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1-19 of 19
Keywords: lipogenesis
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Articles
Sophia Bustraan, Jane Bennett, Chad Whilding, Betheney R. Pennycook, David Smith, Alexis R. Barr, Jon Read, David Carling, Alice Pollard
Journal:
Biochemical Journal
Biochem J (2024) 481 (5): 345–362.
Published: 23 February 2024
... the contribution of the repression of lipogenesis by AMPK in these processes, we compared the effect of pharmacological inhibition of acetyl-CoA carboxylase (ACC). We show that AMPK activation inhibits adipogenesis in a time- and concentration-dependent manner. Transient AMPK activation during adipogenic...
Includes: Supplementary data
Articles
SREBP-1c and lipogenesis in the liver: an update
Available to PurchaseIn Collection
Celebrating 100 years of insulin research
Journal:
Biochemical Journal
Biochem J (2021) 478 (20): 3723–3739.
Published: 21 October 2021
... stress hepatic physiology insulin resistance insulin signalling lipogenesis sterol regulatory element-binding proteins In 2002, we wrote a review in the Biochemical Journal on the importance of the transcription factor Sterol Regulatory Element Binding Protein-1c (SREBP-1c...
Articles
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965
Open AccessDanial Ahwazi, Katyayanee Neopane, Greg R. Markby, Franziska Kopietz, Ashley J. Ovens, Morten Dall, Anna S. Hassing, Pamina Gräsle, Yazeed Alshuweishi, Jonas T. Treebak, Ian P. Salt, Olga Göransson, Elton Zeqiraj, John W. Scott, Kei Sakamoto
Journal:
Biochemical Journal
Biochem J (2021) 478 (15): 2977–2997.
Published: 10 August 2021
... in multiple cell types, including hepatocytes, skeletal muscle cells and adipocytes. We observed SBI-0206965 dose dependently attenuated AMPK activator (991)-stimulated ACC phosphorylation and inhibition of lipogenesis in hepatocytes. SBI-0206965 (≥25 μM) modestly inhibited AMPK signalling in C2C12 myotubes...
Includes: Supplementary data
Articles
Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue
Available to PurchaseNusrat Hussain, Sheng-Ju Chuang, Manuel Johanns, Didier Vertommen, Gregory R. Steinberg, Bruce E. Kemp, Mark H. Rider
Journal:
Biochemical Journal
Biochem J (2020) 477 (8): 1373–1389.
Published: 23 April 2020
...Nusrat Hussain; Sheng-Ju Chuang; Manuel Johanns; Didier Vertommen; Gregory R. Steinberg; Bruce E. Kemp; Mark H. Rider We investigated acute effects of two allosteric protein kinase B (PKB) inhibitors, MK-2206 and Akti-1/2, on insulin-stimulated lipogenesis in rat epididymal adipocytes incubated...
Includes: Supplementary data
Articles
Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2013) 451 (1): 1–12.
Published: 14 March 2013
... fatty acid synthesis diacylglycerol acyltransferase heart hypertriglyceridaemia intestine lipogenesis liver muscle TAGs (triacylglycerols; also known as triglycerides) perform multiple functions in mammalian cells and in the traffic of substrates between tissues. They are a major source...
Articles
Endoplasmic reticulum factor ERLIN2 regulates cytosolic lipid content in cancer cells
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2012) 446 (3): 415–425.
Published: 28 August 2012
...Guohui Wang; Xuebao Zhang; Jin-Sook Lee; Xiaogang Wang; Zeng-Quan Yang; Kezhong Zhang Increased de novo lipogenesis is a hallmark of aggressive cancers. Lipid droplets, the major form of cytosolic lipid storage, have been implicated in cancer cell proliferation and tumorigenesis. Recently, we...
Includes: Supplementary data
Articles
Receptor-isoform-selective insulin analogues give tissue-preferential effects
Available to PurchaseSara G. Vienberg, Stephan D. Bouman, Heidi Sørensen, Carsten E. Stidsen, Thomas Kjeldsen, Tine Glendorf, Anders R. Sørensen, Grith S. Olsen, Birgitte Andersen, Erica Nishimura
Journal:
Biochemical Journal
Biochem J (2011) 440 (3): 301–308.
Published: 28 November 2011
... hepatocytes (5%) and for lipogenesis in rat adipocytes (4%). In contrast, the INS-B analogue, which has an increased affinity for human IR-B, had higher relative potencies (compared with HI) for inducing glycogen accumulation (75%) and lipogenesis (130%) than for affecting muscle (45%). For the same blood...
Articles
CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2011) 439 (1): 27–38.
Published: 14 September 2011
.../EBPα (CCAAT/enhancer-binding protein α) and accelerate lipogenesis accompanied with increased GLUT (glucose transporter) 1 and GLUT4. CREBL2 knockdown restrained adipogenic conversion and lipogenesis. Additionally, depletion of CREB could completely block the effects of overexpressed CREBL2, whereas...
Includes: Supplementary data
Articles
Modulation of the hepatic malonyl-CoA–carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids
Available to PurchaseMarie Akkaoui, Isabelle Cohen, Catherine Esnous, Véronique Lenoir, Martin Sournac, Jean Girard, Carina Prip-Buus
Journal:
Biochemical Journal
Biochem J (2009) 420 (3): 429–438.
Published: 27 May 2009
... of lipogenesis stimulated by glucose and insulin. Moreover, CPT1A sensitivity to malonyl-CoA inhibition varies markedly depending on the physiopathological state of the animal. In the present study, we asked whether an increase in CPT1A activity solely or in association with a decreased malonyl-CoA sensitivity...
Includes: Supplementary data
Articles
Functional analysis of rat liver citrate carrier promoter: differential responsiveness to polyunsaturated fatty acids
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2009) 417 (2): 561–571.
Published: 23 December 2008
... and fatty acid synthesis by binding to SREs or to palindromic sequences called E-boxes within their promoter regions [ 15 , 16 ]. Moreover, it has been reported that PUFA regulate the nuclear abundance of SREBP-1 [ 17 – 19 ]. Given the importance of CiC as a key step in lipogenesis and due to the poor...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 375 (2): 489–501.
Published: 15 October 2003
..., which is also induced in lactation. This indicates that SREBP-1 is a major developmental regulator of the programme of lipid synthesis de novo in the lactating mammary gland. Key words: basic helix loop helix, chromatin immunoprecipita- tion, lactation, lipogenesis, STAT5. INTRODUCTION ACC (acetyl-CoA...
Articles
Peroxisome-proliferator-activated receptor-α (PPARα) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2002) 364 (2): 361–368.
Published: 01 June 2002
...Mary C. SUGDEN; Karen BULMER; Geoffrey F. GIBBONS; Brian L. KNIGHT; Mark J. HOLNESS The aim of the present study was to determine whether peroxisome-proliferator-activated receptor-α (PPARα) deficiency disrupts the normal regulation of triacylglycerol (TAG) accumulation, hepatic lipogenesis...
Articles
Chicken ovalbumin upstream-promoter transcription factor and E-box-binding proteins enhance thyroid-hormone responsiveness of the malic enzyme gene in avian hepatocytes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2002) 361 (2): 391–400.
Published: 08 January 2002
... 7 2001 22 10 2001 13 11 2001 The Biochemical Society, London ©2002 2002 enhanceosome fatty acid synthesis lipogenesis nuclear T3 receptor orphan receptor Abbreviations used: CEH, chick embryo hepatocytes; CEF, chick embryo fibroblasts; CAT, chloramphenicol...
Articles
Maureen T. TRAVERS, Amanda J. VALLANCE, Helen T. GOURLAY, Clare A. GILL, Izabella KLEIN, Cynthia B. K. BOTTEMA, Michael C. BARBER
Journal:
Biochemical Journal
Biochem J (2001) 359 (2): 273–284.
Published: 08 October 2001
.... 9 3 2001 2 7 2001 7 8 2001 The Biochemical Society, London ©2001 2001 adipose tissue HepG2 cells insulin signalling lipogenesis preadipocyte Abbreviations used: ACC-α, acetyl-CoA carboxylase-α; BAC, bacterial artificial chromosome; bHLH, basic helix-loop-helix; C...
Articles
Emmanuel COMPE, Georges de SOUSA, Kamel FRANCÇOIS, Régis ROCHE, Roger RAHMANI, Janine TORRESANI, Michel RAYMONDJEAN, Richard PLANELLS
Journal:
Biochemical Journal
Biochem J (2001) 358 (1): 175–183.
Published: 08 August 2001
[email protected] ). 20 3 2001 17 5 2001 11 6 2001 The Biochemical Society, London ©2001 2001 glucose glycolysis hepatocytes lipogenesis Abbreviations used: ACC, acetyl-CoA carboxylase; COUP-TF1, chicken ovalbumin upstream promoter-transcription factor 1; hCOUP-TF1...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 357 (3): 899–904.
Published: 25 July 2001
... transcription glucose DNA regulatory sequences lipogenesis reporter gene Abbreviations used: Ang II, angiotensin II; ADD1, adipocyte determination and differentiation factor 1; CAT, chloramphenicol acetyltransferase; E box, insulin-responsive region; FAS, fatty acid synthase; IRE, insulin...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 344 (3): 873–880.
Published: 08 December 1999
... cells were exposed to lipolytic and anti-lipogenic agents, forskolin and isoproterenol. Taken together, our data show that Id products are functionally involved in modulating ADD1/SREBP-1c transcriptional activity, and thus lipogenesis in adipocytes. 1 To whom correspondence should be addressed...
Articles
Polyunsaturated fatty acids inhibit fatty acid synthase and spot-14-protein gene expression in cultured rat hepatocytes by a peroxidative mechanism
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 341 (2): 371–376.
Published: 08 July 1999
... of antioxidants must be interpretated cautiously and (ii) that in vivo , the inhibitory effect of PUFA on lipogenesis-related genes could be indirect through hormonal or metabolic changes or that their effect on gene expression is somehow linked to peroxidative mechanisms. 1 To whom correspondence should...
Articles
Structure, function and regulation of pyruvate carboxylase
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 340 (1): 1–16.
Published: 10 May 1999
... in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitter substances, and in glucose-induced insulin secretion by pancreatic islets. The reaction catalysed by PC and the physical properties of the enzyme have been studied extensively. Although no high-resolution three-dimensional structure has yet...