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Keywords: kinases
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Biochem J (2021) 478 (17): 3179–3184.
Published: 07 September 2021
... proteolysis and kinase-mediated phosphorylation, enabling integration of signals from multiple pathways into the decision to commit to apoptosis. A new study from Maluch et al. examines how phosphorylation within caspase cleavage sites impacts the efficiency of substrate cleavage. The results demonstrate...
Biochem J (2020) 477 (10): 1951–1970.
Published: 29 May 2020
...Ravi Jain; Sakshi Gupta; Manoj Munde; Soumya Pati; Shailja Singh Upon Plasmodium falciparum merozoites exposure to low [K + ] environment in blood plasma, there is escalation of cytosolic [Ca 2+ ] which activates Ca 2+ -Dependent Protein Kinase 1 (CDPK1), a signaling hub of intra-erythrocytic...
Includes: Supplementary data
Biochem J (2020) 477 (8): 1525–1539.
Published: 29 April 2020
...Matthew J. Byrne; Nazia Nasir; Christine Basmadjian; Chitra Bhatia; Rory F. Cunnison; Katherine H. Carr; Corine Mas-Droux; Sharon Yeoh; Céline Cano; Richard Bayliss Nek7 is a serine/threonine-protein kinase required for proper spindle formation and cytokinesis. Elevated Nek7 levels have been...
Biochem J (2020) 477 (4): 801–814.
Published: 27 February 2020
... variety of disease states. It is regulated through the activity of specific kinases, in particular Unc-51 like autophagy activating kinase 1 (ULK1) and Phosphatidylinositol 3-kinase vacuolar protein sorting 34 (VPS34), which have both been suggested as potential targets for drug development. To identify...
Includes: Supplementary data
Biochem J (2018) 475 (7): 1271–1293.
Published: 09 April 2018
...Alexia F. Kalogeropulou; Jing Zhao; Marc F. Bolliger; Anna Memou; Shreya Narasimha; Tyler P. Molitor; William H. Wilson; Hardy J. Rideout; R. Jeremy Nichols Autosomal-dominant, missense mutations in the leucine-rich repeat protein kinase 2 ( LRRK2 ) gene are the most common genetic predisposition...
Includes: Supplementary data
Biochem J (2018) 475 (5): 905–921.
Published: 09 March 2018
...Alexander S. Moffett; Diwakar Shukla Eukaryotic protein kinases (PKs) are a large family of proteins critical for cellular response to external signals, acting as molecular switches. PKs propagate biochemical signals by catalyzing phosphorylation of other proteins, including other PKs, which can...
Biochem J (2018) 475 (1): 117–135.
Published: 02 January 2018
...Nazma Malik; Thomas Macartney; Annika Hornberger; Karen E. Anderson; Hannah Tovell; Alan R. Prescott; Dario R. Alessi Derailment of the PI3K-AGC protein kinase signalling network contributes to many human diseases including cancer. Recent work has revealed that the poorly studied AGC kinase family...
Includes: Supplementary data
Biochem J (2000) 350 (3): 735–740.
Published: 08 September 2000
...-inducing kinase (NIK), IκB kinase (IKK)-1 and IKK-2 in the BJAB B-cell line. The overexpression of TRAF-6 or NIK was sufficient to activate NF-κB and the Cε promoter, whereas their dominant-negative counterparts decreased the ability of CD40 to activate NF-κB and the Cε promoter. The overexpression of wild...
Biochem J (1999) 343 (3): 637–644.
Published: 25 October 1999
...Hongwei QIAN; Luisa PIPOLO; Walter G. THOMAS Protein kinase C (PKC) phosphorylates the C-terminus of the type 1 angiotensin II receptor (AT 1 ), although the exact site(s) of phosphorylation are unidentified. In the present study, we examined the phosphorylation of epitope-tagged wild-type AT 1A...
Biochem J (1999) 339 (2): 435–442.
Published: 08 April 1999
...Yang FENG; David R. HODGE; Giuseppe PALMIERI; Dan L. CHASE; Dan L. LONGO; Douglas K. FERRIS The polo-like kinase (Plk) family has been shown to have an important role in the regulation of the cell-division cycle, especially in organization of the spindle structure, in species from fungi to humans...