Page 1 | Search Results | Biochemical Journal

1-29 of 29

Sort by

Sort Order Select

Articles

Retraction: Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B

Biochem J (2025) 482 (07): 363.

https://doi.org/10.1042/BJ20030577_RET

Published: 01 April 2025

...: 10.1042/bst0310584 ) and Yang et al., 2006 (DOI: 10.1073/pnas.0602282103 )] and in mammalian cells by numerous laboratories [reviewed in Panwar et al., 2023 (DOI: 10.1038/s41392-023-01608-z )]. Drosophila insulin signalling phosphatase and tensin homologue deleted on chromosome 10 (PTEN...

View articletitled, Retraction: Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B

Articles

Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes

Su-Ping Ng, Wataru Nomura, Haruya Takahashi, Kazuo Inoue, Teruo Kawada, Tsuyoshi Goto, Yoshiharu Inoue

Biochem J (2022) 479 (21): 2279–2296.

https://doi.org/10.1042/BCJ20220271

Published: 04 November 2022

... contributed equally to this work. 27 5 2022 11 10 2022 18 10 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 adipocytes insulin signalling methylglyoxal mTOR signalling TAK1 Some metabolites produced during...

View articletitled, Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes

Includes: Supplementary data

Articles

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

Xiaowen Duan, Dougall M. Norris, Sean J. Humphrey, Pengyi Yang, Kristen C. Cooke, Will P. Bultitude, Benjamin L. Parker, Olivia J. Conway, James G. Burchfield, James R. Krycer, Frances M. Brodsky, David E. James, Daniel J. Fazakerley

Biochem J (2022) 479 (11): 1237–1256.

https://doi.org/10.1042/BCJ20220153

Published: 13 June 2022

... surface GLUT4 in cells stimulated with a submaximal insulin dose, and this was impaired following Trarg1 knockdown, suggesting that TRARG1 acts as a GSK3-mediated regulator in GLUT4 trafficking. These data place TRARG1 within the insulin signaling network and provide insights into how GSK3 regulates GLUT4...

View articletitled, Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

Includes: Supplementary data

Articles

SREBP-1c and lipogenesis in the liver: an update

In Collection

Celebrating 100 years of insulin research

Pascal Ferré, Franck Phan, Fabienne Foufelle

Biochem J (2021) 478 (20): 3723–3739.

https://doi.org/10.1042/BCJ20210071

Published: 21 October 2021

... stress hepatic physiology insulin resistance insulin signalling lipogenesis sterol regulatory element-binding proteins In 2002, we wrote a review in the Biochemical Journal on the importance of the transcription factor Sterol Regulatory Element Binding Protein-1c (SREBP-1c...

View articletitled, SREBP-1c and lipogenesis in the liver: an update

Articles

A new degree of complexi(n)ty in the regulation of GLUT4 trafficking

Luc Bertrand, Marine De Loof, Christophe Beauloye, Sandrine Horman, Laurent Bultot

Biochem J (2021) 478 (7): 1315–1319.

https://doi.org/10.1042/BCJ20210008

Published: 06 April 2021

.... Correspondence: Luc Bertrand ([email protected]) 5 2 2021 11 3 2021 12 3 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 complexin glucose transport GLUT4 insulin signalling muscle metabolism Living...

View articletitled, A new degree of complexi(n)ty in the regulation of GLUT4 trafficking

Articles

Insulin and β-adrenergic receptors mediate lipolytic and anti-lipolytic signalling that is not altered by type 2 diabetes in human adipocytes

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Cecilia Jönsson, Ana P. Castor Batista, Preben Kjølhede, Peter Strålfors

Biochem J (2019) 476 (19): 2883–2908.

https://doi.org/10.1042/BCJ20190594

Published: 11 October 2019

.... beta-adrenergic signalling human adipocytes insulin resistance insulin signalling lipolysis type 2 diabetes Adipocytes were isolated from subcutaneous adipose tissue by collagenase (type 1, Worthington, NJ, U.S.A.) digestion as described [ 13 ]. Cells, at 9% (vol/vol) in supplemented...

View articletitled, Insulin and β-adrenergic receptors mediate lipolytic and anti-lipolytic signalling that is not altered by type 2 diabetes in human adipocytes

Includes: Supplementary data

Articles

Dissecting signalling by individual Akt/PKB isoforms, three steps at once

Cesar Osorio-Fuentealba, Amira Klip

Biochem J (2015) 470 (2): e13–e16.

https://doi.org/10.1042/BJ20150750

Published: 20 August 2015

... translocation insulin signalling Akt kinase, a member of the AGC kinase family, was originally identified as the oncogene transduced by the acute transforming retrovirus (Akt-8) isolated from an insulin-like growth factor 1 (AKR) thymoma [ 1 – 3 ]. Sequence analysis of the viral oncogene and its...

View articletitled, Dissecting signalling by individual Akt/PKB isoforms, three steps at once

Articles

Hypothalamic NUCKS regulates peripheral glucose homoeostasis

Beiying Qiu, Xiaohe Shi, Qiling Zhou, Hui Shan Chen, Joy Lim, Weiping Han, Vinay Tergaonkar

Biochem J (2015) 469 (3): 391–398.

https://doi.org/10.1042/BJ20150450

Published: 23 July 2015

... signalling. Whole-body depletion of NUCKS (NKO) in mice leads to obesity, glucose intolerance and insulin resistance. However, a tissue-specific contribution of NUCKS to the observed phenotypes remains unknown. Considering the pivotal roles of insulin signalling in the brain, especially in the hypothalamus...

View articletitled, Hypothalamic NUCKS regulates peripheral glucose homoeostasis

Articles

Arp2/3 complex regulates adipogenesis by controlling cortical actin remodelling

Wulin Yang, Shermaine Thein, Chun-Yan Lim, Russell E. Ericksen, Shigeki Sugii, Feng Xu, Robert C. Robinson, Jae Bum Kim, Weiping Han

Biochem J (2014) 464 (2): 179–192.

https://doi.org/10.1042/BJ20140805

Published: 14 November 2014

... is essential for efficient glucose transporter 4 (GLUT4) vesicle exocytosis and insulin signal transduction. These results show that the Arp2/3 complex is an essential regulator of adipocyte development through control of the formation of cortical actin structures, which may facilitate nutrient uptake...

View articletitled, Arp2/3 complex regulates adipogenesis by controlling cortical actin remodelling

Includes: Supplementary data

Articles

Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2)

Hao Liu, Junjie Yu, Tingting Xia, Yuzhong Xiao, Qian Zhang, Bin Liu, Yajie Guo, Jiali Deng, Yalan Deng, Shanghai Chen, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Feifan Guo

Biochem J (2014) 464 (2): 281–289.

https://doi.org/10.1042/BJ20141005

Published: 14 November 2014

... also found that insulin signalling is enhanced or impaired in Hep1-6 cells infected with adenoviruses expressing SGK1 (Ad-SGK1) or shRNA directed against the coding region of SGK1 (Ad-shSGK1) respectively. In addition, we determined that SGK1 inhibits ERK1/2 (extracellular-signal-regulated kinase 1/2...

View articletitled, Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2)

Includes: Supplementary data

Articles

Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling

Chia-Lun Wu, Bree Buszard, Chun-Hung Teng, Wei-Lin Chen, Coral G. Warr, Tony Tiganis, Tzu-Ching Meng

Biochem J (2011) 439 (1): 151–159.

https://doi.org/10.1042/BJ20110799

Published: 14 September 2011

... selectivity and the regulation of insulin signalling remain unclear. In the present study we have taken advantage of Drosophila as a model organism to establish the role of the SH3 (Src homology 3)/SH2 adaptor protein Dock (Dreadlocks) and its mammalian counterpart Nck in IR regulation by PTPs. We demonstrate...

View articletitled, Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling

Includes: Supplementary data

Articles

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P 2 in regulating insulin sensitivity defined by knock-in analysis

Stephan Wullschleger, David H. Wasserman, Alex Gray, Kei Sakamoto, Dario R. Alessi

Biochem J (2011) 434 (2): 265–274.

https://doi.org/10.1042/BJ20102012

Published: 11 February 2011

...-in mice that express normal endogenous levels of mutant TAPP1 and TAPP2 that are incapable of binding PtdIns(3,4) P 2 . These homozygous TAPP1 R211L/R211L TAPP2 R218L/R218L double knock-in mice are viable and exhibit significantly enhanced activation of Akt, a key downstream mediator of insulin signalling...

View articletitled, Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P 2 in regulating insulin sensitivity defined by knock-in analysis

Includes: Supplementary data

Articles

Molecular mechanisms of metabolic regulation by insulin in Drosophila

Aurelio A. Teleman

Biochem J (2010) 425 (1): 13–26.

https://doi.org/10.1042/BJ20091181

Published: 14 December 2009

...Aurelio A. Teleman The insulin signalling pathway is highly conserved from mammals to Drosophila . Insulin signalling in the fly, as in mammals, regulates a number of physiological functions, including carbohydrate and lipid metabolism, tissue growth and longevity. In the present review, I discuss...

View articletitled, Molecular mechanisms of metabolic regulation by insulin in Drosophila

Articles

Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo

Madhurima Rajkhowa, Sandra Brett, Daniel J. Cuthbertson, Christopher Lipina, Antonio J. Ruiz-Alcaraz, Giles E. Thomas, Lisa Logie, John R. Petrie, Calum Sutherland

Biochem J (2009) 418 (3): 665–671.

https://doi.org/10.1042/BJ20082176

Published: 25 February 2009

... this reduced cellular insulin sensitivity is not clear. The present study compares the major insulin signalling pathways in skeletal muscle isolated from PCOS and controls. We measured whole-body insulin sensitivity and insulin signalling in skeletal muscle biopsies taken before and after acute exposure...

View articletitled, Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo

Articles

Insulin action on glucose transporters through molecular switches, tracks and tethers

Hilal Zaid, Costin N. Antonescu, Varinder K. Randhawa, Amira Klip

Biochem J (2008) 413 (2): 201–215.

https://doi.org/10.1042/BJ20080723

Published: 26 June 2008

... the insulin signalling and GLUT4 vesicle trafficking events underpinning this response. In spite of this intensive scientific research, there are outstanding questions that continue to challenge us today. The present review summarizes the knowledge in the field, with emphasis on the latest breakthroughs...

View articletitled, Insulin action on glucose transporters through molecular switches, tracks and tethers

Articles

Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes

Qiong L. Zhou, Zhen Y. Jiang, John Holik, Anil Chawla, G. Nana Hagan, John Leszyk, Michael P. Czech

Biochem J (2008) 411 (3): 647–655.

https://doi.org/10.1042/BJ20071084

Published: 14 April 2008

... 2007 15 1 2008 16 1 2008 16 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 Akt substrate of 160 kDa (AS160) GLUT1 GTPase-activating protein (GAP) insulin signalling mammalian target of rapamycin (mTOR) protein kinase B (PKB)/Akt Akt/PKB...

View articletitled, Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes

Articles

Resveratrol is a class IA phosphoinositide 3-kinase inhibitor

Sara Fröjdö, Delphine Cozzone, Hubert Vidal, Luciano Pirola

Biochem J (2007) 406 (3): 511–518.

https://doi.org/10.1042/BJ20070236

Published: 29 August 2007

... and anticancer properties and identify resveratrol as a natural class-specific PI3K inhibitor. 13 2 2007 30 5 2007 6 6 2007 6 6 2007 deacetylase human primary myotube insulin signalling phosphoinositide 3-kinase resveratrol sirtuin Resveratrol is a phytoalexin found...

View articletitled, Resveratrol is a class IA phosphoinositide 3-kinase inhibitor

Includes: Supplementary data

Articles

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling

Claire Chaussade, Gordon W. Rewcastle, Jackie D. Kendall, William A. Denny, Kitty Cho, Line M. Grønning, Mei Ling Chong, Sasha H. Anagnostou, Shaun P. Jackson, Nathalie Daniele, Peter R. Shepherd

Biochem J (2007) 404 (3): 449–458.

https://doi.org/10.1042/BJ20070003

Published: 29 May 2007

... (phosphatidylinositol 3-kinases), it is the p110α isoform (PIK3CA) that plays the predominant role in insulin signalling. We have used isoform-selective inhibitors of class IA PI3K to dissect further the roles of individual p110 isoforms in insulin signalling. These include a p110α-specific inhibitor (PIK-75), a p110α...

View articletitled, Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling

Articles

Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways

Françoise Koumanov, Geoffrey D. Holman

Biochem J (2007) 403 (2): e9.

https://doi.org/10.1042/BJ20070271

Published: 26 March 2007

... to the recent discovery that mutations in the Tbc1d1 gene lead to some cases of severe human obesity. GLUT4 translocation insulin signalling obesity-susceptibility gene Rab GTPase-activating protein (Rab GAP) Tbc1d1 Figure 1 Lienhard's hypothesis for a role of the Tbc1d1 and Tbc1d4 proteins...

View articletitled, Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways

Articles

Insulin signalling: putting the G- in protein-protein interactions

Craig C. MALBON

Biochem J (2004) 380 (1): e11–e12.

https://doi.org/10.1042/bj20040619

Published: 15 May 2004

... biology. 1 To whom correspondence should be addressed (e-mail [email protected] ). 14 4 2004 16 4 2004 19 4 2004 8 6 2004 Gα i2 insulin signalling multivalent signalling protein—protein interaction receptor tyrosine kinase Src homology 2 domain (SH2 domain...

View articletitled, Insulin signalling: putting the G- in protein-protein interactions

Articles

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B

Jose M. LIZCANO, Saif ALRUBAIE, Agnieszka KIELOCH, Maria DEAK, Sally J. LEEVERS, Dario R. ALESSI

Biochem J (2003) 374 (2): 297–306.

https://doi.org/10.1042/bj20030577

Published: 01 September 2003

... (phosphoinositide 3-kinase) activation, generates the lipid second messenger PtdIns(3,4,5) P 3 , which is thought to play a key role in triggering the activation of S6K. Although the major components of the insulin-signalling pathway are conserved in Drosophila , recent studies suggested that S6K activation does...

View articletitled, Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B

Articles

Vertebrate tankyrase domain structure and sterile alpha motif (SAM)-mediated multimerization

Manu DE RYCKER, Ranga N. VENKATESAN, Chao WEI, Carolyn M. PRICE

Biochem J (2003) 372 (1): 87–96.

https://doi.org/10.1042/bj20021450

Published: 15 May 2003

...Manu DE RYCKER; Ranga N. VENKATESAN; Chao WEI; Carolyn M. PRICE Tankyrases 1 and 2 are two highly related poly(ADP-ribose) polymerases that interact with a variety of cytoplasmic and nuclear proteins. Both proteins have been implicated in telomere length regulation, insulin signalling...

View articletitled, Vertebrate tankyrase domain structure and sterile alpha motif (SAM)-mediated multimerization

Articles

Mouse system-N amino acid transporter, mNAT3, expressed in hepatocytes and regulated by insulin-activated and phosphoinositide 3-kinase-dependent signalling

Sumin GU, Paul LANGLAIS, Feng LIU, Jean X. JIANG

Biochem J (2003) 371 (3): 721–731.

https://doi.org/10.1042/bj20030049

Published: 01 May 2003

... properties of mNAT3 suggest that this transporter may play an important role in liver physiology. Key words: amino acid transporter, insulin signalling, liver, mNAT3, phosphoinositide 3-kinase. from muscle. In addition, we have observed a graded distribution of mNAT expression from the central vein...

View articletitled, Mouse system-N amino acid transporter, mNAT3, expressed in hepatocytes and regulated by insulin-activated and phosphoinositide 3-kinase-dependent signalling

Articles

Expression of the splice variants of the p85α regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients

Etienne LEFAI, Marina ROQUES, Nathalie VEGA, Martine LAVILLE, Hubert VIDAL

Biochem J (2001) 360 (1): 117–126.

https://doi.org/10.1042/bj3600117

Published: 08 November 2001

...] and are expressed in insulin-sensitive tissues in humans [12,13]. In contrast, p110d is predominantly ex- pressed in leucocytes [11] and activation of p110c is not dependent on the regulatory subunits that normally participate in insulin signalling [10]. The regulatory subunits act as adapter molecules to activate...

View articletitled, Expression of the splice variants of the p85α regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients

Articles

Promoter I of the ovine acetyl-CoA carboxylase-α gene: an E-box motif at −114 in the proximal promoter binds upstream stimulatory factor (USF)-1 and USF-2 and acts as an insulin-response sequence in differentiating adipocytes

Maureen T. TRAVERS, Amanda J. VALLANCE, Helen T. GOURLAY, Clare A. GILL, Izabella KLEIN, Cynthia B. K. BOTTEMA, Michael C. BARBER

Biochem J (2001) 359 (2): 273–284.

https://doi.org/10.1042/bj3590273

Published: 08 October 2001

... cells the construct is inactive and is not inducible by insulin. By contrast, transfection of a construct corresponding to 132bp of the proximal promoter linked to a luciferase reporter is active and inducible by insulin in all three cell systems. Insulin signalling to the −132bp construct...

View articletitled, Promoter I of the ovine acetyl-CoA carboxylase-α gene: an E-box motif at −114 in the proximal promoter binds upstream stimulatory factor (USF)-1 and USF-2 and acts as an insulin-response sequence in differentiating adipocytes

Articles

Expression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active phosphatidylinositol 3-kinase and protein kinase B

Mireille CORMONT, Nadine GAUTIER, Karine ILC, Yannick Le MARCHAND-BRUSTEL

Biochem J (2001) 356 (1): 143–149.

https://doi.org/10.1042/bj3560143

Published: 08 May 2001

... are consistent with a role of Rab4 ΔCT acting as a dominant negative protein towards Rab4, possibly by binding to Rab4 effectors. adipocyte glucose transport hyperosmolarity insulin signalling zinc Abbreviations used: Rab4 ΔCT, prenylation-deficient, cytosolic form of Rab4; PKB, protein kinase B...

View articletitled, Expression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active phosphatidylinositol 3-kinase and protein kinase B

Articles

Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation

Xianmin XIA, Ginette SERRERO

Biochem J (1999) 341 (3): 831–837.

https://doi.org/10.1042/bj3410831

Published: 26 July 1999

... be addressed (e-mail [email protected]). 9 12 1998 12 4 1999 14 5 1999 The Biochemical Society, London © 1999 1999 AUG usage insulin receptor substrate-1 insulin signalling p50PIK Biochem. J. (1999) 341, 831 837 (Printed in Great Britain) 831 Multiple forms of p55PIK...

View articletitled, Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation

Articles

Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A

Svante RESJÖ, Alina OKNIANSKA, Stanislaw ZOLNIEROWICZ, Vincent MANGANIELLO, Eva DEGERMAN

Biochem J (1999) 341 (3): 839–845.

https://doi.org/10.1042/bj3410839

Published: 26 July 1999

... as a PDE3B phosphatase in itro. In comparison with insulin, calyculin A induced a dramatic activation of PDE3B and both calyculin A and okadaic acid induced phosphorylation on additional sites, which could have a role in signalling pathways not yet identified. Key words: calyculin A, insulin signalling...

View articletitled, Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A

Articles

Insulin and insulin-like growth factor I up-regulate GLUT4 gene expression in fetal brown adipocytes, in a phosphoinositide 3-kinase-dependent manner

Angela M. VALVERDE, Paloma NAVARRO, Teresa TERUEL, Ruben CONEJO, Manuel BENITO, Margarita LORENZO

Biochem J (1999) 337 (3): 397–405.

https://doi.org/10.1042/bj3370397

Published: 25 January 1999

.../GLUT1 mRNA GLUT4/GLUT1 promoter activity GLUT4/GLUT1 protein content insulin signalling Biochem. J. (1999) 337, 397 405 (Printed in Great Britain) 397 Insulin and insulin-like growth factor I up-regulate GLUT4 gene expression in fetal brown adipocytes, in a phosphoinositide 3-kinase-dependent...

View articletitled, Insulin and insulin-like growth factor I up-regulate GLUT4 gene expression in fetal brown adipocytes, in a phosphoinositide 3-kinase-dependent manner

Update search

NARROW

Format

Subjects

Article Type

Date

Availability

Retraction: Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B

Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

SREBP-1c and lipogenesis in the liver: an update

A new degree of complexi(n)ty in the regulation of GLUT4 trafficking

Insulin and β-adrenergic receptors mediate lipolytic and anti-lipolytic signalling that is not altered by type 2 diabetes in human adipocytes

Dissecting signalling by individual Akt/PKB isoforms, three steps at once

Hypothalamic NUCKS regulates peripheral glucose homoeostasis

Arp2/3 complex regulates adipogenesis by controlling cortical actin remodelling

Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2)

Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P 2 in regulating insulin sensitivity defined by knock-in analysis

Molecular mechanisms of metabolic regulation by insulin in Drosophila

Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo

Insulin action on glucose transporters through molecular switches, tracks and tethers

Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes

Resveratrol is a class IA phosphoinositide 3-kinase inhibitor

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling

Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways

Insulin signalling: putting the G- in protein-protein interactions

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B

Vertebrate tankyrase domain structure and sterile alpha motif (SAM)-mediated multimerization

Mouse system-N amino acid transporter, mNAT3, expressed in hepatocytes and regulated by insulin-activated and phosphoinositide 3-kinase-dependent signalling

Expression of the splice variants of the p85α regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients

Promoter I of the ovine acetyl-CoA carboxylase-α gene: an E-box motif at −114 in the proximal promoter binds upstream stimulatory factor (USF)-1 and USF-2 and acts as an insulin-response sequence in differentiating adipocytes

Expression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active phosphatidylinositol 3-kinase and protein kinase B

Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation

Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A

Insulin and insulin-like growth factor I up-regulate GLUT4 gene expression in fetal brown adipocytes, in a phosphoinositide 3-kinase-dependent manner

Email alerts

CONNECT

EXPLORE

Update search

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only