.... glutamicum has focused on cysteine oxidation-based redox-sensing and substrate metabolism-involving regulators. In this study, we characterized the stress-related ligand-binding functions of the C. glutamicum MarR-type regulator CarR ( C. glutamicum antibiotic-responding regulator). We demonstrate that CarR...

...-activated receptor γ), a ligand-dependent transcription factor playing a central role in adipocyte differentiation. In the luciferase reporter assay using both GAL4 chimaera and full-length PPARγ systems, a mevalonate metabolite, FPP (farnesyl pyrophosphate), which is the precursor of almost all isoprenoids...

...Andrew J. Brown In humans, there are 48 members of the superfamily of nuclear receptors. These ligand-activated transcription factors help to integrate our growth, reproduction and metabolism via environmental, nutritional and intrinsic cues. It is therefore not surprising that nuclear receptors...

.... The mechanisms for the mutual antagonism of Ins(1,4,5)P $ binding and Fru(1,6)P # cleavage are unknown. One ligand might bind to aldolase and evoke conformational changes that interfere with binding of the other ligand. Alternatively, the binding of Ins(1,4,5)P $ might involve the same surface charge generated...