..., our method lent direct evidence to the previous hypothesis that lithium treatment could significantly reduce inositol levels in primary cortical neurons, thus diminishing the pool of free inositol available to the phosphoinositide cycle. Correspondence: Adolfo Saiardi ([email protected]...

... automodification and heteromodification of histones. Analysis of the kinetic parameters revealed that pAp acted as a mixed inhibitor that modulated both the K m and the V max of PARP-1. In addition, we showed that upon treatment with lithium, a very potent inhibitor of the enzyme responsible for pAp recycling...

... the inhibitory and stimulatory responses to lithium exhibited by the two transporters. On the basis of these findings, we propose a role for Asp 471 in controlling cation access to GLYT2 Na + sites, ion coupling during transport and the subsequent conformational changes. 1 Deceased. 2 To whom...

...Ulrike Böer; Julia Eglins; Doris Krause; Susanne Schnell; Christof Schöfl; Willhart Knepel The molecular mechanism of the action of lithium salts in the treatment of bipolar disorder is not well understood. As their therapeutic action requires chronic treatment, adaptive neuronal processes...

.... Both lithium and insulin, which inhibit GSK-3 activity, significantly decrease prion peptide-induced cell death both in primary neuronal cultures and in neuroblastoma cells. Finally, the overexpression of a dominant-negative mutant of GSK-3 in transfected neuroblastoma cells efficiently prevents prion...

... biosynthesis kinetics lithium magnesium Abbreviations used: I-1-P, inositol 1-phosphate; IPS, inositol-1-phosphate synthase; IMP, inositol monophosphatase; PI, phosphatidylinositol; PNPP, p -nitrophenyl phosphate. Biochem. J. (2002) 361, 385 390 (Printed in Great Britain) 385 Characterization...