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Keywords: interleukin-6
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Articles

The biology of interleukin-6 family cytokines is regulated by glycosylation

Open Access
Lisa Kohrs, Falk F. R. Buettner, Juliane Lokau, Christoph Garbers
Journal: Biochemical Journal
Biochem J (2025) BCJ20240769.
https://doi.org/10.1042/BCJ20240769
Published: 14 May 2025
...Lisa Kohrs; Falk F. R. Buettner; Juliane Lokau; Christoph Garbers Cytokines of the interleukin-6 (IL-6) family are important soluble mediators with crucial roles in developmental processes, tissue homeostasis, regeneration, and immune cell differentiation. Overshooting activities of IL-6 and other...
View articletitled, The biology of interleukin-6 family cytokines is regulated by glycosylation
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Articles

Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase

Open Access
Charles O. Brown, Kelley Salem, Brett A. Wagner, Soumen Bera, Neeraj Singh, Ajit Tiwari, Amit Choudhury, Garry R. Buettner, Apollina Goel
Journal: Biochemical Journal
Biochem J (2012) 444 (3): 515–527.
https://doi.org/10.1042/BJ20112019
Published: 29 May 2012
...Charles O. Brown; Kelley Salem; Brett A. Wagner; Soumen Bera; Neeraj Singh; Ajit Tiwari; Amit Choudhury; Garry R. Buettner; Apollina Goel IL (interleukin)-6, an established growth factor for multiple myeloma cells, induces myeloma therapy resistance, but the resistance mechanisms remain unclear...
View articletitled, Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase
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Includes: Supplementary data
Articles

IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa

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Sophie Groux-Degroote, Marie-Ange Krzewinski-Recchi, Aurélie Cazet, Audrey Vincent, Sylvain Lehoux, Jean-Jacques Lafitte, Isabelle van Seuningen, Philippe Delannoy
Journal: Biochemical Journal
Biochem J (2008) 410 (1): 213–223.
https://doi.org/10.1042/BJ20070958
Published: 29 January 2008
... that inflammation may affect glycosylation and sulfation of various glycoproteins, including mucins. In the present study, we show that incubation of macroscopically healthy fragments of human bronchial mucosa with IL-6 (interleukin-6) or IL-8 results in a significant increase in the expression of α1,3/4...
View articletitled, IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa
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Includes: Supplementary data
Articles

Cr(VI)-stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck

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Kimberley A. O'hara, Rasilaben J. Vaghjiani, Antonia A. Nemec, Linda R. Klei, Aaron Barchowsky
Journal: Biochemical Journal
Biochem J (2007) 402 (2): 261–269.
https://doi.org/10.1042/BJ20061427
Published: 12 February 2007
... microscopy confirmed that Cr(VI) increased nuclear localization of phosphorylated STAT3 for more than 72 h in both primary and BEAS 2B human airway cells. Cr(VI) induced transactivation of both a STAT3-driven luciferase reporter construct and the endogenous inflammatory gene IL-6 (interleukin-6). Inhibition...
View articletitled, Cr(VI)-stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck
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Articles

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling

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Patrick FISCHER, Ute LEHMANN, Radoslaw M. SOBOTA, Jochen SCHMITZ, Claudia NIEMAND, Sonja LINNEMANN, Serge HAAN, Iris BEHRMANN, Akihiko YOSHIMURA, James A. JOHNSTON, Gerhard MÜLLER-NEWEN, Peter C. HEINRICH, Fred SCHAPER
Journal: Biochemical Journal
Biochem J (2004) 378 (2): 449–460.
https://doi.org/10.1042/bj20030893
Published: 01 March 2004
...Patrick FISCHER; Ute LEHMANN; Radoslaw M. SOBOTA; Jochen SCHMITZ; Claudia NIEMAND; Sonja LINNEMANN; Serge HAAN; Iris BEHRMANN; Akihiko YOSHIMURA; James A. JOHNSTON; Gerhard MÜLLER-NEWEN; Peter C. HEINRICH; Fred SCHAPER The immediate early response of cells treated with IL-6 (interleukin-6...
View articletitled, The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling
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Articles

Interferons activate the p42/44 mitogen-activated protein kinase and JAK-STAT (Janus kinase-signal transducer and activator transcription factor) signalling pathways in hepatocytes: differential regulation by acute ethanol via a protein kinase C-dependent mechanism

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Van-Anh T. NGUYEN, Jianping CHEN, Feng HONG, Edward J. N. ISHAC, Bin GAO
Journal: Biochemical Journal
Biochem J (2000) 349 (2): 427–434.
https://doi.org/10.1042/bj3490427
Published: 10 July 2000
..., Janus kinase-signal transducer and activator transcription factor ; p42/44 MAPK, p42/44 mitogen-activated protein kinase ; PKB/Akt, protein kinase B; IFN, interferon; IL-6, interleukin-6 ; IRS1, insulin receptor substrate-1 ; JNK, c-Jun N-terminal kinase ; PKC, protein kinase C; DMSA, DNA gel-mobility...
View articletitled, Interferons activate the p42/44 mitogen-activated protein kinase and JAK-STAT (Janus kinase-signal transducer and activator transcription factor) signalling pathways in hepatocytes: differential regulation by acute ethanol via a protein kinase C-dependent mechanism
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Articles

Cytoplasmic STAT proteins associate prior to activation

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Serge HAAN, Marcin KORTYLEWSKI, Iris BEHRMANN, Werner MÜLLER-ESTERL, Peter C. HEINRICH, Fred SCHAPER
Journal: Biochemical Journal
Biochem J (2000) 345 (3): 417–421.
https://doi.org/10.1042/bj3450417
Published: 25 January 2000
... 7 12 1999 The Biochemical Society, London © 2000 2000 DNA binding HepG2 hepatoma cells interleukin-6 A375 melanoma cells nuclear translocation Biochem. J. (2000) 345, 417 421 (Printed in Great Britain) 417 RESEARCH COMMUNICATION Cytoplasmic STAT proteins associate prior...
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Articles

Extrahepatic synthesis of plasminogen in the human cornea is up-regulated by interleukins-1α and -1β

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Sally S. TWINING, Patricia M. WILSON, Chatri NGAMKITIDECHAKUL
Journal: Biochemical Journal
Biochem J (1999) 339 (3): 705–712.
https://doi.org/10.1042/bj3390705
Published: 26 April 1999
... of plasminogen by the cornea was confirmed by immunoprecipitation of metabolically labelled plasminogen, sequencing of its cDNA obtained by reverse transcriptase-PCR and inhibition of protein synthesis. Interleukins-1α and -1β stimulated corneal plasminogen synthesis 2-3-fold; however, interleukin-6 decreased...
View articletitled, Extrahepatic synthesis of plasminogen in the human cornea is up-regulated by interleukins-1α and -1β
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Articles

Identification of a Leu-Ile internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor

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Stefan THIEL, Iris BEHRMANN, Andreas TIMMERMANN, Heike DAHMEN, Gerhard MÜLLER-NEWEN, Fred SCHAPER, Jan TAVERNIER, Vincent PITARD, Peter C. HEINRICH, Lutz GRAEVE
Journal: Biochemical Journal
Biochem J (1999) 339 (1): 15–19.
https://doi.org/10.1042/bj3390015
Published: 25 March 1999
... and homodimeric gp130}gp130 complex are endocytosed via distinct internalization signals. Keywords: dileucine, endocytosis, gp130, interleukin-6, LIF receptor. motif we constructed chimaeric receptors consisting of the extracellular domains of the IL-5 receptor (IL-5R) a and b chains respectively...
View articletitled, Identification of a Leu-Ile internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor
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