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Articles

AMPK inhibits liver gluconeogenesis: fact or fiction?

In Collection

Cell signaling in the 21st century

Manuel Johanns, Louis Hue, Mark H. Rider

Biochem J (2023) 480 (1): 105–125.

https://doi.org/10.1042/BCJ20220582

Published: 13 January 2023

...Manuel Johanns; Louis Hue; Mark H. Rider Is there a role for AMPK in the control of hepatic gluconeogenesis and could targeting AMPK in liver be a viable strategy for treating type 2 diabetes? These are frequently asked questions this review tries to answer. After describing properties of AMPK...

View article titled, AMPK inhibits liver gluconeogenesis: fact or fiction?

Articles

Deciphering signal transduction networks in the liver by mechanistic mathematical modelling

In Collection

Towards systems biochemistry

Lorenza A. D’Alessandro, Ursula Klingmüller, Marcel Schilling

Biochem J (2022) 479 (12): 1361–1374.

https://doi.org/10.1042/BCJ20210548

Published: 24 June 2022

...Lorenza A. D’Alessandro; Ursula Klingmüller; Marcel Schilling In health and disease, liver cells are continuously exposed to cytokines and growth factors. While individual signal transduction pathways induced by these factors were studied in great detail, the cellular responses induced by repeated...

View article titled, Deciphering signal transduction networks in the liver by mechanistic mathematical modelling

Articles

Tracking biochemical changes induced by iron loading in AML12 cells with synchrotron live cell, time-lapse infrared microscopy

Clinton J. Kidman, Cyril D.S. Mamotte, M. Adrien Eynaud, Juliane Reinhardt, Jitraporn Vongsvivut, Mark J. Tobin, Mark J. Hackett, Ross M. Graham

Biochem J (2021) 478 (6): 1227–1239.

https://doi.org/10.1042/BCJ20200653

Published: 19 March 2021

... with serious health consequences, including non-alcoholic fatty liver disease (NAFLD). Considered the hepatic manifestation of metabolic syndrome, NAFLD is characterised by dysregulated lipid metabolism leading to a lipid storage phenotype. Mild to moderate increases in hepatic iron have been observed in ∼30...

View article titled, Tracking biochemical changes induced by iron loading in AML12 cells with synchrotron live cell, time-lapse infrared microscopy

Includes: Multimedia, Supplementary data

Articles

Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier

Jonathan J. Kopel, Yangzom D. Bhutia, Sathish Sivaprakasam, Vadivel Ganapathy

Biochem J (2021) 478 (3): 463–486.

https://doi.org/10.1042/BCJ20200877

Published: 05 February 2021

... in citrate entry into cells via the transporter. These findings raise doubts as to the utility of mouse models to evaluate NaCT biology in humans. NaCT-mediated citrate entry in the liver impacts fatty acid and cholesterol synthesis, fatty acid oxidation, glycolysis, and gluconeogenesis; in neurons...

View article titled, Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier

Articles

RORα phosphorylation by casein kinase 1α as glucose signal to regulate estrogen sulfation in human liver cells

Hao Hu, Masahiko Negishi

Biochem J (2020) 477 (18): 3583–3598.

https://doi.org/10.1042/BCJ20200427

Published: 28 September 2020

...Hao Hu; Masahiko Negishi Estrogen sulfotransferase (SULT1E1) metabolically inactivates estrogen and SULT1E1 expression is tightly regulated by multiple nuclear receptors. Human fetal, but not adult, livers express appreciable amounts of SULT1E1 protein, which is mimicked in human hepatoma-derived...

View article titled, RORα phosphorylation by casein kinase 1α as glucose signal to regulate estrogen sulfation in human liver cells

Includes: Supplementary data

Articles

Differential reduction in cardiac and liver monolysocardiolipin acyltransferase-1 and reduction in cardiac and liver tetralinoleoyl-cardiolipin in the α-subunit of trifunctional protein heterozygous knockout mice

Edgard M. Mejia, Jamal A. Ibdah, Genevieve C. Sparagna, Grant M. Hatch

Biochem J (2015) 471 (1): 123–129.

https://doi.org/10.1042/BJ20150648

Published: 21 September 2015

...Edgard M. Mejia; Jamal A. Ibdah; Genevieve C. Sparagna; Grant M. Hatch The contribution of α-subunit of trifunctional protein (αTFP) to cardiolipin (CL) (diphosphatidylglycerol) remodelling and mitochondrial supercomplex formation was examined in heart and liver mitochondria from wild-type (WT...

View article titled, Differential reduction in cardiac and liver monolysocardiolipin acyltransferase-1 and reduction in cardiac and liver tetralinoleoyl-cardiolipin in the α-subunit of trifunctional protein heterozygous knockout mice

Articles

Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver

David J. McGarry, Wenzhang Chen, Probir Chakravarty, Douglas L. Lamont, C. Roland Wolf, Colin J. Henderson

Biochem J (2015) 469 (1): 25–32.

https://doi.org/10.1042/BJ20141256

Published: 19 June 2015

... with tandem mass tagging to provide precise, extensive coverage of S-glutathionylated targets in mouse liver. Critically, we show significant enrichment of S-glutathionylated mitochondrial and Krebs cycle proteins, identifying that S-glutathionylation is heavily involved in energy metabolism processes in vivo...

View article titled, Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver

Includes: Supplementary data

Articles

Metabolomic profiling in liver of adiponectin-knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action

Ying Liu, Sanjana Sen, Sivaporn Wannaiampikul, Rengasamy Palanivel, Ruby L. C. Hoo, Ruth Isserlin, Gary D. Bader, Rungsunn Tungtrongchitr, Yves Deshaies, Aimin Xu, Gary Sweeney

Biochem J (2015) 469 (1): 71–82.

https://doi.org/10.1042/BJ20141455

Published: 19 June 2015

.... In the present study, we conducted a comprehensive and unbiased metabolomic profiling of liver tissue from AdKO (adiponectin-knockout) mice, with and without adiponectin supplementation, fed on an HFD (high-fat diet) to derive insight into the mechanisms and consequences of insulin resistance. Hepatic lipid...

View article titled, Metabolomic profiling in liver of adiponectin-knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action

Includes: Supplementary data

Articles

Regulation of IGFBP-2 expression during fasting

Hye Suk Kang, Mi-Young Kim, Seung-Jae Kim, Jae-Ho Lee, Yong-Deuk Kim, Young-Kyo Seo, Jae-Hoon Bae, Goo-Taeg Oh, Dae-Kyu Song, Yong-Ho Ahn, Seung-Soon Im

Biochem J (2015) 467 (3): 453–460.

https://doi.org/10.1042/BJ20141248

Published: 17 April 2015

... of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In the present study, we demonstrated the transcriptional regulation of the Igfbp-2 gene by peroxisome-proliferator-activated receptor (PPAR) α in the liver. During...

View article titled, Regulation of IGFBP-2 expression during fasting

Articles

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

Colin J. Henderson, Lesley A. McLaughlin, Maria Osuna-Cabello, Malcolm Taylor, Ian Gilbert, Aileen W. McLaren, C. Roland Wolf

Biochem J (2015) 465 (3): 479–488.

https://doi.org/10.1042/BJ20140582

Published: 22 January 2015

... the endogenous Cyp1a1 gene promoter; this line was then crossed on to a floxed POR mouse. A 40 mg/kg dose of the Cyp1a1 inducer 3-methylcholanthrene (3MC) eliminated POR expression in both liver and small intestine, whereas treatment at 4 mg/kg led to a more targeted deletion in the liver. Using this approach...

View article titled, Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

Includes: Supplementary data

Articles

Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2)

Hao Liu, Junjie Yu, Tingting Xia, Yuzhong Xiao, Qian Zhang, Bin Liu, Yajie Guo, Jiali Deng, Yalan Deng, Shanghai Chen, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Feifan Guo

Biochem J (2014) 464 (2): 281–289.

https://doi.org/10.1042/BJ20141005

Published: 14 November 2014

... (serum- and glucocorticoid-regulated kinase 1) have been identified, a direct effect of SGK1 on insulin sensitivity has not been previously reported. In the present study, we generated liver-specific SGK1-knockout mice and found that these mice developed glucose intolerance and insulin resistance. We...

View article titled, Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2)

Includes: Supplementary data

Articles

Mitochondrial–nuclear genome interactions in non-alcoholic fatty liver disease in mice

Angela M. Betancourt, Adrienne L. King, Jessica L. Fetterman, Telisha Millender-Swain, Rachel D. Finley, Claudia R. Oliva, David R. Crowe, Scott W. Ballinger, Shannon M. Bailey

Biochem J (2014) 461 (2): 223–232.

https://doi.org/10.1042/BJ20131433

Published: 26 June 2014

...Angela M. Betancourt; Adrienne L. King; Jessica L. Fetterman; Telisha Millender-Swain; Rachel D. Finley; Claudia R. Oliva; David R. Crowe; Scott W. Ballinger; Shannon M. Bailey NAFLD (non-alcoholic fatty liver disease) involves significant changes in liver metabolism characterized by oxidative...

View article titled, Mitochondrial–nuclear genome interactions in non-alcoholic fatty liver disease in mice

Includes: Supplementary data

Articles

Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity

Kate M. Dudek, Laura Suter, Veerle M. Darras, Emma L. Marczylo, Timothy W. Gant

Biochem J (2013) 453 (1): 71–82.

https://doi.org/10.1042/BJ20130049

Published: 13 June 2013

...Kate M. Dudek; Laura Suter; Veerle M. Darras; Emma L. Marczylo; Timothy W. Gant Recent work has demonstrated the importance of post-transcriptional gene regulation in toxic responses. In the present study, we used two rat models to investigate mRNA translation in the liver following xenobiotic...

View article titled, Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity

Includes: Supplementary data

Articles

Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia

Victor A. Zammit

Biochem J (2013) 451 (1): 1–12.

https://doi.org/10.1042/BJ20121689

Published: 14 March 2013

...Victor A. Zammit The liver regulates both glycaemia and triglyceridaemia. Hyperglycaemia and hypertriglyceridaemia are both characteristic of (pre)diabetes. Recent observations on the specialised role of DGAT2 (diacylglycerol acyltransferase 2) in catalysing the de novo synthesis...

View article titled, Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia

Articles

AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

Hong Yu Wang, Serge Ducommun, Chao Quan, Bingxian Xie, Min Li, David H. Wasserman, Kei Sakamoto, Carol Mackintosh, Shuai Chen

Biochem J (2013) 449 (2): 479–489.

https://doi.org/10.1042/BJ20120702

Published: 14 December 2012

... tissue and soleus muscle, low in EDL (extensor digitorum longus) muscle and detectable in liver only after enrichment. Despite having lower blood glucose levels under both fasted and random-fed conditions, the AS160-knockout mice exhibited insulin resistance in both muscle and liver in a euglycaemic...

View article titled, AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

Includes: Supplementary data

Articles

Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice

Nam Ho Jeoung, Yasmeen Rahimi, Pengfei Wu, W. N. Paul Lee, Robert A. Harris

Biochem J (2012) 443 (3): 829–839.

https://doi.org/10.1042/BJ20112197

Published: 16 April 2012

... 2012 glucose heart hypothermia ketoacidosis liver pyruvate dehydrogenase complex (PDH complex) pyruvate dehydrogenase kinase (PDHK) skeletal muscle The PDH complex (pyruvate dehydrogenase complex) plays a pivotal role in controlling the concentrations of glucose in the fed...

View article titled, Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice

Articles

Serum copper as a novel biomarker for resistance to thyroid hormone

Jens Mittag, Thomas Behrends, Kristina Nordström, Joao Anselmo, Björn Vennström, Lutz Schomburg

Biochem J (2012) 443 (1): 103–109.

https://doi.org/10.1042/BJ20111817

Published: 14 March 2012

... 2012 Biochemical Society 2012 copper kidney liver resistance to thyroid hormone (RTH) thyroid hormone receptor To investigate the underlying molecular mechanism, we analysed changes in gene expression induced by T 3 treatment in the liver and kidney. Real-time PCR analyses...

View article titled, Serum copper as a novel biomarker for resistance to thyroid hormone

Includes: Supplementary data

Articles

Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation

Ana Luísa De Sousa-Coelho, Pedro F. Marrero, Diego Haro

Biochem J (2012) 443 (1): 165–171.

https://doi.org/10.1042/BJ20111748

Published: 14 March 2012

... in liver and its expression induces a metabolic state that mimics long-term fasting. Thus FGF21 is critical for the induction of hepatic fat oxidation, ketogenesis and gluconeogenesis, metabolic processes which are essential for the adaptive metabolic response to starvation. In the present study, we have...

View article titled, Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation

Articles

Homo- and hetero-dimeric architecture of the human liver Na + -dependent taurocholate co-transporting protein

Ingrid T. G. W. Bijsmans, Rianne A. M. Bouwmeester, Joachim Geyer, Klaas Nico Faber, Stan F. J. van de Graaf

Biochem J (2012) 441 (3): 1007–1016.

https://doi.org/10.1042/BJ20111234

Published: 16 January 2012

... the presence of NTCP dimers in rat liver membranes and U2OS cells stably expressing NTCP. Co-immunoprecipitation of tagged NTCP proteins revealed a physical interaction between subunits. The C-terminus of NTCP was not required for subunit interaction, but was essential for exit from the ER (endoplasmic...

View article titled, Homo- and hetero-dimeric architecture of the human liver Na + -dependent taurocholate co-transporting protein

Includes: Supplementary data

Articles

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

Paul J. Meakin, Alex J. Harper, D. Lee Hamilton, Jennifer Gallagher, Alison D. McNeilly, Laura A. Burgess, Lobke M. Vaanholt, Kirsten A. Bannon, Judy Latcham, Ishrut Hussain, John R. Speakman, David R. Howlett, Michael L.J. Ashford

Biochem J (2012) 441 (1): 285–296.

https://doi.org/10.1042/BJ20110512

Published: 14 December 2011

...-type littermates. BACE1 −/− mice are also protected from diet-induced obesity. BACE1-deficient skeletal muscle and liver exhibit improved insulin sensitivity. In a skeletal muscle cell line, BACE1 inhibition increased glucose uptake and enhanced insulin sensitivity. The loss of BACE1 is associated...

View article titled, Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

Includes: Supplementary data

Articles

Receptor-isoform-selective insulin analogues give tissue-preferential effects

Sara G. Vienberg, Stephan D. Bouman, Heidi Sørensen, Carsten E. Stidsen, Thomas Kjeldsen, Tine Glendorf, Anders R. Sørensen, Grith S. Olsen, Birgitte Andersen, Erica Nishimura

Biochem J (2011) 440 (3): 301–308.

https://doi.org/10.1042/BJ20110880

Published: 28 November 2011

...), are tissue-dependent. Therefore we have developed insulin analogues with different binding affinities for the two isoforms to test whether tissue-preferential biological effects can be attained. In rats and mice, IR-B is the most prominent isoform in the liver (>95%) and fat (>90%), whereas in muscles...

View article titled, Receptor-isoform-selective insulin analogues give tissue-preferential effects

Articles

Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1

Alex Odermatt, Thierry Da Cunha, Carlos A. Penno, Charlie Chandsawangbhuwana, Christian Reichert, Armin Wolf, Min Dong, Michael E. Baker

Biochem J (2011) 436 (3): 621–629.

https://doi.org/10.1042/BJ20110022

Published: 27 May 2011

...Alex Odermatt; Thierry Da Cunha; Carlos A. Penno; Charlie Chandsawangbhuwana; Christian Reichert; Armin Wolf; Min Dong; Michael E. Baker The oxidized bile acid 7-oxoLCA (7-oxolithocholic acid), formed primarily by gut micro-organisms, is reduced in human liver to CDCA (chenodeoxycholic acid...

View article titled, Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1

Includes: Supplementary data

Articles

Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response

Noam Bourquard, Carey J. Ng, Srinivasa T. Reddy

Biochem J (2011) 436 (1): 91–100.

https://doi.org/10.1042/BJ20101891

Published: 27 April 2011

... Journal compilation © 2011 Biochemical Society 2011 apolipoprotein E (apoE) insulin receptor substrate-1 (IRS-1) liver macrophage paraoxonase paraoxonase 2 (PON2) Atherosclerosis and diabetes are tightly intertwined disorders linked by extensive epidemiological and clinical data [ 1...

View article titled, Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response

Includes: Supplementary data

Articles

Endocytosis of hyaluronidase-1 by the liver

Marie-Christine Gasingirwa, Jacqueline Thirion, Jeannine Mertens-Strijthagen, Simone Wattiaux-De Coninck, Bruno Flamion, Robert Wattiaux, Michel Jadot

Biochem J (2010) 430 (2): 305–313.

https://doi.org/10.1042/BJ20100711

Published: 13 August 2010

... enzyme. To test this proposal we have investigated the uptake and intracellular distribution of rhHyal-1 (recombinant human Hyal-1) by mouse liver, making use of centrifugation methods. Experiments were performed on wild-type mice injected with 125 I-labelled rhHyal-1 and on Hyal-1 −/− mice injected...

View article titled, Endocytosis of hyaluronidase-1 by the liver

Articles

Modulation of the hepatic malonyl-CoA–carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids

Marie Akkaoui, Isabelle Cohen, Catherine Esnous, Véronique Lenoir, Martin Sournac, Jean Girard, Carina Prip-Buus

Biochem J (2009) 420 (3): 429–438.

https://doi.org/10.1042/BJ20081932

Published: 27 May 2009

...Marie Akkaoui; Isabelle Cohen; Catherine Esnous; Véronique Lenoir; Martin Sournac; Jean Girard; Carina Prip-Buus Liver mitochondrial β-oxidation of LCFAs (long-chain fatty acids) is tightly regulated through inhibition of CPT1A (carnitine palmitoyltransferase 1A) by malonyl-CoA, an intermediate...

View article titled, Modulation of the hepatic malonyl-CoA–carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids

Includes: Supplementary data

Articles

High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo

Sudheer K. Mantena, Denty Paul Vaughn, Jr, Kelly K. Andringa, Heather B. Eccleston, Adrienne L. King, Gary A. Abrams, Jeannette E. Doeller, David W. Kraus, Victor M. Darley-Usmar, Shannon M. Bailey

Biochem J (2009) 417 (1): 183–193.

https://doi.org/10.1042/BJ20080868

Published: 12 December 2008

...Sudheer K. Mantena; Denty Paul Vaughn, Jr; Kelly K. Andringa; Heather B. Eccleston; Adrienne L. King; Gary A. Abrams; Jeannette E. Doeller; David W. Kraus; Victor M. Darley-Usmar; Shannon M. Bailey NAFLD (non-alcoholic fatty liver disease), associated with obesity and the cardiometabolic syndrome...

View article titled, High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo

Articles

A functional link between housekeeping selenoproteins and phase II enzymes

Aniruddha Sengupta, Bradley A. Carlson, James A. Weaver, Sergey V. Novoselov, Dmitri E. Fomenko, Vadim N. Gladyshev, Dolph L. Hatfield

Biochem J (2008) 413 (1): 151–161.

https://doi.org/10.1042/BJ20080277

Published: 12 June 2008

... synthesis is dependent on Sec tRNA and the expression of this class of proteins can be modulated by altering Sec tRNA expression. The gene encoding Sec tRNA ( Trsp ) is a single-copy gene and its targeted removal in liver demonstrated that selenoproteins are essential for proper function wherein...

View article titled, A functional link between housekeeping selenoproteins and phase II enzymes

Articles

Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP

Nikolas G. Tsatsos, Michael N. Davies, Brennon L. O'callaghan, Howard C. Towle

Biochem J (2008) 411 (2): 261–270.

https://doi.org/10.1042/BJ20071156

Published: 27 March 2008

...Nikolas G. Tsatsos; Michael N. Davies; Brennon L. O'callaghan; Howard C. Towle In the liver, induction of genes encoding enzymes involved in de novo lipogenesis occurs in response to increased glucose metabolism. ChREBP (carbohydrate-response-element-binding protein) is a basic helix–loop–helix...

View article titled, Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP

Includes: Supplementary data

Articles

The interaction of liver fatty-acid-binding protein (FABP) with anionic phospholipid vesicles: is there extended phospholipid anchorage under these conditions?

Robert M. Hagan, Jane Worner-Gibbs, David C. Wilton

Biochem J (2008) 410 (1): 123–129.

https://doi.org/10.1042/BJ20071109

Published: 29 January 2008

...Robert M. Hagan; Jane Worner-Gibbs; David C. Wilton Liver FABP (fatty-acid-binding protein) binds a variety of non-polar anionic ligands including fatty acids, fatty acyl CoAs, lysophospholipids and bile acids. Liver FABP is also able to bind to anionic phospholipid vesicles under conditions of low...

View article titled, The interaction of liver fatty-acid-binding protein (FABP) with anionic phospholipid vesicles: is there extended phospholipid anchorage under these conditions?

Articles

Stem cells in the adult pancreas and liver

Zoë D. Burke, Shifaan Thowfeequ, Macarena Peran, David Tosh

Biochem J (2007) 404 (2): 169–178.

https://doi.org/10.1042/BJ20070167

Published: 14 May 2007

... (which means treating diseases with the body's own cells). Potential targets for cellular therapy include diabetes and liver failure. However, in order for stem cells to be clinically useful, we must learn to identify them and to regulate their differentiation. We will use the intestine as a classical...

View article titled, Stem cells in the adult pancreas and liver

Articles

Lysosomes and Fas-mediated liver cell death

Robert Wattiaux, Simone Wattiaux-De Coninck, Jacqueline Thirion, Mańe-Christine Gasingirwa, Michel Jadot

Biochem J (2007) 403 (1): 89–95.

https://doi.org/10.1042/BJ20061738

Published: 13 March 2007

... then contribute to the permeabilization of the outer mitochondrial membrane; they could also activate effector caspases. The present study aims at testing whether the membrane of liver lysosomes is disrupted during Fas-mediated cell death of hepatocytes in vivo , a process implicated in several liver pathologies...

View article titled, Lysosomes and Fas-mediated liver cell death

Articles

Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c

Margarita Teran-Garcia, Aaron W. Adamson, Gang Yu, Caterina Rufo, Gabriela Suchankova, Thomas D. Dreesen, Michael Tekle, Steven D. Clarke, Thomas W. Gettys

Biochem J (2007) 402 (3): 591–600.

https://doi.org/10.1042/BJ20061722

Published: 26 February 2007

...-regulatory-element binding-protein (SREBP) polyunsaturated fatty acids (PUFA) liver We have demonstrated previously [ 15 ] that the Fasn gene contains two PUFA response regions and the proximal PUFA-RR FASN accounted for the majority of the PUFA response. A better understanding of the key...

View article titled, Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c

Articles

Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor

Franck Hansmannel, Sylvie Mordier, Patrick B. Iynedjian

Biochem J (2006) 399 (2): 275–283.

https://doi.org/10.1042/BJ20060811

Published: 27 September 2006

...Franck Hansmannel; Sylvie Mordier; Patrick B. Iynedjian The transcription activator SREBP-1c (sterol-regulatory-element-binding protein-1c) is induced by insulin in the liver and is considered a master regulator of lipogenic genes such as FASN (fatty acid synthase). The question of whether SREBP-1c...

View article titled, Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor

Articles

Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells

Amalia Fernández-Martínez, Belén Mollá, Rafael Mayoral, Lisardo Boscá, Marta Casado, Paloma Martín-Sanz

Biochem J (2006) 398 (3): 371–380.

https://doi.org/10.1042/BJ20060780

Published: 29 August 2006

...Amalia Fernández-Martínez; Belén Mollá; Rafael Mayoral; Lisardo Boscá; Marta Casado; Paloma Martín-Sanz We have investigated the mechanism of COX-2 (cyclo-oxygenase 2)-dependent inhibition of apoptosis in liver, a key pathway underlying proliferative actions of COX-2 in liver cancers, cirrhosis...

View article titled, Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells

Articles

Role of Nrf2 in the regulation of the Mrp2 ( ABCC2 ) gene

Valeska Vollrath, Ana M. Wielandt, Mirentxu Iruretagoyena, Jose Chianale

Biochem J (2006) 395 (3): 599–609.

https://doi.org/10.1042/BJ20051518

Published: 11 April 2006

... with these enzymes, we hypothesized that the regulation of Mrp2 gene expression is also dependent on Nrf2. Using BHA (butylated hydroxyanisole), which is a classical activator of the ARE–Nrf2 pathway, we observed an increase in the transcriptional activity of Mrp2 , GCLC and Gsta1 / Gsta2 genes in the mouse liver...

View article titled, Role of Nrf2 in the regulation of the Mrp2 ( ABCC2 ) gene

Articles

Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine–homocysteine S -methyltransferase

Janet D. Sparks, Heidi L. Collins, Doru V. Chirieac, Joanne Cianci, Jenny Jokinen, Mark P. Sowden, Chad A. Galloway, Charles E. Sparks

Biochem J (2006) 395 (2): 363–371.

https://doi.org/10.1042/BJ20051966

Published: 28 March 2006

... and non-esterified fatty acid levels. Betaine plus Met restriction induced hepatic BHMT 4-fold and ApoB mRNA 3-fold compared with Met restriction alone. No changes in percentage of edited ApoB mRNA were observed on the test diets. An increase in liver ApoB mRNA correlated with an 82% and 46% increase...

View article titled, Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine–homocysteine S -methyltransferase

Articles

Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2 H and 13 C NMR

Natasha Hausler, Jeffrey Browning, Matthew Merritt, Charles Storey, Angela Milde, F. Mark H. Jeffrey, A. Dean Sherry, Craig R. Malloy, Shawn C. Burgess

Biochem J (2006) 394 (2): 465–473.

https://doi.org/10.1042/BJ20051174

Published: 10 February 2006

... state and insulin. In livers isolated from fed mice and perfused with a mixture of substrates including lactate/pyruvate (10:1, w/w), hepatic glucose production had substantial contributions from glycogen, PEP (phosphoenolpyruvate) and glycerol. Inversion of the lactate/pyruvate ratio (1:10, w/w...

View article titled, Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2 H and 13 C NMR

Articles

Localization of a portion of the liver isoform of fatty-acid-binding protein (L-FABP) to peroxisomes

Vasily D. Antonenkov, Raija T. Sormunen, Steffen Ohlmeier, Leen Amery, Marc Fransen, Guy P. Mannaerts, J. Kalervo Hiltunen

Biochem J (2006) 394 (2): 475–484.

https://doi.org/10.1042/BJ20051058

Published: 10 February 2006

...Vasily D. Antonenkov; Raija T. Sormunen; Steffen Ohlmeier; Leen Amery; Marc Fransen; Guy P. Mannaerts; J. Kalervo Hiltunen The liver isoform of fatty-acid-binding protein (L-FABP) facilitates the cellular uptake, transport and metabolism of fatty acids and is also involved in the regulation of gene...

View article titled, Localization of a portion of the liver isoform of fatty-acid-binding protein (L-FABP) to peroxisomes

Articles

Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin–26 S proteasome system in the living rat

John E. Dominy, Jr, Lawrence L. Hirschberger, Relicardo M. Coloso, Martha H. Stipanuk

Biochem J (2006) 394 (1): 267–273.

https://doi.org/10.1042/BJ20051510

Published: 27 January 2006

...John E. Dominy, Jr; Lawrence L. Hirschberger; Relicardo M. Coloso; Martha H. Stipanuk Mammalian metabolism of ingested cysteine is conducted principally within the liver. The liver tightly regulates its intracellular cysteine pool to keep levels high enough to meet the many catabolic and anabolic...

View article titled, Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin–26 S proteasome system in the living rat

Articles

In yeast, loss of Hog1 leads to osmosensitivity of autophagy

Tanja Prick, Michael Thumm, Karl Köhrer, Dieter Häussinger, Stephan Vom Dahl

Biochem J (2006) 394 (1): 153–161.

https://doi.org/10.1042/BJ20051243

Published: 27 January 2006

...Tanja Prick; Michael Thumm; Karl Köhrer; Dieter Häussinger; Stephan Vom Dahl In mammalian liver, proteolysis is regulated by the cellular hydration state in a microtubule- and p38 MAPK (p38 mitogen-activated protein kinase)-dependent fashion. Osmosensing in liver cells towards proteolysis...

View article titled, In yeast, loss of Hog1 leads to osmosensitivity of autophagy

Articles

Liver fatty-acid-binding protein (L-FABP) gene ablation alters liver bile acid metabolism in male mice

Gregory G. Martin, Barbara P. Atshaves, Avery L. Mcintosh, John T. Mackie, Ann B. Kier, Friedhelm Schroeder

Biochem J (2005) 391 (3): 549–560.

https://doi.org/10.1042/BJ20050296

Published: 25 October 2005

...-binding proteins. Male L-FABP (liver fatty-acid-binding protein) gene-ablated mice were used to determine a role for L-FABP, the major liver bile acid-binding protein, in bile acid and biliary cholesterol metabolism. First, in control-fed mice L-FABP gene ablation alone increased the total bile acid pool...

View article titled, Liver fatty-acid-binding protein (L-FABP) gene ablation alters liver bile acid metabolism in male mice

Articles

Defective insulin receptor activation and altered lipid rafts in Niemann–Pick type C disease hepatocytes

Saara Vainio, Igor Bykov, Martin Hermansson, Eija Jokitalo, Pentti Somerharju, Elina Ikonen

Biochem J (2005) 391 (3): 465–472.

https://doi.org/10.1042/BJ20050460

Published: 25 October 2005

... lipid raft liver Niemann–Pick type C sphingolipidosis Niemann–Pick type C (NPC) disease is an autosomal, recessively inherited lysosomal storage disorder, characterized by endo-lysosomal accumulation of unesterified cholesterol and sphingolipids [ 1 ]. The disease is caused by mutations...

View article titled, Defective insulin receptor activation and altered lipid rafts in Niemann–Pick type C disease hepatocytes

Articles

Immunodetection of the expression of microsomal proteins encoded by the glucose 6-phosphate transporter gene

Silvia SENESI, Paola MARCOLONGO, Tamas KARDON, Giovanna BUCCI, Andrey SUKHODUB, Ann BURCHELL, Angelo BENEDETTI, Rosella FULCERI

Biochem J (2005) 389 (1): 57–62.

https://doi.org/10.1042/BJ20050213

Published: 21 June 2005

...Silvia SENESI; Paola MARCOLONGO; Tamas KARDON; Giovanna BUCCI; Andrey SUKHODUB; Ann BURCHELL; Angelo BENEDETTI; Rosella FULCERI Glucose 6-phosphate transport has been well characterized in liver microsomes. The transport is required for the functioning of the glucose-6-phosphatase enzyme...

View article titled, Immunodetection of the expression of microsomal proteins encoded by the glucose 6-phosphate transporter gene

Articles

Pregnenolone-16α-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms

Carylyn J. MAREK, Steven J. TUCKER, Dimitrios K. KONSTANTINOU, Lucy J. ELRICK, Dee HAEFNER, Charalambos SIGALAS, Graeme I. MURRAY, Bryan GOODWIN, Matthew C. WRIGHT

Biochem J (2005) 387 (3): 601–608.

https://doi.org/10.1042/BJ20041598

Published: 26 April 2005

...Carylyn J. MAREK; Steven J. TUCKER; Dimitrios K. KONSTANTINOU; Lucy J. ELRICK; Dee HAEFNER; Charalambos SIGALAS; Graeme I. MURRAY; Bryan GOODWIN; Matthew C. WRIGHT The effect of liver growth stimulation [using the rodent PXR (pregnane X receptor) activator PCN (pregnenolone-16α-carbonitrile...

View article titled, Pregnenolone-16α-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms

Includes: Supplementary data

Articles

CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor α ( PPAR α) in mice

Katsutaka OISHI, Hidenori SHIRAI, Norio ISHIDA

Biochem J (2005) 386 (3): 575–581.

https://doi.org/10.1042/BJ20041150

Published: 08 March 2005

... that circadian expression of mouse PPARα mRNA requires the basic helix–loop–helix PAS (Per-Arnt-Sim) protein CLOCK, a core component of the negative-feedback loop that drives circadian oscillators in mammals. The circadian expression of PPARα mRNA was abolished in the liver of homozygous Clock mutant mice. Using...

View article titled, CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor α ( PPAR α) in mice

Includes: Supplementary data

Articles

On the mechanism of the increase in cardiolipin biosynthesis and resynthesis in hepatocytes during rat liver regeneration

Jennifer WEBSTER, Jenny Y. JIANG, Biao LU, Fred Y. XU, William A. TAYLOR, Mathew MYMIN, Manna ZHANG, Gerald Y. MINUK, Grant M. HATCH

Biochem J (2005) 386 (1): 137–143.

https://doi.org/10.1042/BJ20040655

Published: 08 February 2005

... resynthesis in isolated rat liver hepatocytes prepared 48 h subsequent to two-thirds PHx (partial hepatectomy). The pool size of CL and its de novo biosynthesis from [1,3- 3 H]glycerol were increased 3.3-fold ( P <0.05) and 3.1-fold ( P <0.05) respectively in hepatocytes prepared from PHx rats compared...

View article titled, On the mechanism of the increase in cardiolipin biosynthesis and resynthesis in hepatocytes during rat liver regeneration

Articles

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

Alfonso MORA, Christopher LIPINA, François TRONCHE, Calum SUTHERLAND, Dario R. ALESSI

Biochem J (2005) 385 (3): 639–648.

https://doi.org/10.1042/BJ20041782

Published: 24 January 2005

...Alfonso MORA; Christopher LIPINA; François TRONCHE; Calum SUTHERLAND; Dario R. ALESSI The liver plays an important role in insulin-regulated glucose homoeostasis. To study the function of the PDK1 (3-phosphoinositide-dependent protein kinase-1) signalling pathway in mediating insulin's actions...

View article titled, Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

Articles

Tumour necrosis factor α decreases glucose-6-phosphatase gene expression by activation of nuclear factor κB

Rolf GREMPLER, Anne KIENITZ, Torsten WERNER, Marion MEYER, Andreas BARTHEL, Fabienne AILETT, Calum SUTHERLAND, Reinhard WALTHER, Dieter SCHMOLL

Biochem J (2004) 382 (2): 471–479.

https://doi.org/10.1042/BJ20040160

Published: 24 August 2004

... glucose-6-phosphatase insulin liver sepsis G6Pase (glucose-6-phosphatase) catalyses the final step of the metabolic pathways that are central to hepatic glucose production, i.e. gluconeogenesis and glycogen breakdown [ 1 ]. Thus G6Pase has an important role in blood glucose homoeostasis. G6Pase...

View article titled, Tumour necrosis factor α decreases glucose-6-phosphatase gene expression by activation of nuclear factor κB

Articles

Kinetics and control of oxidative phosphorylation in rat liver mitochondria after dexamethasone treatment

Damien ROUSSEL, Jean-François DUMAS, Gilles SIMARD, Yves MALTHIÈRY, Patrick RITZ

Biochem J (2004) 382 (2): 491–499.

https://doi.org/10.1042/BJ20040696

Published: 24 August 2004

...Damien ROUSSEL; Jean-François DUMAS; Gilles SIMARD; Yves MALTHIÈRY; Patrick RITZ The present investigation was undertaken in order to evaluate the contributions of ATP synthesis and proton leak reactions to the rate of active respiration of liver mitochondria, which is altered following...

View article titled, Kinetics and control of oxidative phosphorylation in rat liver mitochondria after dexamethasone treatment

Articles

Regulation of Cyp2a5 transcription in mouse primary hepatocytes: roles of hepatocyte nuclear factor 4 and nuclear factor I

Johanna ULVILA, Satu ARPIAINEN, Olavi PELKONEN, Kaoru AIDA, Tatsuya SUEYOSHI, Masahiko NEGISHI, Jukka HAKKOLA

Biochem J (2004) 381 (3): 887–894.

https://doi.org/10.1042/BJ20040387

Published: 27 July 2004

...Johanna ULVILA; Satu ARPIAINEN; Olavi PELKONEN; Kaoru AIDA; Tatsuya SUEYOSHI; Masahiko NEGISHI; Jukka HAKKOLA The cytochrome P4502a5 ( Cyp2a5 ) gene is expressed principally in liver and olfactory mucosa. In the present study, the transcriptional mechanisms of hepatocyte-specific expression...

View article titled, Regulation of Cyp2a5 transcription in mouse primary hepatocytes: roles of hepatocyte nuclear factor 4 and nuclear factor I

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