... biomolecular target for treatments of Alzheimer's disease (AD). We describe the engineering of cognate Anticalins as a novel type of neutralizing protein reagent based on the human lipocalin scaffold. Phage display selection from a genetic random library comprising variants of the human lipocalin 2 (Lcn2...

...Winfried Meining; Arne Skerra We describe the 2.3 Å (1 Å=0.1 nm) X-ray structure of α 1 m (α 1 -microglobulin), an abundant protein in human blood plasma, which reveals the β-barrel fold typical for lipocalins with a deep pocket lined by four loops at its open rim. Loop #1 harbours the residue Cys...

...Ayano Fukuhara; Mao Yamada; Ko Fujimori; Yuya Miyamoto; Toshihide Kusumoto; Hidemitsu Nakajima; Takashi Inui L-PGDS [lipocalin-type PGD (prostaglandin D) synthase] is a dual-functional protein, acting as a PGD 2 -producing enzyme and a lipid transporter. L-PGDS is a member of the lipocalin...

...Chacko Jobichen; Aaron Z. Fernandis; Adrian Velazquez-Campoy; Ka Yin Leung; Yu-Keung Mok; Markus R. Wenk; J. Sivaraman Lipocalins are a broad family of proteins identified initially in eukaryotes and more recently in Gram-negative bacteria. The functions of lipocalin or lipid-binding proteins...

...Randall P. Watson; Jerome Demmer; Edward N. Baker; Vickery L. Arcus Lipocalins are extracellular proteins (17–25 kDa) that bind and transport small lipophilic molecules. The three-dimensional structure of the first lipocalin from a metatherian has been determined at different values of pH both...

...Wang-Kai Fang; Li-Yan Xu; Xiao-Feng Lu; Lian-Di Liao; Wei-Jia Cai; Zhong-Ying Shen; En-Min Li Recent studies suggest that NGAL (neutrophil gelatinase-associated lipocalin) is a novel iron transporter with functions distinct from that of transferrin and mediates a new iron-delivery pathway. To get...

... reading frame. The deduced protein corresponds to Lopap, a prothrombin activator previously isolated by our group from the bristles of this species. The mature protein is composed by 185 amino acids and shares similarity with members of the lipocalin family. The cDNA encoding the mature form was amplified...

... study, a possible role of 24p3, a lipocalin, in MK886-induced apoptosis was investigated. Exposure of murine prolymphoid progenitor cells (FL5.12) to 20 μM MK886 for 16 h dramatically increased 24p3 mRNA and protein expression. Induction could also be achieved with another FLAP inhibitor, MK591...

...Manickavasagam SUNDARAM; Daan M. F. van AALTEN; John B. C. FINDLAY; Asipu SIVAPRASADARAO Members of the lipocalin superfamily share a common structural fold, but differ from each other with respect to the molecules with which they interact. They all contain eight β-strands (A—H) that fold to form...