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Keywords: intramembrane proteolysis
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Articles

Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74

Available to Purchase
Susann Hüttl, Felix Helfrich, Torben Mentrup, Sebastian Held, Akio Fukumori, Harald Steiner, Paul Saftig, Regina Fluhrer, Bernd Schröder
Journal: Biochemical Journal
Biochem J (2016) 473 (10): 1405–1422.
https://doi.org/10.1042/BCJ20160156
Published: 11 May 2016
...-mediated processing. Therefore we propose that elements within the transmembrane segment and the luminal juxtamembrane domain facilitate intramembrane proteolysis of CD74 by SPPL2a. 1 To whom correspondence should be addressed: (email [email protected] ). 22 10 2015 15 3...
View articletitled, Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74
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Articles

Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes

Open Access
Bianca Schrul, Katja Kapp, Irmgard Sinning, Bernhard Dobberstein
Journal: Biochemical Journal
Biochem J (2010) 427 (3): 523–534.
https://doi.org/10.1042/BJ20091005
Published: 14 April 2010
... type II membrane proteins. Signal peptides are trapped by the catalytically inactive SPP mutant SPP D/A . Preproteins and misfolded membrane proteins interact with both SPP and the SPP D/A mutant, and are not substrates for SPP-mediated intramembrane proteolysis. Proteins interacting with SPP are found...
View articletitled, Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes
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Includes: Supplementary data