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Keywords: integrin
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Biochem J (2021) 478 (9): 1689–1703.
Published: 10 May 2021
...Zuoning Han; Yanling Ma; Gary Cao; Zhengping Ma; Ruihua Chen; Mary Ellen Cvijic; Dong Cheng Hepatic stellate cells (HSCs) are thought to play key roles in the development of liver fibrosis. Extensive evidence has established the concept that αV integrins are involved in the activation of latent...
Includes: Supplementary data
Biochem J (2018) 475 (9): 1583–1595.
Published: 09 May 2018
...Midori Oyama; Yoshinobu Kariya; Yukiko Kariya; Kana Matsumoto; Mayumi Kanno; Yoshiki Yamaguchi; Yasuhiro Hashimoto Osteopontin (OPN) is an extracellular glycosylated phosphoprotein that promotes cell adhesion by interacting with several integrin receptors. We previously reported that an OPN mutant...
Includes: Supplementary data
Biochem J (2016) 473 (18): 2691–2715.
Published: 12 September 2016
... Ig-like molecules with one to three Ig-like loops. Furthermore, nectins and Necls cis -interact with membrane receptors and integrins, some of which are associated with the nectin-mediated cell adhesions, and play roles in the regulation of many cellular functions, such as cell polarization, movement...
Biochem J (2014) 464 (3): 301–313.
Published: 05 December 2014
...A. Paul Mould; Susan E. Craig; Sarah K. Byron; Martin J. Humphries; Thomas A. Jowitt Failure of Arg-Gly-Asp (RGD)-based inhibitors to reverse integrin-ligand binding has been reported, but the prevalence of this phenomenon among integrin heterodimers is currently unknown. In the present study we...
Includes: Supplementary data
Biochem J (2014) 463 (1): 93–102.
Published: 08 September 2014
... adhesion primarily through its association with several integrins such as αvβ3, and its phosphorylation affects these processes. However, the mechanism by which OPN O -glycosylation affects these processes is not completely understood. In the present study, we demonstrated that OPN O -glycosylation self...
Includes: Supplementary data
Biochem J (2014) 462 (1): 89–101.
Published: 24 July 2014
... suppression impaired development of the trunk with aberrant morphology of muscle fibres and altered expression of integrin α5. The arrangement and adhesion of muscle cells were abnormally disorganized in tm4sf5 morphants with reduced muscle fibre masses, where integrin α5-related signalling molecules...
Includes: Supplementary data
Biochem J (2014) 460 (1): 69–80.
Published: 25 April 2014
.... CRT regulated cell adhesion through α1,2-linked fucosylation of β1 integrin and this modification was catalysed by FUT1. To clarify the roles for FUT1 in bladder cancer, we transfected the human FUT1 gene into CRT-RNAi stable cell lines. FUT1 overexpression in CRT-RNAi cells resulted in increased...
Includes: Supplementary data
Biochem J (2013) 454 (1): 109–121.
Published: 26 July 2013
...), ZAP-70 (ζ-chain-associated protein of 70 kDa), Vav1, SLP-76 [SH2 (Src homology 2)-domain-containing leukocyte protein of 76 kDa] and LAT (linker for activation of T-cells) to integrin outside-in signalling in human T-cells. Lck, ZAP-70, SLP-76, Vav1 and LAT were activated by α4β1 outside-in signalling...
Biochem J (2012) 445 (3): 323–332.
Published: 13 July 2012
... p130Cas, but not its phosphorylation-defective mutant, into p130Cas-knockdown myoblasts restored F-actin assembly, MAL nuclear localization and myotube formation. Depletion of the adhesion molecule integrin β3, a key regulator of myogenic differentiation as well as actin cytoskeletal organization...
Includes: Supplementary data
Biochem J (2012) 442 (1): 13–25.
Published: 27 January 2012
... Society 2012 adhesion E3 ligase integrin migration RhoGTPase ubiquitin In human fibroblasts, fibronectin binding induces ubiquitylation of the α5 subunit, which mediates sorting of the internalized α5β1 integrin together with fibronectin into MVEs (multivesicular endosomes) before...
Biochem J (2011) 437 (3): 461–467.
Published: 13 July 2011
...Jenson Lim; Neil A. Hotchin; Emmanuelle Caron During αMβ2-mediated phagocytosis, the small GTPase Rap1 activates the β2 integrin by binding to a region between residues 732 and 761. Using COS-7 cells transfected with αMβ2, we show that αMβ2 activation by the phorbol ester PMA involves Ser 756 of β2...
Biochem J (2011) 437 (1): 1–12.
Published: 14 June 2011
... Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. β-catenin endothelin integrin lysophosphatidic acid microenvironment ovarian cancer T-cell factor...
Biochem J (2010) 432 (3): 535–547.
Published: 25 November 2010
... inflammation integrin platelet thrombosis Gals (galectins) are a family of carbohydrate-binding proteins that are involved in homoeostasis and pathological events. On the basis of their structure, they are classified into three groups: a prototype such as Gal-1; a chimaera type with Gal-3 as its...
Biochem J (2009) 424 (2): 179–189.
Published: 11 November 2009
...A. Paul Mould; Ewa J. Koper; Adam Byron; Grit Zahn; Martin J. Humphries Integrin α5β1 is a key receptor for the extracellular matrix protein fibronectin. Antagonists of human integrin α5β1 have therapeutic potential as anti-angiogenic agents in cancer and diseases of the eye. However, the structure...
Includes: Supplementary data
Biochem J (2009) 420 (1): 49–56.
Published: 28 April 2009
...Chunlei Gao; Scott D. Blystone Integrin αvβ3-mediated adhesion of haemopoietic cells to vitronectin results in β3 tyrosine phosphorylation and Rho activation which is necessary for adhesion. Previously, we have shown that the RhoGEF (Rho guanine-nucleotide-exchange factor) Vav1 could associate...
Biochem J (2009) 418 (3): 491–506.
Published: 25 February 2009
... adhesion receptor, the integrins, co-operate with other types of receptor to control diverse aspects of cell fate. In particular we discuss: (i) how β3 and β1 integrins work together with growth factors to control angiogenesis; (ii) how α6β4 integrin co-operates with receptor tyrosine kinases in normal...
Biochem J (2008) 410 (3): 495–502.
Published: 27 February 2008
...Ardcharaporn Vararattanavech; Man-Li Tang; Hoi-Yeung Li; Chi-Hang Wong; S. K. Alex Law; Jaume Torres; Suet-Mien Tan The current paradigm is that integrin is activated via inside-out signalling when its cytoplasmic tails and TMs (transmembrane helices) are separated by specific cytosolic protein(s...
Biochem J (2007) 407 (2): 153–159.
Published: 25 September 2007
... prognostic indicator as well as a potential therapeutic target in OSCC. 1 To whom correspondence should be addressed (email stackm@missouri.edu ). 31 7 2007 21 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 integrin oral squamous cell carcinoma (OSCC...
Biochem J (2007) 405 (3): 417–428.
Published: 13 July 2007
... supported primary human aortic SMC (smooth-muscle cell) attachment through α5β1 and α4β1 integrins. Cells on fibulin-5 spread poorly and displayed prominent membrane ruffles but no stress fibres or focal adhesions, unlike cells on fibronectin that also binds these integrins. Cell migration and proliferation...
Biochem J (2007) 401 (3): 689–699.
Published: 12 January 2007
...Severine van Slambrouck; Wim F. A. Steelant Invasion is a complex process controlled by secretion and activation of proteases, alteration of integrin levels and GSL (glycosphingolipid) patterns. Differential organization of GSLs with specific membrane proteins and signal transducers in GEMs (GSL...
Biochem J (2006) 398 (1): 55–62.
Published: 27 July 2006
... nucleus in response to LPA (lysophosphatidic acid). Several lines of evidence suggest an important role for cell-matrix interaction in regulating the constitutive nuclear localization of LPA 1 . First, the RGDS peptide, which blocks cell matrix-induced integrin clustering and cytoskeletal rearrangement...
Biochem J (2006) 394 (3): 647–656.
Published: 24 February 2006
... fibronectin. NEU3 markedly enhanced tyrosine phosphorylation of integrin β4 with recruitment of Shc and Grb-2 only on laminin-5, and NEU3 was co-immunoprecipitated by an anti-(integrin β4) antibody, suggesting that association of NEU3 with integrin β4 might facilitate promotion of the integrin-derived...
Biochem J (2005) 387 (1): 101–108.
Published: 22 March 2005
... integrin α4β1. The present study characterizes the integrin binding properties of the disintegrin-like domains of human ADAM7, ADAM28 and ADAM33 with the integrins α4β1, α4β7 and α9β1. Cell-adhesion assays demonstrated that, similar to ADAM28, the ADAM7 disintegrin domain supported α4β1-dependent Jurkat...
Biochem J (2005) 387 (1): 57–66.
Published: 22 March 2005
...Daniel MONLEÓN; Vicent ESTEVE; Helena KOVACS; Juan J. CALVETE; Bernardo CELDA Echistatin is a potent antagonist of the integrins α v β 3 , α 5 β 1 and α IIb β 3 . Its full inhibitory activity depends on an RGD (Arg-Gly-Asp) motif expressed at the tip of the integrin-binding loop and on its C...
Biochem J (2005) 385 (1): 309–317.
Published: 14 December 2004
...Zhefeng ZHAO; Joanna GRUSZCZYNSKA-BIEGALA; Anna ZOLKIEWSKA The extracellular domain of integrin α7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD + to intact C2C12 skeletal muscle cells. The effect of ADP-ribosylation on the structure or function...
Biochem J (2004) 380 (2): 401–407.
Published: 01 June 2004
...Stephanie J. BARTON; Mark A. TRAVIS; Janet A. ASKARI; Patrick A. BUCKLEY; Susan E. CRAIG; Martin J. HUMPHRIES; A. Paul MOULD The ligand-binding activity of integrins is regulated by shape changes that convert these receptors from a resting (or inactive) state to an active state. However, the...
Biochem J (2004) 379 (2): 317–323.
Published: 15 April 2004
...Jun YAMANOUCHI; Takaaki HATO; Tatsushiro TAMURA; Shigeru FUJITA Integrin cytoplasmic tails regulate integrin activation including an increase in integrin affinity for ligands. Although there is ample evidence that the membrane-proximal regions of the α and β tails interact with each other to...
Biochem J (2004) 379 (1): 141–150.
Published: 01 April 2004
...Hwang-Phill KIM; Mi-Sook LEE; Jiyon YU; Jin-Ah PARK; Hyun-Soon JONG; Tae-You KIM; Jung Weon LEE; Yung-Jue BANG Signalling by integrin-mediated cell anchorage to extracellular matrix proteins is co-operative with other receptor-mediated signalling pathways to regulate cell adhesion, spreading...
Biochem J (2004) 378 (2): 559–567.
Published: 01 March 2004
...)pyrazolo[3,4-d]pyrimidine}. We have also shown that expression of activated Src in breast cancer cells increased the expression of α2-integrin and that overexpression of α2-integrin suppressed FAK-CD-mediated loss of adhesion. Our results suggest a model in which Src regulates adhesion and survival through...
Biochem J (2004) 377 (2): 449–457.
Published: 15 January 2004
...Suresh K. ALAHARI; Hani NASRALLAH In a previous study [Alahari, Lee and Juliano (2000) J. Cell Biol. 151 , 1141–1154], we have identified a novel protein, nischarin, that specifically interacts with the cytoplasmic tail of the α5 integrin subunit. Overexpression of this protein profoundly affects...
Biochem J (2003) 373 (2): 475–484.
Published: 15 July 2003
...Eric BERGERON; Ajoy BASAK; Etienne DECROLY; Nabil G. SEIDAH The proprotein convertases (PCs) participate in the limited proteolysis of integrin α4 subunit at the H 592 VIS KR 597 ↓ ST site (where underlined residues indicate positively charged amino acids important for PC-mediated cleavage and...
Biochem J (2003) 373 (1): 1–18.
Published: 01 July 2003
... The Biochemical Society, London ©2003 2003 general control 2 (GCN2) integrin mammalian target of rapamycin (mTOR) System A transporter 2 (SAT2) Abbreviations used: eIF, eukaryotic initiation factor; 4E-BP, eIF4E-binding protein; AIB, α-aminoisobutyric acid; ALS, amyotrophic lateral...
Biochem J (2003) 372 (2): 485–493.
Published: 01 June 2003
... unclear. One possible function could be to regulate the processes of chondrocyte hypertrophy through direct cell–type X collagen interactions. Adhesions of embryonic chick chondrocytes, and cell lines with known expression of collagen-binding integrins (MG63 and HOS), were assayed on chick type X collagen...
Biochem J (2003) 372 (1): 121–127.
Published: 15 May 2003
...Clare J. McCLEVERTY; Robert C. LIDDINGTON The α-I domain, found in the α-subunit of the leucocyte integrins such as αMβ2 and αLβ2, switches between the open and closed tertiary conformations, reflecting the high- and low-affinity ligand-binding states of the integrin that are required for regulated...
Biochem J (2002) 368 (1): 1–15.
Published: 15 November 2002
... adhesion formation in cells adhering via certain integrins, and for cell proliferation and migration in response to growth factors. The cytoplasmic domain of syndecan-4 interacts with a number of signalling and structural proteins, and both extracellular and cytoplasmic domains are necessary for regulated...
Biochem J (2002) 365 (3): 591–603.
Published: 01 August 2002
... correspondence should be addressed (e-mail crispy4@med.unc.edu ). 10 1 2002 16 4 2002 3 5 2002 The Biochemical Society, London ©2002 2002 integrin motility phosphotyrosine paxillin Src Abbreviations used: CE, chicken embryo; CHO, Chinese-hamster ovary; ECM...
Biochem J (2002) 365 (1): 287–294.
Published: 01 July 2002
... mutations in the Fn 9 th (3fn9) and 10 th (3fn10) type III repeats obtained after selection on purified integrins αIIbβ3(D 119 Y) and α5β1 are reported. The 3fn9–10(D 1495 A) phage with substitution mutations at Asp 1418 , which is located within the linker region between 3fn9 and 3fn10, enhanced binding to...
Biochem J (2001) 360 (1): 57–66.
Published: 08 November 2001
...Michael D. SCHALLER; Erik M. SCHAEFER Paxillin is a focal-adhesion-associated, tyrosine-phosphorylated protein. In cells transformed by the src, crk or BCR-Abl oncogenes, the phosphotyrosine content of paxillin is elevated. In normal cells paxillin functions in signalling following integrin...
Biochem J (2001) 356 (2): 531–537.
Published: 24 May 2001
...Jinsook JEONG; Innoc HAN; Yangmi LIM; Jungyean KIM; Ilseon PARK; Anne WOODS; John R. COUCHMAN; Eok-Soo OH Fibronectin (FN) is known to transduce signal(s) to rescue cells from detachment-induced apoptosis (anoikis) through an integrin-mediated survival pathway. However, the functions of individual...
Biochem J (2000) 351 (1): 79–86.
Published: 26 September 2000
...Paula STANLEY; Alison MCDOWALL; Paul A. BATES; Joanna BRASHAW; Nancy HOGG The first domain of intercellular adhesion molecule-1 (ICAM-1) binds to the leucocyte function-associated antigen-1 (LFA-1) I domain, which contains the principal ligand-binding site of this leucocyte integrin. Whether the...