... as well as activating local and systemic fuel mobilizing processes. In contrast, following exercise there is a need for refilling the fuel depots mobilized during exercise, particularly the glycogen stores in muscle. This process is facilitated by an increase in insulin sensitivity of the muscles...

... an allosteric regulatory mechanism involving C-terminal sequences and the Akt kinase domain that serves to restrict phosphatase access to the Akt activation loop. Importantly, this interaction can be modified to increase insulin sensitivity and protect cells from ceramide-mediated insulin resistance...

... influence insulin action in metabolic organs vital for the control of insulin sensitivity such as skeletal muscle, liver and adipose tissue [ 3 , 5 , 65 , 103 ]. One of the most widely studied mechanism by which pro-inflammatory cytokines inhibit insulin signalling is through increased S/T (serine/threonine...

... of ASC-2 in the regulation of insulin sensitivity. Although islet cells from 10-week-old ASC-2 +/− mice secreted less insulin than wild-type islets, there was no significant difference in glucose tolerance between ASC-2 +/− and wild-type mice. However, ASC-2 +/− mice did show increased insulin...

... homoeostasis is presently unknown. We have used transgenic mice to analyse the effects of loss of BACE1 on body weight, and lipid and glucose homoeostasis. BACE1 −/− mice are lean, with decreased adiposity, higher energy expenditure, and improved glucose disposal and peripheral insulin sensitivity than wild...

... (18:1) increases TAG accumulation in livers of ATF4 −/− mice. Taken together, these results suggest that ATF4 deficiency is protective for HCD-induced hepatic steatosis and impairment of glucose tolerance and insulin sensitivity. Furthermore, the resistance to hepatic steatosis is at least in part due...

...Yu Wang; Karen S. L. Lam; Ming-hon Yau; Aimin Xu Adiponectin is an insulin-sensitizing adipokine with anti-diabetic, anti-atherogenic, anti-inflammatory and cardioprotective properties. This adipokine is secreted from adipocytes into the circulation as three oligomeric isoforms, including trimeric...