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Keyword: inflammation
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Articles
Biochem J (2019) 476 (22): 3533-3548.
Published: 27 November 2019
... CXCR5 knockdown by specific siRNA effectively inhibited DFO-induced inflammation. The phosphorylation of Akt2, a protective factor of adipose inflammation, was significantly inhibited by CXCL13 treatment during adipogenic differentiation. Mechanistically, CXCL13 induces the expression of PHLPP1, an Akt2...
Articles
Biochem J (2019) 476 (2): 333-352.
Published: 31 January 2019
... © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 inflammation interferons mRNA decay The interferon (IFN) cytokine family consists of type I, II and III IFNs. All family members have important antiviral and antimicrobial activities in...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (5): 839-852.
Published: 06 March 2018
...Hiroyuki Nakayama; Kinya Otsu Mitochondria play a central role in multiple cellular functions, including energy production, calcium homeostasis, and cell death. Currently, growing evidence indicates the vital roles of mitochondria in triggering and maintaining inflammation. Chronic inflammation...
Articles
Biochem J (2018) 475 (4): 775-786.
Published: 23 February 2018
... ) 9 11 2017 16 1 2018 18 1 2018 22 1 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cytokine gC1qR (gC1qBP) inflammation MCP-1 (CCL2) periodontal ligament cells (PDL cells) protein–protein interactions...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (1): 329-340.
Published: 11 January 2018
...) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . high-throughput assay inflammation kinase TPL-2 The pro-inflammatory cytokine tumour necrosis...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (17): 2993-3010.
Published: 17 August 2017
.... 4 1 2017 17 7 2017 19 7 2017 24 7 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 arthritis Barbasco Cambará nociception pain inflammation Arthritis is a chronic inflammatory systemic autoimmune...
Articles
Biochem J (2017) 474 (16): 2733-2747.
Published: 02 August 2017
...Chunyang Du; Tao Zhang; Xia Xiao; Yonghong Shi; Huijun Duan; Yunzhuo Ren Protease-activated receptor-2 (PAR2), which belongs to a specific class of the G-protein-coupled receptors, is central to several inflammation processes. However, the precise molecular mechanism involved remains undefined...
Articles
Biochem J (2017) 474 (4): 521-537.
Published: 03 February 2017
...-91-01 IL-10 inflammation macrophage salt-inducible kinase TNF-α Macrophages play diverse roles in the immune response due to their innate ability to adapt their physiology to the changing needs of the host [ 1 – 3 ]. In response to infection or tissue damage, macrophages acquire an...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (1): 65-78.
Published: 22 December 2016
... the binding of ATF2 to the TNF-responsive element. Altogether, these data suggest that ATF2 could be a potential target to prevent inflammation-induced P. aeruginosa binding in the lung of patients suffering from lung diseases such as chronic bronchitis or cystic fibrosis. Correspondence: Sophie...
Articles
Biochem J (2016) 473 (18): 2717-2736.
Published: 12 September 2016
...@kcl.ac.uk ) 4 4 2016 16 5 2016 18 5 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 cAMP HCN2 ivabradine inflammation Pain is as old as animals — a low-level sensory system that has warned us of harm from time...
Articles
Biochem J (2016) 473 (14): 2061-2071.
Published: 12 July 2016
..., vascular-targeted therapies constitute promising strategies for the treatment of inflammatory pathologies. In the present study, we evaluated the effect of 8,9-dehydrohispanolone-15,16-lactol diterpene (DT) on lung endothelium during inflammation. Lung endothelial cells pre-treated with DT and activated...
Articles
Biochem J (2016) 473 (10): 1281-1295.
Published: 11 May 2016
... multiple aspects of vascular and inflammatory cell phenotype, determining the location, composition and clinical consequences of atherosclerotic plaque formation. atherosclerosis extracellular matrix inflammation microenvironment shear stress Atherosclerosis is a lipid-driven chronic...
Articles
Biochem J (2016) 473 (7): 887-898.
Published: 29 March 2016
... Gal-8 protein where both N- and C-terminal domains were modified in order to display altered glycan recognition, allowed the discrimination of distinctive effects exerted by Gal-8 on CD4 + T-cell responses. galectin glycan affinity inflammation T-cell proliferation T-cell receptor co...
Includes: Supplementary data
Articles
Biochem J (2015) 468 (1): 1-15.
Published: 05 May 2015
... microenvironment is not entirely understood owing to the complex cross-talk between pro-inflammatory and tumorigenic mediators such as cytokines, chemokines, oncogenes, enzymes, transcription factors and immune cells. These molecular mediators are critical linchpins between inflammation and cancer, and their...
Articles
Biochem J (2015) 465 (3): 503-515.
Published: 22 January 2015
... tight junction disruption and barrier dysfunction. apoptosis signal-regulated kinase 1 (Ask1) calcium c-Jun N-terminal kinase (JNK) intestine inflammation MKK7 Src tight junction A major function of the gastrointestinal epithelium is to form a physical barrier between the hostile...
Includes: Supplementary data
Articles
Biochem J (2015) 465 (2): 271-279.
Published: 06 January 2015
...James Ozanne; Alan R. Prescott; Kristopher Clark Macrophages switch to an anti-inflammatory, ‘regulatory’-like phenotype characterized by the production of high levels of interleukin (IL)-10 and low levels of pro-inflammatory cytokines to promote the resolution of inflammation. A potential...
Includes: Supplementary data
Articles
Biochem J (2014) 463 (1): e1-e2.
Published: 08 September 2014
... Journal compilation © 2014 Biochemical Society 2014 inflammation inhibitor of NF-κB kinase β (IKKβ) nuclear factor κB (NF-κB) transforming growth factor β-activated kinase-1 (TAK1) phosphorylation ubiquitination The NF-κB (nuclear factor κB) transcription factor family controls the...
Articles
Biochem J (2014) 462 (2): 303-314.
Published: 07 August 2014
...-terminal proline of the pro-inflammatory cytokine MIF at equimolar concentrations. dopachrome tautomerase epicatechin inflammation macrophage migration inhibitory factor (MIF) myeloperoxidase (MPO) MIF (macrophage migration inhibitory factor) is emerging as an important therapeutic target...
Includes: Supplementary data
Articles
Biochem J (2014) 461 (2): 223-232.
Published: 26 June 2014
... macrosteatosis, inflammation and fibrosis compared with mice containing the C3H/HeN nuclear genome when fed the atherogenic diet. These changes were associated with parallel alterations in inflammation and fibrosis gene expression in wild-type mice, with intermediate responses in MNX mice. Mice with the C57BL/6J...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (3): 479-488.
Published: 11 April 2014
... of inflammation, the function of this protein is not completely understood. In the present study, we examined the regulation of CHI3L1 in primary human skeletal muscle cells. Moreover, we analysed potential autocrine effects of CHI3L1. We show that myotubes express CHI3L1 in a differentiation...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (2): e1-e3.
Published: 28 March 2014
... © 2014 Biochemical Society 2014 cancer cholesterol inflammation liver X receptor metabolism oxysterol Cholesterol plays an essential role in the stability and architecture of the plasma membrane, and as a precursor for bile acid and steroid hormone synthesis in mammals [ 1 ]. Under...
Articles
Biochem J (2014) 458 (2): 187-193.
Published: 14 February 2014
... © 2014 Biochemical Society 2014 cardiovascular disease fibrosis inflammation monocyte macrophage CVDs (cardiovascular diseases) are the leading cause of death in the developed world. Despite marked progress in the understanding of CVD, the underlying mechanisms involved in many of these...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2013) 455 (2): 239-250.
Published: 27 September 2013
... amino acid residues that was identified in its cDNA library. As it induced inflammation and writhing in animals, this protein was named inflamin. It induced two waves of prostanoid production. The first wave peaked at 10 min and 6-oxo PGF 1α (prostaglandin F 1α ) (6-keto PGF 1α ) was the major product...
Includes: Supplementary data
Articles
Biochem J (2013) 454 (1): 1-11.
Published: 26 July 2013
...Robert Stöhr; Massimo Federici For some time now it has been known that diabetes and atherosclerosis are chronic inflammatory diseases that are closely associated with one another and often develop together. In both there is an increase in tissue-wide inflammation that is exhibited by the...
Articles
Biochem J (2013) 451 (1): 55-60.
Published: 14 March 2013
...Ling Liu; Zhou Zhou; Shengping Huang; Yanhong Guo; Yanbo Fan; Ji Zhang; Jifeng Zhang; Mingui Fu; Y. Eugene Chen Endothelial activation characterized by the expression of multiple chemokines and adhesive molecules is a critical initial step of vascular inflammation, which results in recruitment of...
Articles
Biochem J (2013) 451 (1): 101-109.
Published: 14 March 2013
... 1 2013 30 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 β-arrestin-2 desensitization inflammation pain phosphorylation transient receptor potential vanilloid 1 (TRPV1) Post-translational modifications in the TRPV1 (transient receptor...
Articles
Biochem J (2013) 450 (2): 253-264.
Published: 15 February 2013
..., inflammation, fibrosis and neurodegenerative diseases. Different animal models, as well as proteomics approaches for the identification of protease substrates, have helped to reveal more precise molecular signalling events mediated by meprin activity, such as activation and release of pro-inflammatory...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2013) 449 (1): 11-23.
Published: 07 December 2012
... regulates multiple proliferation pathways, overrides cell-cycle check points, promotes replicative immortality and genomic instability, may regulate angiogenesis, has a role in invasion and metastasis, and promotes inflammation. We also argue that there is strong and sufficient evidence to suggest that YB-1...
Articles
Biochem J (2012) 447 (2): 193-204.
Published: 26 September 2012
... © The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis cytoprotection endothelium inflammation protein kinase C (PKC) The vascular endothelium lies at a critical tissue interface and is capable of mounting specific responses to a variety of soluble and physical...
Includes: Supplementary data
Articles
Biochem J (2012) 446 (3): 499-508.
Published: 28 August 2012
... morphological changes to RBCs (red blood cells). It has been suggested that these changes have potential negative clinical effects characterized by inflammation and microcirculatory dysfunction which add to other transfusion-related toxicities. However, the mechanisms linking RBC storage and toxicity remain...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (3): 857-867.
Published: 16 April 2012
...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. bioinformatics cytokine inflammation promoter PIK3CD tumour necrosis factor α (TNFα) PI3Ks (phosphoinositide 3-kinases...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (2): 451-461.
Published: 27 March 2012
... mainiguez@cbm.uam.es ). 14 6 2011 19 12 2011 23 1 2012 23 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cyclo-oxygenase-2 (COX-2) E-prostanoid (EP) receptor gene regulation inflammation lipid mediator microsomal prostaglandin E synthase 1...
Articles
Biochem J (2012) 443 (2): e1-e2.
Published: 27 March 2012
...Robert C. Rickert; Guy S. Salvesen; Carl F. Ware In a paper in this issue of the Biochemical Journal that questions the role of c-IAP1 (cellular inhibitor of apoptosis 1) in inflammation, new results from the Duckett laboratory remind us of the importance of truly knowing the mice we depend on. It...
Articles
Biochem J (2012) 442 (1): 127-137.
Published: 27 January 2012
...Justin S. Bickford; Kimberly J. Newsom; John-David Herlihy; Christian Mueller; Benjamin Keeler; Xiaolei Qiu; Jewell N. Walters; Nan Su; Shannon M. Wallet; Terence R. Flotte; Harry S. Nick Airway inflammation in allergen-induced asthma is associated with eicosanoid release. These bioactive lipids...
Includes: Supplementary data
Articles
Biochem J (2011) 440 (1): 13-21.
Published: 27 October 2011
... 29 7 2011 29 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 drug design enzyme mechanism inflammation membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) microsomal prostaglandin E synthase-1 (mPGES-1) one-third-of-the-sites...
Includes: Supplementary data
Articles
Biochem J (2011) 436 (2): 351-362.
Published: 13 May 2011
... dendritic cells are desirable targets for potential RNAi (RNA interference) therapeutics because they often mediate pathogenic inflammation and autoimmune responses. We recently engineered a complex 5 component glucan-based encapsulation system for siRNA (small interfering RNA) delivery to phagocytes. In...
Includes: Supplementary data
Articles
Biochem J (2011) 436 (1): 123-132.
Published: 27 April 2011
... correspondence should be addressed (email: h.f.galley@abdn.ac.uk ). 21 12 2010 24 2 2011 28 2 2011 28 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 endothelium inflammation oxidative stress peroxiredoxin sepsis thioredoxin Sepsis is a...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (2): 431-439.
Published: 29 March 2011
... previously unknown mechanisms. ER stress plays a critical role in inflammatory induction and COX2 (cyclo-oxygenase 2) is an important mediator of this inflammation. In the present study, we demonstrate the molecular mechanisms of HBx on induction of ER stress and COX2 expression. In addition, HBx reduced...
Articles
Biochem J (2011) 434 (1): 11-24.
Published: 27 January 2011
... 2011 allergy asthma chemokine G-protein-coupled receptor (GPCR) inflammation leucocyte Allergic diseases such as asthma, allergic rhinitis and atopic dermatitis are typified by an undesirable reaction to antigens (allergens) and are characterized by an influx of eosinophils...
Articles
Biochem J (2010) 432 (3): 535-547.
Published: 25 November 2010
... in structure and sequence, different Gals exert distinct effects on their target cells. We have shown that Gal-1 triggers platelet activation, suggesting a role for Gals in thrombus formation. Since Gal-8 is expressed upon endothelial activation and also contributes to inflammation, to understand...
Articles
Biochem J (2010) 430 (2): e1-e4.
Published: 13 August 2010
...Marie-Soleil Gauthier; Neil B. Ruderman In recent years, it has become widely accepted that obesity is characterized by a chronic low-grade inflammation of adipose tissue that predisposes affected individuals to insulin resistance, Type 2 diabetes and other disorders associated with the metabolic...
Articles
Biochem J (2010) 430 (1): 141-149.
Published: 28 July 2010
... and Akt activation between IR-MO and NIR-MO individuals. Our results support the concept that NIR-MO individuals lack the inflammatory response that characterizes the IR-MO patient and that IL-6, IL-1β, ERK and NF-κB are important effectors that mediate the inflammation effects promoting insulin...
Articles
Biochem J (2010) 429 (2): 359-367.
Published: 28 June 2010
... inflammatory sites. 1 To whom correspondence should be addressed (email niclas.karlsson@medkem.gu.se ). 10 3 2010 30 4 2010 5 5 2010 5 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 glycosylation inflammation lubricin mass spectrometry...
Includes: Supplementary data
Articles
Biochem J (2010) 428 (2): 269-279.
Published: 13 May 2010
... 3 2010 23 3 2010 23 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 atherosclerosis inflammation lipoprotein oxidized phospholipid phospholipase platelet-activating factor (PAF) PAF-AH [PAF (platelet-activating factor; 1-O-alkyl-2-acetyl...
Includes: Supplementary data
Articles
Biochem J (2010) 428 (1): 47-54.
Published: 28 April 2010
...Yanjuan Zhu; Ahmer Kodvawala; David Y. Hui Previous studies have shown that apoE (apolipoprotein E) expression in macrophages suppresses inflammatory responses; however, whether endogenously synthesized apoE acts intracellularly or after its secretion in suppressing macrophage inflammation remains...
Articles
Biochem J (2010) 427 (1): 113-124.
Published: 15 March 2010
... granulocyte/macrophage colony-stimulating factor (GM-CSF) inflammation mitogen-activated protein kinase (MAPK) In inflammation, expression of cytokines, chemokines, adhesion molecules and other inflammatory proteins drives inflammatory cell recruitment [ 1 ]. Conversely, the profound anti...
Includes: Supplementary data
Articles
Biochem J (2010) 425 (1): 169-180.
Published: 14 December 2009
... should be addressed (email paramesw@msu.edu ). 18 6 2009 18 9 2009 2 10 2009 2 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 G-protein-coupled-receptor kinase (GRK) inflammation macrophage nuclear factor κB (NF-κB) tumour necrosis factor...
Includes: Supplementary data
Articles
Biochem J (2010) 425 (1): 41-52.
Published: 14 December 2009
... ). 13 7 2009 14 8 2009 18 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 adiponectin Dsb endoplasmic reticulum stress inflammation insulin peroxisome-proliferator-activated receptor γ (PPARγ) transcription factor Adiponectin, a 30-kDa...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2009) 423 (3): 315-321.
Published: 12 October 2009
... many cancer chemopreventives, including ITCs. Due to the emerging role of MIF in the control of malignant cell growth and its clear involvement in inflammation, inhibition of MIF by nutrient ITCs suggests therapeutic strategies for inflammatory diseases and cancer. 1 To whom correspondence...
Includes: Supplementary data
Articles
Biochem J (2009) 423 (1): 119-128.
Published: 14 September 2009
... present study adds to our understanding of the spectrum of effects of this cytokine on gut epithelium that may contribute to bacterial-driven inflammation in the gut. 1 To whom correspondence should be addressed (email Geoffrey.warhurst@manchester.ac.uk ). 9 3 2009 10 7 2009 21 7...