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Keywords: leucine rich repeat kinase
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Articles
Journal:
Biochemical Journal
Biochem J (2025) 482 (07): 357–358.
Published: 26 March 2025
... 17 02 2018 © 2025 The Author(s). 2025 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . kinase leucine rich repeat kinase phosphorylation Rab...
Articles
In Collection
Cell signaling in the 21st century
Eliza Störmer, Jui-Hung Weng, Jian Wu, Daniela Bertinetti, Pallavi Kaila Sharma, Wen Ma, Friedrich W. Herberg, Susan S. Taylor
Journal:
Biochemical Journal
Biochem J (2023) 480 (11): 815–833.
Published: 12 June 2023
... Press and the Biochemical Society under a transformative agreement with UC. GTPases kinases leucine rich repeat kinase molecular dynamics Parkinsons disease Several strategically positioned mutations cause the large multi-domain intracellular LRR-kinase 2 (LRRK2) to become a risk...
Includes: Supplementary data
Articles
Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Deep Chatterjee, Toan K. Phung, Melanie Wightman, Robert Gourlay, Nick Morrice, Sebastian Mathea, Stefan Knapp, Dario R. Alessi
Journal:
Biochemical Journal
Biochem J (2022) 479 (18): 1941–1965.
Published: 23 September 2022
...Asad U. Malik; Athanasios Karapetsas; Raja S. Nirujogi; Deep Chatterjee; Toan K. Phung; Melanie Wightman; Robert Gourlay; Nick Morrice; Sebastian Mathea; Stefan Knapp; Dario R. Alessi Leucine-rich-repeat-kinase 1 (LRRK1) and its homolog LRRK2 are multidomain kinases possessing a ROC-COR A -COR B...
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (19): 3555–3573.
Published: 06 October 2021
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . kinase kinase inhibitor leucine rich repeat kinase Parkinsons disease Rab GTPase Wild-type and homozygous LRRK2 [R1441C] (Jax, stock number: 009346...
Includes: Supplementary data
Articles
In Collection
Protein structure and function
Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Sebastian Mathea, Deep Chatterjee, Prosenjit Pal, Pawel Lis, Matthew Taylor, Elena Purlyte, Robert Gourlay, Mark Dorward, Simone Weidlich, Rachel Toth, Nicole K. Polinski, Stefan Knapp, Francesca Tonelli, Dario R. Alessi
Journal:
Biochemical Journal
Biochem J (2021) 478 (3): 553–578.
Published: 10 February 2021
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . kinase leucine rich repeat kinase phosphorylation Rab GTPase Mammals possess two homologs of the leucine-rich repeat protein kinase termed LRRK1 and LRRK2 [ 1 ]. These are large multidomain enzymes possessing an N...
Includes: Supplementary data
Articles
Raja S. Nirujogi, Francesca Tonelli, Matthew Taylor, Pawel Lis, Alexander Zimprich, Esther Sammler, Dario R. Alessi
Journal:
Biochemical Journal
Biochem J (2021) 478 (2): 299–326.
Published: 22 January 2021
... to assess LRRK2 Rab signalling pathway. Autosomal dominant mutations that hyperactivate leucine-rich repeat kinase 2 (LRRK2) are a frequent cause of late-onset familial Parkinson's disease [ 1 , 2 ]. LRRK2 is a large multi-domain enzyme made up of armadillo, ankyrin, leucine-rich repeats, tandem Roco type...
Includes: Supplementary data
Articles
Alexia F. Kalogeropulou, Jordana B. Freemantle, Pawel Lis, Edmundo G. Vides, Nicole K. Polinski, Dario R. Alessi
Journal:
Biochemical Journal
Biochem J (2020) 477 (22): 4397–4423.
Published: 27 November 2020
... 27 10 2020 30 10 2020 2 11 2020 © 2020 The Author(s) 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . leucine rich repeat kinase...
Includes: Supplementary data
