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Keywords: integrins
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Articles
Biochem J (2020) 477 (1): 1–21.
Published: 08 January 2020
... matrix (ECM). Integrins and their connections to the actin cytoskeleton are crucial for monitoring cell attachment and the physical properties of the substratum. Cell adhesion dynamics are modulated in complex ways by the polymerization of branched and linear actin arrays, which in turn reinforce ECM...
Articles
Biochem J (2019) 476 (13): 1875–1887.
Published: 02 July 2019
...-linking coupled with mass spectrometry (XL–MS), together with modifications that either truncate ChlD or modify single residues. We found that the C-terminal integrin I domain of ChlD governs association with ChlH, the Mg 2+ dependence of which also mediates the cooperative response of the Synechocystis...
Includes: Supplementary data
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Biochem J (2019) 476 (4): 705–718.
Published: 28 February 2019
...Willow Hight-Warburton; Maddy Parsons Integrins are heterodimeric transmembrane receptors that play an essential role in enabling cells to sense and bind to extracellular ligands. Activation and clustering of integrins leads to the formation of focal adhesions at the plasma membrane...
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Articles
Biochem J (2017) 474 (4): 589–596.
Published: 03 February 2017
... with integrins and regulate integrin functions, but the specifics of tetraspanin–integrin interactions are unclear. Using co-immunoprecipitation with integrins as a sole method to detect interaction between integrins and full-length tetraspanins, it has been proposed that the variable region (helices D and E...
Includes: Supplementary data
Articles
Biochem J (2015) 466 (3): 525–536.
Published: 06 March 2015
...Anindita Dutta; Jing Li; Carmine Fedele; Aejaz Sayeed; Amrita Singh; Shelia M. Violette; Thomas D. Manes; Lucia R. Languino The present study establishes that the avβ6 integrin associates with the transforming growth factor (TGF)β receptor (TβR) and is required for the activation of the TGFβ–Smad3...
Articles
Biochem J (2002) 362 (3): 761–768.
Published: 08 March 2002
...Mark D. BASS; Bipin PATEL; Igor G. BARSUKOV; Ian J. FILLINGHAM; Robert MASON; Beverley J. SMITH; Clive R. BAGSHAW; David R. CRITCHLEY The cytoskeletal protein talin, which is thought to couple integrins to F-actin, contains three binding sites (VBS1—VBS3) for vinculin, a protein implicated...
Articles
Biochem J (2002) 361 (2): 203–209.
Published: 08 January 2002
...-to-cell adhesion was confirmed further in integrin activation assays. FACS analysis revealed a higher expression of activated integrins on T cell lines in the presence of increasing amounts of exogenous ADA. Taken together, these results suggest that the ADA—CD26 interaction on the cell surface has a role...
Articles
Biochem J (1999) 341 (2): 257–263.
Published: 08 July 1999
... 636 contains three aligned leucines (residues 608, 615 and 622), which show conservative substitutions in the other two INTRODUCTION Many if not all members of the integrin family of cell adhesion molecules are linked to the actin cytoskeleton via a series of interacting cytoskeletal proteins...
Articles
Articles
Biochem J (1999) 339 (3): 481–488.
Published: 26 April 1999
...Nancy J. BOUDREAU; Peter Lloyd JONES The extracellular matrix (ECM) and integrins collaborate to regulate gene expression associated with cell growth, differentiation and survival. Biochemical and molecular analyses of integrin signalling pathways have uncovered several critical cytoplasmic...