... into fluorescent mounting medium. complexin GLUT4-translocation insulin action skeletal muscle cells SNARE complex Skeletal muscle and adipose tissue are the main insulin-responsive, glucose-disposing depots in the body. During a meal, insulin rapidly increases the number of glucose transporter...

... structure which is then functional and binds the labelling compounds. The identified labelling site is still in the C-terminal domain, but the N-terminal domain supports its labelling. GLUT proteins GLUT4 translocation insulin action This review is based on the 2017 Randle Lecture delivered...

..., diabetes and cardiovascular disease through impaired signalling and metabolism resulting in dysfunction to insulin secretion, insulin action and immune responses. However, exercise may counter excessive levels of oxidative stress and thus improve metabolic and inflammatory outcomes. In the present article...

...Esi Kajno; Timothy E. McGraw; Eva Gonzalez Protein kinase B (Akt) kinases are critical signal transducers mediating insulin action. Genetic studies revealed that Akt1 and Akt2 signalling differentially contribute to sustain lipid and glucose homoeostasis; however Akt isoform-specific effectors...

[email protected] ). 17 5 2011 18 8 2011 18 8 2011 18 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 blood glucose insulin action insulin receptor-A (IR-A) insulin receptor B (IR-B) lipogenesis liver muscle The incidence of Type 2 diabetes...

... sequence and an upstream phospholipid binding domain. Many sorting nexins, including SNX9, also have a C-terminal coiled region. SNX9 additionally has an N-terminal SH3 (Src homology 3) domain. Here we have investigated the cellular localization of SNX9 and the potential role it plays in insulin action...

... demonstrate a crucial role for Akt in the insulin-stimulated cell cycle progression of Xenopus oocytes, whereas Akt may have an ancillary function in progesterone signalling. Key words: cell cycle, insulin action, phosphatase, progesterone signalling. injection of mRNAs, or the modulation of endogenous...

... at Ser 329 in vivo . 1 To whom correspondence should be addressed (e-mail [email protected] ). 13 12 2000 5 2 2001 27 2 2001 The Biochemical Society, London © 2001 2001 Akt apoptosis insulin action gene transcription protein kinase B Biochem. J. (2001) 355...

... Downs syndrome insulin action protein phosphorylation signal transduction Biochem. J. (2001) 355, 609 615 (Printed in Great Britain) 609 The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Be at Ser539 and the microtubule-associated protein tau at Thr212 : potential role...

... 2000 2000 exercise insulin action metabolism signal transduction transport Biochem. J. (2000) 349, 775 781 (Printed in Great Britain) 775 Contraction inhibits insulin-stimulated insulin receptor substrate-1/2- associated phosphoinositide 3-kinase activity, but not protein kinase B...