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Keywords: insulin/IGF (insulin-like growth factor)-like signalling
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Biochem J (2009) 418 (1): 1–12.
Published: 28 January 2009
... elegans and the mouse. IIS [insulin/IGF (insulin-like growth factor)-like signalling] stands out as an important, evolutionarily conserved pathway involved in the determination of lifespan. The pathway has diverse functions in multicellular organisms, and mutations in IIS can affect growth, development...