... into homo- and hetero-tetramers. This is demonstrated in yeast, mammalian cells and native tissue by complementary yeast two-hybrid, chemical cross-linking and co-immunoprecipitation assays. The IP 3 (inositol 1,4,5-trisphosphate) receptor N-terminus (residues 1–667) similarly exhibits tetrameric...

... is properly cited. 1-8-14 motif calcium signalling calmodulin inositol 1,4,5-trisphosphate receptor myosin light chain kinase (MLCK) Ca 2+ channels allow most electrical and many chemical signals to be transduced into the changes in cytosolic Ca 2+ concentration that regulate almost every...

... prevent near-plasma membrane and mitochondrial calcium overload by inhibiting IP 3 Rs (inositol 1,4,5-trisphosphate receptors), which we have shown previously to be involved in abnormal calcium homoeostasis in dystrophic myotubes. Most likely as a consequence, the inhibition of IP 3 R function by Bcl-2...

...Takao MORITA; Akihiko TANIMURA; Akihiro NEZU; Tomohiro KUROSAKI; Yosuke TOJYO We examined the function of GFP-IP 3 R3 (green fluorescent protein-tagged inositol 1,4,5-trisphosphate receptor type 3) in Ca 2+ release and entry using a mutant DT40 cell line (IP 3 R-KO) in which all three IP 3 R genes...

... 2003 11 2 2003 3 3 2003 3 3 2003 The Biochemical Society, London ©2003 2003 carbonic anhydrase-related protein (CARP) cerebellum inositol 1,4,5-trisphosphate receptor ion channel Purkinje cell yeast two-hybrid system Abbreviations used: FKBP, FK506-binding...