...-throughput screening insulin resistance insulin receptor substrate 1 (IRS1) therapeutic target GLUT4 (glucose transporter 4) plays an important role in glucose homoeostasis in both animals and humans. In the basal state, GLUT4 resides in intracellular cytoplasmic vesicles. On insulin stimulation...

... in cultured muscle cells [ 4 , 5 ] and in skeletal muscle of both rodents [ 6 , 7 ] and humans [ 8 ]. However, it is only recently that the mechanistic basis of ceramide-induced insulin resistance is beginning to be understood. ceramide diacylglycerol insulin receptor substrate 1 (IRS1) myriocin...