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Signalling by co-operative higher-order assembly formation: linking evidence at molecular and cellular levels

Bostjan Kobe, Jeffrey D. Nanson, Mikayla Hoad, Antje Blumenthal, Yann Gambin, Emma Sierecki, Katryn J. Stacey, Thomas Ve, Randal Halfmann

Biochem J (2025) 482 (05): 275–294.

https://doi.org/10.1042/BCJ20220094

Published: 05 March 2025

... and innate immunity activation pathways where a binary decision is required. Here, we broaden the concept of SCAF to encapsulate the essential kinetic properties of open-ended assembly in signalling, compare properties of filamentous assemblies and other co-operative assemblies such as biomolecular...

View articletitled, Signalling by co-operative higher-order assembly formation: linking evidence at molecular and cellular levels

Articles

Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12

Elisha H. McCrory, Vyacheslav Akimov, Philip Cohen, Blagoy Blagoev

Biochem J (2022) 479 (23): 2419–2431.

https://doi.org/10.1042/BCJ20220510

Published: 07 December 2022

... License 4.0 (CC BY) . Open access for this article was enabled by the participation of University of Dundee in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. HOIL-1 innate immunity Toll-like receptors...

View articletitled, Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12

Includes: Supplementary data

Articles

Cross-talk of Brassinosteroid signaling in controlling growth and stress responses

Trevor Nolan, Jiani Chen, Yanhai Yin

Biochem J (2017) 474 (16): 2641–2661.

https://doi.org/10.1042/BCJ20160633

Published: 27 July 2017

.... Correspondence: Yanhai Yin ( [email protected] ) 2 3 2017 14 6 2017 22 6 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 Brassinosteroid cross-talk drought innate immunity plant hormones plant signal transduction...

View articletitled, Cross-talk of Brassinosteroid signaling in controlling growth and stress responses

Articles

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

Stefan Vollmer, Sam Strickson, Tinghu Zhang, Nathanael Gray, Katherine L. Lee, Vikram R. Rao, Philip Cohen

Biochem J (2017) 474 (12): 2027–2038.

https://doi.org/10.1042/BCJ20170097

Published: 06 June 2017

... 26 4 2017 4 5 2017 16 5 2017 © 2017 The Author(s) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . innate immunity IRAK MyD88 Pellino...

View articletitled, The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

Includes: Supplementary data

Articles

BST-2 restricts IAV release and is countered by the viral M2 protein

Siqi Hu, Lijuan Yin, Shan Mei, Jian Li, Fengwen Xu, Hong Sun, Xiaoman Liu, Shan Cen, Chen Liang, Ailing Li, Fei Guo

Biochem J (2017) 474 (5): 715–730.

https://doi.org/10.1042/BCJ20160861

Published: 20 February 2017

... The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 BST-2 host restriction factors influenza virus innate immunity M2 Influenza A virus (IAV) is a member of the orthomyxovirus family. IAV infection causes morbidity and mortality in infants...

View articletitled, BST-2 restricts IAV release and is countered by the viral M2 protein

Includes: Supplementary data

Articles

LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33)

Daniel Svensson, Laura Wilk, Matthias Mörgelin, Heiko Herwald, Bengt-Olof Nilsson

Biochem J (2016) 473 (1): 87–98.

https://doi.org/10.1042/BJ20150798

Published: 09 December 2015

... host cells cope with cytotoxic effects caused by the host-defence peptide (HDP) LL-37. Our findings show that LL-37-induced cytotoxicity is counteracted by intracellular p33, suggesting that p33 protects against deleterious activities of the innate immune system. anti-microbial peptide (AMP...

View articletitled, LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33)

Articles

Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans

Hsiang Yu, Huey-Jen Lai, Tai-Wei Lin, Chang-Shi Chen, Szecheng J. Lo

Biochem J (2015) 470 (1): 145–154.

https://doi.org/10.1042/BJ20150563

Published: 06 August 2015

...-induced DNA fragment accumulation in the gonad activates innate immunity responses, we also found that loss of NUC-1 and CRN-7 lead to up-regulation of antimicrobial genes ( abf-2 , spp-1 , nlp-29 , cnc-2 , and lys-7 ). Our observations suggest that an incomplete digestion of DNA fragments resulting from...

View articletitled, Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans

Includes: Multimedia, Supplementary data

Articles

Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses

Megumi Tatematsu, Tsukasa Seya, Misako Matsumoto

Biochem J (2014) 458 (2): 195–201.

https://doi.org/10.1042/BJ20131492

Published: 14 February 2014

...Megumi Tatematsu; Tsukasa Seya; Misako Matsumoto The innate immune system recognizes pathogen- and damage-associated molecular patterns using pattern-recognition receptors that activate a wide range of signalling cascades to maintain host homoeostasis against infection and inflammation. Endosomal...

View articletitled, Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses

Articles

Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Marc Torrent, David Pulido, Javier Valle, M. Victòria Nogués, David Andreu, Ester Boix

Biochem J (2013) 456 (1): 99–108.

https://doi.org/10.1042/BJ20130123

Published: 24 October 2013

... 8 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 The antimicrobial mechanism of human RNases has been conserved along evolution and its activity is retained at an N-terminal antimicrobial domain. antimicrobial peptide drug discovery evolution innate...

View articletitled, Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus

Includes: Supplementary data

Articles

The CARD plays a critical role in ASC foci formation and inflammasome signalling

Martina Proell, Motti Gerlic, Peter D. Mace, John C. Reed, Stefan J. Riedl

Biochem J (2013) 449 (3): 613–621.

https://doi.org/10.1042/BJ20121198

Published: 09 January 2013

... compilation © 2013 Biochemical Society 2013 caspase 1 caspase activation and recruitment domain (CARD) death domain innate immunity inflammasome inflammatory cytokine nucleotide-binding domain leucine-rich repeat-containing receptor (NLR) NLR family CARD domain-containing protein 4 (NLRC4...

View articletitled, The CARD plays a critical role in ASC foci formation and inflammasome signalling

Includes: Supplementary data

Articles

The saposin-like protein SPP-12 is an antimicrobial polypeptide in the pharyngeal neurons of Caenorhabditis elegans and participates in defence against a natural bacterial pathogen

Aylin Hoeckendorf, Mareike Stanisak, Matthias Leippe

Biochem J (2012) 445 (2): 205–212.

https://doi.org/10.1042/BJ20112102

Published: 27 June 2012

...) that interfere with longevity, stress response and innate immunity; and (ii) gene silencing of either or both in a daf-2 -mutant background reduced the lifespan of the worms on Escherichia coli [ 22 ]. During the present study it became evident that, whereas spp-1 is expressed in the intestinal tract, spp...

View articletitled, The saposin-like protein SPP-12 is an antimicrobial polypeptide in the pharyngeal neurons of Caenorhabditis elegans and participates in defence against a natural bacterial pathogen

Includes: Supplementary data

Articles

Copper redistribution in murine macrophages in response to Salmonella infection

Maud E. S. Achard, Sian L. Stafford, Nilesh J. Bokil, Jy Chartres, Paul V. Bernhardt, Mark A. Schembri, Matthew J. Sweet, Alastair G. McEwan

Biochem J (2012) 444 (1): 51–57.

https://doi.org/10.1042/BJ20112180

Published: 26 April 2012

... 28 2 2012 28 2 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 copper redistribution copper sensor 1 (CS1) innate immunity macrophage Salmonella In view of the biocidal action of copper, it is not surprising that systems that confer tolerance...

View articletitled, Copper redistribution in murine macrophages in response to Salmonella infection

Includes: Multimedia, Supplementary data

Articles

Effects on antigen-presenting cells of short-term interaction with the human host defence peptide β-defensin 2

Francesca Morgera, Sabrina Pacor, Luisa Creatti, Nikolinka Antcheva, Lisa Vaccari, Alessandro Tossi

Biochem J (2011) 436 (3): 537–546.

https://doi.org/10.1042/BJ20101977

Published: 27 May 2011

... immunity membrane interaction Mammalian BDs (β-defensins) are small cationic HDPs (host defence peptides), with a characteristic β-sheet fold, that exert their protective functions at the host–environment interface [ 1 ]. They were initially proposed to act as innate immune system effectors...

View articletitled, Effects on antigen-presenting cells of short-term interaction with the human host defence peptide β-defensin 2

Includes: Supplementary data

Articles

Peptidoglycan derived from Staphylococcus epidermidis induces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells

Jennifer Robertson, Sue Lang, Peter A. Lambert, Patricia E. Martin

Biochem J (2010) 432 (1): 133–143.

https://doi.org/10.1042/BJ20091753

Published: 25 October 2010

... blocked with Cx-specific channel blockers. We conclude that acute Cx43 hemichannel signalling plays a role in the initiation of early innate immune responses in the endothelium. 1 To whom correspondence should be addressed (email [email protected] ). 12 11 2009 24 8 2010 3...

View articletitled, Peptidoglycan derived from Staphylococcus epidermidis induces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells

Articles

IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

Hosea Handoyo, Margaret J. Stafford, Eamon McManus, Dionissios Baltzis, Mark Peggie, Philip Cohen

Biochem J (2009) 424 (1): 109–118.

https://doi.org/10.1042/BJ20091271

Published: 23 October 2009

... be addressed (email [email protected] ). © The Authors Journal compilation © 2009 Biochemical Society 2009 innate immunity interleukin-1 (IL-1) interleukin1-receptor-associated kinase 1 (IRAK1) nuclear factor κB (NF-κB) tumour necrosis factor (TNF) tumour progression locus 2 (Tpl2...

View articletitled, IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

Includes: Supplementary data

Articles

Artificial β-defensin based on a minimal defensin template

Nikolinka Antcheva, Francesca Morgera, Luisa Creatti, Lisa Vaccari, Ulrike Pag, Sabrina Pacor, Yechiel Shai, Hans-Georg Sahl, Alessandro Tossi

Biochem J (2009) 421 (3): 435–447.

https://doi.org/10.1042/BJ20082242

Published: 15 July 2009

... [ 15 ]. Orthologous genes in different species may then show different evolutionary patterns, ranging from positive selection for variation, to neutral evolution or conservation [ 16 ]. This is consistent with specific adaptations and specialization within the innate immune or other responses, but what...

View articletitled, Artificial β-defensin based on a minimal defensin template

Includes: Supplementary data

Articles

Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation

Péter Medveczky, Richárd Szmola, Miklós Sahin-Tóth

Biochem J (2009) 420 (2): 335–344.

https://doi.org/10.1042/BJ20090005

Published: 13 May 2009

... metalloproteases of the thermolysin type. 1 To whom correspondence should be addressed (email: [email protected] ). 6 1 2009 9 2 2009 3 3 2009 3 3 2009 antibacterial protein innate immunity lectin-like protein N-terminal proteolytic processing pancreatitis-associated protein...

View articletitled, Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation

Includes: Supplementary data

Articles

Histidine-regulated activity of M-ficolin

Michikazu Tanio, Toshiyuki Kohno

Biochem J (2009) 417 (2): 485–491.

https://doi.org/10.1042/BJ20081640

Published: 23 December 2008

...Michikazu Tanio; Toshiyuki Kohno Human M-ficolin is a pathogen-associated molecular recognition molecule in the innate immune system, and it binds to some sugars, such as GlcNAc ( N -acetylglucosamine), on pathogen surfaces. From previous structural and functional studies of the FD1 (M-ficolin...

View articletitled, Histidine-regulated activity of M-ficolin

Articles

An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis

Henning Fedders, Matthias Michalek, Joachim Grötzinger, Matthias Leippe

Biochem J (2008) 416 (1): 65–75.

https://doi.org/10.1042/BJ20080398

Published: 28 October 2008

... Journal compilation © 2008 Biochemical Society 2008 antimicrobial peptide Ciona intestinalis innate immunity peptide–membrane interaction tunicate univacuolar refractile/non-refractile granulocyte Live C. intestinalis were purchased from the Biologische Anstalt Helgoland (Alfred...

View articletitled, An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis

Articles

Membrane pore formation by pentraxin proteins from Limulus , the American horseshoe crab

John M. Harrington, Hui-Ting Chou, Thomas Gutsmann, Christoph Gelhaus, Henning Stahlberg, Matthias Leippe, Peter B. Armstrong

Biochem J (2008) 413 (2): 305–313.

https://doi.org/10.1042/BJ20071357

Published: 26 June 2008

... and Molecular Biology, Life Sciences Building, University of Georgia, Athens, GA 30602, U.S.A. (email [email protected] ). 2 10 2007 14 3 2008 28 3 2008 28 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 C-reactive protein innate immunity invertebrate...

View articletitled, Membrane pore formation by pentraxin proteins from Limulus , the American horseshoe crab

Includes: Supplementary data

Articles

A novel horse α-defensin: gene transcription, recombinant expression and characterization of the structure and function

Oliver Bruhn, Petra Regenhard, Matthias Michalek, Sven Paul, Christoph Gelhaus, Sascha Jung, Georg Thaller, Rainer Podschun, Matthias Leippe, Joachim Grötzinger, Ernst Kalm

Biochem J (2007) 407 (2): 267–276.

https://doi.org/10.1042/BJ20070747

Published: 25 September 2007

... 2007 10 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 antimicrobial peptide defensin horse innate immunity An important component of the innate immunity, next to the complement pathway and phagocytes, are antimicrobial peptides [ 1 , 2 ], which play...

View articletitled, A novel horse α-defensin: gene transcription, recombinant expression and characterization of the structure and function

Articles

Crucial roles of binding sites for NF-κB and C/EBPs in IκB-ζ-mediated transcriptional activation

Susumu Matsuo, Soh Yamazaki, Koichiro Takeshige, Tatsushi Muta

Biochem J (2007) 405 (3): 605–615.

https://doi.org/10.1042/BJ20061797

Published: 13 July 2007

...′-CTCAGGGCAAACCTGAGTCATC-3′ for the κB site in the IL-8 promoter. CCAAT/enhancer-binding protein (C/EBP) inflammation inhibitor of nuclear factor κB ζ (IκB-ζ) innate immunity nuclear factor κB (NF-κB) transcription Cells alter gene expression profiles in response to environmental changes...

View articletitled, Crucial roles of binding sites for NF-κB and C/EBPs in IκB-ζ-mediated transcriptional activation

Articles

Ligand specificities and structural requirements of two Tachypleus plasma lectins for bacterial trapping

Tun-Hsun Kuo, Shiao-Cheng Chuang, Sing-Yang Chang, Po-Huang Liang

Biochem J (2006) 393 (3): 757–766.

https://doi.org/10.1042/BJ20051108

Published: 13 January 2006

.... The proteins show specific PGN (peptidoglycan)- and LPS-binding activity, suggesting a role in trapping Gram-positive and Gram-negative bacteria respectively in innate immunity. Using BIAcore® assays, the dissociation constant for the TPL-1–PGN complex was measured as 8×10 −8 M. Replacement of Asn 74 , the N...

View articletitled, Ligand specificities and structural requirements of two Tachypleus plasma lectins for bacterial trapping

Articles

Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation

Kevan L. Hartshorn, Antoon Ligtenberg, Mitchell R. White, Martin van Eijk, Max Hartshorn, Lily Pemberton, Uffe Holmskov, Erika Crouch

Biochem J (2006) 393 (2): 545–553.

https://doi.org/10.1042/BJ20050695

Published: 23 December 2005

... of aspiration of oral contents on SP-D-mediated lung functions. collectin glycoprotein-340 influenza A virus innate immunity saliva surfactant protein D Presence and linkage patterns of terminally linked sialic acids on gp-340 preparations were analysed by ELISA, using digoxigenin-labelled...

View articletitled, Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation

Articles

Cecropin P1 and novel nematode cecropins: a bacteria-inducible antimicrobial peptide family in the nematode Ascaris suum

Ajitha Pillai, Satoshi Ueno, Hong Zhang, Jae Min Lee, Yusuke Kato

Biochem J (2005) 390 (1): 207–214.

https://doi.org/10.1042/BJ20050218

Published: 09 August 2005

... against microbes. In invertebrates, primitive ‘innate’ immunity is commonly found. Innate immunity is non-adaptive immunity with extensive recognition of microbes. Although vertebrates, including human beings, possess adaptive immunity with specific non-self recognition based on T- and B-lymphocytes...

View articletitled, Cecropin P1 and novel nematode cecropins: a bacteria-inducible antimicrobial peptide family in the nematode Ascaris suum

Articles

A short guided tour through functional and structural features of saposin-like proteins

Heike Bruhn

Biochem J (2005) 389 (2): 249–257.

https://doi.org/10.1042/BJ20050051

Published: 05 July 2005

... antimicrobial activity innate immunity lipid metabolism lipid-binding membrane interaction saposin-like protein The primary goal of genome sequencing projects is the assignment of a functional context to mere sequence data. Now, right in the middle of the genomics era, it becomes more and more...

View articletitled, A short guided tour through functional and structural features of saposin-like proteins

Articles

Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 ( Tlr4 ) gene expression

Thierry ROGER, Isabelle MICONNET, Anne-Laure SCHIESSER, Hirofumi KAI, Kensuke MIYAKE, Thierry CALANDRA

Biochem J (2005) 387 (2): 355–365.

https://doi.org/10.1042/BJ20041243

Published: 05 April 2005

... immunity macrophage RNA stability Toll-like receptor 4 The innate immune system provides the first line of host defences against microbial pathogens. Detection of invasive microorganisms by the innate immune system is mediated by soluble factors, such as the LBP [LPS (lipopolysaccharide)-binding...

View articletitled, Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 ( Tlr4 ) gene expression

Articles

Cloning and expression of an inhibitor of microbial metalloproteinases from insects contributing to innate immunity

Anja CLERMONT, Marianne WEDDE, Volkhard SEITZ, Lars PODSIADLOWSKI, Dido LENZE, Michael HUMMEL, Andreas VILCINSKAS

Biochem J (2004) 382 (1): 315–322.

https://doi.org/10.1042/BJ20031923

Published: 10 August 2004

... PF01826. 12 12 2003 22 4 2004 28 4 2004 28 4 2004 The Biochemical Society, London 2004 In contrast with the TIMPs, the G. mellonella IMPI is induced in response to injected microbial elicitors of the innate immune response, such as cell wall components from bacteria...

View articletitled, Cloning and expression of an inhibitor of microbial metalloproteinases from insects contributing to innate immunity

Articles

Transcriptomic analysis in the leech Theromyzon tessulatum: involvement of cystatin B in innate immunity

Christophe LEFEBVRE, Claude COCQUERELLE, Franck VANDENBULCKE, David HOT, Ludovic HUOT, Yves LEMOINE, Michel SALZET

Biochem J (2004) 380 (3): 617–625.

https://doi.org/10.1042/bj20040478

Published: 15 June 2004

...Christophe LEFEBVRE; Claude COCQUERELLE; Franck VANDENBULCKE; David HOT; Ludovic HUOT; Yves LEMOINE; Michel SALZET At the present time, there is little information on mechanisms of innate immunity in invertebrate groups other than insects, especially annelids. In the present study, we have...

View articletitled, Transcriptomic analysis in the leech Theromyzon tessulatum: involvement of cystatin B in innate immunity

Articles

Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene

Matthew P. HARDY, Anne F. McGETTRICK, Luke A. J. O'NEILL

Biochem J (2004) 380 (1): 83–93.

https://doi.org/10.1042/bj20040030

Published: 15 May 2004

.... 1 To whom correspondence should be addressed (e-mail [email protected] ). 6 1 2004 6 2 2004 9 2 2004 12 2 2004 The Biochemical Society, London ©2004 2004 innate immunity lipopolysaccharide (LPS) nuclear factor-κB (NF-κB) stimulating protein 1 (Sp1) Toll-like...

View articletitled, Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene

Articles

Structural and biochemical characterization of a new type of lectin isolated from carp eggs

Monica GALLIANO, Lorenzo MINCHIOTTI, Monica CAMPAGNOLI, Alberto SALA, Livia VISAI, Angela AMORESANO, Piero PUCCI, Annarita CASBARRA, Marco CAUCI, Massimiliano PERDUCA, Hugo L. MONACO

Biochem J (2003) 376 (2): 433–440.

https://doi.org/10.1042/bj20030413

Published: 01 December 2003

... should be addressed (e-mail [email protected] ). 17 3 2003 5 9 2003 5 9 2003 5 9 2003 The Biochemical Society, London ©2003 2003 carp fish-egg lectin (FEL) innate immunity primary structure tachylectin-1 tectonin zebrafish Abbreviations used: ES...

View articletitled, Structural and biochemical characterization of a new type of lectin isolated from carp eggs

Articles

A study of host defence peptide β-defensin 3 in primates

Michele BONIOTTO, Nikolinka ANTCHEVA, Igor ZELEZETSKY, Alessandro TOSSI, Valeria PALUMBO, Maria Vittoria VERGA FALZACAPPA, Silvia SGUBIN, Laura BRAIDA, Antonio AMOROSO, Sergio CROVELLA

Biochem J (2003) 374 (3): 707–714.

https://doi.org/10.1042/bj20030528

Published: 15 September 2003

... Society, London ©2003 The Biochemical Society, London © 2003 anti-bacterial anti-microbial peptide innate immunity Abbreviations used: CFU, colony-forming unit; dS, number of synonymous nucleotide substitutions per synonymous site; dN, number of non-synonymous nucleotide substitutions per...

View articletitled, A study of host defence peptide β-defensin 3 in primates

Articles

The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappaB and pro-caspase-1 regulation

Christian STEHLIK, Maryla KRAJEWSKA, Kate WELSH, Stanislaw KRAJEWSKI, Adam GODZIK, John C. REED

Biochem J (2003) 373 (1): 101–113.

https://doi.org/10.1042/bj20030304

Published: 01 July 2003

... are involved in innate immunity, regulating pathways leading to nuclear-factor-κB (NF-κB) and pro-caspase-1 activation. Many PAAD-family proteins have structures reminiscent of Nod-1, a putative intracellular sensor of lipopolysaccharide. Hereditary mutations in some of the PAAD-family genes are associated...

View articletitled, The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappaB and pro-caspase-1 regulation

Articles

POPing the fire into the pyrin?

Sanjeev MARIATHASAN, Domagoj VUCIC

Biochem J (2003) 373 (1): e1–e2.

https://doi.org/10.1042/bj20030304COM

Published: 01 July 2003

... inflammatory disorders. 1 To whom correspondence should be addressed (e-mail [email protected] ). 23 4 2003 9 5 2003 24 6 2003 The Biochemical Society, London ©2003 2003 cryopyrin inhibitory κB kinase (IKK) innate immunity interleukin-1β (IL-1β) pyrin Biochem. J. (2003...

View articletitled, POPing the fire into the pyrin?

Articles

Induction of ASABF (Ascaris suum antibacterial factor)-type antimicrobial peptides by bacterial injection: novel members of ASABF in the nematode Ascaris suum

Ajitha PILLAI, Satoshi UENO, Hong ZHANG, Yusuke KATO

Biochem J (2003) 371 (3): 663–668.

https://doi.org/10.1042/bj20021948

Published: 01 May 2003

...Ajitha PILLAI; Satoshi UENO; Hong ZHANG; Yusuke KATO Recently, invertebrate models have been widely used for the study of innate immunity. Nematodes are novel potential candidates because of the experimental advantages of Caenorhabditis elegans . However, whether nematodes have active immune...

View articletitled, Induction of ASABF (Ascaris suum antibacterial factor)-type antimicrobial peptides by bacterial injection: novel members of ASABF in the nematode Ascaris suum

Articles

A newly established in vitro culture using transgenic Drosophila reveals functional coupling between the phospholipase A2-generated fatty acid cascade and lipopolysaccharide-dependent activation of the immune deficiency (imd) pathway in insect immunity

Masashi YAJIMA, Masatoshi TAKADA, Nahoko TAKAHASHI, Haruhisa KIKUCHI, Shunji NATORI, Yoshiteru OSHIMA, Shoichiro KURATA

Biochem J (2003) 371 (1): 205–210.

https://doi.org/10.1042/bj20021603

Published: 01 April 2003

...Masashi YAJIMA; Masatoshi TAKADA; Nahoko TAKAHASHI; Haruhisa KIKUCHI; Shunji NATORI; Yoshiteru OSHIMA; Shoichiro KURATA Innate immunity is the first line of defence against infectious micro-organisms, and the basic mechanisms of pathogen recognition and response activation are evolutionarily...

View articletitled, A newly established in vitro culture using transgenic Drosophila reveals functional coupling between the phospholipase A2-generated fatty acid cascade and lipopolysaccharide-dependent activation of the immune deficiency (imd) pathway in insect immunity

Articles

Temporin L: antimicrobial, haemolytic and cytotoxic activities, and effects on membrane permeabilization in lipid vesicles

Andrea C. RINALDI, Maria Luisa MANGONI, Anna RUFO, Carla LUZI, Donatella BARRA, Hongxia ZHAO, Paavo K.J. KINNUNEN, Argante BOZZI, Antonio DI GIULIO, Maurizio SIMMACO

Biochem J (2002) 368 (1): 91–100.

https://doi.org/10.1042/bj20020806

Published: 15 November 2002

... fluorescent markers innate immunity liposomes Rana temporaria Abbreviations used: BMAP, bovine myeloid antimicrobial peptide; CFU, colony-forming units; FITC-D 4/20/70, fluorescein isothiocyanate dextrans of 4, 20 and 70kDa average molecular mass respectively; Gal-ONp, 2-nitrophenyl β- d...

View articletitled, Temporin L: antimicrobial, haemolytic and cytotoxic activities, and effects on membrane permeabilization in lipid vesicles

Articles

abf-1 and abf-2, ASABF-type antimicrobial peptide genes in Caenorhabditis elegans

Yusuke KATO, Tomoyasu AIZAWA, Hirokazu HOSHINO, Keiichi KAWANO, Katsutoshi NITTA, Hong ZHANG

Biochem J (2002) 361 (2): 221–230.

https://doi.org/10.1042/bj3610221

Published: 08 January 2002

... defence system due to the antimicrobial peptides. C. elegans can be a novel model for innate immunity. Furthermore, the combination of biochemical identification in Ascaris suum and homologue hunting in C. elegans should be a powerful method of finding rapidly evolved proteins, such as some immune-related...

View articletitled, abf-1 and abf-2, ASABF-type antimicrobial peptide genes in Caenorhabditis elegans

Articles

Human salivary agglutinin binds to lung surfactant protein-D and is identical with scavenger receptor protein gp-340

Toon J. M. LIGTENBERG, Floris J. BIKKER, Jasper GROENINK, Ida TORNOE, Rikke LETH-LARSEN, Enno C. I. VEERMAN, Arie V. NIEUW AMERONGEN, Uffe HOLMSKOV

Biochem J (2001) 359 (1): 243–248.

https://doi.org/10.1042/bj3590243

Published: 24 September 2001

..., and purified SP-D bound gp-340 via protein protein interaction in a calcium-dependent manner [11]. SP-D is a member of the collectin family. Collectins play an important role in innate immunity by binding to specific carbohydrate structures on the surfaces of pathogenic micro-organisms, including bacteria...

View articletitled, Human salivary agglutinin binds to lung surfactant protein-D and is identical with scavenger receptor protein gp-340

Articles

Selective induction of phospholipase D1 in pathogen-activated human monocytes

Massimo LOCATI, Elena RIBOLDI, Raffaella BONECCHI, Pietro TRANSIDICO, Sergio BERNASCONI, Bodduluri HARIBABU, Andrew J. MORRIS, Alberto MANTOVANI, Silvano SOZZANI

Biochem J (2001) 358 (1): 119–125.

https://doi.org/10.1042/bj3580119

Published: 08 August 2001

... should be addressed (e-mail [email protected] ). 12 2 2001 17 5 2001 5 6 2001 The Biochemical Society, London ©2001 2001 chemotactic factors innate immunity signal transduction Abbreviations used: Ara-LAM, arabinoside-terminated lipoarabinomannan; fMLP, fMet...

View articletitled, Selective induction of phospholipase D1 in pathogen-activated human monocytes

Articles

Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor

James MUNDAY, Sheena KERR, Jian NI, Ann L. CORNISH, Jiquan Q. ZHANG, Gavin NICOLL, Helen FLOYD, Marie-Genevieve MATTEI, Paul MOORE, Ding LIU, Paul R. CROCKER

Biochem J (2001) 355 (2): 489–497.

https://doi.org/10.1042/bj3550489

Published: 06 April 2001

... population of natural killer-like cells. The molecular properties and expression pattern suggest that Siglec-10 may function as an inhibitory receptor within the innate immune system. Biochem. J. (2001) 355, 489 497 (Printed in Great Britain) 489 Identification, characterization and leucocyte expression...

View articletitled, Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor

Articles

Identification and characterization of a silencer regulatory element in the 3′-flanking region of the murine CD46 gene

Midori NOMURA, Akira TSUJIMURA, Nasim A. BEGUM, Misako MATSUMOTO, Hiroetsu WABIKO, Kumao TOYOSHIMA, Tsukasa SEYA

Biochem J (2000) 351 (2): 353–365.

https://doi.org/10.1042/bj3510353

Published: 10 October 2000

... expression. These results imply that the effects of the CD46 silencer element encompass the innate immune and reproductive systems, and in mice may determine the testicular germ-cell-dominant expression of CD46. complement fertilization innate immunity silencer testicular germ cell 1 To whom...

View articletitled, Identification and characterization of a silencer regulatory element in the 3′-flanking region of the murine CD46 gene

Articles

Binding of α2-macroglobulin and limulin: regulation of the plasma haemolytic system of the American horseshoe crab, Limulus

Snehasikta SWARNAKAR, Rengasamy ASOKAN, James P. QUIGLEY, Peter B. ARMSTRONG

Biochem J (2000) 347 (3): 679–685.

https://doi.org/10.1042/bj3470679

Published: 25 April 2000

... and pathogenicity. Modulation of the haemolytic system represents a novel function for a # -macro- globulin. Key words: cytolysis, innate immunity, lectin, pentraxin, protein- ase clearance, thiol ester. members of the a # -macroglobulin protein family contain a unique internal b-cysteinyl-c-glutamyl thiol ester...

View articletitled, Binding of α2-macroglobulin and limulin: regulation of the plasma haemolytic system of the American horseshoe crab, Limulus

Articles

Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity

Ziv OREN, Jeffrey C. LERMAN, Gudmundur H. GUDMUNDSSON, Birgitta AGERBERTH, Yechiel SHAI

Biochem J (1999) 341 (3): 501–513.

https://doi.org/10.1042/bj3410501

Published: 26 July 1999

... activities. Most interestingly, LL-37 exists in equilibrium between monomers and oligomers in solution at very low concentrations. Also, it is significantly resistant to proteolytic degradation in solution, and when bound to both INTRODUCTION Peptide antibiotics constitute a major part of the innate immunity...

View articletitled, Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity

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