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Keywords: lactate
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Biochem J (2016) 473 (6): 685–692.
Published: 10 March 2016
... a true metabolic regulator in additional tissues, including muscle and adipose tissues. In the present study, we found that the expression and secretion of FGF21 was very rapidly increased following lactate exposure in adipocytes. Using different pharmacological and knockout mice models, we...
Biochem J (2015) 467 (2): 247–258.
Published: 02 April 2015
...-bromopyruvate (3BP), an analogue of lactate and pyruvate that is known for its alkylating properties. 3BP targets energy metabolism of cancer cells, i.e. both glycolysis and mitochondrial oxidative phosphorylation, while leaving normal cells unharmed. Glycolytic targets of 3BP are both Hk-2 [ 22 ] and GAPDH...
Biochem J (2007) 408 (1): 123–130.
Published: 29 October 2007
...Tiago Costa Leite; Daniel Da Silva; Raquel Guimarães Coelho; Patricia Zancan; Mauro Sola-Penna For a long period lactate was considered as a dead-end product of glycolysis in many cells and its accumulation correlated with acidosis and cellular and tissue damage. At present, the role of lactate in...
Biochem J (2004) 384 (2): 287–293.
Published: 23 November 2004
... cells analysed were in a dynamic state, and cell number, time of plating, culture medium, extracellular volume and time of harvest and assay were strictly controlled. Intra- and extra-cellular lactate and pyruvate levels were measured in homoplasmic wild-type and mutant cells, and correlated with rates...
Biochem J (2003) 370 (3): 995–1001.
Published: 15 March 2003
... ability of GS to bind UDP-glucose. 1 To whom correspondence should be addressed (e-mail abram.katz@fyfa.ki.se ). 21 8 2002 27 11 2002 2 12 2002 15 3 2003 The Biochemical Society, London ©2003 2003 glucose uptake glycogen synthesis insulin lactate phosphorylase...
Biochem J (2000) 349 (3): 667–688.
Published: 25 July 2000
... lactate Biochem. J. (2000) 349, 667 688 (Printed in Great Britain) 667 REVIEW ARTICLE Role of plasma membrane transporters in muscle metabolism Antonio ZORZANO1, Ce! sar FANDOS and Manuel PALACI!N Departament de Bioqu !mica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Av...
Biochem J (2000) 346 (3): 651–657.
Published: 07 March 2000
...) oxidation into the tricarboxylic acid cycle. We further speculate that FA oxidation by skeletal muscle is both forced and facilitated by upregulation of PDK4, which is perceived as an essential component of the operation of the glucose-FA cycle in starvation. pyruvate dehydrogenase complex lactate...
Biochem J (1999) 343 (2): 281–299.
Published: 08 October 1999
...Andrew P. HALESTRAP; Nigel T. PRICE Monocarboxylates such as lactate and pyruvate play a central role in cellular metabolism and metabolic communication between tissues. Essential to these roles is their rapid transport across the plasma membrane, which is catalysed by a recently identified family...