...Brie Sorrenson; Waruni C. Dissanayake; Fengyun Hu; Kate L. Lee; Peter R. Shepherd The presence of adherens junctions and the associated protein β-catenin are requirements for the development of glucose-stimulated insulin secretion (GSIS) in β-cells. Evidence indicates that modulation of β-catenin...

...Waruni C. Dissanayake; Brie Sorrenson; Kate L. Lee; Sandra Barre; Peter R. Shepherd The recent finding that β-catenin levels play an important rate-limiting role in processes regulating insulin secretion lead us to investigate whether its binding partner α-catenin also plays a role in this process...

..., diabetes and cardiovascular disease through impaired signalling and metabolism resulting in dysfunction to insulin secretion, insulin action and immune responses. However, exercise may counter excessive levels of oxidative stress and thus improve metabolic and inflammatory outcomes. In the present article...

... insulin secretion by functioning as a Ca 2+ -sensor protein, but the underlying mechanism has not been elucidated. The present study explored the mechanism by which SCGN enhances glucose-induced insulin secretion in NIT-1 insulinoma cells. To determine whether SCGN influences the first or second phase...

...Hilton K. Takahashi; Laila R. B. Santos; Letícia P. Roma; Jessica Duprez; Christophe Broca; Anne Wojtusciszyn; Jean-Christophe Jonas The glucose stimulation of insulin secretion by pancreatic β-cells depends on increased production of metabolic coupling factors, among which changes in NADPH and ROS...

... by the kinase PIKFyve, therefore its synthesis does not seem to be catalysed directly by any PI3Ks. © The Authors Journal compilation © 2012 Biochemical Society 2012 cell migration glucose transport insulin secretion phosphoinositide phosphoinositide 3-kinase (PI3K) Phosphoinositides...

...Yuichi Nishi; Shimpei Fujimoto; Mayumi Sasaki; Eri Mukai; Hiroki Sato; Yuichi Sato; Yumiko Tahara; Yasuhiko Nakamura; Nobuya Inagaki In pancreatic β-cells, glucose-induced mitochondrial ATP production plays an important role in insulin secretion. The mitochondrial phosphate carrier PiC is a member...

...Ulrika Krus; Olga Kotova; Peter Spégel; Elna Hallgard; Vladimir V. Sharoyko; Anna Vedin; Thomas Moritz; Mary C. Sugden; Thomas Koeck; Hindrik Mulder Tight coupling between cytosolic and mitochondrial metabolism is key for GSIS (glucose-stimulated insulin secretion). In the present study we examined...

... for the control of glucose-stimulated insulin secretion. AGC1 or Aralar1 (aspartate–glutamate carrier 1) is a key component of the malate–aspartate shuttle. Overexpression of AGC1 increases the capacity of the malate–aspartate shuttle, resulting in enhanced metabolism–secretion coupling, both in INS-1E cells...

... (methyl succinate) compared with glucose in mouse and rat islets and to understand the differences. Glycolysis and mitochondrial metabolism both have key roles in the stimulation of insulin secretion by glucose. Both fuels elicited comparable oscillatory patterns of Ca 2+ and changes in plasma...

...Sergio FERNÁNDEZ-PASCUAL; André MUKALA-NSENGU-TSHIBANGU; Rafael MARTÍN del RÍO; Jorge TAMARIT-RODRÍGUEZ We have carried out a detailed examination of l -glutamine metabolism in rat islets in order to elucidate the paradoxical failure of l -glutamine to stimulate insulin secretion. l -Glutamine...

...Frédérique DIRAISON; Laura PARTON; Pascal FERRÉ; Fabienne FOUFELLE; Celia P. BRISCOE; Isabelle LECLERC; Guy A. RUTTER Accumulation of intracellular lipid by pancreatic islet β-cells has been proposed to inhibit normal glucose-regulated insulin secretion (‘glucolipotoxicity’). In the present study...

[email protected] ). 3 1 2003 18 6 2003 3 7 2003 3 7 2003 The Biochemical Society, London ©2003 2003 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) 5′-AMP-activated protein kinase (AMPK) diabetes mellitus glucose homoeostasis insulin secretion pancreatic islet β-cell...

...Victor A. GAULT; Peter R. FLATT; Clifford J. BAILEY; Patrick HARRIOTT; Brett GREER; Mark H. MOONEY; Finbarr P.M. O'HARTE Glucose-dependent insulinotropic polypeptide (GIP) is an important incretin hormone, which potentiates glucose-induced insulin secretion. Antihyperglycaemic actions of GIP...

...Nicolas VOILLEY; Raphaël RODUIT; Raffaela VICARETTI; Christophe BONNY; Gérard WAEBER; Jason R. B. DYCK; Gary D. LOPASCHUK; Marc PRENTKI To gain insight into the function and regulation of malonyl-CoA decarboxylase (MCD) we have cloned rat MCD cDNA from a differentiated insulin-secreting pancreatic...

... in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitter substances, and in glucose-induced insulin secretion by pancreatic islets. The reaction catalysed by PC and the physical properties of the enzyme have been studied extensively. Although no high-resolution three-dimensional structure has yet...