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Keywords: lipogenesis
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Biochem J (2021) 478 (20): 3723–3739.
Published: 21 October 2021
... ) 25 6 2021 28 9 2021 30 9 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 endoplasmic reticulum stress hepatic physiology insulin resistance insulin signalling lipogenesis sterol regulatory element-binding proteins...
Biochem J (2021) 478 (15): 2977–2997.
Published: 10 August 2021
... in multiple cell types, including hepatocytes, skeletal muscle cells and adipocytes. We observed SBI-0206965 dose dependently attenuated AMPK activator (991)-stimulated ACC phosphorylation and inhibition of lipogenesis in hepatocytes. SBI-0206965 (≥25 μM) modestly inhibited AMPK signalling in C2C12 myotubes...
Includes: Supplementary data
Biochem J (2020) 477 (8): 1373–1389.
Published: 23 April 2020
...Nusrat Hussain; Sheng-Ju Chuang; Manuel Johanns; Didier Vertommen; Gregory R. Steinberg; Bruce E. Kemp; Mark H. Rider We investigated acute effects of two allosteric protein kinase B (PKB) inhibitors, MK-2206 and Akti-1/2, on insulin-stimulated lipogenesis in rat epididymal adipocytes incubated...
Includes: Supplementary data
Biochem J (2013) 451 (1): 1–12.
Published: 14 March 2013
... fatty acid synthesis diacylglycerol acyltransferase heart hypertriglyceridaemia intestine lipogenesis liver muscle TAGs (triacylglycerols; also known as triglycerides) perform multiple functions in mammalian cells and in the traffic of substrates between tissues. They are a major source...
Biochem J (2012) 446 (3): 415–425.
Published: 28 August 2012
...Guohui Wang; Xuebao Zhang; Jin-Sook Lee; Xiaogang Wang; Zeng-Quan Yang; Kezhong Zhang Increased de novo lipogenesis is a hallmark of aggressive cancers. Lipid droplets, the major form of cytosolic lipid storage, have been implicated in cancer cell proliferation and tumorigenesis. Recently, we...
Includes: Supplementary data
Biochem J (2011) 440 (3): 301–308.
Published: 28 November 2011
... hepatocytes (5%) and for lipogenesis in rat adipocytes (4%). In contrast, the INS-B analogue, which has an increased affinity for human IR-B, had higher relative potencies (compared with HI) for inducing glycogen accumulation (75%) and lipogenesis (130%) than for affecting muscle (45%). For the same blood...
Biochem J (2011) 439 (1): 27–38.
Published: 14 September 2011
.../EBPα (CCAAT/enhancer-binding protein α) and accelerate lipogenesis accompanied with increased GLUT (glucose transporter) 1 and GLUT4. CREBL2 knockdown restrained adipogenic conversion and lipogenesis. Additionally, depletion of CREB could completely block the effects of overexpressed CREBL2, whereas...
Includes: Supplementary data
Biochem J (2009) 420 (3): 429–438.
Published: 27 May 2009
... of lipogenesis stimulated by glucose and insulin. Moreover, CPT1A sensitivity to malonyl-CoA inhibition varies markedly depending on the physiopathological state of the animal. In the present study, we asked whether an increase in CPT1A activity solely or in association with a decreased malonyl-CoA sensitivity...
Includes: Supplementary data
Biochem J (2009) 417 (2): 561–571.
Published: 23 December 2008
... called E-boxes within their promoter regions [ 15 , 16 ]. Moreover, it has been reported that PUFA regulate the nuclear abundance of SREBP-1 [ 17 – 19 ]. Given the importance of CiC as a key step in lipogenesis and due to the poor knowledge about the transcriptional regulation of Cic gene, we decided...
Biochem J (2003) 375 (2): 489–501.
Published: 15 October 2003
... chromatin immunoprecipitation lactation lipogenesis STAT5 Abbreviations used: ACC, acetyl-CoA carboxylase; ADD1, adipocyte determination and differentiation-dependent factor 1; bHLH-ZIP, basic helix–loop–helix-leucine zipper; ChIP, chromatin immunoprecipitation; EMSA, electrophoretic mobility...
Biochem J (2002) 364 (2): 361–368.
Published: 01 June 2002
...Mary C. SUGDEN; Karen BULMER; Geoffrey F. GIBBONS; Brian L. KNIGHT; Mark J. HOLNESS The aim of the present study was to determine whether peroxisome-proliferator-activated receptor-α (PPARα) deficiency disrupts the normal regulation of triacylglycerol (TAG) accumulation, hepatic lipogenesis...
Biochem J (2002) 361 (2): 391–400.
Published: 08 January 2002
... 7 2001 22 10 2001 13 11 2001 The Biochemical Society, London ©2002 2002 enhanceosome fatty acid synthesis lipogenesis nuclear T3 receptor orphan receptor Abbreviations used: CEH, chick embryo hepatocytes; CEF, chick embryo fibroblasts; CAT, chloramphenicol...
Biochem J (2001) 359 (2): 273–284.
Published: 08 October 2001
.... 9 3 2001 2 7 2001 7 8 2001 The Biochemical Society, London ©2001 2001 adipose tissue HepG2 cells insulin signalling lipogenesis preadipocyte Abbreviations used: ACC-α, acetyl-CoA carboxylase-α; BAC, bacterial artificial chromosome; bHLH, basic helix-loop-helix; C...
Biochem J (2001) 358 (1): 175–183.
Published: 08 August 2001
...@medecine.univ-mrs.fr ). 20 3 2001 17 5 2001 11 6 2001 The Biochemical Society, London ©2001 2001 glucose glycolysis hepatocytes lipogenesis Abbreviations used: ACC, acetyl-CoA carboxylase; COUP-TF1, chicken ovalbumin upstream promoter-transcription factor 1; hCOUP-TF1...
Biochem J (2001) 357 (3): 899–904.
Published: 25 July 2001
... transcription glucose DNA regulatory sequences lipogenesis reporter gene Abbreviations used: Ang II, angiotensin II; ADD1, adipocyte determination and differentiation factor 1; CAT, chloramphenicol acetyltransferase; E box, insulin-responsive region; FAS, fatty acid synthase; IRE, insulin...
Biochem J (1999) 344 (3): 873–880.
Published: 08 December 1999
... cells were exposed to lipolytic and anti-lipogenic agents, forskolin and isoproterenol. Taken together, our data show that Id products are functionally involved in modulating ADD1/SREBP-1c transcriptional activity, and thus lipogenesis in adipocytes. 1 To whom correspondence should be addressed...
Biochem J (1999) 341 (2): 371–376.
Published: 08 July 1999
... of antioxidants must be interpretated cautiously and (ii) that in vivo , the inhibitory effect of PUFA on lipogenesis-related genes could be indirect through hormonal or metabolic changes or that their effect on gene expression is somehow linked to peroxidative mechanisms. 1 To whom correspondence should...
Biochem J (1999) 340 (1): 1–16.
Published: 10 May 1999
... in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitter substances, and in glucose-induced insulin secretion by pancreatic islets. The reaction catalysed by PC and the physical properties of the enzyme have been studied extensively. Although no high-resolution three-dimensional structure has yet...