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Keywords: insulin
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Articles
Biochem J (2021) 478 (21): 3809–3826.
Published: 09 November 2021
...Sara M. Frangos; David J. Bishop; Graham P. Holloway While the etiology of type 2 diabetes is multifaceted, the induction of insulin resistance in skeletal muscle is a key phenomenon, and impairments in insulin signaling in this tissue directly contribute to hyperglycemia. Despite the lack...
Articles
Biochem J (2021) 478 (21): 3827–3846.
Published: 09 November 2021
...Erik A. Richter; Lykke Sylow; Mark Hargreaves The interaction between insulin and exercise is an example of balancing and modifying the effects of two opposing metabolic regulatory forces under varying conditions. While insulin is secreted after food intake and is the primary hormone increasing...
Articles
Biochem J (2021) 478 (3): 633–646.
Published: 12 February 2021
... of the allosteric AMPK activators A-769662 and 991 on glucose uptake in adipocytes. For this purpose, primary rat or human adipocytes, and cultured 3T3-L1 adipocytes, were treated with either of the allosteric activators, or AICAR, and basal and insulin-stimulated glucose uptake was assessed. Additionally...
Includes: Supplementary data
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Biochem J (2020) 477 (8): 1373–1389.
Published: 23 April 2020
...Nusrat Hussain; Sheng-Ju Chuang; Manuel Johanns; Didier Vertommen; Gregory R. Steinberg; Bruce E. Kemp; Mark H. Rider We investigated acute effects of two allosteric protein kinase B (PKB) inhibitors, MK-2206 and Akti-1/2, on insulin-stimulated lipogenesis in rat epididymal adipocytes incubated...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (1): 47–50.
Published: 22 December 2016
... is an interesting idea, as both peptides are incretin hormones that increase glucose-stimulated insulin secretion from pancreatic β-cells by activation of predominantly Gαs-coupled G-protein coupled receptors [ 12 ]. Despite the therapeutic success of GLP-1-based drugs, GIP-based therapies have not been developed...
Articles
Biochem J (2016) 473 (20): 3487–3503.
Published: 11 October 2016
...Jose E. Pietri; Nazzy Pakpour; Eleonora Napoli; Gyu Song; Eduardo Pietri; Rashaun Potts; Kong W. Cheung; Gregory Walker; Michael A. Riehle; Hannah Starcevich; Cecilia Giulivi; Edwin E. Lewis; Shirley Luckhart Insulin-like peptides (ILPs) play important roles in growth and metabolic homeostasis...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (10): 1315–1327.
Published: 11 May 2016
...Paul Duffield Brewer; Estifanos N. Habtemichael; Irina Romenskaia; Adelle C.F. Coster; Cynthia Corley Mastick Insulin increases glucose uptake by increasing the rate of exocytosis of the facilitative glucose transporter isoform 4 (Glut4) relative to its endocytosis. Insulin also releases Glut4 from...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (4): 509–523.
Published: 09 February 2016
...Irene S. Tobias; Manuel Kaulich; Peter K. Kim; Nitya Simon; Estela Jacinto; Steven F. Dowdy; Charles C. King; Alexandra C. Newton Atypical protein kinase C (aPKC) isoenzymes are key modulators of insulin signalling, and their dysfunction correlates with insulin-resistant states in both mice...
Articles
Biochem J (2015) 471 (3): 381–389.
Published: 16 October 2015
...Chun-Yan Lim; Wanjin Hong; Weiping Han Adiponectin, a hormone secreted from adipocytes and released at a high rate into the circulation, plays a pivotal role in maintaining insulin sensitivity at the whole-body level. Despite the importance of this adipokine in metabolic homoeostasis, the mechanism...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2015) 470 (2): 207–221.
Published: 20 August 2015
..., protein synthesis and promotes cellular autophagy. 1 To whom correspondence should be addressed (email h.s.hundal@dundee.ac.uk ). 1 4 2015 8 7 2015 9 7 2015 9 7 2015 amino acid autophagy growth insulin L-type (leucine) amino acid transporter 1 (LAT1) leucine...
Includes: Supplementary data
Articles
Biochem J (2015) 469 (3): 445–454.
Published: 23 July 2015
...Nobuyuki Takenaka; Yukio Sumi; Keiko Matsuda; Junko Fujita; Tetsuya Hosooka; Tetsuya Noguchi; Atsu Aiba; Takaya Satoh Insulin-stimulated glucose uptake in skeletal muscle is mediated by the translocation of the glucose transporter GLUT4 from intracellular storage sites to the plasma membrane...
Includes: Supplementary data
Articles
Biochem J (2015) 469 (1): 71–82.
Published: 19 June 2015
...Ying Liu; Sanjana Sen; Sivaporn Wannaiampikul; Rengasamy Palanivel; Ruby L. C. Hoo; Ruth Isserlin; Gary D. Bader; Rungsunn Tungtrongchitr; Yves Deshaies; Aimin Xu; Gary Sweeney Adiponectin mediates anti-diabetic effects via increasing hepatic insulin sensitivity and direct metabolic effects...
Includes: Supplementary data
Articles
Biochem J (2015) 468 (1): 49–63.
Published: 05 May 2015
...Jelena A. Stamenkovic; Lotta E. Andersson; Alice E. Adriaenssens; Annika Bagge; Vladimir V. Sharoyko; Fiona Gribble; Frank Reimann; Claes B. Wollheim; Hindrik Mulder; Peter Spégel Altered secretion of insulin as well as glucagon has been implicated in the pathogenesis of Type 2 diabetes (T2D...
Includes: Supplementary data
Articles
Biochem J (2015) 466 (3): 467–473.
Published: 06 March 2015
...Xiao Luo; Ting Li; Yue Zhu; Yunbin Dai; Jianwei Zhao; Zhan-Yun Guo; Ming-Wei Wang Insulin-like peptide 5 (INSL5), a member of the insulin/relaxin superfamily, can activate the G-protein-coupled receptor relaxin/insulin-like family peptide receptor 4 (RXFP4), but its precise biological functions...
Articles
Biochem J (2015) 466 (2): 203–218.
Published: 20 February 2015
...Guy A. Rutter; Timothy J. Pullen; David J. Hodson; Aida Martinez-Sanchez Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis in man and many other animals. Defective insulin secretion underlies all forms of diabetes mellitus, a disease currently reaching...
Articles
Biochem J (2014) 458 (3): 491–498.
Published: 28 February 2014
... leptin storage and secretion regulation in 3T3-L1 and primary adipocytes. Leptin is stored in membrane-bound vesicles that are localized predominantly in the ER (endoplasmic reticulum) and close to the plasma membrane of both 3T3-L1 and primary adipocytes. Insulin increases leptin secretion as early...
Includes: Supplementary data
Articles
Biochem J (2014) 457 (1): 69–77.
Published: 10 December 2013
...Angela M. Svendsen; Sofia B. Winge; Maike Zimmermann; Anne B. Lindvig; Caroline B. Warzecha; Waseem Sajid; Mary C. Horne; Pierre De Meyts The mechanisms whereby insulin analogues may cause enhanced mitogenicity through activation of either the IR (insulin receptor) or the IGF-IR (insulin-like...
Includes: Supplementary data
Articles
Biochem J (2013) 456 (2): 219–229.
Published: 08 November 2013
...Ying Feng; Barnabas G. Williams; Françoise Koumanov; Adrian J. Wolstenholme; Geoffrey D. Holman Caenorhabditis elegans is widely used as a model for investigation of the relationships between aging, nutrient restriction and signalling via the DAF-2 (abnormal dauer formation 2) receptor for insulin...
Includes: Supplementary data
Articles
Biochem J (2013) 455 (2): e1–e3.
Published: 27 September 2013
...James S. V. Lally; Gregory R. Steinberg Skeletal muscle is critical for whole-body glucose homoeostasis. Insulin and muscle contractions induced by exercise can increase glucose uptake through distinct intracellular signalling pathways involving PKB (protein kinase B)/Akt and AMPK (AMP-activated...
Articles
Biochem J (2013) 455 (2): 195–206.
Published: 27 September 2013
...-containing phosphatidylinositol 3-phosphate 5-kinase), the lipid kinase that phosphorylates PtdIns3 P to PtdIns(3,5) P 2 , has been implicated in insulin-stimulated glucose uptake. We investigated whether PIKfyve could also be involved in contraction/AMPK (AMP-activated protein kinase)-stimulated glucose...
Includes: Supplementary data
Articles
Biochem J (2013) 450 (2): 365–373.
Published: 15 February 2013
...Tetsuya Kitaguchi; Manami Oya; Yoshiko Wada; Takashi Tsuboi; Atsushi Miyawaki Intracellular cAMP and Ca 2+ are important second messengers that regulate insulin secretion in pancreatic β-cells; however, the molecular mechanism underlying their mutual interaction for exocytosis is not fully...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (3): 503–514.
Published: 29 May 2012
... in adipocytes in response to cellular stimuli with relevance for adipocyte function and/or AMPK signalling. None of the treatments, including insulin, cAMP inducers or AICAR (5-amino-4-imidazolecarboxamide riboside), affected SIK2 activity towards peptide or protein substrates in vitro . However, stimulation...
Articles
Biochem J (2012) 443 (1): 57–64.
Published: 14 March 2012
... underlying these diseases, with the scope to identify common cellular targets for therapy. In the present study we have examined the insulin-like signalling properties of an experimental AD 8-hydroxyquinoline drug known as CQ (clioquinol). The IIS [insulin/IGF-1 (insulin-like growth factor-1) signalling...
Articles
Biochem J (2012) 442 (3): 539–550.
Published: 24 February 2012
...). When introduced into AR42j-B13 cells, Ad-PNM caused a rapid change to a flattened morphology and a cessation of cell division. The expression of exocrine markers is suppressed. Both insulin genes are up-regulated as well as a number of transcription factors normally characteristic of beta cells...
Includes: Supplementary data
Articles
Biochem J (2012) 442 (3): 723–732.
Published: 24 February 2012
... β] plays a role in feedback inhibition of the insulin signalling cascade. Insulin induces the phosphorylation of IKKβ, in vitro and in vivo , and this effect is dependent on intact signalling via PI3K (phosphoinositide 3-kinase), but not PKB (protein kinase B). To test the hypothesis that insulin...
Includes: Supplementary data
Articles
Biochem J (2012) 442 (2): 303–310.
Published: 13 February 2012
...), the first and rate-limiting enzyme of the haem pathway. Acute porphyria attacks are usually treated by the administration of glucose; its effect is apparently related to its ability to inhibit ALAS1 by modulating insulin plasma levels. It has been shown that insulin blunts hepatocyte ALAS1 induction...
Articles
Biochem J (2012) 442 (2): 273–282.
Published: 13 February 2012
... growth factor) and insulin through the AP-1 (activator protein-1) signalling pathway. In human HCC (hepatocellular carcinoma) cells (HepG2 and Hep3B), EGF (50 ng/ml) and insulin (10 nM) stimulated endogenous AKR1B10 expression and promoter activity. In the AKR1B10 promoter, a putative AP-1 element...
Articles
Biochem J (2012) 442 (1): 161–169.
Published: 27 January 2012
... and appetite. However, in these models the PI3K activity is chronically reduced. Therefore we analysed the effects of acutely inhibiting PI3K isoforms alone, or PI3K and mTOR, on glucose metabolism and food intake. In the present study impairments in glucose tolerance, insulin tolerance and increased hepatic...
Includes: Supplementary data
Articles
Biochem J (2011) 440 (3): 397–403.
Published: 28 November 2011
...Louise Knudsen; Pierre De Meyts; Vladislav V. Kiselyov More than 20 years after the description of the two IR (insulin receptor) isoforms, designated IR-A (lacking exon 11) and IR-B (with exon 11), nearly every functional aspect of the alternative splicing both in vitro and in vivo remains...
Articles
Biochem J (2011) 435 (2): 539–544.
Published: 29 March 2011
... for processes including glucose metabolism. Therefore a potential complication of such anticancer drugs is insulin resistance and/or diabetes. In the process of characterizing the metabolic effects of early-phase Akt inhibitors, we discovered an off-target inhibitory effect on mammalian facilitative glucose...
Articles
Biochem J (2011) 435 (2): 463–474.
Published: 29 March 2011
...Charlotte J. Green; Katherine Macrae; Sarah Fogarty; D. Grahame Hardie; Kei Sakamoto; Harinder S. Hundal Sustained over-supply of saturated non-esterified ‘free’ fatty acids has been shown to promote skeletal muscle insulin resistance, which may be driven, in part, by an increase in inflammatory...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (1): 277–284.
Published: 15 March 2011
...Peter Spégel; Siri Malmgren; Vladimir V. Sharoyko; Philip Newsholme; Thomas Koeck; Hindrik Mulder Insulin secretion from pancreatic β-cells is controlled by complex metabolic and energetic changes provoked by exposure to metabolic fuels. Perturbations in these processes lead to impaired insulin...
Includes: Supplementary data
Articles
Biochem J (2010) 432 (3): 515–525.
Published: 25 November 2010
... in the activation process. We have determined the distribution of NHE1 by means of immunofluorescence microscopy and cell-surface biotinylation. We have discovered changes in the distribution of NHE1 that occur when cardiomyocytes are stimulated with insulin that are PI3K (phosphoinositide 3-kinase)-dependent...
Includes: Supplementary data
Articles
Biochem J (2010) 432 (2): 375–386.
Published: 12 November 2010
...Kyota Aoyagi; Mica Ohara-Imaizumi; Chiyono Nishiwaki; Yoko Nakamichi; Shinya Nagamatsu Functional insulin receptor and its downstream effector PI3K (phosphoinositide 3-kinase) have been identified in pancreatic β-cells, but their involvement in the regulation of insulin secretion from β-cells...
Articles
Biochem J (2010) 432 (1): 191–198.
Published: 25 October 2010
..., Akt also plays an essential role in other physiological processes, such as the insulin-regulated transport of glucose into muscle and fat cells. This process, which is essential for whole-body glucose homoeostasis in mammals, is thought to be mediated via Akt-dependent movement of GLUT4 glucose...
Includes: Supplementary data
Articles
Biochem J (2010) 431 (3): 381–390.
Published: 11 October 2010
...Javier Pizarro-Delgado; Matthias Braun; Inés Hernández-Fisac; Rafael Martín-Del-Río; Jorge Tamarit-Rodriguez We have demonstrated recently that branched-chain α-keto acid stimulation of insulin secretion is dependent on islet GABA (γ-aminobutyric acid) metabolism: GABA transamination to succinic...
Includes: Supplementary data
Articles
Biochem J (2010) 430 (3): 511–518.
Published: 27 August 2010
...Andra Noormägi; Julia Gavrilova; Julia Smirnova; Vello Tõugu; Peep Palumaa Insulin, a 51-residue peptide hormone, is an intrinsically amyloidogenic peptide, forming amyloid fibrils in vitro . In the secretory granules, insulin is densely packed together with Zn(II) into crystals of Zn 2 Insulin 6...
Articles
Biochem J (2010) 430 (2): 245–254.
Published: 13 August 2010
... with the induction of Cidea expression by insulin and TO901317 in wild-type mouse hepatocytes, the stimulatory effects were lost in hepatocytes prepared from SREBP-1c -null mice. Adenovirus-mediated overexpression of Cidea in hepatocytes promoted lipid accumulation and triacylglycerol (triglyceride) storage; however...
Articles
Biochem J (2010) 426 (1): 85–90.
Published: 27 January 2010
...Stuart A. Ritchie; Christine F. Kohlhaas; Alasdair R. Boyd; Krishna C. Yalla; Kenneth Walsh; John M. C. Connell; Ian P. Salt Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser...
Articles
Biochem J (2010) 425 (1): 41–52.
Published: 14 December 2009
... distinct roles in the regulation of energy homoeostasis. The serum levels of adiponectin are negatively correlated with obesity and insulin resistance, yet the underlying mechanisms remain elusive. In the present review, we summarize recent progress made on the mechanisms regulating adiponectin gene...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2009) 424 (3): 399–410.
Published: 10 December 2009
...Faiyaz Ahmad; Rebecka Lindh; Yan Tang; Iida Ruishalme; Anita Öst; Bobby Sahachartsiri; Peter Strålfors; Eva Degerman; Vincent C. Manganiello In adipocytes, PDE3B (phosphodiesterase 3B) is an important regulatory effector in signalling pathways controlled by insulin and cAMP-increasing hormones...
Includes: Supplementary data
Articles
Biochem J (2009) 421 (3): 371–376.
Published: 15 July 2009
... zinc transporter ZnT-8, which provides zinc for insulin-hexamer formation. Polymorphic variants in amino acid residue 325 of human ZnT-8 are associated with altered susceptibility to Type 2 diabetes and ZnT-8 autoantibody epitope specificity changes in Type 1 diabetes. To assess the physiological...
Includes: Supplementary data
Articles
Biochem J (2009) 419 (3): 645–653.
Published: 14 April 2009
... expression. Lipophilic molecules were extracted from rat livers, saponified and re-constituted as an LE (lipophilic extract). LE synergized with insulin to induce primary hepatocyte, but not β-cell, Gck expression in an SREBP-1c (sterol-regulatory-element-binding protein-1c)-independent manner. The dramatic...
Articles
Biochem J (2009) 419 (2): 359–368.
Published: 27 March 2009
...Javier Pizarro-Delgado; Inés Hernández-Fisac; Rafael Martín-Del-Río; Jorge Tamarit-Rodriguez We have previously shown that oxo-4-methylpentanoate promotes islet GABA (γ-aminobutyric acid) metabolism and stimulates insulin secretion. The main aim of this work was to explore the participation...
Articles
Biochem J (2009) 419 (2): 475–484.
Published: 27 March 2009
...Hilal Zaid; Ilana Talior-Volodarsky; Costin Antonescu; Zhi Liu; Amira Klip Dietary glucose is taken up by skeletal muscle through GLUT4 (glucose transporter 4). We recently identified by MS proteins displaying insulin-dependent co-precipitation with Myc-tagged GLUT4 from L6 myotubes, including...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (2): 611–620.
Published: 23 December 2008
...-phosphate to glucose. We show here that, in HepG2 hepatoma cells, EGF (epidermal growth factor) inhibits basal mouse G6Pase fusion gene transcription. Several studies have shown that insulin represses basal mouse G6Pase fusion gene transcription through FOXO1 (forkhead box O1), but Stoffel and colleagues...
Articles
Biochem J (2009) 417 (1): 235–246.
Published: 12 December 2008
...) of HIF-1 α mRNA. Overexpression of CPEB1 and CPEB2 affected HIF-1α protein levels mediated by the 3′-UTR of HIF-1 α mRNA. Stimulation of neuroblastoma SK-N-MC cells with insulin and thus activation of endogenous CPEBs increased the expression of a luciferase reporter gene fused to the 3′-UTR of HIF-1 α...
Articles
Biochem J (2008) 415 (1): 1–10.
Published: 12 September 2008
...Sreenath S. Andrali; Megan L. Sampley; Nathan L. Vanderford; Sabire Özcan Production and secretion of insulin from the β-cells of the pancreas is very crucial in maintaining normoglycaemia. This is achieved by tight regulation of insulin synthesis and exocytosis from the β-cells in response...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2008) 412 (1): 93–101.
Published: 25 April 2008
...Junko Kawai; Mica Ohara-Imaizumi; Yoko Nakamichi; Tadashi Okamura; Yoshihiro Akimoto; Satsuki Matsushima; Kyota Aoyagi; Hayato Kawakami; Takashi Watanabe; Hirotaka Watada; Ryuzo Kawamori; Shinya Nagamatsu Sulfonylurea and glinide drugs display different effects on insulin granule motion in single β...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2008) 411 (1): 41–51.
Published: 13 March 2008
...-bisphosphate) and is also a glucokinase-binding protein. The role of fructose 2,6-P 2 in regulating glucose metabolism and insulin secretion in pancreatic β-cells is unresolved. We down-regulated the endogenous isoforms of PFK-2/FBPase-2 with siRNA (small interfering RNA) and expressed KA (kinase active...