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Loss of peroxiredoxin 6 alters lipid composition and distribution resulting in increased sensitivity to ferroptosis

Daniel J. Lagal, Ángel Ortiz-Alcántara, José R. Pedrajas, Brian McDonagh, J. Antonio Bárcena, Raquel Requejo-Aguilar, C. Alicia Padilla

Biochem J (2024) 481 (24): 1997–2015.

https://doi.org/10.1042/BCJ20240445

Published: 23 December 2024

... and cholesterol, so called lipid rafts [ 4 ], have been related to signaling pathways involved in cancer progression; they can recruit or exclude signaling proteins, including kinases and phosphatases in response to external and intracellular stimuli leading to dynamic changes in cell size and composition [ 5 , 6...

View articletitled, Loss of peroxiredoxin 6 alters lipid composition and distribution resulting in increased sensitivity to ferroptosis

Includes: Supplementary data

Articles

Revisiting the role of cholesterol in regulating the pore-formation mechanism of Vibrio cholerae cytolysin, a membrane-damaging β-barrel pore-forming toxin

Reema Kathuria, Anish Kumar Mondal, Rohan Sharma, Samarjit Bhattacharyya, Kausik Chattopadhyay

Biochem J (2018) 475 (19): 3039–3055.

https://doi.org/10.1042/BCJ20180387

Published: 10 October 2018

... acts to facilitate the cholesterol-dependent pore-formation mechanism of the toxin. pore-forming toxin Vibrio cholerae cytolysin membranes cholesterol oligomerization lipid raft Pore-forming toxins (PFTs) represent a unique class of membrane-damaging proteins that are implicated...

View articletitled, Revisiting the role of cholesterol in regulating the pore-formation mechanism of Vibrio cholerae cytolysin, a membrane-damaging β-barrel pore-forming toxin

Includes: Supplementary data

Articles

Caveolae optimize tissue factor–Factor VIIa inhibitory activity of cell-surface-associated tissue factor pathway inhibitor

Susan A. Maroney, Paul E. Ellery, Jeremy P. Wood, Josephine P. Ferrel, Catherine E. Bonesho, Alan E. Mast

Biochem J (2012) 443 (1): 259–266.

https://doi.org/10.1042/BJ20111994

Published: 14 March 2012

... in humans, suggesting that it results in embryonic death in humans as well as in mice. caveola caveolin-1 lipid raft membrane cholesterol tissue factor tissue factor pathway inhibitor (TFPI) TFPI is an alternatively spliced protein, with two forms identified in humans [ 3 – 5...

View articletitled, Caveolae optimize tissue factor–Factor VIIa inhibitory activity of cell-surface-associated tissue factor pathway inhibitor

Articles

MAL, but not MAL2, expression promotes the formation of cholesterol-dependent membrane domains that recruit apical proteins

Sai P. Ramnarayanan, Pamela L. Tuma

Biochem J (2011) 439 (3): 497–504.

https://doi.org/10.1042/BJ20110803

Published: 13 October 2011

...Sai P. Ramnarayanan; Pamela L. Tuma Our recent studies have been aimed at understanding the mechanisms regulating apical protein sorting in polarized epithelial cells. In particular, we have been investigating how lipid rafts serve to sort apical proteins in the biosynthetic pathway. The recent...

View articletitled, MAL, but not MAL2, expression promotes the formation of cholesterol-dependent membrane domains that recruit apical proteins

Articles

Function of MRP1/ABCC1 is not dependent on cholesterol or cholesterol-stabilized lipid rafts

Peter Meszaros, Karin Klappe, Ina Hummel, Dick Hoekstra, Jan Willem Kok

Biochem J (2011) 437 (3): 483–491.

https://doi.org/10.1042/BJ20110427

Published: 13 July 2011

...Peter Meszaros; Karin Klappe; Ina Hummel; Dick Hoekstra; Jan Willem Kok MRP1 (multidrug-resistance-related protein 1)/ABCC1 (ATP-binding cassette transporter C1) has been localized in cholesterol-enriched lipid rafts, which suggests a role for these lipid rafts and/or cholesterol in MRP1 function...

View articletitled, Function of MRP1/ABCC1 is not dependent on cholesterol or cholesterol-stabilized lipid rafts

Includes: Supplementary data

Articles

Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event

Catherine A. Parr-Sturgess, David J. Rushton, Edward T. Parkin

Biochem J (2010) 432 (2): 283–294.

https://doi.org/10.1042/BJ20100321

Published: 12 November 2010

... the possibility of bi-directional cell–cell Notch signalling. In the present study we have unequivocally identified the sheddase responsible for shedding Jagged1 as ADAM17, the activity of which has previously been shown to be localized within specialized microdomains of the cell membrane known as ‘lipid rafts...

View articletitled, Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event

Includes: Supplementary data

Articles

Light on fluorescent lipids in rafts: a lesson from model membranes

Nicoletta Kahya

Biochem J (2010) 430 (3): e7–e9.

https://doi.org/10.1042/BJ20101196

Published: 27 August 2010

...Nicoletta Kahya Tracking fluorescent lipids in cellular membranes has been applied for decades to shed light on membrane trafficking, sorting, endocytosis and exocytosis, viral entry, and to understand the functional relevance of membrane heterogeneity, phase separation and lipid rafts. However...

View articletitled, Light on fluorescent lipids in rafts: a lesson from model membranes

Articles

Fluorescent probe partitioning in giant unilamellar vesicles of ‘lipid raft’ mixtures

Janos Juhasz, James H. Davis, Frances J. Sharom

Biochem J (2010) 430 (3): 415–423.

https://doi.org/10.1042/BJ20100516

Published: 27 August 2010

... Journal compilation © 2010 Biochemical Society 2010 confocal fluorescence microscopy fluorescent probe giant unilamellar vesicle lipid raft liquid-ordered phase partitioning The number of fluorescence probes used for imaging membrane domains is steadily increasing [ 17 – 19 ]. However...

View articletitled, Fluorescent probe partitioning in giant unilamellar vesicles of ‘lipid raft’ mixtures

Includes: Supplementary data

Articles

Co-segregation of AMPA receptors with G M1 ganglioside in synaptosomal membrane subfractions

Andy A. Cole, Ayse Dosemeci, Thomas S. Reese

Biochem J (2010) 427 (3): 535–540.

https://doi.org/10.1042/BJ20091344

Published: 14 April 2010

...Andy A. Cole; Ayse Dosemeci; Thomas S. Reese Biochemical studies have suggested that certain synaptic proteins associate with lipid rafts to perform key functions within the synapse. However, variability in biochemical preparations raises questions as to which synaptic proteins actually associate...

View articletitled, Co-segregation of AMPA receptors with G M1 ganglioside in synaptosomal membrane subfractions

Articles

Vimentin-mediated signalling is required for IbeA+ E. coli K1 invasion of human brain microvascular endothelial cells

Feng Chi, Timothy D. Jong, Lin Wang, Yannan Ouyang, Chunhua Wu, Wei Li, Sheng-He Huang

Biochem J (2010) 427 (1): 79–90.

https://doi.org/10.1042/BJ20091097

Published: 15 March 2010

... and inhibition of ERK1/2 phosphorylation by PD098059 resulted in reduced IbeA+ E. coli invasion. Fourthly, IbeA+ E. coli and IbeA-coated beads induced the clustering of vimentin that was correlated with increased entry of bacteria and beads. Lastly, IbeA+ E. coli K1 invasion was inhibited by lipid-raft...

View articletitled, Vimentin-mediated signalling is required for IbeA+ E. coli K1 invasion of human brain microvascular endothelial cells

Includes: Supplementary data

Articles

Doppel and PrP C co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells

Anna Caputo, Daniela Sarnataro, Vincenza Campana, Maddalena Costanzo, Alessandro Negro, M. Catia Sorgato, Chiara Zurzolo

Biochem J (2010) 425 (2): 341–351.

https://doi.org/10.1042/BJ20091050

Published: 23 December 2009

.... We show that both proteins localize prevalently on the basolateral surface of FRT cells, in both singly and doubly transfected clones. Interestingly we found that they associate with DRMs (detergent-resistant membranes) or lipid rafts, from where they can be co-immunoprecipitated in a cholesterol...

View articletitled, Doppel and PrP C co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells

Includes: Supplementary data

Articles

Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency

Wim J. van Blitterswijk, Jeffrey B. Klarenbeek, Arnold H. van der Luit, Maaike C. Alderliesten, Menno van Lummel, Marcel Verheij

Biochem J (2010) 425 (1): 225–236.

https://doi.org/10.1042/BJ20090455

Published: 14 December 2009

... line, S49 AR , made resistant to ALP, was found previously to be impaired in ALP uptake via lipid-raft-mediated endocytosis. In the present paper, we report that these cells display cross-resistance to Fas/CD95 ligation [FasL (Fas ligand)], and can be gradually resensitized by prolonged culturing...

View articletitled, Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency

Includes: Supplementary data

Articles

Cholesterol-dependent phase separation in cell-derived giant plasma-membrane vesicles

Ilya Levental, Fitzroy J. Byfield, Pramit Chowdhury, Feng Gai, Tobias Baumgart, Paul A. Janmey

Biochem J (2009) 424 (2): 163–167.

https://doi.org/10.1042/BJ20091283

Published: 11 November 2009

... [email protected] ). 17 8 2009 28 9 2009 7 10 2009 7 10 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 giant plasma-membrane vesicle (GPMV) lipid raft liquid ordered Several lines of evidence, including the identification [ 1...

View articletitled, Cholesterol-dependent phase separation in cell-derived giant plasma-membrane vesicles

Includes: Supplementary data

Articles

Biomembrane liquid–liquid phase separation and detergent resistance: a relationship strengthened

David Holowka

Biochem J (2009) 424 (2): e5–e6.

https://doi.org/10.1042/BJ20091623

Published: 11 November 2009

...David Holowka Since evidence first appeared for ‘detergent-resistant membranes’ in the early to mid-1990s, cell biologists from a wide spectrum of biological sciences have been intrigued by the functional relevance of this indication of membrane heterogeneity, commonly referred to as ‘lipid rafts...

View articletitled, Biomembrane liquid–liquid phase separation and detergent resistance: a relationship strengthened

Articles

Urokinase-receptor-mediated phenotypic changes in vascular smooth muscle cells require the involvement of membrane rafts

Julia Kiyan, Graham Smith, Hermann Haller, Inna Dumler

Biochem J (2009) 423 (3): 343–351.

https://doi.org/10.1042/BJ20090447

Published: 12 October 2009

...Julia Kiyan; Graham Smith; Hermann Haller; Inna Dumler The cholesterol-enriched membrane microdomains lipid rafts play a key role in cell activation by recruiting and excluding specific signalling components of cell-surface receptors upon receptor engagement. Our previous studies have demonstrated...

View articletitled, Urokinase-receptor-mediated phenotypic changes in vascular smooth muscle cells require the involvement of membrane rafts

Articles

Plasma membrane microdomains from hybrid aspen cells are involved in cell wall polysaccharide biosynthesis

Laurence Bessueille, Nicolas Sindt, Michel Guichardant, Soraya Djerbi, Tuula T. Teeri, Vincent Bulone

Biochem J (2009) 420 (1): 93–103.

https://doi.org/10.1042/BJ20082117

Published: 28 April 2009

..., such as signal transduction, endocytosis and protein trafficking, have been attributed to plant lipid rafts and DRMs. The data available are essentially based on proteomics and more approaches need to be undertaken to elucidate the precise function of individual populations of DRMs in plants. We report here...

View articletitled, Plasma membrane microdomains from hybrid aspen cells are involved in cell wall polysaccharide biosynthesis

Includes: Supplementary data

Articles

Isolation at physiological temperature of detergent-resistant membranes with properties expected of lipid rafts: the influence of buffer composition

Xi Chen, Angela Jen, Alice Warley, M. Jayne Lawrence, Peter J. Quinn, Roger J. Morris

Biochem J (2009) 417 (2): 525–533.

https://doi.org/10.1042/BJ20081385

Published: 23 December 2008

... raft non-ionic detergent prion protein Thy-1 Lipid rafts are postulated to be nanodomains within the cell-surface membrane, formed by local condensation of cholesterol with saturated lipids to form distinct patches of L o (liquid ordered) phase within the general fluid ‘sea’ of L d (liquid...

View articletitled, Isolation at physiological temperature of detergent-resistant membranes with properties expected of lipid rafts: the influence of buffer composition

Includes: Supplementary data

Articles

Fucoganglioside α-fucosyl(α-galactosyl)-G M1 : a novel member of lipid membrane microdomain components involved in PC12 cell neuritogenesis

Yasuhiro Yamazaki, Yasuhiro Horibata, Yasuko Nagatsuka, Yoshio Hirabayashi, Tsutomu Hashikawa

Biochem J (2007) 407 (1): 31–40.

https://doi.org/10.1042/BJ20070090

Published: 12 September 2007

... ganglioside G M1a lipid raft neuritogenesis Src family kinase Gangliosides, sialic acid-containing GSLs (glycosphingolipids), are ubiquitously expressed in eukaryotic cells and are mainly found in the outer leaflet of the plasma membrane [ 1 ]. Previous studies have proposed that they form...

View articletitled, Fucoganglioside α-fucosyl(α-galactosyl)-G M1 : a novel member of lipid membrane microdomain components involved in PC12 cell neuritogenesis

Articles

Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains

Gonzalo P. Solis, Maja Hoegg, Christina Munderloh, Yvonne Schrock, Edward Malaga-Trillo, Eric Rivera-Milla, Claudia A. O. Stuermer

Biochem J (2007) 403 (2): 313–322.

https://doi.org/10.1042/BJ20061686

Published: 26 March 2007

...: Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1. 9 11 2006 20 12 2006 5 1 2007 5 1 2007 The Biochemical Society, London 2007 cross-linking flotillin lipid raft membrane microdomain...

View articletitled, Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains

Includes: Supplementary data

Articles

Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts

Arnold H. Van der Luit, Marianne Budde, Shuraila Zerp, Wendy Caan, Jeffrey B. Klarenbeek, Marcel Verheij, Wim J. van Blitterswijk

Biochem J (2007) 401 (2): 541–549.

https://doi.org/10.1042/BJ20061178

Published: 21 December 2006

.... To this end, ALP is internalized by lipid raft-dependent endocytosis and inhibits phosphatidylcholine synthesis. A variant cell-line, S49 AR , which is resistant to ALP, was shown previously to be unable to internalize ALP via this lipid raft pathway. The reason for this uptake failure is not understood...

View articletitled, Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts

Articles

Spatial segregation of transport and signalling functions between human endothelial caveolae and lipid raft proteomes

Richard R. Sprenger, Ruud D. Fontijn, Jan van Marle, Hans Pannekoek, Anton J. G. Horrevoets

Biochem J (2006) 400 (3): 401–410.

https://doi.org/10.1042/BJ20060355

Published: 28 November 2006

...Richard R. Sprenger; Ruud D. Fontijn; Jan van Marle; Hans Pannekoek; Anton J. G. Horrevoets Lipid rafts and caveolae are biochemically similar, specialized domains of the PM (plasma membrane) that cluster specific proteins. However, they are morphologically distinct, implying different, possibly...

View articletitled, Spatial segregation of transport and signalling functions between human endothelial caveolae and lipid raft proteomes

Articles

A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia

Tamara Roitbak, Zurab Surviladze, Ritva Tikkanen, Angela Wandinger-Ness

Biochem J (2005) 392 (1): 29–38.

https://doi.org/10.1042/BJ20050645

Published: 08 November 2005

... propose that the polycystin multiprotein complex is embedded in a cholesterol-containing signalling microdomain specified by flotillin-2, which is distinct from classical light-buoyant-density, detergent-resistant domains. Recent investigations determined a possible association between lipid rafts...

View articletitled, A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia

Includes: Supplementary data

Articles

Defective insulin receptor activation and altered lipid rafts in Niemann–Pick type C disease hepatocytes

Saara Vainio, Igor Bykov, Martin Hermansson, Eija Jokitalo, Pentti Somerharju, Elina Ikonen

Biochem J (2005) 391 (3): 465–472.

https://doi.org/10.1042/BJ20050460

Published: 25 October 2005

... in the plasma membrane, alters the properties of lipid rafts and interferes with the function of a raft-associated plasma-membrane receptor. Such a mechanism may participate in the pathogenesis of NPC disease and contribute to insulin resistance in other disorders of lipid metabolism. Cells were serum-starved...

View articletitled, Defective insulin receptor activation and altered lipid rafts in Niemann–Pick type C disease hepatocytes

Articles

Ras plasma membrane signalling platforms

John F. HANCOCK, Robert G. PARTON

Biochem J (2005) 389 (1): 1–11.

https://doi.org/10.1042/BJ20050231

Published: 21 June 2005

.... Muncke, R. G. Parton and J. F. Hancock, unpublished work). The clustering of H-rasG12V and K-rasG12V is insensitive to acute cholesterol depletion, indicating that neither domain is a classical lipid raft [ 28 ]. The minimal membrane anchor of H-ras targets GFP (GFP–tH) and mRFP (mRFP–tH) to cholesterol...

View articletitled, Ras plasma membrane signalling platforms

Articles

Rho GTPases and leucocyte-induced endothelial remodelling

Jaime MILLÁN, Anne J. RIDLEY

Biochem J (2005) 385 (2): 329–337.

https://doi.org/10.1042/BJ20041584

Published: 07 January 2005

... (ICAM-1) lipid raft transmigration vascular cell adhesion molecule-1 (VCAM-1) VE-cadherin Leucocytes need to cross the endothelium in order to enter tissues during inflammatory and immune responses [ 1 , 2 ]. Leucocyte TEM (trans-endothelial migration; also known as extravasation...

View articletitled, Rho GTPases and leucocyte-induced endothelial remodelling

Articles

Targeting of Helicobacter pylori vacuolating toxin to lipid raft membrane domains analysed by atomic force microscopy

Nicholas A. GEISSE, Timothy L. COVER, Robert M. HENDERSON, J. Michael EDWARDSON

Biochem J (2004) 381 (3): 911–917.

https://doi.org/10.1042/BJ20031719

Published: 27 July 2004

... becomes associated with detergent-resistant membranes, indicating that it binds preferentially to lipid rafts. In the present study, we have used atomic force microscopy to examine directly the association of VacA with lipid domains in supported lipid bilayers. VacA did not bind to lipid bilayers at pH...

View articletitled, Targeting of Helicobacter pylori vacuolating toxin to lipid raft membrane domains analysed by atomic force microscopy

Articles

Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells

Ryan R. McWILLIAMS, Elizabeth GIDEY, Laura FOUASSIER, Scott A. WEED, R. Brian DOCTOR

Biochem J (2004) 380 (1): 181–191.

https://doi.org/10.1042/bj20031577

Published: 15 May 2004

... and detergent solubility studies revealed Shank2E complexed with actin and co-distributed with actin in detergent-insoluble lipid rafts. These findings indicate epithelial cells express an ankyrin repeat-containing Shank2 isoform, termed Shank2E, that is poised to co-ordinate actin-dependent events...

View articletitled, Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells

Articles

Effect of glycosylphosphatidylinositol (GPI)-phospholipase D overexpression on GPI metabolism

Karl J. MANN, Matthew R. HEPWORTH, Nandita S. RAIKWAR, Mark A. DEEG, Daniel SEVLEVER

Biochem J (2004) 378 (2): 641–648.

https://doi.org/10.1042/bj20031326

Published: 01 March 2004

... to occur early in the secretory pathway and, in agreement with this proposal, GPI-PLD activity in GPI-PLD-HeLa cells was detected not only in the endoplasmic reticulum and Golgi apparatus, but also in the plasma membrane. The enzyme was also active in lipid rafts, membrane microdomains in which GPI...

View articletitled, Effect of glycosylphosphatidylinositol (GPI)-phospholipase D overexpression on GPI metabolism

Articles

Lipid rafts: heterogeneity on the high seas

Linda J. PIKE

Biochem J (2004) 378 (2): 281–292.

https://doi.org/10.1042/bj20031672

Published: 01 March 2004

...Linda J. PIKE Lipid rafts are membrane microdomains that are enriched in cholesterol and glycosphingolipids. They have been implicated in processes as diverse as signal transduction, endocytosis and cholesterol trafficking. Recent evidence suggests that this diversity of function is accompanied...

View articletitled, Lipid rafts: heterogeneity on the high seas

Articles

Human scavenger receptor class B type II (SR-BII) and cellular cholesterol efflux

Jane V. MULCAHY, Dave R. RIDDELL, James S. OWEN

Biochem J (2004) 377 (3): 741–747.

https://doi.org/10.1042/bj20030307

Published: 01 February 2004

... should be addressed (e-mail [email protected] ). 25 2 2003 12 9 2003 21 10 2003 21 10 2003 The Biochemical Society, London ©2004 2004 caveolae cholesteryl ester intracellular signalling lipid raft scavenger receptor class B type I Src homology 3 (SH3...

View articletitled, Human scavenger receptor class B type II (SR-BII) and cellular cholesterol efflux

Articles

Deep-apical tubules: dynamic lipid-raft microdomains in the brush-border region of enterocytes

Gert H. HANSEN, Jens PEDERSEN, Lise-Lotte NIELS-CHRISTIANSEN, Lissi IMMERDAL, E. Michael DANIELSEN

Biochem J (2003) 373 (1): 125–132.

https://doi.org/10.1042/bj20030235

Published: 01 July 2003

...Gert H. HANSEN; Jens PEDERSEN; Lise-Lotte NIELS-CHRISTIANSEN; Lissi IMMERDAL; E. Michael DANIELSEN The brush border of small intestinal enterocytes is highly enriched in cholesterol- and glycosphingolipid-containing membrane microdomains, commonly termed as lipid ‘rafts’. Functionally, transcytosis...

View articletitled, Deep-apical tubules: dynamic lipid-raft microdomains in the brush-border region of enterocytes

Articles

Organization on the plasma membrane of the retinitis pigmentosa protein RP2: investigation of association with detergent-resistant membranes and polarized sorting

J. Paul CHAPPLE, Celene GRAYSON, Alison J. HARDCASTLE, Tracey A. BAILEY, Karl MATTER, Peter ADAMSON, Catriona H. GRAHAM, Keith R. WILLISON, Michael E. CHEETHAM

Biochem J (2003) 372 (2): 427–433.

https://doi.org/10.1042/bj20021475

Published: 01 June 2003

... of unknown function, which is targeted to the plasma membrane by dual N-terminal acyl-modification. Dual-acylated proteins are targeted to lipid rafts, and some are subject to polarized sorting. Therefore we investigated the organization of RP2 on the plasma membrane. Endogenous RP2 protein was predominantly...

View articletitled, Organization on the plasma membrane of the retinitis pigmentosa protein RP2: investigation of association with detergent-resistant membranes and polarized sorting

Articles

Ceramide: second messenger or modulator of membrane structure and dynamics?

Wim J. van BLITTERSWIJK, Arnold H. van der LUIT, Robert Jan VELDMAN, Marcel VERHEIJ, Jannie BORST

Biochem J (2003) 369 (2): 199–211.

https://doi.org/10.1042/bj20021528

Published: 15 January 2003

... part in a metabolic flux towards sphingomyelin, diacylglycerol and glycosphingolipids, which drives lipid raft formation and vesicular transport towards the plasma membrane. At the cell surface, receptor clustering in lipid rafts and the formation of endosomes can be facilitated by transient ceramide...

View articletitled, Ceramide: second messenger or modulator of membrane structure and dynamics?

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