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Keywords: lifespan
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Biochem J (2014) 459 (1): 127–135.
Published: 14 March 2014
... suppression of the activities of mitochondrial ETC (electron-transport chain) oxidoreductases retards the aging process and extends lifespan. Underexpression of both CcO subunits, induced by RNAi, resulted in decreases in the respective mRNA and protein levels, CcO holoenzyme activity, rate of mitochondrial...
Includes: Supplementary data
Biochem J (2012) 441 (1): 417–424.
Published: 14 December 2011
... alleviates the associated neurotoxicity. We also reveal that astragalan can extend the adult lifespan of wild-type and polyQ nematodes, indicating a connection of its anti-aging benefit with the toxicity-suppressing effect. Further examination demonstrates that astragalan can extend the lifespan of daf-2 and...
Includes: Supplementary data
Biochem J (2009) 418 (1): 1–12.
Published: 28 January 2009
... elegans and the mouse. IIS [insulin/IGF (insulin-like growth factor)-like signalling] stands out as an important, evolutionarily conserved pathway involved in the determination of lifespan. The pathway has diverse functions in multicellular organisms, and mutations in IIS can affect growth, development...
Biochem J (2006) 397 (3): 519–527.
Published: 13 July 2006
...Jiandi Zhang Resveratrol mimics calorie restriction to extend lifespan of Caenorhabditis elegans , yeast and Drosophila , possibly through activation of Sir2 (silent information regulator 2), a NAD + -dependent histone deacetylase. In the present study, resveratrol is shown to inhibit the insulin...
Includes: Supplementary data