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Keywords: liquid–liquid phase separationClose
Journal: Biochemical Journal
Biochem J (2019) 476 (10): 1401–1417.
Published: 21 May 2019
... that K274Q mutation enhanced the oligomerization of tau. The K274Q mutation also strongly decreased the critical concentration for the liquid–liquid phase separation of tau. The oligomeric forms of K274Q-tau were found to be more toxic than wild tau to neuroblastoma cells. Using circular dichroism and...
Includes: Supplementary data