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Keywords: internalization
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Biochem J (2021) 478 (10): 1907–1919.
Published: 24 May 2021
... entered the cells to exert its antagonist activity. The internalization of CGA-N12 was energy-dependent and accompanied by actin cytoskeleton-, clathrin-, sulfate proteoglycan-, endosome-, and lipid-depleting agent-mediated endocytosis. Moreover, the CGA-N12 internalization pathway was related...
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Biochem J (2019) 476 (3): 483–497.
Published: 05 February 2019
... microscopy, CGA-N9 accumulated in cells without destroying the integrity of the cell membrane; the peptide was initially localized to the cell membrane and subsequently internalized into the cytosol. An investigation of the cellular internalization mechanism revealed that most CGA-N9 molecules entered...
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Biochem J (2018) 475 (22): 3687–3706.
Published: 30 November 2018
... 10 2018 29 10 2018 29 10 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 anti-inflammatory mechanism antimicrobial peptide internalization MAPK NF-κB U937 cells were seeded into 6-well plates (5 × 10 5 cells...
Includes: Supplementary data
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Biochem J (2011) 437 (2): 169–183.
Published: 28 June 2011
... correspondence should be addressed (email [email protected] ). 15 2 2011 12 4 2011 15 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis internalization neuropilin signal transduction vascular endothelial growth factor (VEGF) vascular...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 423 (3): 303–314.
Published: 12 October 2009
... of events has been proposed. Two essential factors of HCV entry are the tight junction proteins claudin-1 and occludin. Cell polarity therefore seems to be a key for HCV entry. This raises several exciting questions on the HCV internalization pathway. Clathrin-dependent endocytosis is probably the route...
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Biochem J (2007) 407 (1): 141–151.
Published: 12 September 2007
... into an IFNα/β differential JAK/STAT signalling nor does it change the dynamics of the engaged receptor. Importantly, however, our data highlight a differential effect upon routing of IFNAR2. Following binding of IFNα2, IFNAR2 is internalized, but, instead of being routed towards degradation as it is when...
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Biochem J (2006) 399 (1): 1–7.
Published: 13 September 2006
... 8 2006 The Biochemical Society, London 2006 antimicrobial peptide cell-penetrating peptide drug delivery internalization translocation mechanism The affinity of each CPP for lipid bilayers may be the key factor for their main mechanism of uptake. Penetratin, for instance...
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Biochem J (2006) 397 (1): 31–38.
Published: 14 June 2006
... (Janus kinase 1) respectively. Ligand-induced down-regulation of the type I IFNR is a major mechanism of negative regulation of cellular signalling and involves the internalization and lysosomal degradation of IFNAR1. IFNα promotes the phosphorylation of IFNAR1 on Ser 535 , followed by recruitment...
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Biochem J (2005) 385 (1): 115–123.
Published: 14 December 2004
...Christophe D. PROULX; May SIMAAN; Emanuel ESCHER; Stéphane A. LAPORTE; Gaétan GUILLEMETTE; Richard LEDUC Most G-protein-coupled receptors that undergo agonist-dependent internalization require the presence of specific cytoplasmic-tail residues to initiate interactions with proteins of the endocytic...
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Biochem J (2003) 373 (1): 19–24.
Published: 01 July 2003
... processing, tissue inhibitor of MMPs (TIMP) binding and constitutive internalization. However, the fate of internalized MT1-MMP is not known. Acidification of intracellular vacuolar compartments is essential for membrane trafficking, protein sorting and degradation. This acidification is controlled...
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Biochem J (2001) 355 (3): 639–645.
Published: 24 April 2001
... of the Lys 46 -Ser 47 bond with elimination of the GFD. Using recombinant forms of uPA, we show that a uPA variant lacking the GFD (r-uPA∆GFD) and unable to associate with uPAR is rapidly cleared from the cell surface. Binding and internalization of r-uPA∆GFD are markedly decreased in the presence of 39kDa...
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Biochem J (2001) 354 (3): 561–572.
Published: 08 March 2001
... -based internalization signal, identified in the C-terminal tail of the channel. Mutation of the Tyr 1424 residue could partly inhibit the endocytosis of CFTR and its association with the adapter protein AP-2. To reveal additional endosomal targeting signals, site-directed mutagenesis of both a chimaera...
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Biochem J (2000) 346 (2): 329–336.
Published: 22 February 2000
... internalization protein trafficking zinc uptake Biochem. J. (2000) 346, 329 336 (Printed in Great Britain) 329 Zinc-regulated ubiquitin conjugation signals endocytosis of the yeast ZRT1 zinc transporter Raad S. GITAN and David J. EIDE1 Department of Nutritional Sciences, 217 Gwynn Hall, University...