflammation towards a pro- or anti-inflammatory response. Unexpectedly, several recent studies have identified oxysterols as critical signalling molecules...

View article titled, Liver X receptor: from metabolism to cancer

Articles

Involvement of monocytes/macrophages as key factors in the development and progression of cardiovascular diseases

María Fernández-Velasco, Silvia González-Ramos, Lisardo Boscá

Biochem J (2014) 458 (2): 187–193.

https://doi.org/10.1042/BJ20131501

Published: 14 February 2014

... pathologies myocardial infarction and atherosclerosis. Mo are innate immune cells derived from the myeloid lineage in the bone marrow [ 23 ]; however, under certain conditions, such as inflammation, extramedullary monocytopoiesis has been reported [ 12 , 24 ]. Consequently, some authors have suggested...

View article titled, Involvement of monocytes/macrophages as key factors in the development and progression of cardiovascular diseases

Includes: Multimedia, Supplementary data

Articles

Characterization of inflamin, the first member of a new family of snake venom proteins that induces inflammation

Bhaskar Barnwal, R. Manjunatha Kini

Biochem J (2013) 455 (2): 239–250.

https://doi.org/10.1042/BJ20130599

Published: 27 September 2013

... amino acid residues that was identified in its cDNA library. As it induced inflammation and writhing in animals, this protein was named inflamin. It induced two waves of prostanoid production. The first wave peaked at 10 min and 6-oxo PGF 1α (prostaglandin F 1α ) (6-keto PGF 1α ) was the major product...

View article titled, Characterization of inflamin, the first member of a new family of snake venom proteins that induces inflammation

Includes: Supplementary data

Articles

Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes

Robert Stöhr, Massimo Federici

Biochem J (2013) 454 (1): 1–11.

https://doi.org/10.1042/BJ20130121

Published: 26 July 2013

...Robert Stöhr; Massimo Federici For some time now it has been known that diabetes and atherosclerosis are chronic inflammatory diseases that are closely associated with one another and often develop together. In both there is an increase in tissue-wide inflammation that is exhibited...

View article titled, Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes

Articles

Zc3h12c inhibits vascular inflammation by repressing NF-κB activation and pro-inflammatory gene expression in endothelial cells

Ling Liu, Zhou Zhou, Shengping Huang, Yanhong Guo, Yanbo Fan, Ji Zhang, Jifeng Zhang, Mingui Fu, Y. Eugene Chen

Biochem J (2013) 451 (1): 55–60.

https://doi.org/10.1042/BJ20130019

Published: 14 March 2013

...Ling Liu; Zhou Zhou; Shengping Huang; Yanhong Guo; Yanbo Fan; Ji Zhang; Jifeng Zhang; Mingui Fu; Y. Eugene Chen Endothelial activation characterized by the expression of multiple chemokines and adhesive molecules is a critical initial step of vascular inflammation, which results in recruitment...

View article titled, Zc3h12c inhibits vascular inflammation by repressing NF-κB activation and pro-inflammatory gene expression in endothelial cells

Articles

Phosphorylation regulates TRPV1 association with β-arrestin-2

Elaine D. Por, Ruben Gomez, Armen N. Akopian, Nathaniel A. Jeske

Biochem J (2013) 451 (1): 101–109.

https://doi.org/10.1042/BJ20121637

Published: 14 March 2013

...) and β1-integrin (M-106, Santa Cruz Biotechnology). β-arrestin-2 desensitization inflammation pain phosphorylation transient receptor potential vanilloid 1 (TRPV1) Capsaicin, 8-Br (8-Br-cAMP), H-89 and GFX (GF 109203X) were purchased from Sigma–Aldrich. TBB (4,5,6,7...

View article titled, Phosphorylation regulates TRPV1 association with β-arrestin-2

Articles

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

Claudia Broder, Christoph Becker-Pauly

Biochem J (2013) 450 (2): 253–264.

https://doi.org/10.1042/BJ20121751

Published: 15 February 2013

..., inflammation, fibrosis and neurodegenerative diseases. Different animal models, as well as proteomics approaches for the identification of protease substrates, have helped to reveal more precise molecular signalling events mediated by meprin activity, such as activation and release of pro-inflammatory...

View article titled, The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

Includes: Multimedia, Supplementary data

Articles

YB-1: oncoprotein, prognostic marker and therapeutic target?

Annette Lasham, Cristin G. Print, Adele G. Woolley, Sandra E. Dunn, Antony W. Braithwaite

Biochem J (2013) 449 (1): 11–23.

https://doi.org/10.1042/BJ20121323

Published: 07 December 2012

... regulates multiple proliferation pathways, overrides cell-cycle check points, promotes replicative immortality and genomic instability, may regulate angiogenesis, has a role in invasion and metastasis, and promotes inflammation. We also argue that there is strong and sufficient evidence to suggest that YB-1...

View article titled, YB-1: oncoprotein, prognostic marker and therapeutic target?

Articles

Protein kinase Cϵ activity induces anti-inflammatory and anti-apoptotic genes via an ERK1/2- and NF-κB-dependent pathway to enhance vascular protection

Odile Dumont, Hayley Mylroie, Andrea Bauer, Damien Calay, Andrea Sperone, Clare Thornton, Shahir S. Hamdulay, Nadira Ali, Joseph J. Boyle, Joan R. Choo, Allen M. Samarel, Dorian O. Haskard, Anna M. Randi, Paul C. Evans, Justin C. Mason

Biochem J (2012) 447 (2): 193–204.

https://doi.org/10.1042/BJ20120574

Published: 26 September 2012

... The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis cytoprotection endothelium inflammation protein kinase C (PKC) The vascular endothelium lies at a critical tissue interface and is capable of mounting specific responses to a variety of soluble and physical factors...

View article titled, Protein kinase Cϵ activity induces anti-inflammatory and anti-apoptotic genes via an ERK1/2- and NF-κB-dependent pathway to enhance vascular protection

Includes: Supplementary data

Articles

Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity

Ryan Stapley, Benjamin Y. Owusu, Angela Brandon, Marianne Cusick, Cilina Rodriguez, Marisa B. Marques, Jeffrey D. Kerby, Scott R. Barnum, Jordan A. Weinberg, Jack R. Lancaster, Jr, Rakesh P. Patel

Biochem J (2012) 446 (3): 499–508.

https://doi.org/10.1042/BJ20120675

Published: 28 August 2012

... to RBCs (red blood cells). It has been suggested that these changes have potential negative clinical effects characterized by inflammation and microcirculatory dysfunction which add to other transfusion-related toxicities. However, the mechanisms linking RBC storage and toxicity remain unclear...

View article titled, Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity

Includes: Supplementary data

Articles

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter

Maria A. Whitehead, Michele Bombardieri, Costantino Pitzalis, Bart Vanhaesebroeck

Biochem J (2012) 443 (3): 857–867.

https://doi.org/10.1042/BJ20112214

Published: 16 April 2012

... correspondence should be addressed (email [email protected] ). 22 12 2011 29 2 2012 29 2 2012 29 2 2012 PI3Ks (phosphoinositide 3-kinases) phosphorylate inositol lipids in cellular membranes in response to a variety of stimuli. The involvement of PI3Ks in immunity, inflammation...

View article titled, Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter

Includes: Supplementary data

Articles

Involvement of PGE 2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages

Manuel D. Díaz-Muñoz, Inés C. Osma-García, Manuel Fresno, Miguel A. Iñiguez

Biochem J (2012) 443 (2): 451–461.

https://doi.org/10.1042/BJ20111052

Published: 27 March 2012

...-prostanoid (EP) receptor gene regulation inflammation lipid mediator microsomal prostaglandin E synthase 1 (mPGES-1) PGs (prostaglandins) and TXs (thromboxanes) are important lipid mediators involved in physiological and pathological processes. These agents are generated from the conversion of AA...

View article titled, Involvement of PGE 2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages

Articles

Mousing around with caspases and IAPs

Robert C. Rickert, Guy S. Salvesen, Carl F. Ware

Biochem J (2012) 443 (2): e1–e2.

https://doi.org/10.1042/BJ20120402

Published: 27 March 2012

...Robert C. Rickert; Guy S. Salvesen; Carl F. Ware In a paper in this issue of the Biochemical Journal that questions the role of c-IAP1 (cellular inhibitor of apoptosis 1) in inflammation, new results from the Duckett laboratory remind us of the importance of truly knowing the mice we depend...

View article titled, Mousing around with caspases and IAPs

Articles

Induction of group IVC phospholipase A 2 in allergic asthma: transcriptional regulation by TNFα in bronchoepithelial cells

Justin S. Bickford, Kimberly J. Newsom, John-David Herlihy, Christian Mueller, Benjamin Keeler, Xiaolei Qiu, Jewell N. Walters, Nan Su, Shannon M. Wallet, Terence R. Flotte, Harry S. Nick

Biochem J (2012) 442 (1): 127–137.

https://doi.org/10.1042/BJ20111269

Published: 27 January 2012

...Justin S. Bickford; Kimberly J. Newsom; John-David Herlihy; Christian Mueller; Benjamin Keeler; Xiaolei Qiu; Jewell N. Walters; Nan Su; Shannon M. Wallet; Terence R. Flotte; Harry S. Nick Airway inflammation in allergen-induced asthma is associated with eicosanoid release. These bioactive lipids...

View article titled, Induction of group IVC phospholipase A 2 in allergic asthma: transcriptional regulation by TNFα in bronchoepithelial cells

Includes: Supplementary data

Articles

Microsomal prostaglandin E synthase-1 exhibits one-third-of-the-sites reactivity

Shan He, Yiran Wu, Daqi Yu, Luhua Lai

Biochem J (2011) 440 (1): 13–21.

https://doi.org/10.1042/BJ20110977

Published: 27 October 2011

... Blue Tetrazolium) Color Development Substrate (Promega) to visualize the proteins. A control experiment using a WT and R126A mixture and a parallel experiment using R126A and His–WT mixture were performed in the same manner. drug design enzyme mechanism inflammation membrane-associated...

View article titled, Microsomal prostaglandin E synthase-1 exhibits one-third-of-the-sites reactivity

Includes: Supplementary data

Articles

Glucan particles for selective delivery of siRNA to phagocytic cells in mice

Gregory J. Tesz, Myriam Aouadi, Matthieu Prot, Sarah M. Nicoloro, Emilie Boutet, Shinya U. Amano, Anca Goller, Mengxi Wang, Chang-An Guo, William E. Salomon, Joseph V. Virbasius, Rebecca A. Baum, Mark J. O'Connor, Jr, Ernesto Soto, Gary R. Ostroff, Michael P. Czech

Biochem J (2011) 436 (2): 351–362.

https://doi.org/10.1042/BJ20110352

Published: 13 May 2011

... and dendritic cells are desirable targets for potential RNAi (RNA interference) therapeutics because they often mediate pathogenic inflammation and autoimmune responses. We recently engineered a complex 5 component glucan-based encapsulation system for siRNA (small interfering RNA) delivery to phagocytes...

View article titled, Glucan particles for selective delivery of siRNA to phagocytic cells in mice

Includes: Supplementary data

Articles

Mitochondrial protection by the thioredoxin-2 and glutathione systems in an in vitro endothelial model of sepsis

Damon A. Lowes, Helen F. Galley

Biochem J (2011) 436 (1): 123–132.

https://doi.org/10.1042/BJ20102135

Published: 27 April 2011

... be addressed (email: [email protected] ). 21 12 2010 24 2 2011 28 2 2011 28 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 endothelium inflammation oxidative stress peroxiredoxin sepsis thioredoxin Sepsis is a severe infection...

View article titled, Mitochondrial protection by the thioredoxin-2 and glutathione systems in an in vitro endothelial model of sepsis

Includes: Supplementary data

Articles

Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4

Hyun Kook Cho, Kyu Jin Cheong, Hye Young Kim, JaeHun Cheong

Biochem J (2011) 435 (2): 431–439.

https://doi.org/10.1042/BJ20102071

Published: 29 March 2011

... by previously unknown mechanisms. ER stress plays a critical role in inflammatory induction and COX2 (cyclo-oxygenase 2) is an important mediator of this inflammation. In the present study, we demonstrate the molecular mechanisms of HBx on induction of ER stress and COX2 expression. In addition, HBx reduced...

View article titled, Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4

Articles

Targeting chemokine receptors in allergic disease

James E. Pease

Biochem J (2011) 434 (1): 11–24.

https://doi.org/10.1042/BJ20101132

Published: 27 January 2011

... 2011 allergy asthma chemokine G-protein-coupled receptor (GPCR) inflammation leucocyte Allergic diseases such as asthma, allergic rhinitis and atopic dermatitis are typified by an undesirable reaction to antigens (allergens) and are characterized by an influx of eosinophils...

View article titled, Targeting chemokine receptors in allergic disease

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