... on behalf of the Biochemical Society 2019 hepatocellular carcinoma leukaemia toxicology Bacillus thuringiensis synthesises crystalline parasporal inclusions during sporulation and this salient feature makes it distinguishable from other Bacillus species [ 1 ]. The inclusion proteins have...

... 2019 26 7 2019 26 7 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 AMPK CIP2A leukaemia metabolic regulation oxidative phosphorylation PP2A Protein phosphatase 2A (PP2A) is an abundant cellular phosphatase...

...Elitza Deltcheva; Rachael Nimmo The RUNX1 transcription factor is a critical regulator of normal haematopoiesis and its functional disruption by point mutations, deletions or translocations is a major causative factor leading to leukaemia. In the majority of cases, genetic changes in RUNX1...

...; however, the mechanism by which this occurs is not completely understood. In the present study we demonstrate that direct inhibition of anti-apoptotic BCL2 proteins with ABT-263 is sufficient to induce C 16 -ceramide synthesis in multiple cell lines, including human leukaemia and myeloma cells. ABT-263...

... roles in development and are abnormally expressed in many cancers. In the present study, we show that the interaction between WDR5 and peptides from the catalytic domain of MLL (mixed-lineage leukaemia protein) (KMT2) can be antagonized with a small molecule. Structural and biophysical analysis show...

... translocations in lymphoid malignancies. chromosomal translocation double-strand break DNA damage leukaemia single-strand break V(D)J recombination 1 To whom correspondence should be addressed (email [email protected] ). 25 6 2012 13 8 2012 15 8 2012 15 8...

..., differentiation and apoptosis in human leukaemia cell lines and primary myeloid leukaemia cells. The results showed that at low concentrations (<1 μM), CS055 induced G 1 arrest. At moderate concentrations (0.5 μM–2 μM), CS055 induced differentiation, as determined by the increased expression of the myeloid...

... the lymphoid microenvironment, leading to release of leukaemia and lymphoma cells from their protective niche. These encouraging findings have given further momentum to PI3K drug development efforts in both cancer and immune diseases. 1 David Fruman is a scientific advisor to Intellikine, a company...

... or by reducing nutrient demand, but blocking apoptosis was ineffective. Importantly, AAL-149, a FTY720 analogue that lacks FTY720's dose-limiting toxicity, also triggered transporter loss and killed patient-derived leukaemias while sparing cells isolated from normal donors. As they target the metabolic profile...

... Biochemical Society 2011 glutaminolysis leukaemia nutrient limitation sphingosine 1-phosphate transporter Warburg effect Tumour therapy has for many years relied on fairly non-specific drugs that are severely cytotoxic [ 1 ]. With the increased understanding of tumour cell biology [ 2...

... use, distribution and reproduction in any medium, provided the original work is properly cited. apoptosis cancer DNA damage drug conjugate leukaemia polyamine The development of a ‘magic bullet’ for cancer therapy would revolutionize current treatment. Although some headway has been...

...Georgia A. Kotzia; Katerina Lappa; Nikolaos E. Labrou Bacterial L-ASNases ( L -asparaginases) catalyse the conversion of L -asparagine into L -aspartate and ammonia, and are widely used for the treatment of ALL (acute lymphoblastic leukaemia). In the present paper, we describe an efficient approach...

...-R8) and its D -enantiomer (D-R8) in CD34 + leukaemia cells. We found that, at 4–12 °C, L -R8 uniformly labels the cytoplasm and nucleus, but in cells incubated with D-R8 there is additional labelling of the nucleolus which is still prominent at 30 °C incubations. At temperatures between 12 and 30 °C...

... reported [ 58 ]. cAMP cancer therapy glucocorticoid leukaemia methylxanthine phosphodiesterase Following the identification of cAMP in 1958 by Rall and Sutherland [ 1 ], research focused for more than a decade on elucidating the role that this ‘second messenger’ played in regulating...

.../Abl, the hallmark of chronic myeloid leukaemia, has been connected with several signalling pathways, such as those involving protein kinase B/Akt, JNK (c-Jun N-terminal kinase) or ERKs (extracellular-signal-regulated kinases) 1 and 2. However, no data about the p38 MAPK (mitogen-activated protein...

... transformation and the prospect of its use as a clinically relevant factor. Using leukaemia cells from medullar blood of human patients and several established human cancer cell lines, we have developed a competitive RT (reverse transcriptase)-PCR assay to quantify simultaneously K-type (kidney-type) and L-type...

.... In peripheral blood cells, the highest levels of NALP1 were observed in CD3 + (T-lymphocytes), CD15 + (granulocytes) and CD14 + (monocytes) cell populations. Notably, the expression of NALP1 was significantly increased in the bone marrow blast cell population of some patients with acute leukaemia, but not among...

...Ngai CHEUNG; Chi Wai SO; Judy W. P. YAM; C. K. C. SO; Randy Y. C. POON; Dong-Yan JIN; Li Chong CHAN EEN (extra eleven nineteen), also known as EA2 (endophilin A2), a fusion partner of the MLL (mixed-lineage leukaemia) gene in human acute leukaemia, is a member of the endophilin A family, involved...

... neoplasias and in the differentiation of haematopietic cells, we have investigated their expression in human leukaemias and in leukaemic cell lines induced to terminal differentiation. Here we report HMGA1 overexpression in most fresh human leukaemias of different origin and in several leukaemic cell lines...

...Dorina AVRAM; Andrew FIELDS; Thanaset SENAWONG; Acharawan TOPARK-NGARM; Mark LEID Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting proteins 1 and 2 [CTIP1/Evi9/B cell leukaemia (Bcl) l1a and CTIP2/Bcl11b respectively] are highly related C 2 H 2 zinc finger proteins...

... abundant, and are found in an assortment of adult and fetal tissues [3]. In contrast, usage Abbreviations used: CBS, cystathionine b-synthase; UTR, untranslated region; AML, acute myeloid leukaemia; DS, Down s syndrome; Sp, specificity protein ; NF, nuclear factor ; USF-1, upstream stimulatory factor 1...

...Randi HOVLAND; Anne P. DØSKELAND; Thor S. EIKHOM; Bernard ROBAYE; Stein O. DØSKELAND An elevated cAMP concentration results in growth arrest and protein synthesis-dependent apoptosis in the promyelocytic leukaemia cell line IPC-81. A comparison of two-dimensional gels of extracts from these cells...