...Alexia F. Kalogeropulou; Elena Purlyte; Francesca Tonelli; Sven M. Lange; Melanie Wightman; Alan R. Prescott; Shalini Padmanabhan; Esther Sammler; Dario R. Alessi Mutations enhancing the kinase activity of leucine-rich repeat kinase-2 (LRRK2) cause Parkinson's disease (PD) and therapies that reduce...

...Susanne Herbst; Patrick A. Lewis Since the discovery of mutations in leucine-rich repeat kinase 2 (LRRK2) as an underlying genetic cause for the development of Parkinson's disease (PD) in 2004 (Neuron 44 , 601–607; Neuron 44 , 595–600), and subsequent efforts to develop LRRK2 kinase inhibitors...

...Margaux Leemans; Christian Galicia; Egon Deyaert; Elise Daems; Linda Krause; Jone Paesmans; Els Pardon; Jan Steyaert; Arjan Kortholt; Frank Sobott; Dagmar Klostermeier; Wim Versées Mutations in the Parkinson's disease (PD)-associated protein leucine-rich repeat kinase 2 (LRRK2) commonly lead...

...) . centrosome cohesion leucine-rich repeat kinase protein phosphorylation Rab protein Parkinson's disease (PD) is a neurodegenerative disorder which affects ∼1% of people over 65 years [ 1 ]. Apart from ageing, environmental as well as genetic factors contribute to PD risk. Mutations in several genes...

... disease-associated protein LRRK2 (leucine-rich repeat kinase 2). We previously demonstrated that the Roco protein from Chlorobium tepidum (CtRoco) undergoes a dimer–monomer cycle during the GTPase reaction, with the protein being mainly dimeric in the nucleotide-free and GDP (guanosine-5′-diphosphate...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . kinase Leucine-rich repeat kinase Parkinson's disease signalling phosphorylation Rab proteins VPS35 For experiments shown in Figure 4 , 9–10-week-old...

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 kinases leucine-rich repeat kinase Parkinson's disease phosphorylation/dephosphorylation SQSTM1 Autosomal-dominant, missense mutations in the leucine-rich repeat protein kinase 2 (LRRK2) gene...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . antibodies leucine-rich repeat kinase Parkinson's disease protein kinase Rab GTPases Rab10 Littermate-matched wild-type and homozygous mutant mouse...

...Ying Fan; Andrew J.M. Howden; Adil R. Sarhan; Pawel Lis; Genta Ito; Terina N. Martinez; Kathrin Brockmann; Thomas Gasser; Dario R. Alessi; Esther M. Sammler There is compelling evidence for the role of the leucine-rich repeat kinase 2 (LRRK2) and in particular its kinase function in Parkinson's...