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Articles

Integrin αVβ1 regulates procollagen I production through a non-canonical transforming growth factor β signaling pathway in human hepatic stellate cells

Zuoning Han, Yanling Ma, Gary Cao, Zhengping Ma, Ruihua Chen, Mary Ellen Cvijic, Dong Cheng

Biochem J (2021) 478 (9): 1689–1703.

https://doi.org/10.1042/BCJ20200749

Published: 10 May 2021

...Zuoning Han; Yanling Ma; Gary Cao; Zhengping Ma; Ruihua Chen; Mary Ellen Cvijic; Dong Cheng Hepatic stellate cells (HSCs) are thought to play key roles in the development of liver fibrosis. Extensive evidence has established the concept that αV integrins are involved in the activation of latent...

View article titled, Integrin αVβ1 regulates procollagen I production through a non-canonical transforming growth factor β signaling pathway in human hepatic stellate cells

Includes: Supplementary data

Articles

Biological role of site-specific O-glycosylation in cell adhesion activity and phosphorylation of osteopontin

Midori Oyama, Yoshinobu Kariya, Yukiko Kariya, Kana Matsumoto, Mayumi Kanno, Yoshiki Yamaguchi, Yasuhiro Hashimoto

Biochem J (2018) 475 (9): 1583–1595.

https://doi.org/10.1042/BCJ20170205

Published: 09 May 2018

...Midori Oyama; Yoshinobu Kariya; Yukiko Kariya; Kana Matsumoto; Mayumi Kanno; Yoshiki Yamaguchi; Yasuhiro Hashimoto Osteopontin (OPN) is an extracellular glycosylated phosphoprotein that promotes cell adhesion by interacting with several integrin receptors. We previously reported that an OPN mutant...

View article titled, Biological role of site-specific O-glycosylation in cell adhesion activity and phosphorylation of osteopontin

Includes: Supplementary data

Articles

Nectin spot: a novel type of nectin-mediated cell adhesion apparatus

Kiyohito Mizutani, Yoshimi Takai

Biochem J (2016) 473 (18): 2691–2715.

https://doi.org/10.1042/BCJ20160235

Published: 12 September 2016

... Ig-like molecules with one to three Ig-like loops. Furthermore, nectins and Necls cis -interact with membrane receptors and integrins, some of which are associated with the nectin-mediated cell adhesions, and play roles in the regulation of many cellular functions, such as cell polarization, movement...

View article titled, Nectin spot: a novel type of nectin-mediated cell adhesion apparatus

Articles

Disruption of integrin–fibronectin complexes by allosteric but not ligand-mimetic inhibitors

A. Paul Mould, Susan E. Craig, Sarah K. Byron, Martin J. Humphries, Thomas A. Jowitt

Biochem J (2014) 464 (3): 301–313.

https://doi.org/10.1042/BJ20141047

Published: 05 December 2014

...A. Paul Mould; Susan E. Craig; Sarah K. Byron; Martin J. Humphries; Thomas A. Jowitt Failure of Arg-Gly-Asp (RGD)-based inhibitors to reverse integrin-ligand binding has been reported, but the prevalence of this phenomenon among integrin heterodimers is currently unknown. In the present study we...

View article titled, Disruption of integrin–fibronectin complexes by allosteric but not ligand-mimetic inhibitors

Includes: Supplementary data

Articles

Osteopontin O -glycosylation contributes to its phosphorylation and cell-adhesion properties

Yoshinobu Kariya, Mayumi Kanno, Kana Matsumoto-Morita, Midori Konno, Yoshiki Yamaguchi, Yasuhiro Hashimoto

Biochem J (2014) 463 (1): 93–102.

https://doi.org/10.1042/BJ20140060

Published: 08 September 2014

... and adhesion primarily through its association with several integrins such as αvβ3, and its phosphorylation affects these processes. However, the mechanism by which OPN O -glycosylation affects these processes is not completely understood. In the present study, we demonstrated that OPN O -glycosylation self...

View article titled, Osteopontin O -glycosylation contributes to its phosphorylation and cell-adhesion properties

Includes: Supplementary data

Articles

TM4SF5 suppression disturbs integrin α5-related signalling and muscle development in zebrafish

Yoon-Ju Choi, Hyun Ho Kim, Jeong-gyun Kim, Hye-Jin Kim, Minkyung Kang, Mi-Sook Lee, Jihye Ryu, Haeng Eun Song, Seo Hee Nam, Doohyung Lee, Kyu-Won Kim, Jung Weon Lee

Biochem J (2014) 462 (1): 89–101.

https://doi.org/10.1042/BJ20140177

Published: 24 July 2014

... suppression impaired development of the trunk with aberrant morphology of muscle fibres and altered expression of integrin α5. The arrangement and adhesion of muscle cells were abnormally disorganized in tm4sf5 morphants with reduced muscle fibre masses, where integrin α5-related signalling molecules...

View article titled, TM4SF5 suppression disturbs integrin α5-related signalling and muscle development in zebrafish

Includes: Supplementary data

Articles

Calreticulin activates β1 integrin via fucosylation by fucosyltransferase 1 in J82 human bladder cancer cells

Yi-Chien Lu, Chiung-Nien Chen, Chia-Ying Chu, JenHer Lu, Bo-Jeng Wang, Chia-Hua Chen, Min-Chuan Huang, Tsui-Hwa Lin, Chin-Chen Pan, Swey-Shen Alex Chen, Wen-Ming Hsu, Yung-Feng Liao, Pei-Yi Wu, Hsin-Yi Hsia, Cheng-Chi Chang, Hsinyu Lee

Biochem J (2014) 460 (1): 69–80.

https://doi.org/10.1042/BJ20131424

Published: 25 April 2014

.... CRT regulated cell adhesion through α1,2-linked fucosylation of β1 integrin and this modification was catalysed by FUT1. To clarify the roles for FUT1 in bladder cancer, we transfected the human FUT1 gene into CRT-RNAi stable cell lines. FUT1 overexpression in CRT-RNAi cells resulted in increased...

View article titled, Calreticulin activates β1 integrin via fucosylation by fucosyltransferase 1 in J82 human bladder cancer cells

Includes: Supplementary data

Articles

CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins

Ann-Marie Cimo, Zamal Ahmed, Bradley W. McIntyre, Dorothy E. Lewis, John E. Ladbury

Biochem J (2013) 454 (1): 109–121.

https://doi.org/10.1042/BJ20130485

Published: 26 July 2013

...), ZAP-70 (ζ-chain-associated protein of 70 kDa), Vav1, SLP-76 [SH2 (Src homology 2)-domain-containing leukocyte protein of 76 kDa] and LAT (linker for activation of T-cells) to integrin outside-in signalling in human T-cells. Lck, ZAP-70, SLP-76, Vav1 and LAT were activated by α4β1 outside-in signalling...

View article titled, CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins

Articles

p130Cas-dependent actin remodelling regulates myogenic differentiation

Keiko Kawauchi, Wee Wee Tan, Keigo Araki, Farhana Binte Abu Bakar, Minsoo Kim, Hideaki Fujita, Hiroaki Hirata, Yasuhiro Sawada

Biochem J (2012) 445 (3): 323–332.

https://doi.org/10.1042/BJ20112169

Published: 13 July 2012

..., but not its phosphorylation-defective mutant, into p130Cas-knockdown myoblasts restored F-actin assembly, MAL nuclear localization and myotube formation. Depletion of the adhesion molecule integrin β3, a key regulator of myogenic differentiation as well as actin cytoskeletal organization, attenuated p130Cas...

View article titled, p130Cas-dependent actin remodelling regulates myogenic differentiation

Includes: Supplementary data

Articles

Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration

Antje Schaefer, Micha Nethe, Peter L. Hordijk

Biochem J (2012) 442 (1): 13–25.

https://doi.org/10.1042/BJ20111815

Published: 27 January 2012

... Society 2012 adhesion E3 ligase integrin migration RhoGTPase ubiquitin In the present review, we provide an overview of the regulation and consequences of ubiquitylation of proteins that control cytoskeletal dynamics, cell adhesion and cell migration. We briefly sketch the complexity...

View article titled, Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration

Articles

Ser 756 of β2 integrin controls Rap1 activity during inside-out activation of αMβ2

Jenson Lim, Neil A. Hotchin, Emmanuelle Caron

Biochem J (2011) 437 (3): 461–467.

https://doi.org/10.1042/BJ20101666

Published: 13 July 2011

...Jenson Lim; Neil A. Hotchin; Emmanuelle Caron During αMβ2-mediated phagocytosis, the small GTPase Rap1 activates the β2 integrin by binding to a region between residues 732 and 761. Using COS-7 cells transfected with αMβ2, we show that αMβ2 activation by the phorbol ester PMA involves Ser 756 of β2...

View article titled, Ser 756 of β2 integrin controls Rap1 activity during inside-out activation of αMβ2

Articles

Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment

Maria V. Barbolina, Rebecca J. Burkhalter, M. Sharon Stack

Biochem J (2011) 437 (1): 1–12.

https://doi.org/10.1042/BJ20110112

Published: 14 June 2011

..., accumulating evidence suggests a role for Wnt signalling in ovarian tumorigenesis in the absence of genetic mutations, suggesting alternative mechanisms for Wnt pathway activation in EOC ( Figure 1 B) [ 8 – 10 ]. β-catenin endothelin integrin lysophosphatidic acid microenvironment ovarian cancer...

View article titled, Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment

Articles

Human platelets express and are activated by galectin-8

Maria Albertina Romaniuk, Maria Virginia Tribulatti, Valentina Cattaneo, Maria Jose Lapponi, Felisa Concepcion Molinas, Oscar Campetella, Mirta Schattner

Biochem J (2010) 432 (3): 535–547.

https://doi.org/10.1042/BJ20100538

Published: 25 November 2010

... (lipopolysaccharide), as checked using a Limulus test, was less than 0.5 ng/mg of the purified protein. galectin glycan inflammation integrin platelet thrombosis Blood samples were obtained from healthy donors who had not taken non-steroidal anti-inflammatory drugs in the 10 days before sampling...

View article titled, Human platelets express and are activated by galectin-8

Articles

Mapping the ligand-binding pocket of integrin α5β1 using a gain-of-function approach

A. Paul Mould, Ewa J. Koper, Adam Byron, Grit Zahn, Martin J. Humphries

Biochem J (2009) 424 (2): 179–189.

https://doi.org/10.1042/BJ20090992

Published: 11 November 2009

...A. Paul Mould; Ewa J. Koper; Adam Byron; Grit Zahn; Martin J. Humphries Integrin α5β1 is a key receptor for the extracellular matrix protein fibronectin. Antagonists of human integrin α5β1 have therapeutic potential as anti-angiogenic agents in cancer and diseases of the eye. However, the structure...

View article titled, Mapping the ligand-binding pocket of integrin α5β1 using a gain-of-function approach

Includes: Supplementary data

Articles

A Pyk2–Vav1 complex is recruited to β3-adhesion sites to initiate Rho activation

Chunlei Gao, Scott D. Blystone

Biochem J (2009) 420 (1): 49–56.

https://doi.org/10.1042/BJ20090037

Published: 28 April 2009

...Chunlei Gao; Scott D. Blystone Integrin αvβ3-mediated adhesion of haemopoietic cells to vitronectin results in β3 tyrosine phosphorylation and Rho activation which is necessary for adhesion. Previously, we have shown that the RhoGEF (Rho guanine-nucleotide-exchange factor) Vav1 could associate...

View article titled, A Pyk2–Vav1 complex is recruited to β3-adhesion sites to initiate Rho activation

Articles

Signal co-operation between integrins and other receptor systems

Charles H. Streuli, Nasreen Akhtar

Biochem J (2009) 418 (3): 491–506.

https://doi.org/10.1042/BJ20081948

Published: 25 February 2009

... of adhesion receptor, the integrins, co-operate with other types of receptor to control diverse aspects of cell fate. In particular we discuss: (i) how β3 and β1 integrins work together with growth factors to control angiogenesis; (ii) how α6β4 integrin co-operates with receptor tyrosine kinases in normal...

View article titled, Signal co-operation between integrins and other receptor systems

Articles

Permissive transmembrane helix heterodimerization is required for the expression of a functional integrin

Ardcharaporn Vararattanavech, Man-Li Tang, Hoi-Yeung Li, Chi-Hang Wong, S. K. Alex Law, Jaume Torres, Suet-Mien Tan

Biochem J (2008) 410 (3): 495–502.

https://doi.org/10.1042/BJ20071218

Published: 27 February 2008

...Ardcharaporn Vararattanavech; Man-Li Tang; Hoi-Yeung Li; Chi-Hang Wong; S. K. Alex Law; Jaume Torres; Suet-Mien Tan The current paradigm is that integrin is activated via inside-out signalling when its cytoplasmic tails and TMs (transmembrane helices) are separated by specific cytosolic protein(s...

View article titled, Permissive transmembrane helix heterodimerization is required for the expression of a functional integrin

Articles

Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity

Zonggao Shi, M. Sharon Stack

Biochem J (2007) 407 (2): 153–159.

https://doi.org/10.1042/BJ20071037

Published: 25 September 2007

... as a prognostic indicator as well as a potential therapeutic target in OSCC. 1 To whom correspondence should be addressed (email [email protected] ). 31 7 2007 21 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 integrin oral squamous cell carcinoma (OSCC...

View article titled, Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity

Articles

Fibulin-5 binds human smooth-muscle cells through α5β1 and α4β1 integrins, but does not support receptor activation

Amanda C. Lomas, Kieran T. Mellody, Lyle J. Freeman, Daniel V. Bax, C. Adrian Shuttleworth, Cay M. Kielty

Biochem J (2007) 405 (3): 417–428.

https://doi.org/10.1042/BJ20070400

Published: 13 July 2007

... supported primary human aortic SMC (smooth-muscle cell) attachment through α5β1 and α4β1 integrins. Cells on fibulin-5 spread poorly and displayed prominent membrane ruffles but no stress fibres or focal adhesions, unlike cells on fibronectin that also binds these integrins. Cell migration and proliferation...

View article titled, Fibulin-5 binds human smooth-muscle cells through α5β1 and α4β1 integrins, but does not support receptor activation

Articles

Clustering of monosialyl-Gb5 initiates downstream signalling events leading to invasion of MCF-7 breast cancer cells

Severine van Slambrouck, Wim F. A. Steelant

Biochem J (2007) 401 (3): 689–699.

https://doi.org/10.1042/BJ20060944

Published: 12 January 2007

...Severine van Slambrouck; Wim F. A. Steelant Invasion is a complex process controlled by secretion and activation of proteases, alteration of integrin levels and GSL (glycosphingolipid) patterns. Differential organization of GSLs with specific membrane proteins and signal transducers in GEMs (GSL...

View article titled, Clustering of monosialyl-Gb5 initiates downstream signalling events leading to invasion of MCF-7 breast cancer cells

Articles

Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA 1 ) in mammalian cells

Catherine M. Waters, Bahman Saatian, Noreen A. Moughal, Yutong Zhao, Gabor Tigyi, Viswanathan Natarajan, Susan Pyne, Nigel J. Pyne

Biochem J (2006) 398 (1): 55–62.

https://doi.org/10.1042/BJ20060155

Published: 27 July 2006

... to the nucleus in response to LPA (lysophosphatidic acid). Several lines of evidence suggest an important role for cell-matrix interaction in regulating the constitutive nuclear localization of LPA 1 . First, the RGDS peptide, which blocks cell matrix-induced integrin clustering and cytoskeletal rearrangement...

View article titled, Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA 1 ) in mammalian cells

Articles

Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling

Kengo Kato, Kiyoto Shiga, Kazunori Yamaguchi, Keiko Hata, Toshimitsu Kobayashi, Kaoru Miyazaki, Shigeru Saijo, Taeko Miyagi

Biochem J (2006) 394 (3): 647–656.

https://doi.org/10.1042/BJ20050737

Published: 24 February 2006

... on fibronectin. NEU3 markedly enhanced tyrosine phosphorylation of integrin β4 with recruitment of Shc and Grb-2 only on laminin-5, and NEU3 was co-immunoprecipitated by an anti-(integrin β4) antibody, suggesting that association of NEU3 with integrin β4 might facilitate promotion of the integrin-derived...

View article titled, Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling

Articles

ADAM disintegrin-like domain recognition by the lymphocyte integrins α4β1 and α4β7

Lance C. BRIDGES, Dean SHEPPARD, Ron D. BOWDITCH

Biochem J (2005) 387 (1): 101–108.

https://doi.org/10.1042/BJ20041444

Published: 22 March 2005

... by the integrin α4β1. The present study characterizes the integrin binding properties of the disintegrin-like domains of human ADAM7, ADAM28 and ADAM33 with the integrins α4β1, α4β7 and α9β1. Cell-adhesion assays demonstrated that, similar to ADAM28, the ADAM7 disintegrin domain supported α4β1-dependent Jurkat...

View article titled, ADAM disintegrin-like domain recognition by the lymphocyte integrins α4β1 and α4β7

Articles

Conformation and concerted dynamics of the integrin-binding site and the C-terminal region of echistatin revealed by homonuclear NMR

Daniel MONLEÓN, Vicent ESTEVE, Helena KOVACS, Juan J. CALVETE, Bernardo CELDA

Biochem J (2005) 387 (1): 57–66.

https://doi.org/10.1042/BJ20041343

Published: 22 March 2005

...Daniel MONLEÓN; Vicent ESTEVE; Helena KOVACS; Juan J. CALVETE; Bernardo CELDA Echistatin is a potent antagonist of the integrins α v β 3 , α 5 β 1 and α IIb β 3 . Its full inhibitory activity depends on an RGD (Arg-Gly-Asp) motif expressed at the tip of the integrin-binding loop and on its C...

View article titled, Conformation and concerted dynamics of the integrin-binding site and the C-terminal region of echistatin revealed by homonuclear NMR

Articles

ADP-ribosylation of integrin α7 modulates the binding of integrin α7β1 to laminin

Zhefeng ZHAO, Joanna GRUSZCZYNSKA-BIEGALA, Anna ZOLKIEWSKA

Biochem J (2005) 385 (1): 309–317.

https://doi.org/10.1042/BJ20040590

Published: 14 December 2004

...Zhefeng ZHAO; Joanna GRUSZCZYNSKA-BIEGALA; Anna ZOLKIEWSKA The extracellular domain of integrin α7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD + to intact C2C12 skeletal muscle cells. The effect of ADP-ribosylation on the structure or function...

View article titled, ADP-ribosylation of integrin α7 modulates the binding of integrin α7β1 to laminin

Articles

Novel activating and inactivating mutations in the integrin beta1 subunit A domain

Stephanie J. BARTON, Mark A. TRAVIS, Janet A. ASKARI, Patrick A. BUCKLEY, Susan E. CRAIG, Martin J. HUMPHRIES, A. Paul MOULD

Biochem J (2004) 380 (2): 401–407.

https://doi.org/10.1042/bj20031973

Published: 01 June 2004

...Stephanie J. BARTON; Mark A. TRAVIS; Janet A. ASKARI; Patrick A. BUCKLEY; Susan E. CRAIG; Martin J. HUMPHRIES; A. Paul MOULD The ligand-binding activity of integrins is regulated by shape changes that convert these receptors from a resting (or inactive) state to an active state. However...

View article titled, Novel activating and inactivating mutations in the integrin beta1 subunit A domain

Articles

Suppression of integrin activation by the membrane-distal sequence of the integrin alphaIIb cytoplasmic tail

Jun YAMANOUCHI, Takaaki HATO, Tatsushiro TAMURA, Shigeru FUJITA

Biochem J (2004) 379 (2): 317–323.

https://doi.org/10.1042/bj20031753

Published: 15 April 2004

...Jun YAMANOUCHI; Takaaki HATO; Tatsushiro TAMURA; Shigeru FUJITA Integrin cytoplasmic tails regulate integrin activation including an increase in integrin affinity for ligands. Although there is ample evidence that the membrane-proximal regions of the α and β tails interact with each other...

View article titled, Suppression of integrin activation by the membrane-distal sequence of the integrin alphaIIb cytoplasmic tail

Articles

TGF-beta1 (transforming growth factor-beta1)-mediated adhesion of gastric carcinoma cells involves a decrease in Ras/ERKs (extracellular-signal-regulated kinases) cascade activity dependent on c-Src activity

Hwang-Phill KIM, Mi-Sook LEE, Jiyon YU, Jin-Ah PARK, Hyun-Soon JONG, Tae-You KIM, Jung Weon LEE, Yung-Jue BANG

Biochem J (2004) 379 (1): 141–150.

https://doi.org/10.1042/bj20031408

Published: 01 April 2004

...Hwang-Phill KIM; Mi-Sook LEE; Jiyon YU; Jin-Ah PARK; Hyun-Soon JONG; Tae-You KIM; Jung Weon LEE; Yung-Jue BANG Signalling by integrin-mediated cell anchorage to extracellular matrix proteins is co-operative with other receptor-mediated signalling pathways to regulate cell adhesion, spreading...

View article titled, TGF-beta1 (transforming growth factor-beta1)-mediated adhesion of gastric carcinoma cells involves a decrease in Ras/ERKs (extracellular-signal-regulated kinases) cascade activity dependent on c-Src activity

Articles

Activated Src increases adhesion, survival and alpha2-integrin expression in human breast cancer cells

Hee Boong PARK, Vita GOLUBOVSKAYA, Lihui XU, Xihui YANG, Jin Woo LEE, Sean SCULLY, II, Rolf Joseph CRAVEN, William G. CANCE

Biochem J (2004) 378 (2): 559–567.

https://doi.org/10.1042/bj20031392

Published: 01 March 2004

...)pyrazolo[3,4-d]pyrimidine}. We have also shown that expression of activated Src in breast cancer cells increased the expression of α2-integrin and that overexpression of α2-integrin suppressed FAK-CD-mediated loss of adhesion. Our results suggest a model in which Src regulates adhesion and survival through...

View article titled, Activated Src increases adhesion, survival and alpha2-integrin expression in human breast cancer cells

Articles

A membrane proximal region of the integrin alpha5 subunit is important for its interaction with nischarin

Suresh K. ALAHARI, Hani NASRALLAH

Biochem J (2004) 377 (2): 449–457.

https://doi.org/10.1042/bj20030411

Published: 15 January 2004

...Suresh K. ALAHARI; Hani NASRALLAH In a previous study [Alahari, Lee and Juliano (2000) J. Cell Biol. 151 , 1141–1154], we have identified a novel protein, nischarin, that specifically interacts with the cytoplasmic tail of the α5 integrin subunit. Overexpression of this protein profoundly affects...

View article titled, A membrane proximal region of the integrin alpha5 subunit is important for its interaction with nischarin

Articles

Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage

Eric BERGERON, Ajoy BASAK, Etienne DECROLY, Nabil G. SEIDAH

Biochem J (2003) 373 (2): 475–484.

https://doi.org/10.1042/bj20021630

Published: 15 July 2003

...Eric BERGERON; Ajoy BASAK; Etienne DECROLY; Nabil G. SEIDAH The proprotein convertases (PCs) participate in the limited proteolysis of integrin α4 subunit at the H 592 VIS KR 597 ↓ ST site (where underlined residues indicate positively charged amino acids important for PC-mediated cleavage...

View article titled, Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage

Articles

Amino acid transporters: roles in amino acid sensing and signalling in animal cells

Russell HYDE, Peter M. TAYLOR, Harinder S. HUNDAL

Biochem J (2003) 373 (1): 1–18.

https://doi.org/10.1042/bj20030405

Published: 01 July 2003

... The Biochemical Society, London ©2003 2003 general control 2 (GCN2) integrin mammalian target of rapamycin (mTOR) System A transporter 2 (SAT2) Abbreviations used: eIF, eukaryotic initiation factor; 4E-BP, eIF4E-binding protein; AIB, α-aminoisobutyric acid; ALS, amyotrophic lateral sclerosis...

View article titled, Amino acid transporters: roles in amino acid sensing and signalling in animal cells

Articles

Partial characterization of cell-type X collagen interactions

Steven P. LUCKMAN, Elaine REES, Alvin P. L. KWAN

Biochem J (2003) 372 (2): 485–493.

https://doi.org/10.1042/bj20021572

Published: 01 June 2003

... unclear. One possible function could be to regulate the processes of chondrocyte hypertrophy through direct cell–type X collagen interactions. Adhesions of embryonic chick chondrocytes, and cell lines with known expression of collagen-binding integrins (MG63 and HOS), were assayed on chick type X collagen...

View article titled, Partial characterization of cell-type X collagen interactions

Articles

Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies

Clare J. McCLEVERTY, Robert C. LIDDINGTON

Biochem J (2003) 372 (1): 121–127.

https://doi.org/10.1042/bj20021273

Published: 15 May 2003

...Clare J. McCLEVERTY; Robert C. LIDDINGTON The α-I domain, found in the α-subunit of the leucocyte integrins such as αMβ2 and αLβ2, switches between the open and closed tertiary conformations, reflecting the high- and low-affinity ligand-binding states of the integrin that are required for regulated...

View article titled, Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies

Articles

Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling

Mark D. BASS, Martin J. HUMPHRIES

Biochem J (2002) 368 (1): 1–15.

https://doi.org/10.1042/bj20021228

Published: 15 November 2002

... for adhesion formation in cells adhering via certain integrins, and for cell proliferation and migration in response to growth factors. The cytoplasmic domain of syndecan-4 interacts with a number of signalling and structural proteins, and both extracellular and cytoplasmic domains are necessary for regulated...

View article titled, Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling

Articles

Characterization of an activated mutant of focal adhesion kinase: ‘SuperFAK’

Veronica GABARRA-NIECKO, Patricia J. KEELY, Michael D. SCHALLER

Biochem J (2002) 365 (3): 591–603.

https://doi.org/10.1042/bj20020065

Published: 01 August 2002

... be addressed (e-mail [email protected] ). 10 1 2002 16 4 2002 3 5 2002 The Biochemical Society, London ©2002 2002 integrin motility phosphotyrosine paxillin Src Abbreviations used: CE, chicken embryo; CHO, Chinese-hamster ovary; ECM, extracellular matrix; EGFR...

View article titled, Characterization of an activated mutant of focal adhesion kinase: ‘SuperFAK’

Articles

In vitro selection of fibronectin gain-of-function mutations

Patricia H. TANI, Joseph C. LOFTUS, Ron D. BOWDITCH

Biochem J (2002) 365 (1): 287–294.

https://doi.org/10.1042/bj20020067

Published: 01 July 2002

...). The mutations in the Fn 9 th (3fn9) and 10 th (3fn10) type III repeats obtained after selection on purified integrins αIIbβ3(D 119 Y) and α5β1 are reported. The 3fn9–10(D 1495 A) phage with substitution mutations at Asp 1418 , which is located within the linker region between 3fn9 and 3fn10, enhanced binding...

View article titled, In vitro selection of fibronectin gain-of-function mutations

Articles

Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin

Michael D. SCHALLER, Erik M. SCHAEFER

Biochem J (2001) 360 (1): 57–66.

https://doi.org/10.1042/bj3600057

Published: 08 November 2001

...Michael D. SCHALLER; Erik M. SCHAEFER Paxillin is a focal-adhesion-associated, tyrosine-phosphorylated protein. In cells transformed by the src, crk or BCR-Abl oncogenes, the phosphotyrosine content of paxillin is elevated. In normal cells paxillin functions in signalling following integrin...

View article titled, Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin

Articles

Rat embryo fibroblasts require both the cell-binding and the heparin-binding domains of fibronectin for survival

Jinsook JEONG, Innoc HAN, Yangmi LIM, Jungyean KIM, Ilseon PARK, Anne WOODS, John R. COUCHMAN, Eok-Soo OH

Biochem J (2001) 356 (2): 531–537.

https://doi.org/10.1042/bj3560531

Published: 24 May 2001

...Jinsook JEONG; Innoc HAN; Yangmi LIM; Jungyean KIM; Ilseon PARK; Anne WOODS; John R. COUCHMAN; Eok-Soo OH Fibronectin (FN) is known to transduce signal(s) to rescue cells from detachment-induced apoptosis (anoikis) through an integrin-mediated survival pathway. However, the functions of individual...

View article titled, Rat embryo fibroblasts require both the cell-binding and the heparin-binding domains of fibronectin for survival

Articles

The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain

Paula STANLEY, Alison MCDOWALL, Paul A. BATES, Joanna BRASHAW, Nancy HOGG

Biochem J (2000) 351 (1): 79–86.

https://doi.org/10.1042/bj3510079

Published: 26 September 2000

...Paula STANLEY; Alison MCDOWALL; Paul A. BATES; Joanna BRASHAW; Nancy HOGG The first domain of intercellular adhesion molecule-1 (ICAM-1) binds to the leucocyte function-associated antigen-1 (LFA-1) I domain, which contains the principal ligand-binding site of this leucocyte integrin. Whether...

View article titled, The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain

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