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Keywords: insulin sensitivity
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Biochem J (2021) 478 (21): 3827–3846.
Published: 09 November 2021
... as well as activating local and systemic fuel mobilizing processes. In contrast, following exercise there is a need for refilling the fuel depots mobilized during exercise, particularly the glycogen stores in muscle. This process is facilitated by an increase in insulin sensitivity of the muscles...
Biochem J (2015) 471 (1): 37–51.
Published: 21 September 2015
... to the Akt activation loop. Importantly, this interaction can be modified to increase insulin sensitivity and protect cells from ceramide-mediated insulin resistance. ceramide dephosphorylation resistance insulin sensitivity protein kinase A protein kinase B/Akt The serine/threonine Akt...
Includes: Supplementary data
Biochem J (2014) 461 (2): 177–188.
Published: 26 June 2014
... 24 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 Table 1 Changes in insulin sensitivity resulting from genetic manipulation of SOCS1 and SOCS3 in different tissues SOCS protein Cell type/tissue Treatment Insulin sensitivity Reference(s...
Biochem J (2012) 447 (3): 437–447.
Published: 05 October 2012
... of ASC-2 in the regulation of insulin sensitivity. Although islet cells from 10-week-old ASC-2 +/− mice secreted less insulin than wild-type islets, there was no significant difference in glucose tolerance between ASC-2 +/− and wild-type mice. However, ASC-2 +/− mice did show increased insulin...
Includes: Supplementary data
Biochem J (2012) 441 (1): 285–296.
Published: 14 December 2011
... homoeostasis is presently unknown. We have used transgenic mice to analyse the effects of loss of BACE1 on body weight, and lipid and glucose homoeostasis. BACE1 −/− mice are lean, with decreased adiposity, higher energy expenditure, and improved glucose disposal and peripheral insulin sensitivity than wild...
Includes: Supplementary data
Biochem J (2011) 438 (2): 283–289.
Published: 12 August 2011
... (18:1) increases TAG accumulation in livers of ATF4 −/− mice. Taken together, these results suggest that ATF4 deficiency is protective for HCD-induced hepatic steatosis and impairment of glucose tolerance and insulin sensitivity. Furthermore, the resistance to hepatic steatosis is at least in part due...
Biochem J (2008) 409 (3): 623–633.
Published: 15 January 2008
...Yu Wang; Karen S. L. Lam; Ming-hon Yau; Aimin Xu Adiponectin is an insulin-sensitizing adipokine with anti-diabetic, anti-atherogenic, anti-inflammatory and cardioprotective properties. This adipokine is secreted from adipocytes into the circulation as three oligomeric isoforms, including trimeric...