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Keywords: liver X receptor
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Biochem J (2016) 473 (7): 899–910.
Published: 29 March 2016
... (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP), mono-ADP-ribosylates and positively regulates liver X receptor α (LXRα) and LXRβ activity. Overexpression of TIPARP enhanced LXR-reporter gene activity. TIPARP knockdown or deletion reduced LXR regulated target gene expression levels in HepG2 cells...
Includes: Supplementary data
Biochem J (2014) 459 (2): e1–e3.
Published: 28 March 2014
...Nicolas Venteclef; Pascal Ferré Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Accumulation of cholesterol and its intermediates, such as oxysterols, lead to activation of the nuclear receptors LXRs (liver X receptors). LXR is an important...
Biochem J (2012) 447 (2): 301–311.
Published: 26 September 2012
... reductase and the synthesis of cholesterol in cardiomyocytes, their main target cells. Surprisingly this did not promote intracellular cholesterol accumulation. The glycosides activated the liver X receptor transcription factor and increased the expression of ABCA1 (ATP-binding cassette protein A1...
Includes: Supplementary data
Biochem J (2003) 376 (2): 351–360.
Published: 01 December 2003
... investigated the regulation of sPLA 2 gene expression in rat aortic SMCs by oxysterols. We found that oxysterol ligands that bind to the LXR (liver X receptor), including 25-HC (25-hydroxycholesterol) and 22( R )-HC, cause the accumulation of sPLA 2 mRNA and an increased enzyme activity. Transient transfection...
Biochem J (2002) 368 (3): 855–864.
Published: 15 December 2002
... expression was not altered. Liver X receptor (LXR) activation by T0901317 increased gene expression of SREBP-1c, SREBP-1a, FAS and acetyl-CoA carboxylase without altering SREBP-2. 20:5, but not 18:1, prevented the full expression of SREBP-1c mRNA by T0901317. T0901317 increased SREBP-1 mass without altering...