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Keywords: leucine
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Articles
Biochem J (2021) 478 (4): 765–776.
Published: 24 February 2021
...: Zoltan Arany ( zarany@pennmedicine.upenn.edu ) 16 12 2020 1 2 2021 3 2 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 branched chain amino acids isoleucine leucine organismal metabolism valine The three...
Articles
Biochem J (2020) 477 (9): 1579–1599.
Published: 05 May 2020
... treated by surgical intervention combined with high toxicity chemotherapy. In search of alternative metabolic approaches to address the challenges in treating bone sarcomas, we assessed the growth dependence of these cancers on leucine, one of the branched-chain amino acids (BCAAs), and BCAA metabolism...
Includes: Supplementary data
Articles
Biochem J (2015) 470 (2): 207–221.
Published: 20 August 2015
... (ii) that leucine can promote mTORC1 activity independently of lysosomal mTOR localization [ 14 ]. Furthermore, given the diversity of signals that mTORC1 is able to integrate and the range of downstream cellular responses that it regulates, it is highly likely that other, hitherto unidentified...
Includes: Supplementary data
Articles
Biochem J (2007) 407 (1): 113–120.
Published: 12 September 2007
...Helen L. Eley; Steven T. Russell; Michael J. Tisdale In the present study, the BCAAs (branched-chain amino acids) leucine and valine caused a significant suppression in the loss of body weight in mice bearing a cachexia-inducing tumour (MAC16), producing a significant increase in skeletal muscle...